Tiny tissue samples could unlock secrets of early arthritis

NCT ID NCT07473414

Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at joint tissue from people with early osteoarthritis to find different patterns of inflammation. Researchers will take small samples using a needle under local anesthetic, along with blood tests. The goal is to better understand how the disease starts and progresses, which could lead to more targeted treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this research could help doctors identify different types of osteoarthritis earlier and guide more personalized treatments.
What could go wrong: This is a small, early-stage observational study with only 30 participants. It is not testing a treatment, so it may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of early osteoarthritis defined by the following clinical criteria: 1. score ≤ 85% in at least two of the four categories of the KOOS questionnaire: pain, symptoms/signs, function and quality of life; 2. presence of tenderness on palpation of the joint space or crepitus (clinical examination); 3. Kellgren and Lawrence (KL) score of 0 or 3 (X-rays). * Referred for therapeutic management including an intra-articular injection in the affected knee * Patient affiliated with a social security scheme * Patient able to understand the protocol and having signed an informed consent form. Exclusion Criteria: * Minors * Adults under guardianship or trusteeship * Pregnant women * Breastfeeding women * Protected patients * Curative anticoagulation * Thrombocytopenia \< 50,000 platelets/mm3 * Patients who object to participating in the study.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Tiny tissue samples could unlock secrets of early arthritis

What the study statuses mean