Nantes University Hospital

This trial tests a treatment strategy for adults with acute myeloid leukemia (AML) that did not respond to standard induction chemotherapy. Participants receive clofarabine and intermediate-dose Ara-C chemotherapy, followed by a reduced-intensity allogeneic stem cell transplant u…

Researchers test a reduced-toxicity conditioning regimen before allogeneic stem cell transplant in children and young adults with blood cancers. The regimen combines fludarabine, full-dose busulfan, and anti-thymocyte globulin. The trial measures transplant-related mortality at o…

Researchers test a reduced-intensity conditioning regimen before allogeneic stem cell transplant in adults with high-risk AML, MDS, or ALL who cannot tolerate standard intensive treatment. The regimen combines clofarabine, busulfan, and thymoglobulin. The trial measures relapse r…

Researchers are testing a gene therapy called rAAV2/4.hRPE65 in people with Leber congenital amaurosis or severe early-onset retinal degeneration caused by mutations in the RPE65 gene. The treatment delivers a working copy of the gene directly into one eye through a single inject…

Researchers test a gentler conditioning regimen before allogeneic stem cell transplantation in adults with blood cancers. The goal is to see if this reduced-toxicity approach lowers the risk of death within the first year after transplant. Participants receive fludarabine, busulf…

NUTRIREA-3 compares two feeding strategies for adults on ventilators with shock. One group receives low-calorie low-protein feeding for the first week, while the other receives standard-calorie standard-protein feeding. Researchers track survival and time to leave the ICU to see …

Researchers test whether adding high-dose radiotherapy to standard chemoembolization slows tumor growth better than chemoembolization alone in adults with hepatocellular carcinoma. Participants have liver tumors up to 9 cm that cannot be removed by surgery or treated with percuta…

Researchers compare two approaches to managing antibiotics in adults hospitalized with community-acquired pneumonia. One approach uses doctors' clinical reassessment to decide whether to continue, stop, or change antibiotics. The other uses blood levels of a marker called procalc…

Adults with B-cell acute lymphoblastic leukemia that has come back or stopped responding to treatment have few options. This phase 2 trial tests whether adding epratuzumab, an antibody that attaches to the CD22 protein found on most of these leukemia cells, to standard chemothera…

This trial tests whether cooling brain-dead organ donors to 34-35°C, called therapeutic hypothermia, helps the kidneys they donate work better in recipients. Researchers compare two groups of kidney transplant recipients: those who receive a kidney from a donor kept cool and thos…

People who receive a haploidentical stem cell transplant for a blood cancer face a high risk that the disease will come back. Researchers are testing whether giving zoledronic acid with low-dose interleukin-2 soon after the transplant can expand a type of donor immune cell called…

Researchers are comparing two ways to treat blocked leg arteries: doing the procedure as an outpatient visit versus keeping patients overnight in the hospital. The study enrolls 160 adults with peripheral arterial disease who need a minimally invasive procedure to open their arte…

Critically ill patients in the intensive care unit often accumulate too much fluid, which can lead to complications. This trial tests whether a furosemide-based algorithm can safely reduce fluid overload in patients who are on mechanical ventilation and have gained at least 3% of…

Lentigo maligna is an early form of melanoma that appears on sun-exposed skin, often on the face. Doctors usually remove it with surgery, but it can be hard to decide how much tissue to take. This trial tests whether applying imiquimod cream for four weeks before surgery can shri…

This study tested whether adding extra dental checkups and video calls with a dentist could improve oral hygiene in children with cleft deformities. Sixty children aged 3 to 15 took part. The program included a longer dental visit and teleconsultations every two months. Researche…

Progressive supranuclear palsy (PSP) is a rare brain disease that steadily damages movement, balance, and thinking. Researchers are testing valproic acid, a drug already used for epilepsy and mood disorders, to see if it can protect brain cells by blocking an enzyme involved in t…

Researchers compare two three-drug combinations, VTD and VCD, as initial treatment for people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. Participants receive four cycles of either combination. The trial measures how well each combination re…

Researchers are testing whether adding tocilizumab, a drug that blocks an inflammation signal called IL-6, to standard chemotherapy helps adults with high-risk acute myeloid leukemia. Participants receive idarubicin and cytarabine, the usual induction chemotherapy, plus a single …

Researchers at Nantes University Hospital are testing a computer model that describes how glucose and insulin interact in people with type 1 diabetes. The model aims to help doctors choose insulin pump settings, including basal rate, insulin sensitivity, and carbohydrate ratios. …

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that s…

Researchers are testing whether hydrocortisone, a steroid the body makes naturally, helps severely injured patients who may not produce enough of it on their own. The trial enrolls about 150 people hospitalized after major trauma, all on breathing machines for at least two days. …

Researchers are testing a combination of three drugs, obinutuzumab, ibrutinib, and GDC-0199, in people with mantle cell lymphoma. The trial includes patients whose cancer has come back or stopped responding to treatment, as well as those who have not yet received treatment. The g…

This Phase II trial tests whether adding rituximab to standard first-line treatment with ciclosporine and corticosteroids improves remission rates in adults who develop chronic graft versus host disease after a stem cell transplant. Participants receive rituximab infusions once a…

Researchers compare two corticosteroid treatments for inflammatory macular edema, a condition where swelling in the center of the retina blurs vision. Adults with the condition receive either a subconjunctival injection of triamcinolone or an intravitreal implant of dexamethasone…

Researchers are testing whether spironolactone, a drug usually used for high blood pressure, can treat moderate acne in adult women as effectively as doxycycline, a common antibiotic. The trial enrolls women with acne who have not recently used certain treatments. Participants re…

Researchers are testing a two-step radioimmunotherapy for people with medullary thyroid cancer that has come back. Participants receive a bispecific antibody followed by a radioactive peptide. The goal is to see if this targeted radiation can shrink tumors and how safe it is.

Researchers compare two ways to restore blood flow in the common femoral artery, a vessel in the upper leg. One group receives a self-expandable nitinol stent placed inside the artery, and the other has open surgery. The trial enrolls 120 adults with narrowed or blocked arteries …

Researchers are testing whether a once-daily form of raltegravir can keep HIV suppressed in adults who already have the virus under control with standard antiretroviral therapy. The trial enrolls about 100 adults with HIV-1 who have been on stable treatment for at least six month…

This trial tests whether a steroid-free immunosuppression regimen can prevent rejection after a first kidney transplant. Participants receive rabbit anti-T-lymphocyte serum, mycophenolate mofetil, and cyclosporine, with one group also getting standard steroids for six months and …

People with peripheral arterial disease often need minimally invasive procedures that thread catheters through the femoral artery in the groin. Afterward, doctors use closure devices to stop bleeding at the puncture site. This trial randomly assigns participants to one of two dev…

Researchers are testing a combination of carfilzomib, melphalan, and prednisone in adults over 65 with newly diagnosed multiple myeloma. The trial first aims to find the highest dose of carfilzomib that people can tolerate without severe side effects. Then it will measure how wel…

Pre-eclampsia is a serious pregnancy complication that can harm both mother and baby, and the only cure is delivering the baby. Researchers are testing whether citrulline, a natural amino acid, can safely prolong pregnancy for women hospitalized with pre-eclampsia before 36 weeks…

Researchers are testing whether teleconsultations guided by a kidney transplant failure risk score can improve follow-up care for kidney transplant patients. The trial enrolls adults who received a deceased donor kidney transplant one year earlier and have internet access. Partic…

Researchers are studying how the antibiotic ertapenem behaves in patients with severe burns who are on breathing machines. The trial measures drug levels in the blood after two intravenous doses to see how the body processes the medicine. They also check whether a standard 1-gram…

Atypical hemolytic uremic syndrome (aHUS) is a rare disease that damages the kidneys by causing blood clots in small vessels. The drug eculizumab blocks the complement system and has greatly reduced kidney failure, but doctors do not know how long patients should stay on it. This…

Researchers are testing whether a bundle of actions can reduce antibiotic prescribing by general practitioners. The bundle includes visits from medical representatives who discuss antibiotic resistance, challenge common misconceptions, give feedback on prescribing habits, and dem…

Researchers are testing whether adding the experimental drug MLN9708 to lenalidomide and dexamethasone can help adults under 66 with newly diagnosed multiple myeloma. Participants receive three cycles of the triplet, then a stem cell transplant, followed by more triplet and maint…

This study looked at whether it is safe for people with multiple sclerosis to receive their natalizumab (Tysabri) infusions at home instead of at a hospital. Researchers compared serious side effects, quality of life, and costs over one year in 295 patients. The goal was to see i…

This trial compares standard knee replacement surgery to surgery using custom cutting blocks designed from each patient's anatomy. The goal is to see if these personalized tools lead to better knee function, less bleeding, shorter surgery time, and lower overall costs. About 95 p…

This study looked at whether giving romiplostim, a drug that boosts platelet production, could reduce the need for platelet transfusions in patients with low platelet counts after heart or lung transplantation or use of heart/lung support devices. Researchers compared a group of …

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This study looks at whether a new method of measuring parathyroid hormone (PTH) can help doctors better manage calcium and phosphate levels in people on hemodialysis. About 80 patients with end-stage kidney disease will be randomly assigned to have their PTH measured either with …

This study compared three emergency treatments for dangerously high potassium levels: insulin with dextrose, nebulized salbutamol, or a combination of both. Researchers measured how well each lowered potassium within 60 minutes. The trial involved 419 adults in emergency departme…

This study tested a new drug called FR104 in 10 people who received a kidney transplant. The goal was to see if the drug is safe and helps prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study tests whether a simpler device called pOpmètre can accurately measure arterial stiffness in children aged 4 to 8. Arterial stiffness is an important sign of heart and blood vessel health. The standard device, Sphygmocor, is harder to use in children. If pOpmètre works …

When a general practitioner spots a skin lesion that might be melanoma, the patient is referred to a dermatologist, but some never go and others wait too long. This trial tests whether the GP calling the dermatologist directly and emailing a smartphone photo of the lesion shorten…

Researchers test a two-step PET scan to find colorectal cancer that has spread to the liver or other organs. The scan uses an antibody that sticks to a protein called CEA on cancer cells, then a radioactive peptide that lights up those cells. Adults with colorectal cancer that ma…

Researchers are testing whether ultrasound can reliably show joint damage and inflammation in people with septic arthritis, a painful joint infection. The trial follows 28 adults with septic arthritis in the shoulder, elbow, wrist, hip, knee, or ankle. Participants receive standa…

Researchers want to know how many people with neuropathy of unknown cause carry a mutation in the TTR gene, which leads to a rare and potentially fatal inherited disease called familial amyloid neuropathy. The study enrolls up to 400 adults under 90 who have neuropathy confirmed …

Researchers are testing whether tissue samples taken during a routine colon exam can help tell apart Parkinson's disease from two similar conditions: multiple system atrophy and progressive supranuclear palsy. The study includes 34 people aged 50 to 80, some with these conditions…

Researchers compare PET scans and MRI to see which imaging method detects more myeloma lesions in adults under 65 with newly diagnosed multiple myeloma. Participants receive both scans at diagnosis, after three cycles of chemotherapy, and at the end of treatment. The study also t…

Young children who arrive at the emergency department with a fever and no obvious cause often get blood tests and antibiotics just in case. Researchers are testing whether a rapid finger-prick procalcitonin test, combined with a set of clinical rules, can help doctors identify wh…

This study tested whether a bedside ultrasound (POCUS) can accurately detect or rule out bowel obstruction in 150 adults with abdominal pain. Doctors performed the ultrasound after a physical exam, then compared results to a CT scan. The goal is to see if this quick, radiation-fr…

This study tested whether a 3D cone-beam CT scan (a type of X-ray) can diagnose non-cancerous salivary gland diseases as well as MRI. Fifty adults with symptoms like swelling or pain in their salivary glands underwent both imaging methods. The goal was to see if the 3D-CBCT could…

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can help doctors safely avoid CT scans in children with mild traumatic brain injury. Over 1,500 children across Europe participated. The goal was to see if these blood tests are accurate enough to …

This study aims to create a better way to detect acute kidney injury early after heart surgery. Researchers will combine blood and urine tests with patient information to build a scoring system. The goal is to identify high-risk patients quickly so doctors can take steps to prote…

This study looked at whether two blood tests, eLIFT and FibroMeter, can accurately detect liver fibrosis (scarring) in people with type 2 diabetes. The researchers compared these blood tests to standard methods like FibroScan and liver biopsy. The goal is to find a simpler, less …

This study tested whether a special camera technique (virtual chromoendoscopy) can find pre-cancerous or cancerous spots in Barrett's esophagus better than the standard method of taking random biopsies. 110 adults with Barrett's esophagus took part. The goal was to see if the new…

Researchers are testing whether giving azacitidine, a chemotherapy drug, together with donor lymphocyte infusions after a stem cell transplant can prevent relapse in people with high-risk acute myeloid leukemia or myelodysplastic syndrome. About 30 patients will receive the combi…

Heavy drinkers who need a breathing machine in intensive care often become agitated, which can lead to pulling out tubes, falling, or harming themselves or staff. This Phase 3 trial tests whether baclofen, a drug that calms the nervous system, can prevent these dangerous events b…

Very premature infants born before 28 weeks often have a blood vessel near the heart, called the patent ductus arteriosus, that stays open when it should close. A large opening can strain the heart and may affect brain development. In this trial, researchers use an early echocard…

Major non-cardiac surgery triggers a strong inflammatory response that can lead to sepsis, lung failure, and death. Researchers are testing whether two intravenous doses of dexamethasone, a steroid, given at the end of surgery and 24 hours later can dampen that response and reduc…

Researchers compare two ways to deliver oxygen before and during breathing-tube placement in surgery patients who are hard to intubate. One method uses a high-flow nasal cannula, the other uses a standard face mask. The trial measures how often oxygen levels drop below 95% or req…

Patients on a breathing machine need the cuff around their endotracheal tube kept at about 25 cmH2O to seal the airway. Nurses usually check and adjust this pressure by hand every few hours, which can let the pressure drop too low between checks. This trial tests whether a mechan…

This study tests whether giving general practitioners a list of patients who have not completed colorectal cancer screening encourages those patients to get screened. Over 48,000 patients aged 50-74 are involved, and their doctors either receive the list or do not. The goal is to…

Many people with gastroesophageal reflux disease still have heartburn even when they take proton pump inhibitors. The SIRUP trial compares the Stretta procedure, which uses radiofrequency energy on the esophagus, with a sham procedure in adults who have at least three heartburn e…

Researchers test whether breathing a mix of oxygen and nitrous oxide helps turn a breech baby during a procedure called external cephalic version (ECV). The trial enrolls 150 pregnant women at term with a singleton breech or transverse baby. Half receive the gas mixture and half …

Researchers are testing whether combining virtual reality exposure with a mild form of brain stimulation can help people who fear heights. The study enrolls adults with a fear of heights but without a diagnosed phobia. Participants receive two virtual reality sessions, each paire…

After heart surgery, part of a lung can collapse, a common problem called atelectasis. Researchers are testing whether adding a breathing device called EzPAP, which provides positive pressure on exhale, to standard manual chest physiotherapy helps clear this collapse better than …

People with peripheral artery disease often need procedures that thread a catheter through an artery in the groin. Doctors usually use a closure device to seal the puncture, but manual pressure may work just as well and cost less. This pilot study tests whether 30 patients can sa…

Researchers are testing whether Iberogast, a herbal blend used for digestive complaints, can relieve constipation in people with Parkinson's disease. The trial enrolls 45 adults aged 30 to 80 who have Parkinson's disease and functional constipation. Participants take Iberogast fo…

Researchers are testing whether injecting botulinum toxin A along with the local anesthetic ropivacaine into painful pelvic floor muscle trigger points eases chronic myofascial pelviperineal pain better than ropivacaine alone. The trial enrolls adults who have had pelvic or perin…

Researchers test whether low-level laser therapy can speed up orthodontic tooth movement in children with Class II canine alignment. Each child acts as their own control: one side of the mouth receives real laser treatment and the other gets a fake, inactive laser. All participan…

Researchers are testing whether taking citrulline by mouth helps people with intestinal failure build protein more effectively. The study includes adults with short bowel syndrome who are fed orally and not on parenteral nutrition. Participants receive either citrulline or a plac…

Researchers compare two drugs that reduce stomach acid, rabeprazole and omeprazole, in obese adults with gastroesophageal reflux. Participants receive a single dose of each drug, plus a placebo, and researchers measure stomach acid for 24 hours after each dose. The goal is to see…

Researchers are testing whether a combination of creative and physical activities helps chronically ill patients strengthen their emotion management skills. The trial enrolls 150 adults with a chronic illness who receive care at Nantes University Hospital. Participants choose one…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in the tendon. Standard treatment flushes the deposit with fluid, but the calcium often dissolves slowly. Researchers are testing whether injecting sodium thiosulfate, a chemical that…

Obese patients with a BMI over 35 face higher risks when they need a breathing tube for surgery. This trial compares two ways to give extra oxygen beforehand: high-flow oxygen through a nose tube (Optiflow) and BiPAP through a face mask. Researchers will measure oxygen levels at …

Researchers are studying whether early osteopathic manipulative treatment, a gentle hands-on technique, helps healthy newborns with suboptimal breastfeeding behavior. The trial enrolls 128 mother-baby pairs and randomly assigns each newborn to receive the treatment or no treatmen…

Researchers are testing whether placing preterm twins together in one bed, called cobedding, helps them gain weight faster than keeping them in separate beds. The study includes 64 twins born between 30 and 34 weeks of gestation who are cared for in a neonatal intensive care unit…

Researchers are testing whether combining a mild brain stimulation technique called tDCS with virtual reality can reduce anxious rumination in healthy people who tend to ruminate. The study enrolls 20 adults who score high on a rumination scale but do not have a psychiatric or an…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in a tendon. A common treatment is ultrasound-guided needling and lavage to break up and flush out the deposit, often followed by a corticosteroid injection to prevent a pain flare. R…

Researchers test whether a camera called Fluobeam helps surgeons locate parathyroid glands faster during surgery for mild primary hyperparathyroidism. The trial enrolls adults with this condition who need surgery. Half the participants undergo surgery with the camera, and half wi…

Researchers are testing whether memantine, a drug already used for Alzheimer's disease, can ease symptoms or slow decline in people with frontotemporal dementia. The trial enrolls adults aged 45 to 75 with mild to moderate FTD and compares memantine against a placebo over one yea…

Shots and blood draws cause pain and anxiety in children, and numbing creams take time to work. Researchers are testing a device that uses cold, vibration, and distraction to block needle pain. The trial compares this device with standard numbing cream in children aged 4 to 15 at…

This trial compares two ways to give oxygen before placing a breathing tube in intensive care patients who are not severely hypoxemic. Participants receive either high flow nasal cannula oxygen or a standard face mask for four minutes before intubation. Researchers measure the lo…

Pudendal neuralgia is a painful condition caused by a trapped nerve in the pelvis. Researchers at Nantes University Hospital are comparing three injection mixtures placed near the pudendal nerve: lidocaine alone, lidocaine plus a steroid, and lidocaine plus steroid plus a large v…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study tested whether Phycocare, a supplement made from spirulina, can reduce nerve damage caused by the chemotherapy drug oxaliplatin in people with metastatic gastrointestinal cancers. 73 participants took either Phycocare or a placebo daily for 9 months. The goal was to se…

This study tested a set of dermo-cosmetic products (hand/foot serum, nail strengthener, dissolving oil, and gloves/slippers) in 20 multiple myeloma patients receiving bispecific antibody therapy. The goal was to see if these natural-based products could prevent or reduce skin and…

This study tested two ways of applying compression bandages for venous leg ulcers: one that covers the heel and one that leaves it uncovered. Researchers measured the pressure under the bandage and checked ankle swelling in 102 patients. The goal was to see if leaving the heel ou…

This pilot study tested a procedure that combines a needle tenotomy (breaking up scar tissue with a needle) with an injection of platelet-rich plasma (PRP) for people with chronic plantar fasciitis that didn't improve with standard treatments like physical therapy or steroid shot…

Researchers at Nantes University Hospital are studying central coherence, the brain's ability to pull complex information into a coherent whole, in women with restrictive anorexia nervosa. The study compares patients in the active phase of the illness with healthy volunteers. All…

Researchers at Nantes University Hospital are comparing how people with different behavioral addictions think, feel, and process social situations. The study includes people with gambling disorder, sexual addiction, and eating disorders with bulimia episodes, along with healthy v…

Researchers are testing whether taking citrulline by mouth helps healthy adults build more protein throughout their bodies. Twelve healthy volunteers receive either citrulline or a placebo for seven days, then switch to the other. The study uses a safe tracer infusion to measure …

Researchers at Nantes University Hospital are studying whether nerves feel stiffer in people with three rare peripheral neuropathies: CIDP, CMT1a, and anti-MAG neuropathy. They use ultrasound shear wave elastography to measure nerve stiffness in 36 participants aged 18 to 65 and …

Children with unilateral cerebral palsy often rely on their stronger arm, leaving the weaker arm underused. Constraint-induced therapy forces them to use the weaker arm for hours a day over several weeks, and clinical tests show it improves movement. This study uses wearable sens…

Researchers are studying whether children born prematurely who had acute kidney failure as newborns show signs of reduced kidney function later in childhood. The study compares about 50 preterm children with a history of neonatal kidney failure to 25 preterm children without it. …

Researchers at Nantes University Hospital are studying how the immune system behaves in adults with Gaucher disease. The study collects one blood sample from each participant to measure macrophage activity and immune cell profiles. The goal is to understand how different parts of…

Researchers want to know whether two genes, PCSK9 and FXR, help cause the combination of insulin resistance and abnormal blood fats that often comes with obesity. The study enrolls 111 adults with a high body mass index who are scheduled for bariatric surgery. During surgery, doc…

Researchers at Nantes University Hospital are studying whether year 6 medical students feel more stressed when they solve diagnostic problems with real patients in an outpatient clinic compared to a hospital ward. The study measures anxiety with a questionnaire and cortisol level…

Researchers at Nantes University Hospital are studying how joint damage from bleeding affects walking in adults with moderate hemophilia. About 24 participants will have their gait measured with motion capture and force platforms during a single visit. The study also collects cli…

Researchers want to know whether the number of other health conditions a person has affects their quality of life after transcatheter aortic valve implantation. The study follows 150 patients aged 75 and older who receive a new aortic valve through a catheter. Before the procedur…

Animal-derived heart valves replace damaged human valves, but many fail within about a decade. Researchers suspect the recipient's immune response may speed up that breakdown. This international study follows people who receive pig, cow, or horse tissue valves, using echocardiogr…

Researchers are studying natural killer (NK) cells in people who receive stem cell transplants for leukemia. The study follows 92 patients and their donors, looking at genes called KIR and HLA that control how NK cells work. By tracking NK cells during immune recovery, researcher…

This study compares bowel function and quality of life in adults who had a sigmoidectomy, a surgery to remove the sigmoid colon, for either diverticulitis or sigmoid cancer. Researchers will measure incontinence using a standard score and track stool form with the Bristol stool c…

This study aims to identify the unique molecular signature of immune cells called T cells that mistakenly attack the liver in autoimmune liver diseases like autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. Researchers will analyze blood sampl…

This trial tests whether a brief online training program can improve how general practitioners and GP residents manage malnutrition and prescribe adapted physical activity in older adults. Doctors are randomly assigned to receive either malnutrition training or physical activity …

This completed study looked at immune markers called DAMPs in 88 young children (3 months or younger) after heart surgery. Researchers collected extra blood samples to measure inflammation-related proteins and gene activity. The goal was to better understand how the body's immune…

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study looked at whether virtualizing how incoming calls are distributed across emergency medical communication centers can improve how quickly calls are answered. Researchers analyzed over 1 million calls from five centers in France. The goal was to see if this change could …

This completed study looked at how safety-focused the culture is in French intensive care units (ICUs). Researchers surveyed nearly 4,800 staff members to measure safety attitudes and linked them to how teams review serious medical errors. The goal was to understand current safet…

This completed study from France looked at health records of 2 million adults to see if having pneumonia increases the chance of later heart problems like heart attacks, strokes, or heart failure. Researchers compared people who had pneumonia with similar people who did not. The …

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This study looked at how chemotherapy affects the gut microbiome in 40 people with non-Hodgkin's lymphoma. Researchers collected stool samples to analyze changes in gut bacteria after treatment. The goal was to better understand why chemotherapy causes digestive problems like dia…

This study looked at the quality of life of 756 children adopted from other countries who arrived in France between 2008 and 2013. Researchers used an online survey to assess their health, behavior, and school adjustment one to seven years after arrival. The goal is to find out w…

This completed study looked at a new antibody called anti-SIRPα as a potential immunotherapy for liver cancer. Researchers used blood and tissue samples from 30 liver cancer patients to see how the antibody affects immune cells. The goal was to understand whether blocking the SIR…

This study looked at 50 intensive care patients to see how a contrast dye used in CT scans changes two kidney injury markers (TIMP-2 and IGFBP7) in urine. The goal was to understand if the dye causes a measurable increase in these markers. It was a small, observational study with…

This study looked at 96 people with a rare condition called acrodermatitis enteropathica, which causes severe zinc deficiency. Researchers analyzed blood samples to find genetic mutations in 56 genes related to zinc handling. The goal was to better understand the genetic causes o…

This study looked at 76 children aged 3 to 15 getting dental care with nitrous oxide (laughing gas). Researchers watched for signs that kids wanted to keep the mask on longer, like hand gestures or asking to keep it. The goal was to see if there's a risk of children misusing the …

This study looked at whether the ratio of urea to creatinine in urine can help identify malnutrition in intensive care patients with brain injury. Malnutrition is common in the ICU and raises the risk of infections. Researchers measured this ratio in 309 adults and tracked six ty…

This study looked back at 80 French patients with calciphylaxis, a rare and often fatal condition causing painful skin ulcers, mostly in people with severe kidney disease. Researchers aimed to describe patient characteristics, how doctors diagnose and treat the condition, and wha…

This study looked at 70 people aged 75 and older with atrial fibrillation who were taking a Xaban blood thinner (dabigatran, rivaroxaban, or apixaban) during an unplanned hospital stay. Researchers wanted to see if certain clinical or lab factors were linked to higher drug levels…

This completed study from Nantes University Hospital looked at 144 people to see if there is a link between materialism (how much someone values money and possessions) and problem gambling. Researchers compared a group of problem gamblers with a group of non-problem gamblers usin…

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This study compared staph bacteria from 57 patients with implant infections to 31 from healthy nasal carriers. Researchers looked at the bacteria's genes and ability to form biofilms (slimy coatings). The goal was to find what makes some staph strains more dangerous around implan…

This study looks at whether being born too early changes the structure of the optic nerve, which sends visual signals from the eye to the brain. Researchers will compare eye scans from children aged 5 to 10 who were born prematurely with those born full-term. The tests are painle…

This completed study surveyed 657 adults visiting pharmacies in France to find out which substances they use to help them sleep. Participants filled out a questionnaire listing any medical or non-medical sleep aids. The goal was to get a clear picture of current sleep medication …

This study looked at 287 patients with acute kidney injury caused by tubular necrosis. Researchers measured two substances in urine (PIIINP and NGAL) to see if they could predict whether kidney function would return or if chronic kidney disease would develop. The goal is to find …

This study looked at records from over 864,000 people in France who had surgery for a torn anterior cruciate ligament (ACL) in the knee. The goal was to see if doing physiotherapy before the surgery (called prehab) affected how much time people took off work and how much healthca…

This completed observational study looked at how often young people with sickle cell disease (under 26) in France develop problematic use of painkillers and a gas mixture called EMONO. Researchers interviewed over 1,000 patients by phone to check for signs of addiction or depende…

This study tested whether children under 16 with a history of mild beta-lactam (like penicillin) allergies could safely take the drug again without first having skin tests. Researchers used a questionnaire to identify low-risk kids and then gave them an oral dose. The goal was to…

This study looked at 57 kidney transplant patients to see if high blood pressure is related to having too much fluid in the body. Patients measured their blood pressure and fluid levels at home between 30 and 90 days after their transplant. The goal was to find a connection that …

This study tested whether wearing a sleeve changes the accuracy of automated blood pressure cuffs in 75 ICU patients. Researchers compared readings taken over a thick sleeve, thin sleeve, and bare arm against a more precise arterial line. They also tested two different measuremen…

This study looked at 100 adults with atopic dermatitis (eczema) who were prescribed tralokinumab. Researchers tracked how many developed eye problems like conjunctivitis within 4 months of starting the drug. The goal was to better understand these side effects in real-world use, …

This study aimed to find new blood markers that can show liver damage in people with anorexia nervosa. Researchers compared blood samples from 19 patients with and without signs of liver injury. The goal is to improve detection and understanding of liver problems in this conditio…

This study looked at how common liver scarring (fibrosis) is in people with anorexia nervosa. Researchers used a special scan called Fibroscan to measure liver stiffness in 43 patients when they were admitted to the hospital. The goal was to learn more about liver health in this …

This study looked at 346 adults who had a cardiac arrest outside the hospital. Doctors used an ultrasound within the first 12 minutes of CPR to see if a still heart (no movement) meant the heart would not restart. The goal was to help decide on next steps like ECMO or organ donat…

This study tests whether measuring two substances in the blood—FLT3L and IL-6—during chemotherapy can help predict survival in people with acute myeloid leukemia (AML). Researchers will track 201 newly diagnosed AML patients across 25 French hospitals. The goal is to confirm that…

This completed study at Nantes University Hospital analyzed the lung microbiome and immune cells in 82 healthy volunteers undergoing scheduled surgery. Researchers collected respiratory samples to identify which bacteria live in healthy lungs and how they interact with the body's…

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia remember personal events from their past. Researchers tested 39 participants using a detailed scale to see if memories were specific (like a single event in time and place) or more gener…

This study looked at whether shared genetic markers (HLA) between a child and a lung donor increase the risk of organ rejection in mothers who had a lung transplant. Researchers collected DNA from children born to 11 transplant women in France between 2012 and 2021. The goal is t…

This study looked at whether using a face mask to help obese patients breathe during a short pause in anesthesia makes intubation safer. Over 700 patients with a BMI of 35 or higher took part. The goal was to see which method leads to fewer complications like low oxygen levels or…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study looked at how the brains of people with gambling disorder differ from those without it. Researchers tested memory, decision-making, and other thinking skills in 50 participants. The goal was to find brain weaknesses that could be improved with special training programs…

This completed study looked at how the COVID-19 pandemic affected online gambling in France and Sweden, using data from 120,000 gamblers. Researchers compared gambling behaviors before and during the pandemic, including money spent and types of games played. They also examined di…