Could a red light boost blood flow in leg arteries?
NCT ID NCT03203239
First seen May 12, 2026 · Last updated Jun 22, 2026 · Updated 9 times
Summary
This study is testing whether shining a red light (670 nm) on the calf muscle for 5 minutes can increase blood flow in people with peripheral artery disease (PAD). Forty adults with PAD will receive the light treatment and an ultrasound contrast injection to measure blood flow. Two blood samples will also be taken to check for nitric oxide, a molecule that helps blood vessels widen. The goal is to see if light can trigger vasodilation, which might lead to new ways to ease leg pain during walking.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Red light (670 nm) and octafluoropropane (Definity) contrast agent
What this could lead to
If it works, this could point toward a simple light-based treatment to improve blood flow in people with peripheral artery disease.
What could go wrong
This is a very small, early study with only 40 people. It is designed to measure blood flow changes, not to treat symptoms, so any benefit is uncertain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.