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Tailored blood thinners could save limbs in PAD patients

NCT ID NCT07613840

Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 2 times

Summary

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned to either the personalized plan or standard treatment. Their medications will be adjusted based on blood test results over a year to see if the tailored approach reduces clots, amputations, and repeat procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Aspirin and Clopidogrel (blood thinners)
What this could lead to
If it works, this could lead to a more effective, personalized way to prevent blood clots and reduce amputations in people with peripheral artery disease after surgery.
What could go wrong
This is an early-stage trial with 484 participants, so results may not apply to everyone. The personalized plan may not reduce clots or could increase bleeding risks compared to standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 484 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with a named arterial extremity injury or named vessel revascularization for atherosclerosis requiring open and/or closed revascularization. * Patients at the age of 18 or older Exclusion Criteria: * Patients who are younger than 18 years old * Known pregnancy (females of childbearing potential will have a pregnancy test prior to surgery as per standard of care) * Prisoners, defined as those who have been directly admitted from a correctional facility. * No atherosclerosis * Subject has active stomach ulcers * Subject has severe hepatic impairment * Subject has a recent history of intracranial hemorrhage. If the patient has a history of cerebral hemorrhage with no new central nervous system disease of \>1 year, the study team will consult with the

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Conditions

The condition(s) this trial relates to.

peripheral arterial disease thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation Peripheral arterial disease(PAD) Platelet aggregation inhibitors Pru(platelet reactivity unit) Thromboelastography (TEG) Thrombosis Thrombosis (stent thrombosis)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Salem Hospital (Mass General Brigham)

    RECRUITING

    Salem, Massachusetts, 01970, United States

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