DEPRESSIVE DISORDER

This study aims to find the best way to treat moderate depression in a general doctor's office. It will compare three approaches: standard care from a doctor, standard therapy from a psychologist, and a structured, step-by-step medication plan managed by a doctor. The goal is to …

This study is testing whether adding a digital mindfulness program to regular medical care helps adults with emotional disorders like depression or anxiety recover faster and stay better over two years. Researchers will compare people who get the mindfulness program plus their us…

This study is testing if nicotine patches can help older adults with depression who are struggling with thinking problems like poor memory and focus. Researchers want to see if adding a nicotine patch to standard antidepressant medication improves both mood and cognitive function…

This study is exploring if a single guided therapy session using psilocybin (the active compound in 'magic mushrooms') can help adults whose depression hasn't responded to standard antidepressants. All 24 participants will receive the mushroom therapy, but half will also take the…

This study aims to improve depression care in India by testing whether a simple talk therapy or a common antidepressant medication works better for different people. It will enroll 1500 adults with moderate to severe depression to receive one of these treatments. The main goal is…

This study is testing whether a new, fast-acting drug called (2R,6R)-HNK can help people with major depression who haven't gotten better with standard treatments. Fifty participants will receive intravenous infusions of either the study drug or a placebo over several weeks to see…

This study is testing whether a modified version of a talk therapy called Dialectical Behavior Therapy (DBT) can help people with anxiety or depression. Researchers will enroll 250 adults in Taiwan and randomly assign them to receive either the new therapy or continue with their …

This study is testing a therapy program designed to help children and teenagers manage anxiety and depression. It involves both the young person and their parent or caregiver. Researchers want to see how well this specific type of talk therapy works by measuring changes in sympto…

This study is testing a group therapy program called Resilience Training for Teens that aims to prevent high school students with mild emotional symptoms from developing serious mental illnesses. Researchers will work with 70 teens aged 14-19 who are experiencing early signs of d…

This study is testing if a faster schedule of a non-invasive brain stimulation treatment can help people who have both depression and Long COVID. Researchers will compare a standard 6-week treatment to an intensified 5-day treatment to see if the faster approach better reduces in…

This study is testing whether a non-invasive brain stimulation technique called Temporal Interference Stimulation (TIS) can improve memory and reduce symptoms in people with depression. Researchers will compare 30 patients receiving either real or sham TIS treatment to 30 healthy…

This study is testing a brief program called Omnis Salutis, designed to help recent Veterans manage stress-related conditions like PTSD, depression, and anxiety. The program involves three sessions where Veterans learn to communicate their health goals to providers and loved ones…

This study is testing whether a structured breathing practice is a practical and acceptable way to help teenagers with anxiety and depression. It involves 40 teens, ages 12-17, from both rural and non-rural areas. The main goal is to see if the breathing program is easy to use an…

This study is testing whether a new combination therapy called EL-SHIN Therapy can help reduce symptoms of depression and improve quality of life. The therapy combines lavender therapy, gratitude exercises, and fasting with light exercise over 3-4 weeks. Researchers are looking f…

This study is testing whether a smartphone app that helps people make healthy lifestyle changes can reduce symptoms of depression. Researchers will compare adults who use the app alongside their regular doctor visits to those who only receive regular care. The app guides users to…

This study aims to understand how stimulating the vagus nerve affects the heart, blood pressure, immune system, and metabolism. It will enroll 144 adults who already have or will receive a vagus nerve stimulator for drug-resistant epilepsy or major depression. This is purely a re…

This study is building a large research platform to collect detailed information from people with mood disorders like depression and bipolar disorder. It aims to find biological markers (like clues from blood or brain scans) that can help match people to the right treatments fast…

This study aims to create a detailed map of thinking problems in people with various brain and mental health conditions, such as schizophrenia, depression, and bipolar disorder. Researchers will compare 600 patients to healthy volunteers using computer-based thinking tests and op…

This study aims to understand the connection between inflammatory bowel disease (IBD) and depression by looking at gut bacteria and body chemicals. Researchers will compare samples from 120 people in three groups: those with both conditions, those with just IBD, and healthy indiv…

This study aims to understand the daily challenges and stressors faced by children aged 8-12 who have depressive symptoms. Researchers will interview the children and hold focus groups with their parents to learn what situations cause emotional difficulty and how they cope. The i…

This study aims to find out if a patient's anxiety or depression levels can influence how well their breast cancer responds to immunotherapy. Researchers will observe 120 women with triple-negative breast cancer who are receiving standard treatment, tracking their mental health a…