Family secrets of mood disorders revealed in major study
NCT ID NCT00071786
First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 2 times
Summary
This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time. The goal was to find risk factors and better ways to prevent and treat these health problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,944 people
The number who actually took part.
- Started
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May 2004
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Community Sample
- Ages
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7 to 120 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Since this study is based on systematic recruitment from the local community and other non-clinical settings such as screening protocols from volunteers, there are no specific diagnostic inclusion and exclusion criteria. However, the study targets individuals with mood spectrum conditions and migraine. Criteria for the specific subgroups of mood and anxiety disorders are presented in Table 1. Individuals who do not meet criteria are classified as controls. INCLUSION CRITERIA: 1. the ability to comprehend the interview, and 2. probands must agree to contact at least two relatives (contacting relatives is not required in cases where the participant is enrolled in just the mobile technologies assessments (EMA and Actigraphy). EXCLUSION CRITERIA: The only exclusion criteria include impaired ability to comprehend the interview or inability to read. SPECIFIC INCLUSION AND EXCLUSION CRITERIA BY PROBAND GROUP: GENERAL INCLUSION CRITERIA: The only inclusion criteria for the study are that the person be English-speaking and ability to read and comprehend the interview. BIPOLAR I INCLUSION CRITERIA: Lifetime history of DSM-IV Bipolar I or Manic Episode BIPOLAR II INCLUSION CRITERIA: Lifetime history of DSM-IV Bipolar II with duration of hypomania reduced to 2 or more days (according to RDC) MAJOR DEPRESSION INCLUSION CRITERIA: Lifetime history of at least 2 episodes of DSM-IV Major Depression PANIC/GAD INCLUSION CRITERIA: Lifetime history of DSM-IV diagnosis for Panic Disorder or GAD PHOBIAS INCLUSION CRITERIA: Lifetime history of DSM-IV diagnosis for social anxiety disorder, agoraphobia, or specific phobias (greater than or equal to 3) MIGRAINE INCLUSION CRITERIA: Lifetime history of IHS migraine with or without Aura GENERAL EXCLUSION CRITERIA: The only exclusion criteria include impaired ability to comprehend the interview or inability to read.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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Other studies related to the condition(s) this trial covers.
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