Brain scans seek clues to teen POTS mystery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

POTS sample Inclusion Criteria: * symptomatic ≥ 40 bpm rise in heart rate in the first 10 min of a tilt table study without a drop in blood pressure * Clinical symptoms of orthostatic intolerance Exclusion Criteria: * Pregnant or breastfeeding * Cognitive defects that preclude answering questionnaires or following assessment directions * Other chronic diseases * Unstable medical conditions * Use of narcotics * Limited English proficiency * Investigator discretion that participant would not be suitable to participate * A phone older than 5 years old or unable to support EMA software POST INFECTION Inclusion Criteria: * acute upper respiratory or gastrointestinal infection that required admission to the acute care units but not requiring an ICU stay Exclusion Criteria: * Pregnant or breastfeeding * Chronic prescriptions, history of POTS or orthostatic symptoms, recent inpatient psychiatric admissions, substance use disorder, trauma such as a motor vehicle accident, surgery, or other significant physical or emotional trauma in the last 5 years * Cognitive defects that preclude answering questionnaires or following assessment directions * Other unstable chronic diseases * Unstable medical conditions * Use of narcotics * Severe depression or anxiety (untreated / unstable) * Limited English proficiency * Investigator discretion that participant would not be suitable to participate * A phone older than 5 years old or unable to support EMA software HEALTHY CONTROLS Inclusion Criteria: * Apparently healthy with no known chronic illnesses Exclusion Criteria: * Pregnant or breastfeeding * History of POTS or orthostatic symptoms, migraines, fibromyalgia, chronic fatigue, PTSD. Functional gastrointestinal disorders, fainting, dysmenorrhea, or other chronic pain syndrome, inpatient psychiatric admissions, substance use disorder, trauma such as a motor vehicle accident, surgery, or other significant physical or emotional trauma in the last 5 years * Cognitive defects that preclude answering questionnaires or following assessment directions * Other chronic unstable diseases * Unstable medical conditions * Use of narcotics * Severe depression or anxiety (untreated / unstable) * Limited English proficiency * Investigator discretion that participant would not be suitable to participate * A phone older than 5 years old or unable to support EMA software