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Breathing tube safety: can high flow nasal oxygen prevent oxygen crashes during intubation?

NCT ID NCT02700321

Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

This trial compares two ways to give oxygen before placing a breathing tube in intensive care patients who are not severely hypoxemic. Participants receive either high flow nasal cannula oxygen or a standard face mask for four minutes before intubation. Researchers measure the lowest oxygen level during the procedure to see which method keeps oxygen levels steadier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High flow nasal cannula oxygen
What this could lead to
If high flow nasal cannula oxygen works better, intensive care teams could use it to keep oxygen levels steadier during intubation, which may reduce complications from low oxygen.
What could go wrong
This is a single comparison in a specific group of patients who are not severely hypoxemic, so the results may not apply to sicker patients or other settings. The trial may find no meaningful difference between the two methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

192 people

The number who actually took part.

Started

Apr 2016

Finished

Oct 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults older than 18 years regardless of the gender * Requiring orotracheal intubation in intensive care unit * "No severely hypoxemic respiratory failure" defined as Oxygen Pression (Pa02)/FI02 \> 200 mmHg measured in the 4 hours before inclusion Exclusion Criteria: * Not the first Intubation during this stay in intensive care unit * Contraindication to oro-tracheal intubation * Intubation without anaesthesic rapid sequence induction * Intubation during cardiac arrest * Real emergency (as asphyxia) with immediate intubation needed (without time enough for randomization) * Nasopharyngeal obstacle with contraindication to use Optiflow device * Patients with a documented Cormack IV exposition before inclusion * Protected adult * Pregnancy or breastfeeding * Lack of consent * Patient already enrolled in another study that could interfere with the primary objective of this study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Need for intubation, no severe hypoxemia

Contacts and locations

Locations

  • Brest hospital, CHU La cavale Blanche, medical intensive care unit

    Brest, 29609, France

  • CHD LES OUDOUAIRIES Service de réanimation polyvalente

    La Roche-sur-Yon, 85925, France

  • Ch Le Mans

    Le Mans, 72033, France

  • Nantes University Hospital, Hôtel Dieu, Medical intensive care unit

    Nantes, 44093, France

  • Nantes University hospital, Hôpital Laennec, pneumology intensive care unit

    Saint-Herblain, 44800, France

  • Nantes university hospital, hôtel Dieu, Anesthesia intensive care unit

    Nantes, 44093, France

  • Rennes university hospital, Hôpital Pontchaillou, medical intensive care unit

    Rennes, 35033, France

  • Tours university hospital, hôpital Bretonneau, medical intensive care unit

    Tours, 37044, France