MOOD DISORDERS

This study is testing whether using a person's genetic information can help doctors choose psychiatric medications that are more effective and cause fewer side effects. It will compare this genetic-guided approach to standard medication selection in 2,500 people with mood, anxiet…

This study is testing a new coordinated care program called I-CONNECT for older adults who have depression or bipolar disorder along with at least two chronic physical conditions like diabetes or high blood pressure. Researchers want to see if this program, which provides a perso…

This study tests whether giving multiple brain stimulation treatments per day works better than one daily treatment for depression in people aged 60+. All participants receive active treatment, but some get multiple sessions daily for a shorter period while others get one session…

This study is testing whether a new, fast-acting drug called (2R,6R)-HNK can help people with major depression who haven't gotten better with standard treatments. Fifty participants will receive intravenous infusions of either the study drug or a placebo over several weeks to see…

This study is testing whether a single session combining a non-invasive brain stimulation technique (rTMS) with training in emotion regulation skills can help people who struggle to calm down when upset. Researchers want to see if this combined approach changes brain activity and…

This study is testing whether a single session of whole-body heat therapy, with or without a follow-up cold water plunge, can help reduce symptoms of depression. It will involve about 112 adults currently experiencing depression, who will be randomly assigned to one of the two tr…

This study is testing a smartphone app designed to help people recover from knee or hip replacement surgery. The app uses digital therapy techniques and coach support to help patients manage anxiety, depression, and pain. Researchers want to see if using the app can help patients…

This study is testing a brief therapy called Imagery Rescripting to help reduce symptoms of depression. It will be offered by mental health assistants in a primary care doctor's office. The therapy involves working with patients to rewrite negative memories linked to their low mo…

This study aims to develop and improve brain scanning (MRI) techniques to better understand how mood and anxiety disorders affect the brain. Researchers will scan the brains of healthy volunteers and people with major depression while they perform simple tasks. The goal is to cre…

This study is building a large research platform to collect detailed information from people with mood disorders like depression and bipolar disorder. It aims to find biological markers (like clues from blood or brain scans) that can help match people to the right treatments fast…

This study aims to understand how stimulating different parts of the brain with magnetic pulses affects symptoms of several mental health conditions. Researchers will enroll 180 adults with depression, anxiety, OCD, or schizophrenia to receive non-invasive brain stimulation at ra…

This study is not a treatment trial. Its main purpose is to screen a large number of people—including those with mood or anxiety disorders and healthy volunteers—to understand these conditions better and to find suitable participants for future research studies. Participants unde…

This study is testing whether a virtual reality device can detect changes in eye movements in people who have been taking psychiatric medications for at least three months. Researchers want to see if the device can identify patterns linked to medication use, similar to how police…