Gas mixture tested to help turn breech babies
NCT ID NCT01948115
First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time
Summary
Researchers test whether breathing a mix of oxygen and nitrous oxide helps turn a breech baby during a procedure called external cephalic version (ECV). The trial enrolls 150 pregnant women at term with a singleton breech or transverse baby. Half receive the gas mixture and half receive medical air, and researchers compare how often the baby turns head-down, along with pain and side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- equimolar mixture of oxygen and nitrous oxide
- What this could lead to
- If it works, this could make the procedure to turn a breech baby more comfortable and more likely to succeed, helping some women avoid a cesarean delivery.
- What could go wrong
- The gas may not improve success rates or may cause side effects like nausea. The trial is small and single-blind, so results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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150 people
The number who actually took part.
- Start date
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Nov 2013
- Finished
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Dec 2015
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * age ≥ 18 years * pregnancy at term (≥36 weeks) * singleton foetus in breech or transverse presentation * acceptance of ECV * signature of informed consent Exclusion Criteria: * contraindications of ECV: placenta praevia, obstacle praevia, multiple pregnancy, foetal death, foetal heart rhythm disorder, lack of amniotic fluid, HIV-positive patient * contraindications of equimolar mixture of oxygen and nitrous oxide : patient who require pure oxygen ventilation, disorders of consciousness that impede the cooperation of the patient, pneumothorax, pulmonary embolism, ocular surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Nantes University Hospital
Nantes, 44093, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.