Peripheral arterial disease

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study compares a new balloon coated with everolimus to standard paclitaxel-coated balloons for opening blocked leg arteries in people with peripheral artery disease. About 410 participants will be randomly assigned to one of the two balloons. The goal is to see if the new ba…

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every …

This study is collecting information from 5,000 people with peripheral vascular disease who are being treated with Boston Scientific drug-eluting devices in everyday medical practice. The goal is to see how well these devices work and how safe they are in a wide range of patients…

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned…

This study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This registry follows 1000 people who received Advanta VXT or Flixene grafts to repair peripheral arteries. Researchers will check how well the grafts stay open and how often serious problems like amputation or repeat surgery occur. The goal is to confirm these devices are safe a…

This trial tests a special balloon coated with a drug (paclitaxel) to treat blockages in the leg arteries caused by cholesterol buildup. The balloon is inflated to open the artery and release the drug to help keep it open. The study will include 200 people and check if the balloo…

This trial tests whether applying perinatal tissue allografts to chronic diabetic foot ulcers, along with standard wound care, leads to more ulcers healing completely within 12 weeks compared to standard care alone. Adults with type 1 or 2 diabetes who have a nonhealing foot ulce…

This trial tests whether a clopidogrel-based antiplatelet regimen is as effective as aspirin plus low-dose rivaroxaban in preventing heart attacks, strokes, and other vascular events. Adults with a history of heart attack or peripheral artery disease will be randomly assigned to …

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study tests a new tool called Golazo that removes plaque from leg arteries in people with peripheral artery disease (PAD). About 159 adults with moderate to severe symptoms will be treated at up to 20 U.S. sites. The goal is to see if the device is safe and works well to imp…

This phase 3 trial is testing two experimental drugs, REGN7508 and REGN9933, to prevent serious blood clots in people with peripheral artery disease who recently had leg surgery to improve blood flow. The study will enroll about 7,050 participants and compare the drugs to a place…

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This trial tests whether a 12-week supervised treadmill exercise program can improve blood flow and walking distance in people with peripheral artery disease (PAD). It also explores whether adding nitrate-rich beetroot juice helps those who don't respond to exercise alone. Two hu…

This study compares taking two blood thinners (clopidogrel and aspirin) for 1 month versus 6 months after a leg artery procedure. The goal is to see if the longer treatment keeps the treated artery open longer and prevents serious events like heart attack or stroke without causin…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people with severe leg artery disease (chronic limb-threatening ischemia) avoid amputation or death. About 200 adults who recently had a procedure to restore leg blood flow will take either colc…

This study tests whether using a tiny ultrasound camera inside the blood vessels during a minimally invasive leg artery procedure leads to better results for people with peripheral artery disease. About 350 adults with leg pain or wounds from blocked arteries will be randomly ass…

This early-stage trial compares a new investigational drug, CG-0255, to the established blood thinner Plavix in 136 healthy adults aged 18-55. The goal is to see if CG-0255 is processed by the body similarly to Plavix and has the same effect on preventing blood clots. Participant…

This study tests whether computer alerts can help doctors prescribe cholesterol-lowering drugs to people with peripheral artery disease (PAD) who aren't taking them. About 400 adults with PAD will be randomly assigned to have their doctors receive an alert or not. The goal is to …

This study is testing a new laser device called the Thor system to treat blockages in the leg arteries caused by peripheral artery disease (PAD). About 155 adults with PAD will receive the laser treatment and be followed for a year. The main goals are to see if the device is safe…

This registry is following 240 people who receive the GORE VIABAHN VBX stent graft to treat blocked or damaged arteries in the abdomen, pelvis, or limbs. Researchers are tracking how well the device works and any serious side effects over time. The goal is to see if the stent gra…

This study tests whether a fabric-covered stent (GORE VBX) works better than standard bare metal stents for people with severe blockages in the iliac arteries, which supply blood to the legs. About 244 participants with leg pain or tissue loss will be randomly assigned to receive…

This study tracks 500 people getting the Serranator balloon to open blocked leg arteries (peripheral artery disease) or dialysis fistulas. Doctors will check if the device works safely in everyday use. The goal is to improve blood flow without major complications.

The PROVE trial is testing whether a weight loss program combined with walking exercise can improve or maintain walking ability in people with peripheral artery disease (PAD) who are overweight. 212 participants will be randomly assigned to either weight loss plus exercise or exe…

This study tests a device that uses light and magnets (COMS) to help heal chronic leg ulcers. About 122 people with venous leg ulcers will receive either standard care plus COMS or standard care alone. The goal is to see if the device speeds up wound healing and improves quality …

This study tests whether using a special shockwave device to break up calcium before placing a stent works better than the usual balloon angioplasty in people with peripheral artery disease (PAD) and heavily calcified leg arteries. About 120 participants will be randomly assigned…

This study compares two balloon treatments used after placing a stent in long blockages of the leg arteries. About 180 people with peripheral artery disease will receive either a drug-coated balloon or a standard balloon. The goal is to see which keeps the artery open longer and …

This study looks at whether doing handgrip exercises for 12 weeks can lower blood pressure in people with peripheral artery disease (PAD). Researchers will split 30 participants into two groups: one does handgrip training, the other is encouraged to be more active. Blood pressure…

This study tests a special balloon coated with medicine (SELUTION SLR™ 014) to open blocked arteries below the knee in people with severe leg pain or wounds that threaten the limb. About 376 adults with chronic limb-threatening ischemia will be randomly assigned to get either the…

This study tests an investigational drug called SRSD107 in people with chronic coronary artery disease or peripheral arterial disease. The goal is to see if it safely reduces a protein involved in blood clotting, which may lower the risk of dangerous clots. About 104 adults will …

This study is testing a device called the LimFlow Stent Graft System for people with late-stage chronic limb-threatening ischemia, a severe form of peripheral artery disease where blood flow to the leg is critically low. The device creates a new connection between a vein and arte…

This study tests a new drug called APAC, which is designed to prevent blood clots in people with blocked leg arteries. The trial includes 42 adults with peripheral arterial disease or chronic limb-threatening ischemia. Researchers will check if APAC is safe and well-tolerated, an…

This study is tracking 1,000 people with severe leg artery disease (chronic limb-threatening ischemia) who are getting a drug-coated balloon to open blocked arteries below the knee. The balloon releases a drug (paclitaxel) to help keep the artery open. Researchers want to see if …

This study tests a new device called the efemoral vascular scaffold system (EVSS) in 100 people with blocked leg arteries that cause pain or trouble walking. The scaffold is placed inside the artery to hold it open and improve blood flow. Researchers will check if the device is s…

This study tests a procedure that connects an artery to a vein in the foot to bring blood to tissues when standard treatments have failed. It includes 50 patients with severe leg artery disease and active wounds. The goal is to see if the procedure is safe and can prevent major a…

This study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…

This study tests whether a daily low dose of colchicine, an anti-inflammatory drug, can prevent heart attacks, strokes, and severe leg complications in people with peripheral artery disease (PAD). About 6,150 participants with symptomatic PAD will receive either colchicine or a p…

This study tests whether using carbon dioxide gas instead of standard iodinated contrast dye during leg artery procedures can prevent serious kidney problems. About 1,960 people with peripheral artery disease who are at higher risk for kidney injury will be randomly assigned to r…

This study tests whether a team of healthcare professionals using a special algorithm can lower 'bad' cholesterol (LDL-C) more effectively than standard care in people with heart or blood vessel disease. About 100 adults with high cholesterol and known vascular disease will be ra…

This study tests whether a laser device called the Auryon Atherectomy System, used with standard balloon angioplasty, works better than balloon angioplasty alone for people with severe leg artery blockages (critical limb ischemia). The trial will enroll 224 adults who are at risk…

This study tests a special balloon coated with sirolimus, a drug that helps keep arteries open, versus a standard balloon for people with severe leg artery disease below the knee. About 368 adults with advanced symptoms like pain at rest or non-healing wounds will be randomly ass…

This study tests a special filter device designed to catch debris during procedures that clear blockages in the leg arteries. The goal is to prevent small particles from traveling downstream and causing serious complications. About 150 adults with leg artery disease will be enrol…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This study is tracking 600 people with peripheral artery disease (PAD) who are treated with the Rotarex device, a rotating catheter that cuts and removes plaque from blocked leg arteries. The goal is to see how well the device restores blood flow and how often serious complicatio…

This study compares two treatments for long blockages (15-25 cm) in the leg's main artery. One is bypass surgery, which uses a vein or artificial tube to reroute blood flow. The other is a less invasive procedure using a balloon to open the artery, often with a stent. The trial w…

This study tests whether taking spirulina (a microalgae) or seaweed (Gelidium corneum) supplements for 20 weeks can improve markers of heart health and change gut bacteria in people at high risk for heart disease. The trial includes 150 adults aged 50 or older with conditions lik…

This study tests whether a gel made from a patient's own blood, called Plasma Rich in Growth Factors (PRGF), can heal foot ulcers better than standard care. It includes 38 diabetic adults with poor leg blood flow. The treatment is applied topically during regular wound care visit…

This study is checking how safe and effective the ZENFLEX Pro drug-eluting stent is for people with peripheral artery disease (PAD) — narrowed or blocked arteries in the leg. About 153 adults with leg pain or sores will get the stent and be followed for a year. The main goal is t…

This study is tracking 500 people who had a procedure using the Pounce Thrombectomy System, a device that removes blood clots from arteries in the legs without open surgery. The goal is to see how well the device restores blood flow and how safe it is. The study is retrospective,…

This study tests whether injecting donor stem cells (Stempeucel) into the leg muscle can help people with critical limb ischemia, a severe form of peripheral artery disease. Ten Malaysian patients who cannot have surgery or angioplasty will receive the stem cells and be followed …

This study is testing whether a device that measures how long it takes for a pulse to travel through the arms and legs can detect peripheral artery disease (PAD), a condition where leg arteries become narrowed. Researchers will compare this new method to the standard ankle-brachi…

This study is testing a device called Laser Speckle Contrast Imaging (LSCI) that uses a laser to measure blood flow in the leg. The goal is to see if it can help doctors monitor blood flow before, during, and after surgery to restore circulation. The study will enroll 30 people s…

This Phase 3 trial tests whether a new contrast agent called gadopiclenol works as well as the standard agent (Dotarem) for MRI scans to find blocked arteries in the neck, legs, or abdomen. About 315 adults with suspected vascular disease will receive both agents in random order …

This study will check how common peripheral artery disease (PAD) is in people who need surgery for lumbar spinal stenosis (LSS). Both conditions can cause leg pain, making PAD hard to spot. Researchers will use a special CT scan to find PAD and compare it with simpler tests like …

This study at Mayo Clinic is testing a new, non-invasive ultrasound technique to detect peripheral arterial disease (PAD) earlier and more easily. Researchers will compare the ultrasound results with standard tests like ankle-brachial index and CT scans. The study includes 400 pe…

This study is testing a new imaging technique called photoacoustic tomography (PACT) to see blood vessels and oxygen levels in the feet without using dyes or needles. The goal is to help doctors diagnose lower extremity artery disease (LEAD) more accurately and earlier. Researche…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study tests whether a community-based exercise program can improve walking ability and heart health in people with peripheral artery disease who have recently had a procedure to open blocked leg arteries. Researchers will enroll 30 participants and measure how long they can …

This study tests a once-daily pill called orforglipron in about 1205 people with peripheral artery disease (PAD) who have leg pain when walking. The goal is to see if the drug helps them walk farther without pain and improves their quality of life. Participants will be followed f…

This study tests whether wearing a virtual reality headset with calming scenes and hypnotic speech can lower pain and anxiety during minimally invasive leg artery surgery done under local anesthesia. About 90 adults with peripheral artery disease will take part. The main goal is …

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over 50 with PAD will use special heated trousers for 90 minutes a day at home for 12 weeks. Researchers will measure c…

This study tests whether a personalized exercise program—focusing on the specific leg muscles affected by blocked arteries—can help people with peripheral arterial disease walk longer distances without pain. Participants are randomly assigned to either a tailored muscle-strengthe…

This pilot study tests whether a 12-week home-based exercise program using a small pedal exerciser can help people with moderate-to-severe peripheral artery disease (PAD) walk farther and feel better. Twelve adults with severe PAD will be randomly assigned to either the home exer…

This early-phase trial tests whether a single dose of Vumerity (diroximel fumarate) can improve blood vessel function and walking ability in 20 people aged 50-75 with peripheral artery disease (PAD). Participants will receive either Vumerity or a placebo, and researchers will mea…

This study tests a new, pain-free exercise program for people with peripheral artery disease (PAD), which causes leg pain when walking. Researchers will compare it to standard painful exercise over 3 months in 100 adults aged 40 and older. The goal is to see if the pain-free prog…

This study tests whether taking cocoa flavanols daily for six months can improve walking distance in people aged 55 and older with peripheral artery disease (PAD), a condition that causes leg pain and limits mobility. Researchers will compare a cocoa flavanol supplement to a plac…

This study tests two home-based walking programs for veterans with peripheral artery disease (PAD), a condition that causes leg pain when walking. Participants will either use a website, have telehealth coaching, or get usual care. The goal is to see if these programs help them w…

This study tests whether a special exercise program using blood flow restriction cuffs can improve walking ability and quality of life in people with peripheral arterial disease (PAD). About 81 adults with stable leg pain from PAD will do low-intensity calf raises while wearing c…

This study tests a home-based exercise program called Smart MOVE! for Veterans with peripheral artery disease (PAD), a condition that limits walking ability. Participants will use a wearable activity monitor and receive behavioral coaching via the MOVE! program. The goal is to se…

This study tests whether metformin, a standard diabetes drug, can improve walking ability in people with peripheral artery disease (PAD) who experience leg pain during activity. Researchers will give 200 Veterans either metformin or a placebo for several months and measure change…

This study tests whether combining the DASH diet (a heart-healthy eating plan) with a home-based walking program can improve walking ability and quality of life in people with peripheral artery disease (PAD). PAD causes leg pain during walking due to narrowed arteries. The study …

This study tests whether drinking beetroot juice daily for 4 months can improve walking distance in people with peripheral artery disease (PAD). Researchers will compare a beetroot juice group to a placebo group in 210 adults aged 50 and older. The main goal is to see if beetroot…

This pilot study tests whether fisetin, a natural compound found in strawberries, can reduce aging cells and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will receive either fisetin or a placebo for 4 months. The main goal is to…

This study tests whether shining a specific red light on the legs each day before a walking session can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to poor blood flow. The trial will involve 32 adults aged 50 and o…

This study tests whether adding nitrate-rich beetroot juice to exercise helps people with peripheral artery disease (PAD) walk farther and with less pain. 210 adults aged 50+ with PAD will be assigned to either supervised treadmill or home walking, plus either beetroot juice or a…

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who lost a leg due to diabetes or artery disease will take part.

This study tests whether taking MitoQ for six months can improve walking ability and quality of life in people with peripheral artery disease who experience leg pain while walking. Researchers will measure treadmill walking distance, daily step counts, and leg muscle health in 60…

This study compares a new type of below-knee amputation (Ewing amputation) to the standard surgery in 120 veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. Participants are randomly assigned to one of the two surger…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study tests whether a fuzzy wale compression stockinet can help wounds heal faster and lower costs after a leg amputation due to poor blood flow. About 40 adults will be enrolled. The goal is to see if this special sock reduces infections, pain, and time until a prosthetic l…

This study tests a new type of supervised exercise for people with peripheral artery disease (PAD), which causes leg pain when walking due to blocked arteries. Researchers want to see if using muscle oxygen levels to guide exercise is better than standard therapy. The study invol…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether high-frequency spinal cord stimulation can reduce leg pain and improve quality of life in people with both peripheral arterial disease (PAD) and painful diabetic neuropathy. Fifteen adults who already have a spinal cord stimulator implanted will receive t…

This study tests whether a TENS pain-relief device, combined with video coaching sessions from a physiotherapist, can help people with leg pain from peripheral artery disease (PAD) become more active. Forty-eight participants will either get the TENS device plus coaching or usual…

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the b…

This study tests a non-invasive device that measures blood flow in the skin of people with severe leg artery disease. Researchers will compare results from 15 patients before and after a procedure to open blocked arteries, and also compare them to 15 healthy volunteers. The goal …

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study looks at how often sleep apnea occurs in people with peripheral artery disease (blocked leg arteries). Researchers will monitor 295 adults with leg artery disease using a sleep test. The goal is to better understand the connection between these two conditions, which ma…

This study explores whether a thermal imaging camera can detect changes in blood flow to the legs after a procedure to reopen blocked arteries. Researchers will compare temperature readings from the camera with standard ankle-brachial index measurements in 25 people with severe p…

This study tests a new device called the Spur scaffold, used with a drug-coated balloon, to treat blocked arteries below the knee in people with chronic limb-threatening ischemia (CLTI). The study includes 40 high-risk patients—those with diabetes or on dialysis—and measures how …

This study tracks 98 people with peripheral artery disease who had a stent placed in their iliac artery. Researchers want to see which patients later develop serious limb complications, like needing another procedure or amputation. They will also check if frailty plays a role. Th…

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This study is testing whether a new 3D ultrasound system can help people with blood vessel disease better understand their condition. Researchers will give 270 patients a 3D image of their blocked or narrowed vessels instead of the usual hand-drawn sketch. They want to see if thi…

This study is testing whether a quick ultrasound measurement of blood flow in the foot (called systolic rise time) can predict major limb events like amputation or severe ischemia in people with critical limb ischemia. Researchers will follow 134 patients for 6 months after surge…

This study is testing a new ultrasound technique called super-resolution ultrasound microvascular imaging (SRUMI) to see if it can predict how peripheral artery disease (PAD) will progress. Researchers will scan the legs of 300 people with PAD and compare the images to standard t…

This registry is following 2,000 people with chronic coronary artery disease who are taking long-term blood thinners (antiplatelet or anticoagulant drugs). The goal is to track how often serious bleeding or clotting events (like heart attacks or strokes) occur. By understanding t…

This study is testing whether shining a red light (670 nm) on the calf muscle for 5 minutes can increase blood flow in people with peripheral artery disease (PAD). Forty adults with PAD will receive the light treatment and an ultrasound contrast injection to measure blood flow. T…

This study is gathering information from 50 Canadians with Peripheral Artery Disease (PAD) who are treated in heart clinics and can still walk. Researchers want to measure inflammation levels and physical abilities to better understand the condition. The results will help doctors…

This study looks at whether a simple leg strength test, the 30-second sit-to-stand test, gives the same results when done over a video call as in person. Researchers will enroll 45 adults with peripheral artery disease (PAD) to compare both methods. If remote testing proves relia…

This study looks at whether a type of diabetes medicine called SGLT-2 inhibitors (or 'flozins') can help prevent serious heart and limb problems in people who have had surgery to open blocked leg arteries. Researchers will compare 300 patients who took the drug after surgery with…

This study uses MRI scans to look at plaque buildup in leg arteries of people with peripheral arterial disease. Researchers want to see which plaques are hard to cross with a guidewire and which devices cause the least damage to the vessel wall. The study includes patients underg…

This study compares two techniques for guiding a needle into a blocked leg artery from the opposite direction (retrograde). One uses a live X-ray map, the other uses ultrasound. Researchers want to see which is safer and more successful in 32 people with severe leg artery disease…

This study will use tiny probes called microdialysis to measure chemicals related to blood flow, inflammation, and antibiotics right inside the amputation stump after surgery. Researchers will compare results between diabetic and non-diabetic patients to understand why some stump…

This study is creating a large registry of 14,000 people with peripheral artery disease (PAD) to compare the long-term results of treatments that use stents versus those that do not. Researchers will track outcomes like repeat procedures, amputations, and walking ability over 12 …

This study checks if a 6-minute stepper test is a reliable way to measure exercise ability in people with peripheral artery disease (PAD). Researchers will compare it to standard tests like the 6-minute walk test and a treadmill test. The goal is to find a simple, low-cost tool t…

This study aims to better understand how blood flow and oxygen use in the legs are affected in people with peripheral artery disease (PAD). Researchers will use a non-invasive device that shines near-infrared light on the leg to measure oxygen levels. The study will include 120 p…

This observational study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, peripheral artery disease, or overweight…

This study installs a 'black box' recording system in hybrid operating rooms to capture and analyze errors during vascular procedures. Researchers will study how teamwork, leadership, and the environment affect surgical performance and patient safety. The goal is to identify high…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study looks at how narrowed leg arteries (peripheral artery disease) might affect heart function. Researchers will use advanced heart ultrasound to measure subtle changes in heart muscle strain in 162 participants. They will also check for links to metabolism and organ damag…

This study is testing whether a new imaging device called MIMOSA Pro can measure oxygen levels in leg tissue as accurately as standard tests like ankle-brachial index or Doppler ultrasound. Researchers will compare the device's readings to those from traditional methods in 60 adu…