Squeeze away hypertension? handgrip training shows promise
NCT ID NCT03896334
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood pressure without medication.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- isometric handgrip training (a simple squeezing exercise)
- What this could lead to
- If it works, this could offer a simple, drug-free exercise routine to help control blood pressure and reduce heart disease risk.
- What could go wrong
- This is a completed study, but the effects on 24-hour blood pressure are still uncertain. The exercise may not work for everyone, and results may vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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139 people
The number who actually took part.
- Started
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Apr 2019
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of hypertension, controlled by up to three antihypertensive medications * Blood pressure levels between 130 and 180 mmHg * No high cardiovascular risk (no other cardiovascular, metabolic or pulmonary disease nor any signals or symptoms of these disease) * Not engaged in a physical exercise program for at least six months * Not present cognitive impairment (Montreal Cognitive Assessment ≥ 26 points) Exclusion Criteria: * Adherence to less than 85% of training sessions * Diagnosis of other cardiovascular diseases or diabetes during the course of the study * Adherence to another supervised physical exercise program * Change in medication class and/ or dose during the study * Aggravation of the disease (i.e. blood pressure above 180 or use of four or more medications).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Federal Rural University of Pernambuco
Recife, Brazil
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Federal University of Amazonas
Parintins, Brazil
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Federal University of Sergipe
Aracaju, Brazil
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Universidade Federal de Santa Catarina
Florianópolis, Santa Catarina, 88040-900, Brazil
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Universidade Nove de Julho
São Paulo, Brazil
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