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Grape and olive supplement shows promise against arthritis inflammation

NCT ID NCT02566798

Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joint fluid samples. The goal is to find a natural way to manage osteoarthritis inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
grape and olive extract (Oléogrape®SEED)
What this could lead to
If it works, this could point toward a natural supplement that eases inflammation in osteoarthritis, potentially reducing pain and slowing joint damage.
What could go wrong
This is a very small, early study with only 12 people, lasting just 7 days. It measures lab markers, not actual symptom relief, so results may not translate to real-world benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Start date

Dec 2015

Finished

Apr 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 50 years old and over * Patients with knee osteoarthritis (ACR criteria) * Patients requiring injection of hyaluronic acid (no corticosteroid associated) * Radiological stage of knee osteoarthritis 1, 2 or 3 (Kellgren-Lawrence) * Informed consent form signed Exclusion Criteria: * younger than 50 years * protected adult * Pregnant woman * Radiological Stage 4 osteoarthritis (Kellgren-Lawrence) * knee osteoarthritis secondary to arthritis * Taking a long term treatment of osteoarthritis (Piasclédine®, Diacéréine®, glucosamine, chondroitin) * inflammatory pathology other than osteoarthritis * Taking anti-inflammatory medications * Refusal to participate in the study * Use of food supplements with anti-inflammatory properties * Arthroscopy less than 6 months * corticosteroid injection \<3 months * INR\> 4 or TCA\> 2 (anticoagulants) * Being allergic to lactose

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

Contacts and locations

Locations

  • CHU de Nantes

    Nantes, 44093, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.