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Squeeze away hypertension? handgrip training shows promise

NCT ID NCT03896334

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood pressure without medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
isometric handgrip training (a simple squeezing exercise)
What this could lead to
If it works, this could offer a simple, drug-free exercise routine to help control blood pressure and reduce heart disease risk.
What could go wrong
This is a completed study, but the effects on 24-hour blood pressure are still uncertain. The exercise may not work for everyone, and results may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

139 people

The number who actually took part.

Started

Apr 2019

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of hypertension, controlled by up to three antihypertensive medications * Blood pressure levels between 130 and 180 mmHg * No high cardiovascular risk (no other cardiovascular, metabolic or pulmonary disease nor any signals or symptoms of these disease) * Not engaged in a physical exercise program for at least six months * Not present cognitive impairment (Montreal Cognitive Assessment ≥ 26 points) Exclusion Criteria: * Adherence to less than 85% of training sessions * Diagnosis of other cardiovascular diseases or diabetes during the course of the study * Adherence to another supervised physical exercise program * Change in medication class and/ or dose during the study * Aggravation of the disease (i.e. blood pressure above 180 or use of four or more medications).

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Federal Rural University of Pernambuco

    Recife, Brazil

  • Federal University of Amazonas

    Parintins, Brazil

  • Federal University of Sergipe

    Aracaju, Brazil

  • Universidade Federal de Santa Catarina

    Florianópolis, Santa Catarina, 88040-900, Brazil

  • Universidade Nove de Julho

    São Paulo, Brazil

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