Nantes University Hospital

This study looks at whether people with well-controlled atopic dermatitis (eczema) can safely take dupilumab less often without losing control of their disease. About 256 teens and adults who have been on the standard every-2-week dose for at least a year will either stay on that…

This study tests a personalized approach for people newly diagnosed with multiple myeloma. After initial treatment, doctors use a sensitive test to see if any cancer cells remain. Based on the results, patients receive one of two combinations of T-cell redirecting drugs (teclista…

This study tests whether a fecal microbiota transplant (FMT) from a healthy donor can delay or prevent recurrent pouchitis in people with ulcerative colitis who have had ileal pouch-anal anastomosis surgery. About 42 adults with chronic pouchitis will receive either FMT or a sham…

This study tests whether a minimally invasive clip repair (MitraClip) is as effective as open-heart surgery for people with severe mitral regurgitation who are at high risk for surgery. About 330 participants will be randomly assigned to one of the two treatments and followed for…

This study is testing whether a new radioactive tracer called PentixaFor can improve PET scans for people with multiple myeloma. The goal is to see if it finds cancer spots better than the standard FDG tracer, both at first diagnosis and when the disease comes back. About 45 adul…

This study tests whether a special heart scan (dynamic SPECT) can accurately detect leftover blockages in heart attack survivors, compared to the current standard invasive test (FFR). About 60 adults with multiple blocked arteries will get both tests. If the scan works well, it c…

This study tests whether phycocyanin, a natural antioxidant from spirulina, can reduce nerve damage caused by oxaliplatin chemotherapy in people with metastatic gastrointestinal cancers. About 110 participants will receive either phycocyanin or a placebo during their treatment. T…

This study looks at whether giving extra oxygen through the nose during a hospital stay can lower the chance of wound problems after ankle fracture surgery. It focuses on patients who are at higher risk due to conditions like diabetes, smoking, or complex fractures. About 200 adu…

This study aims to find new genes linked to two types of congenital heart defects where the heart's main arteries are connected incorrectly. Researchers will analyze DNA from up to 300 children with these conditions and their parents. The goal is to improve understanding of these…

This study aims to find new genes that cause very low cholesterol levels (FHBL). Researchers are recruiting people with extremely low LDL cholesterol and their family members to collect DNA samples. By analyzing the genetic material, they hope to discover new targets for understa…

This study looks at how a measure called the Hemoglobin Glycation Index (HGI) changes over time in 750 adults with diabetes who use continuous glucose monitors. HGI helps doctors understand how well blood sugar is controlled. The goal is to see if HGI stays stable or varies, whic…

This study looks at how social factors like income, housing, and lifestyle affect the risk of a brain aneurysm bursting. Researchers will use artificial intelligence to analyze health records from 1,800 adults. The goal is to better predict who is at risk and improve prevention.