New 3D X-Ray technique could replace MRI for salivary gland diagnosis
NCT ID NCT02883140
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a 3D cone-beam CT scan (a type of X-ray) can diagnose non-cancerous salivary gland diseases as well as MRI. Fifty adults with symptoms like swelling or pain in their salivary glands underwent both imaging methods. The goal was to see if the 3D-CBCT could accurately detect and locate problems like stones or narrow ducts.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- iodinated contrast agent (HEXABRIX 320)
- What this could lead to
- If successful, this could make diagnosing salivary gland diseases faster and more accessible using 3D-CBCT instead of MRI.
- What could go wrong
- This is a small pilot study with only 50 participants, so results may not apply to everyone. The 3D-CBCT method involves radiation and contrast injection, which carry small risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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50 people
The number who actually took part.
- Started
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Jun 2016
- Finished
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Aug 2019
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Male or female, over 18 years old with unilateral or bilateral parotid or submandibular salivary symptoms (salivary swelling, salivary colic, pain, salivary infections), with an acute evolution (\<14 days), subacute (2-12 weeks) or chronic one (\>3 months)
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female, over 18 years old. * With unilateral or bilateral parotid or submandibular salivary symptoms (salivary swelling, salivary colic, pain, salivary infections), with an acute evolution (\<14 days), subacute (2-12 weeks) or chronic one (\>3 months). * With or without initial imaging (ultrasonography). * Understanding the technique and its interest in the diagnostic and therapeutic management. * Accepting the examination and the salivary catheterization. * Positive catheterization test Exclusion Criteria: * Patient whose physical or mental condition make him unable to understand the examination and to consent to the study. * Allergy to iodine. * Salivary infection under treatment. * Damage to the oral mucosa preventing salivary catheterization. * Contraindication to MRI: metal or valvular prosthesis, pacemaker, claustrophobia. * Current or suspected pregnancy. * Patient refusing the examination or the catheterization. * Salivary symptoms of tumor appearance: Unilateral palpable mass, facial palsy, multiple lymph nodes in parotid and / or pre-auricular and / or neck areas. * Salivary neoplasm demonstrated by a prior diagnostic testing. * Patient who underwent head and neck scan in the previous 6 months. Conventional or three dimensional sialography achieved in the previous 6 months. * Salivary catheterization failure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de Nantes
Nantes, 44093, France