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Can a 5-Minute clamp before surgery save lives?

NCT ID NCT03718312

Disease control Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether briefly stopping blood flow to the aorta before surgery (called ischemic pre-conditioning) could reduce complications in people undergoing open repair of a thoracoabdominal aortic aneurysm. 65 patients were randomly assigned to receive either the pre-conditioning procedure or standard clamping. The main goals were to see if it lowered the chance of serious lung or kidney problems after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ischemic pre-conditioning (brief clamping and release of the aorta before surgery)
What this could lead to
If it works, this could reduce serious lung and kidney complications after major aortic surgery.
What could go wrong
This is a small, completed trial with only 65 participants, so results may not apply to everyone. The procedure itself carries risks during the clamping phase.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Jul 2019

Finished

Jul 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient \> 18 and \<85 years old 2. Patient having a planned surgery for a thoracoabdominal aortic aneurysm by direct approach, 3. Patient with aortic aneurysm requiring supra-visceral aortic clamping and visceral artery reconstruction, 4. Aortic aneurysmal patient with or without distal femoral circulatory assistance, 5. Patient with aortic aneurysm of atheromatous or dissecting etiology, 6. Woman of childbearing potential with effective contraception (estrogen-progestin or intrauterine device or tubal ligation), postmenopausal woman (≥ 12 months of amenorrhea not induced by therapy) 7. Patient who read and understood the newsletter and signed the consent form 8. Patient affiliated with a social security scheme Exclusion Criteria: 1. Patient with aortic aneurysms requiring supra-visceral aortic clamping but not requiring visceral artery reconstruction (supra-visceral aortic clamping for renal aortic juxtaposition aorta), 2. Patient with thoraco abdominal aortic aneurysms requiring a circulatory arrest (aortic aneurysms affecting the descending thoracic aorta or the aortic arch) 3. Patient requiring emergency aortic surgery 4. Patient under treatment known as interfering with PCI (Nicorandil or oral antidiabetic agents), 5. Pregnant or lactating woman (negative result of baseline blood test) 6. Participation in another interventional study within 28 days before randomization or during this study 7. Person deprived of liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults, 8. Patient under the protection of justice, patient under guardianship or curatorship.

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Conditions

The condition(s) this trial relates to.

aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic aneurysm Surgery

Contacts and locations

Locations

  • University Hospital, Rouen

    Rouen, 76031, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.