Nantes University Hospital

This study tests whether the drug belatacept can protect kidney function in heart transplant patients who are at high risk of chronic kidney disease. About 25 adults who had a heart transplant 3 months ago and have declining kidney function will receive belatacept along with redu…

This study tests a newer pacing method called left bundle branch area pacing against standard pacing in people who need a pacemaker after a TAVI heart valve procedure. About 266 participants will be randomly assigned to one of the two pacing types. The goal is to see if the newer…

This study tests whether amoxicillin alone is as effective as the broader-spectrum amoxicillin/clavulanate for treating community-acquired pneumonia in adults aged 65 and older who are hospitalized but not in intensive care. The goal is to see if using a narrower antibiotic can r…

This early-phase study tests whether a patient's own immune cells, grown in a lab, can be safely infused to help the body accept a new kidney without strong anti-rejection drugs. Nine living-donor kidney recipients will receive increasing doses of these 'Eight Treg' cells. The ma…

This study tests whether a single drug (cyclophosphamide) given after a stem cell transplant can prevent graft-versus-host disease (GVHD) as well as standard multiple-drug approaches. About 82 adults with blood cancers will receive one of two conditioning regimens before transpla…

This study tests whether romiplostim, a drug that boosts platelet production, can safely increase platelet counts in patients with low platelets (thrombocytopenia) before they undergo heart surgery. About 136 adults scheduled for cardiac surgery will receive either romiplostim or…

This study tests a new radioactive drug called [177Lu]Lu-PentixaTher for people with acute leukemia that has come back or not responded to other treatments. The drug targets a protein (CXCR4) on leukemia cells to deliver radiation directly to the cancer. The trial will include up…

This study tests whether the antifungal drug posaconazole can better prevent serious fungal infections in blood cancer patients who have received a stem cell transplant. These patients are at high risk because their immune systems are weak. The study will check drug levels in the…

This study compares two chemotherapy regimens given before a stem cell transplant in 302 adults with AML in remission. The goal is to see if a stronger drug (clofarabine) can improve survival at 2 years compared to the standard drug (fludarabine). Participants must be at least 18…

This study tests whether adding a cognitive remediation program (brain training) to standard ADHD medication (methylphenidate) helps adults with both ADHD and addiction. About 248 participants will be split into two groups: one gets the brain training, the other a control program…

This study looks at whether it is safe to wait for lab results before giving antibiotics to patients on breathing machines who may have pneumonia. About 686 adults in intensive care will be randomly assigned to get antibiotics right away or only after the infection is confirmed. …

This study tests whether giving the steroid dexamethasone early after a severe burn can lower the risk of major complications like lung or kidney failure and death. It involves 478 adults with burns covering at least 20% of their body who are on a breathing machine. The goal is t…

This study tests whether giving a concentrated saltwater solution early after a traumatic brain injury can help patients survive and regain independence. About 760 adults with severe head injuries will receive either the saltwater infusion or standard care. The goal is to see if …

This study tests a new treatment for people with blood cancer who have had a stem cell transplant. The treatment uses specially designed immune cells (T cells) that can recognize and kill cancer cells that share a specific marker (HLA-DPB1*04:01). The goal is to see if this cell …

This study tests a special PET/CT scan that uses a radioactive tracer to see if it can find liver cancer (HCC) more accurately than standard scans. About 40 adults with newly diagnosed or suspected returning liver cancer will take part. The goal is to improve how doctors detect a…

This study tests a new brain monitoring tool for babies and children under 2 in intensive care. Many seizures are invisible to caregivers, and current monitors miss up to 36% of them. The new approach combines a simplified EEG with expert review to improve detection and help doct…

This study tests a new way to do PET scans that uses two different tracers at the same time to get more detailed images of liver cancer and pancreatic tumors. Researchers want to see if this method is safe and finds more tumors than standard single-tracer scans. About 28 adults w…

This study looks at whether emergency doctors can use a quick bedside ultrasound to rule out a small bowel obstruction in patients with belly pain, vomiting, and other symptoms. About 667 adults with a low or moderate chance of blockage will get an ultrasound first, then a CT sca…

This study compares two dental imaging methods—standard panoramic X-ray and 3D cone beam CT—in 170 people hospitalized for infective endocarditis, a rare but life-threatening heart valve infection. The goal is to see if the 3D scan detects more hidden mouth infections that might …

This study tests a new radioactive tracer called 89Zr-TLX250 to see if it can better detect liver cancer, bile duct cancer, and certain neuroendocrine tumors on PET-CT scans. The tracer targets a protein (CAIX) found on these cancer cells. Researchers will compare the number and …

This study aims to see if a simple finger-prick (capillary) blood test can accurately measure carbon monoxide levels compared to standard blood draws from a vein or artery. Researchers will enroll 120 adults in emergency rooms who show symptoms like headache or nausea and have a …

This study tests a new, playful program for children aged 3 to 6 who need an MRI. The program uses four fun modules themed around the ocean to help kids practice lying still, handling loud noises, and being in a tunnel. The goal is to see if this preparation helps children comple…

This study tests whether a diet low in polyamines (natural compounds found in many foods) can reduce pain after major abdominal surgery. About 278 adults will follow this diet for a week before and after surgery. The goal is to see if it lowers pain scores and the need for pain m…

This study compares two ways of managing early rotator cuff tendinopathy (shoulder pain). One group gets monthly check-ups for 3 months to adjust treatment quickly, while the other group has only one follow-up at 3 months. The goal is to see if closer monitoring leads to faster p…

This study looks at whether low-risk pregnant women can safely start labor at home instead of staying in the hospital. About 258 women will be randomly assigned to either go home or stay in the hospital after a balloon catheter is placed to start labor. The goal is to see if goin…

This study tests whether injecting botulinum toxin (Botox) into the uterine muscle can reduce severe period pain in women who haven't gotten relief from standard treatments like painkillers or hormones. About 222 adult women with severe primary dysmenorrhea will receive either Bo…

This study tests whether a high-dose capsaicin patch (the stuff that makes chili peppers hot) can relieve chronic tailbone pain. About 188 adults with pain lasting over 3 months will receive either the active patch or a low-dose placebo patch. The main goal is to see if more peop…

This study looks at two different exercise programs done before ACL surgery to see which one helps people regain knee strength and muscle size more effectively. About 84 adults with a first-time ACL injury will take part in a 9-week program. One group does focused strength traini…

This study tests three different sleep medicines (propofol, ketamine, and a mix of both) to find which one works best for placing a breathing tube quickly and safely in people having emergency surgery. About 1,200 adults at risk of stomach contents entering the lungs will take pa…

This study looks at 30 adults with a kidney condition called idiopathic nephrotic syndrome to see if changes in gut and urine bacteria are linked to immune system problems. Researchers will collect blood, stool, and urine samples to analyze bacteria and immune cells. The goal is …

This study tests whether a personalized program of nutrition and physical therapy, started early in the ICU and continued at home, helps people recover better after being on a breathing machine and heart-support medications. About 830 adults will be randomly assigned to either us…

This study looks at how well the right side of the heart works with the lungs in people with heart valve problems. Researchers will use a thin tube (catheter) to get precise measurements and compare them to standard imaging tests like echocardiograms. The goal is to see if simple…

This study looks at wastewater from nursing homes to see if it can predict how many residents carry antibiotic-resistant bacteria. Researchers will collect stool samples from 1,600 elderly residents and compare that to bacteria levels in the facility's wastewater. The goal is to …

This study follows over 2,700 people seeking help for behavioral addictions (like gambling or gaming) at a French hospital. Researchers want to learn what factors affect how the addiction changes over time and whether patients stay in treatment. No new treatment is being tested; …

This study tracks 30 adults with asthma to see if daily changes in indoor and outdoor air pollution are linked to asthma attacks. Participants will have sensors placed in their homes to measure pollutants like fine particles and volatile organic compounds. The goal is to better u…

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce emergency hospital visits. About 1,050 residents will take part, and researchers will track how well the screening works and if it leads to better…

This study aims to validate a French version of a questionnaire that measures quality of life in people with primary hyperparathyroidism, a condition that can cause fatigue, bone pain, and mood changes. Researchers will enroll 548 adults, both before and after surgery, to see if …

This study is creating a large group of 465 people with acute hidrosadenitis, a painful skin condition. Researchers will track their health over time, collect blood and urine samples, and use questionnaires to identify different forms of the disease. The goal is to better underst…

This study is gathering information from 80 adults who have both ADHD and an addiction. Researchers will track their symptoms and daily functioning over 12 months while they receive standard care. The goal is to learn more about how these conditions interact, not to test a new tr…

This study looks at whether bariatric surgery can slow or reverse biological aging in people with obesity. Researchers will track 300 adults before and after surgery, measuring changes in biological age, fat cell health, gut bacteria, and daily body rhythms. The goal is to unders…

This study looks at whether certain immune cells, influenced by gut bacteria, can help prevent the body from rejecting a kidney transplant. Researchers will study blood samples from 15 donor-recipient pairs before and after transplant. The goal is to understand how these cells wo…

This study looks at the DNA of 650 infants who died suddenly and unexpectedly, along with their parents. Researchers want to find genetic changes that might raise the risk of Sudden Infant Death Syndrome (SIDS). By understanding these genetic factors, doctors may one day be able …

This study looks at whether a connected watch can track heart rhythm better than usual check-ups in people who develop atrial fibrillation after heart surgery. About 106 adults will either use the watch or get standard care with ECGs at 3, 6, and 12 months. The goal is to see if …

This study aims to understand why multiple sclerosis (MS) is mild for some people but quickly becomes severe for others. Researchers will analyze blood cells from 130 people, including those with aggressive MS, non-aggressive MS, and healthy volunteers. By comparing their genes a…

This study is creating a large collection of medical data and biological samples from 1100 people with brain aneurysms. The goal is to better understand which aneurysms are likely to rupture by looking at genetics, imaging, and patient history. Participants must be adults with a …

This study looks at infants under 6 months old who need heart surgery. During surgery, the thymus gland is often fully removed to help the surgeon reach the heart. The thymus is important for building a strong immune system early in life. Researchers want to see if removing only …

This study is for 80 people with a genetic heart condition called arrhythmogenic cardiomyopathy, which can cause sudden death or heart failure. Researchers want to see if a special PET-MRI scan can detect inflammation in the heart muscle without needing a biopsy. The goal is to b…

This study watches 350 adults who had heart or chest surgery and also had COVID-19 around the time of their operation. Researchers track how well the heart and other organs recover, without giving any new treatment. The goal is to learn from real-world data to improve care for fu…

This study looks at the connection between gut bacteria, body fat changes, and fear of weight gain in women with anorexia nervosa. Researchers will collect stool and blood samples from 60 women admitted for refeeding to identify bacterial patterns and chemical markers. The goal i…

This study follows 450 babies born with serious heart defects to check for developmental delays as early as 6 months old. Researchers want to understand why over half of these children face challenges with learning, behavior, or motor skills. By identifying risk factors early, th…

This study follows 403 adults with primary hyperparathyroidism who are having surgery to remove overactive parathyroid glands. Researchers will check heart health, kidney function, bone strength, and quality of life before surgery and at 6 months, 1 year, 3 years, and 5 years aft…

This study aims to understand why some people with chronic lymphocytic leukemia (CLL) do not respond to a newer type of drug called BTK degraders. Researchers will collect blood, bone marrow, or lymph node samples from 60 patients over 9 years and follow them for 5 years. By stud…

This study looks at 50 organ donors to measure how low oxygen levels drop when their heart stops during a Maastricht III procedure. The goal is to better understand what happens at the moment of cardiac arrest. No treatment is given—it is purely observational.

This study tests whether a remote monitoring platform can help patients avoid readmission after colorectal surgery. About 362 adults will be randomly assigned to either 30 days of home monitoring or standard discharge care. Researchers will track hospital stays, unplanned readmis…

This study looks at whether clindamycin, an antibiotic, can be used instead of vancomycin to prevent infections in people having heart surgery with a heart-lung machine. Many patients are allergic to standard antibiotics, and vancomycin can be hard to use and cause side effects. …

This study follows 819 children under 2 years old who have a medium to giant congenital nevus (a type of birthmark). Researchers want to learn how often these children have brain or nerve problems, and how the birthmark affects their quality of life. The goal is to create better …

This study compares two methods for inserting a breathing tube in emergency situations outside the hospital: using a bougie (a flexible guide) versus the tube alone. About 710 adults who need emergency intubation and have no signs of a difficult airway will take part. The goal is…

This study looks at whether measuring certain proteins in the blood can help predict outcomes for people with acute myeloid leukemia, high-risk myelodysplastic syndrome, or chronic myelomonocytic leukemia who receive a gentler type of chemotherapy. Researchers will collect blood …

This study is collecting health information and biological samples from 730 adults newly diagnosed with lung cancer. Researchers aim to track how patients respond to treatments in real-world settings, including those often excluded from clinical trials. The goal is to better unde…

This study is following 1,000 people who have small, unruptured brain aneurysms (between 3 and 7 mm) that are not causing symptoms. Researchers want to see if a special MRI technique that looks at the aneurysm wall can predict which aneurysms will grow over three years. The goal …

This study looks at how to set the breathing machine (jet ventilator) during a procedure that destroys tumors with heat or cold. The goal is to find the best air pressure setting to keep patients safe and reduce breathing problems. About 560 adults having tumor ablation will be r…

This study aims to better predict who is at risk of sudden cardiac death or heart failure among people with inherited heart conditions. Researchers will use artificial intelligence to analyze medical data from 1,000 participants, including heart tests, genetic information, and bl…

This study looks at how people with advanced cancer feel about stopping medications that may no longer be helpful. Many patients take multiple drugs, which can cause side effects and lower quality of life. Researchers will interview about 325 patients and use questionnaires to un…

This study is creating a group of 200 acne patients to learn more about the disease. Researchers will track things like acne severity, quality of life, and treatment costs. They also collect skin samples to study bacteria. The goal is to better understand acne and help doctors gi…

This study aims to understand why some children develop severe bacterial infections that require intensive care. Researchers will analyze the genes and immune systems of 1,401 children who were hospitalized for such infections between 2015 and 2018 in France. By comparing their g…

This study looks at children born with serious heart defects to understand why many also face learning, attention, or behavior challenges. Researchers will follow 1,206 children aged 3 to 11 and use genetic testing to find possible shared causes. The goal is to detect delays earl…

This study looks at whether eating oil rich in oleic acid (a healthy fat in olive and sunflower oil) changes how fat cells process cholesterol in women with obesity. About 40 women scheduled for weight-loss surgery will take either regular sunflower oil or an oleic-acid-rich vers…

This study looks at how walking patterns and MRI brain scans can help explain walking difficulties in people with multiple sclerosis (MS). About 100 adults with MS will wear a small device while walking and have an MRI scan. The goal is to better understand walking problems, not …

This study looks at how eating more plant-based foods during pregnancy might affect the health of the mother and newborn. Researchers will track the diets of 670 pregnant women and measure things like blood fats and pregnancy outcomes. The goal is to understand if a plant-heavy d…

This study aims to find how common hidden heart artery blockages are in people with familial hypercholesterolemia (inherited high cholesterol) who have no symptoms. Researchers will use a special CT scan to look for significant blockages in 600 participants. The goal is to better…

This study follows children born very early (before 35 weeks) to see if they have a higher risk of insulin resistance as they grow up. Researchers will measure body fat, blood sugar, and other health markers in kids aged 8 to 14. The goal is to understand how early birth affects …

This study looks at whether training nursing home caregivers in oral hygiene can improve the oral health-related quality of life for elderly residents. Researchers will train staff and then measure changes in residents' well-being and caregivers' anxiety levels after 6 months. Th…

This study looks at how spinal cord injury changes the nerves and lining of the gut. Researchers will take small tissue samples from the colon of 40 people with spinal cord injury during a routine colonoscopy. The goal is to understand these gut changes and find new ways to treat…

This study aims to create an artificial intelligence tool that analyzes photos of skin damage around a melanoma scar to predict whether a patient will respond to anti-PD-1 immunotherapy. Researchers will enroll 700 adults with advanced melanoma or other skin cancers. The goal is …