Virginia Commonwealth University

This study tests whether a low-dose anti-inflammatory drug called colchicine can safely reduce inflammation in people who cannot take statins due to side effects. Statins lower cholesterol and inflammation, but some people have to stop them. The study will enroll 30 adults aged 1…

This study tests two drugs, neratinib and valproate, together in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find the safest and most effective dose, and then see how well the combination works against cancers with a RAS m…

This early-stage trial tests an experimental drug called GZ17-6.02 in 30 men with castration-resistant prostate cancer that has worsened despite hormone therapy. The main goal is to see if the drug can delay cancer growth for at least 6 months. Researchers will also measure chang…

This study tests whether capsules containing gut bacteria from healthy donors can safely reduce alcohol cravings and drinking in 80 adults with alcohol-related liver disease and cirrhosis. Participants will receive either the bacteria capsules or a placebo, and researchers will t…

This study tests whether a skin patch containing rotigotine, a drug already approved for Parkinson's disease, can help people with cocaine use disorder use less cocaine and improve their thinking skills. About 40 adults will receive either the rotigotine patch or a placebo patch,…

This study tests whether an oral medication (azacitidine) can help prevent acute myeloid leukemia from coming back in patients who are eligible for a stem cell transplant but cannot get one due to racial or socioeconomic reasons. About 12 adults whose leukemia is in remission wil…

This study tests whether adding a combination of two antibiotics and aspirin to standard chemotherapy can help people with stage IV colorectal cancer. About 97 participants will receive either chemo alone or chemo plus the microbiome therapy. The goal is to see if the added treat…

This early study tests whether adding a freezing spray (cryospray) to usual treatments can prevent the windpipe from narrowing again in people with benign (non-cancer) airway stenosis. About 12 adults will receive the spray during a standard procedure, and doctors will check if t…

This study tests a video game-based therapy for children aged 4-7 with intermittent exotropia, a condition where one eye drifts outward. The therapy uses a headset to show different images to each eye, training them to work together. The goal is to improve eye control and reduce …

This study tests whether adding the oral drug zanubrutinib to standard chemotherapy (R-CHOP) helps more people with diffuse large B-cell lymphoma (DLBCL) achieve complete remission. It is for patients whose tumors have certain genetic changes (MYD88, CD79B, NOTCH1 mutations or CD…

This study looks at whether it is better to do bone grafting right after pulling a back tooth or to wait. The goal is to keep enough bone for a dental implant later. About 40 adults will take part, and researchers will track their pain, healing, and quality of life using a simple…

This study is testing a treatment plan for people with rectal cancer that can be surgically removed. Participants receive a combination of chemotherapy (mFOLFOX) and a short course of radiation before surgery. The goal is to see if this approach improves the chance of being cance…

This study is for adults aged 70 or older, or those who are frail, with advanced non-small cell lung cancer that has a low PD-L1 score. The goal is to see if using a reduced dose of chemotherapy together with an immunotherapy drug (anti-PD-1) causes fewer side effects that force …

This study tests a program to help Black women with breast cancer follow their prescribed treatment plan, including chemotherapy and hormone therapy. Researchers will compare the program to standard care in 250 participants to see if it improves treatment start, reduces delays, a…

This study is testing whether a heart medication called sacubitril-valsartan is tolerable and feasible for young adult cancer survivors (diagnosed at or before age 39) who have early-stage heart failure (Stage B) without symptoms. The goal is to see if the drug can help prevent t…

This early-phase study tests whether a daily pill called olutasidenib can safely help adults with a specific type of acute myeloid leukemia (IDH1-mutant AML) stay in remission after standard chemotherapy. About 15 participants will take the drug for at least 4 months while doctor…

This study looks at whether a urine test (CXCL10) can spot kidney transplant rejection more accurately than a standard blood test, especially when the blood test misses it. Researchers will collect urine samples from 50 adult kidney transplant patients who are already having a bi…

This study tests a program called Bridging the Gap for adults treated in the hospital for violent injuries like gunshot wounds. The goal is to see if the program reduces future violence, firearm use, and re-injury. Researchers will follow 616 participants to compare outcomes betw…

This study tests whether community health workers can help care partners of people with traumatic brain injury (TBI) manage the transition from hospital rehab to home. About 126 care partners will receive support via texts, calls, and check-ins. The goal is to improve care partne…

This study is testing a program that helps people with obesity who are waiting for a kidney transplant. The program includes education on weight loss and tools to support healthy eating and lifestyle changes. About 30 adults will take part to see if the program improves their qua…

This study is testing a mobile app designed to help cancer survivors who have finished treatment manage their pain and other symptoms. The app provides tools and support to boost confidence in self-care. About 25 participants will use the app for a short time to see if it is easy…

This study tests whether a drug called anakinra can make the heart more sensitive to inotropes (medications that strengthen heart contractions) in people with advanced heart failure. By reducing inflammation, doctors hope to lower the dose of inotropes needed, which may decrease …

This study looks at the best way to protect the roof of the mouth after a gum graft. About 56 adults will try one of three different protective dressings. Researchers will track pain, swelling, bleeding, and whether patients would choose the same method again. The goal is to find…

This study tests a computer tool called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. About 126 participants will either use the tool or receive usual care. The goal is to see if the tool improves their confidence and ability to manag…

This study tests two remote therapies for adults with anorexia who recently completed intensive treatment. Participants receive 24 weeks of either Positive Affect Treatment or standard psychoeducation via teletherapy. The goal is to see if targeting reward mechanisms helps mainta…

This study is testing whether giving radiation therapy for breast cancer in just 3 sessions over 2 days is safe and effective. It involves 170 women aged 45-79 who have had a lumpectomy for early-stage breast cancer. The goal is to see if this shorter treatment causes fewer side …

This study compares an intensive lifestyle program to standard weight loss advice in 32 women aged 18-25 with a BMI of 25-50. The goal is to see if the intensive program leads to greater reductions in weight, waist size, and body fat, and also improves markers of inflammation ove…

This study compares two virtual programs for adults with brain tumors who have trouble with thinking or memory. One program combines cognitive rehab with mindfulness training; the other offers brain health education videos. The goal is to see if these programs are practical and l…

This study tests a training program for healthcare practitioners to help them better treat chronic pain without relying on opioids. About 1,188 patients and their doctors will take part. The program teaches team-based, behavioral approaches to pain management, with the goal of im…

This study tests whether adding the drug valbenazine to standard botox injections can better reduce neck muscle spasms and pain in people with cervical dystonia. About 20 adults aged 18–75 with idiopathic cervical dystonia will receive valbenazine daily for 12 weeks while continu…

This study tests if a home-based exercise program can improve heart and lung fitness in men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). The study will compare 60 men who exercise at home to those who receive only healthy living education…

This study tests a technique called heart rate variability biofeedback, which uses breathing exercises to help people with long-lasting symptoms after a mild concussion. The goal is to reduce issues like headaches, dizziness, memory problems, and mood changes. The trial includes …

This study tests a program called "Mindful Moms" to see if it can improve mood and health in pregnant women with depressive symptoms. About 200 pregnant women with mild to moderate depression will either take the mindfulness program or attend group education workshops. The goal i…

This early study looks at whether breast cancer patients can use azelaic acid cream twice a day during radiation to help manage skin irritation. About 33 adults with darker or sun-sensitive skin who are getting radiation will try the cream. The goal is to see if it's practical an…

This study looks at how long-term e-cigarette use impacts the health of tiny blood vessels in the body. Researchers will measure blood vessel function in 44 frequent e-cigarette users aged 18-29 using special laser techniques. The goal is to understand the mechanisms behind poten…

This study tests whether an AI-powered chatbot can help African American adults learn more about oral cancer and its prevention compared to traditional educational handouts. About 60 participants will be split into two groups, and their knowledge will be measured before and after…

This study is testing an online version of a tablet-based assessment that asks children ages 3 to 7 to copy shapes on a touch screen. The goal is to see if this digital tool can quickly and automatically score prewriting skills, replacing slower, subjective paper tests. Researche…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study aims to understand why people with Lewy body dementia (including Parkinson's disease dementia) have sudden changes in attention and thinking, called cognitive fluctuations. Researchers will use brain scans, EEG (a test that records brain waves), and thinking tests in 1…

This study looks at how a gentle, non-invasive brain stimulation technique affects the way people learn and adapt their movements. Researchers will measure how accurately 60 right-handed adults (ages 18-40) reach for targets before and after 20 minutes of stimulation. The goal is…

This study looks at whether support programs in hospitals can reduce violence and firearm use among injured teens. About 300 youth aged 10-17 and their caregivers will take part. Researchers will track things like re-injury, gun carrying, and risky behaviors to see if the program…

This 24-month study follows up to 1000 people with limb girdle muscular dystrophy, myotonic dystrophy type 2, or late-onset Pompe disease. Researchers will test simple physical tasks like walking and timed tests to see which measurements best track disease changes over time. The …

This study looks at how the size of small attachments on clear aligners (like Invisalign) affects how well a specific tooth can be moved. About 40 people getting Invisalign treatment will be randomly assigned to one of three attachment sizes. The goal is to find which size works …

This study aims to understand how people with a leg amputation get around in their community, whether by walking with a prosthetic or using a wheelchair or scooter. Researchers will track 50 participants' movements using GPS and activity monitors for 10-21 days, along with questi…

This study looks at how exercise affects blood vessel function in people with PTSD or generalized anxiety disorder compared to healthy individuals. Researchers want to understand if harmful substances in the blood called oxidants play a role in blood vessel damage. The study invo…

This study is creating a registry of 60 kidney transplant patients who have a BK virus infection. Researchers will track their immune responses over time by analyzing blood and urine samples. The goal is to better understand how the virus and the body's defenses interact, which c…

This study looks at how the brain works in teenagers with POTS, a condition that causes a fast heart rate and dizziness when standing. Researchers will use brain scans and questionnaires to see if a specific brain area is linked to symptoms. The goal is to better understand POTS,…

This study involves 20 adults who already have a special type of pacemaker. Researchers want to see if it is safe and possible to perform an exercise test inside an MRI machine. They will measure how well the heart pumps and how much exercise people can do under different pacemak…

This study is testing a program called FearLess to see if it helps people with brain tumors and their caregivers deal with the fear of the cancer coming back. The researchers want to find out if the study methods work well, including how they recruit participants and keep them in…

This study follows 240 adults with NASH-related cirrhosis to find better ways to detect early signs of liver decompensation, such as internal bleeding, fluid buildup, or confusion. Researchers will track deaths and complications over time using routine exams and tests. The goal i…

This study looks at whether a new digital stethoscope can help parents of infants with fast heart rates (tachyarrhythmia) record clear heart rhythm readings at home. About 100 babies under 1 year old will take part. The goal is to see if parents can capture high-quality ECG recor…

This study tests a hospital-based program for youth aged 13-17 who have been injured by violence. The goal is to see if the program can reduce future violence and risky behaviors. Researchers will track participants' attitudes, re-injury rates, and other outcomes over time.

This study looks at how stressful experiences in childhood may impact heart and blood vessel health later in life. Researchers will measure heart function, blood vessel response, and lung function in 120 people aged 9 to 30. No treatments or medications are given—the goal is simp…

This study looks at whether doing physical activity before a gentle brain stimulation technique (HD-tDCS) can lower anxiety more than either method by itself. Researchers will measure anxiety levels and brain activity in 29 healthy adults aged 18 to 50. Participants must not have…

This study follows 50 adults with paroxysmal atrial fibrillation (AF) who are scheduled for catheter ablation. Researchers use exercise cardiac MRI before and 5-6 months after the procedure to measure how well the heart's left atrium works during exercise. The goal is to understa…

This study is testing whether a robotic device can safely and easily monitor blood flow in the brains of 30 adults with severe traumatic brain injury. The device uses ultrasound through the skull and is designed to work automatically for long periods. Researchers want to see if i…

This study looks at what helps or hinders transgender and gender-diverse youth (ages 15-21) from taking part in research. Researchers will ask participants about their experiences and reasons for joining studies. The goal is to make research more inclusive and better represent th…

This study compares two methods of controlling a prosthetic arm for adults with below-elbow limb loss. One method uses signals from two muscles, while the other uses signals from several muscles to better understand the user's intended movement. The goal is to see which method is…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study looks at how the brains of teenagers with Postural Tachycardia Syndrome (POTS) process what they see. Researchers will use brain scans to compare brain activity in teens with POTS and healthy teens. The goal is to learn more about how different parts of the brain commu…

This study tests whether a patient navigation program helps more Black adults who are at high risk for lung cancer complete their lung cancer screening. Researchers will enroll 675 people and track how many get a low-dose CT scan. The goal is to see if having a guide through the …