Nantes University Hospital

This study will test a new line of modular prostheses (the Pantheon range) in 375 people who have lost large amounts of bone due to cancer, complex fractures, or failed previous surgeries. The implants are designed to be adjusted during surgery for a precise fit and include a spe…

This study tests a home monitoring program for infants and toddlers (0-36 months) recovering from heart surgery. Families use sensors and an alert system to track the child's health at home, with medical teams responding to any warning signs. The goal is to reduce serious complic…

This study compares two ways of managing body temperature in people who are unconscious after a cardiac arrest that happened in the hospital. One group will be cooled to 33°C (therapeutic hypothermia), and the other will have their temperature kept normal. The goal is to see whic…

This early-stage study tests the safety of a drug called Anakinra in 15 people who receive a pancreas transplant. The drug aims to prevent dangerous blood clots and organ rejection after surgery. Participants will be monitored for one year to track side effects and how well the t…

This study follows 3000 people with severe or complicated obesity who are taking semaglutide (Wegovy) in France. Researchers will track weight changes, who stays on the drug, and what factors predict success. The goal is to understand how this medication works outside of controll…

This study looks at 100 adults with wet age-related macular degeneration who switched to a higher dose (8 mg) of the drug aflibercept. The goal is to see if this new dose allows them to go longer between eye injections while still controlling the disease. Researchers will compare…

This early-phase study tests adding tocilizumab to standard chemotherapy (venetoclax and azacitidine) for adults with acute myeloid leukemia who cannot handle strong treatment. The goal is to find the safest dose and see if the combination helps control the disease. Only 12 parti…

This study compares two antibiotic treatments for a serious heart valve infection caused by staph bacteria. About 422 adults with infected artificial heart valves will be randomly assigned to receive either a standard regimen containing rifampin or a simpler regimen without it. T…

This study looks at how well children aged 6 to 16 adapt to special glasses designed to slow down nearsightedness (myopia). Researchers will check if kids find the lenses comfortable and easy to wear in daily life. The goal is to see if these glasses can help manage myopia progre…

This study tests whether limiting food intake to an 8-hour daytime window (and fasting for 16 hours) can reduce liver fat in people with obesity and a type of fatty liver disease called MASLD. Researchers will enroll 72 adults and measure liver fat using MRI before and after 12 w…

This study tests a new method to treat atrial fibrillation (a common heart rhythm problem) during open-heart surgery. About 200 adults having heart surgery will receive a special procedure that isolates the pulmonary veins using a device called GeminiS. The goal is to see if this…

This study tests a new, less invasive way to screen for stomach cancer using a swallowable video capsule guided by a robot and artificial intelligence. Researchers will compare how well this capsule finds suspicious spots in the stomach compared to the standard endoscopy procedur…

This study compares two ways to repair the skin after removing a melanoma: a skin graft (taking skin from another body part) versus a flap (moving nearby skin with its blood supply). The goal is to see which method leads to faster healing and better quality of life. About 40 adul…

This study tests whether using a gentle brain stimulation technique (tDCS) at home works as well as receiving it in a hospital for people with moderate to severe depression. Sixty-six adults will either perform the sessions at home with nurse support or in the hospital. The goal …

This study will test a home monitoring program called EPOCA for 250 adults recovering from colorectal or weight-loss surgery. The program uses connected devices, video calls, and a care team to support patients at home after early discharge. The goal is to see if this approach ca…

This study looks at whether a special training program for ICU staff can improve care for patients on breathing machines when life support is being withdrawn. About 720 adults in intensive care will take part. The goal is to make patients more comfortable and support their famili…

This study tests whether adding lidocaine to standard pain treatment can lower the amount of strong opioids needed by adults with sickle cell disease during a severe pain crisis in the ICU. About 104 participants will be randomly assigned to receive either lidocaine or a placebo …

This study tests whether adding a cognitive training program to standard addiction treatment can improve overall self-confidence in people recovering from alcohol use disorder. About 130 adults who have been sober for 1 to 4 weeks will be randomly assigned to receive either the e…

This pilot study will test whether psilocybin-assisted psychotherapy is a feasible and safe treatment for gambling disorder. Researchers plan to enroll 30 adults with gambling disorder to see if they can complete the full treatment and follow-up. The study aims to gather early da…

This study tests a non-invasive treatment for vulvodynia, a condition causing long-term vulvar pain. Researchers will review medical records from 50 women who received four sessions of low-intensity shock wave therapy. The goal is to see if this treatment reduces pain and improve…

This study follows 80 adults who had a procedure called percutaneous endoscopic caecostomy (PEC) for severe chronic constipation that didn't get better with standard treatments. Researchers will check long-term quality of life and how well the procedure is tolerated by phone inte…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis caused by stroke or spinal cord injury, compared to healthy volunteers. Researchers will measure tendon stiffness, length, and volume using ultrasound and strength tests. The goal is…

This study looks at how jaw bone quality changes over time in people with medication-related osteonecrosis of the jaw (MRONJ), a condition linked to drugs like bisphosphonates. Researchers will review past CBCT scans from 25 adults to measure bone density and structure at diagnos…

This study aims to see if a standard 12-lead electrocardiogram (ECG) can predict whether a patient is eligible for a subcutaneous defibrillator (S-ICD), a device that prevents sudden cardiac arrest. Currently, a special 3-lead screening ECG is required, but researchers hope to us…

This study collects blood and bone marrow samples from 80 people with B-cell non-Hodgkin lymphoma to learn why some cancers become resistant to chemotherapy and newer therapies. Researchers will analyze the tumor and its environment, and create lab models to test new treatments. …

This study tests a new type of PET scan that uses a special tracer to see active scarring in the heart. It aims to help doctors better stage transthyretin cardiac amyloidosis, a condition where protein buildup causes heart failure. About 40 adults with this disease will get the s…

This study looks back at medical records of 100 adults with non-infectious posterior uveitis, a chronic eye disease that can cause vision loss from repeated inflammation. Researchers want to see how often and how severely inflammation returns after treatment with a fluocinolone a…

This study looks at whether analyzing synovial tissue can help doctors better manage pigmented villonodular synovitis (PVNS), a rare joint disease that causes pain and joint damage. Researchers will collect tissue samples from 30 adults with PVNS to see if the tissue's features c…

This study will collect medical information and blood samples from 800 people with autoimmune liver diseases. Researchers will compare those who respond well to treatment with those who do not, looking for new markers in the immune system and cells. The goal is to understand why …

This study tests a new, non-invasive ultrasound method to see how well it can track muscle changes in boys and men with Duchenne or Becker muscular dystrophy. Researchers will compare their muscles to those of healthy people and follow them for a year. The goal is to find better …

This study looks at joint tissue from 30 people with early knee osteoarthritis to identify different types of inflammation. Researchers will take small tissue samples using a needle guided by ultrasound, along with blood tests. The goal is to better understand how the disease sta…

This study looks at how consistent digital overlay methods are for analyzing bite marks in forensic dentistry. Researchers will take 3D dental scans from 30 adults and have four operators create overlays twice each. The goal is to see if the results are repeatable and reproducibl…

This study looks at whether a new, painless ultrasound method can measure fat inside the muscles of older adults (75+) who are in a rehabilitation program after a hospital stay. The goal is to see if having more fat in the muscles makes it harder to regain physical strength and m…

This study collects blood and bone marrow samples from 55 adults with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome. Researchers will analyze natural killer (NK) cells and their interactions with cancer cells over time. The goal is to learn whi…

This study will collect extra blood and bone marrow samples from 1,000 adults with acute myeloid leukemia, acute lymphoid leukemia, or high-risk myelodysplastic syndrome. The samples will be used by researchers to better understand these diseases and find new ways to diagnose and…

This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries, a sign of heart risk. Researchers will compare 206 adults aged 40-69 with and without gum disease, measuring artery stiffness with a simple device. The goal is to better understand how g…

This study looks at medical records from over 5,600 people with HIV in France to find out how many need special dental care because of blood or immune issues. The goal is to provide clear guidelines so dentists can avoid unnecessary precautions and reduce stigma. No new treatment…