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Blood's tiny RNA clues could unlock the stroke 'Clock'

NCT ID NCT03905434

Knowledge-focused Sponsor: Virginia Commonwealth University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to healthy controls to see if certain microRNAs are different. They will also check if these microRNAs differ between patients with good versus poor collateral blood flow, which might help doctors estimate stroke onset time and guide treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood sampling for exosomal microRNA analysis
What this could lead to
If certain microRNAs are found, they could become a blood test to estimate stroke onset time and guide treatment decisions.
What could go wrong
This is a small, early study. The identified microRNAs may not be specific or reliable enough for clinical use, and results may not generalize beyond this patient group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2018

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients aged \>18 years presenting to the Emergency Department at Ohio State Wexner Medical Center with acute ischemic stroke within 6 hours of last known well will be screened. The investigators will include patients with acute anterior circulation LVO as identified by CT Angiogram. Healthy subjects will be used as controls to assess differentially expressed miRNAs specific to stroke population.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. Age 18 years or older. 2. Diagnosis of Acute Ischemic Stroke secondary to LVO 3. LVO from presumed embolic source (\<50% ICA) 4. CT perfusion/RAPID images showing salvageable penumbra (evaluated by PI) Exclusion: 1. \>50% stenosis of internal carotid artery 2. \>50% stenosis of bilateral vertebral arteries. 3. Patients with moderate to severe intracranial atherosclerotic disease as seen in CTA of head and neck. 4. Known moderate to severe PVD or symptomatic CAD 5. Past medical history of stent or coronary artery bypass surgery 6. Prisoners 7. Pregnant women 8. Previous stroke within 30 days 9. Intracranial vascular malformation or evidence of moya-moya disease 10. Serious advanced or terminal illness per judgment of the investigator with life expectancy \<1yr 11. Known allergy to iodine that precludes CTA or CTP studies 12. Presumed septic embolus or suspected bacterial endocarditis

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Conditions

The condition(s) this trial relates to.

cerebrovascular disorder Ischemic Stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebrovascular disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23298, United States

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