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Can biomarkers end the guesswork in depression treatment?

NCT ID NCT06408012

Knowledge-focused Sponsor: St. Joseph's Healthcare Hamilton Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study is building a Canadian platform to collect standardized biomarker data from 900 people with mood disorders like depression and bipolar disorder. The goal is to create a large, organized pool of participants and data that can be used in future trials to match individuals to the right treatment faster. No new treatment is being tested here; instead, the focus is on gathering information to improve research.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this platform could help identify biomarkers that match people with mood disorders to the right treatments faster, reducing trial-and-error.
What could go wrong
This is an observational platform, not a treatment trial. It may not directly lead to new therapies, and biomarker discovery is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals who meet criteria for bipolar or depressive disorders as defined by DSM-5.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria Patients: 1. 16 years of age or older. 2. Meet criteria for bipolar or depressive disorders as defined by DSM-5. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires. Inclusion Criteria Healthy Comparison (HC) Participants: 1. 16 years of age or older. 2. No history of psychiatric disorders (according to DSM-5) or significant unstable medical conditions. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.

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Conditions

The condition(s) this trial relates to.

Bipolar and Related Disorders bipolar disorder depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar and related disorders Depressive disorder Mood disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    9 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre for Addiction and Mental Health

    RECRUITING

    Toronto, Ontario, M6J 1H4, Canada

  • McMaster University

    RECRUITING

    Hamilton, Ontario, L8P 3B6, Canada

  • Nova Scotia Health Authority

    RECRUITING

    Halifax, Nova Scotia, B3H 2E2, Canada

  • Ontario Shores Centre for Mental Health Sciences

    RECRUITING

    Whitby, Ontario, L1N 5S9, Canada

  • Queen's University

    RECRUITING

    Kingston, Ontario, K7L4X3, Canada

  • University Health Network

    RECRUITING

    Toronto, Ontario, M5T 2S8, Canada

  • University of British Columbia

    RECRUITING

    Vancouver, British Columbia, V6T 2A1, Canada

  • University of Calgary

    RECRUITING

    Calgary, Alberta, T2N 4Z6, Canada

  • University of Ottawa

    RECRUITING

    Ottawa, Ontario, K1Z 7K4, Canada

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