DEPRESSIVE DISORDER

This study tests a brief group therapy called Resilience Training for Teens. It aims to prevent serious mental illness in high school students aged 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens will participate to see if the training hel…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study compares two schedules of repetitive transcranial magnetic stimulation (rTMS) in 42 adults with depression and Post-COVID condition. One group gets one session daily for six weeks; the other gets six sessions daily for five days. Researchers will measure changes in dep…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to improve brain function and reduce symptoms. The goal is to help 120 adults with treat…

This early study tests if a precise type of radiation (stereotactic radiotherapy) can safely reduce symptoms in people with severe depression that hasn't responded to standard treatments. Nine adults aged 18-50 will receive the treatment and be monitored for changes in mood and s…

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for guided exerc…

This study looks at whether nicotine patches can improve mood and thinking in older adults (60+) with depression. Researchers believe nicotine may help the brain's control center work better. 60 participants will receive either a nicotine patch or a placebo patch for 12 weeks, an…

This study tests whether a single dose of psilocybin mushrooms (the active ingredient in magic mushrooms) can help adults with depression that hasn't improved with standard treatments. Half of the 24 participants will also take the antidepressant fluoxetine (Prozac) to see if it …

This study tests a new therapy called EL-SHIN Therapy to see if it can help reduce symptoms of depression, anxiety, and stress. Researchers will enroll 80 adults who are moderately depressed, anxious, and stressed. Participants must be non-Muslim, English-speaking, and believe in…

This study tests a modified version of dialectical behavior therapy (DBT) for people with anxiety or depressive disorders. Researchers will enroll 250 adults across two medical centers to see if this therapy improves symptoms, daily functioning, and quality of life. The goal is t…

This study tests whether a smartphone app that gives personalized lifestyle advice can help reduce depression symptoms in adults visiting their general practitioner. Participants set goals in areas like sleep, diet, and exercise, and track their mood. The app is used alongside re…

This study tests three ways to treat moderate depression in adults aged 18 to 65: usual care from a family doctor, therapy from a psychologist, or a structured step-by-step medication plan from a doctor. The goal is to see which approach works best. Participants will be followed …

This study is testing a therapy program called Unified Protocol for children and teens (ages 7-17) with anxiety or depression, along with their parents. The program uses cognitive-behavioral techniques to help manage emotions. Researchers will measure changes in symptoms and pare…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation (TIS) can improve memory and mood in people with depression. Sixty adults aged 18 to 65 with moderate to severe depression will receive TIS while their memory and depressi…

This study aims to improve depression care in Indian primary care settings. It will involve 1,500 adults with moderate to severe depression, who will receive either a type of talk therapy (Healthy Activity Program) or antidepressant medication (fluoxetine). The goal is to see if …

This study tests a 3-session program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use. The program teaches veterans about whole health and how to communicate their needs to doctors and loved ones. Researchers want to see if it improves soc…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study looks at how people with conditions like schizophrenia, depression, bipolar disorder, Alzheimer's, Parkinson's, stroke, or epilepsy think and make decisions. Researchers will compare their performance on computer tasks to healthy volunteers. The goal is to create a det…

This study looks at gut bacteria and related chemicals in people who have both inflammatory bowel disease (IBD) and depression. Researchers want to find unique patterns that might explain why these two conditions often occur together. The study involves 120 adults divided into th…

This study looks at whether a person's mental state—like anxiety or depression—can influence how well immunotherapy works for triple-negative breast cancer. About 120 women will receive standard treatment, complete mood questionnaires, and give blood and saliva samples. The goal …

This study is creating a large, standardized database of information from 900 people with mood disorders like depression and bipolar disorder. Researchers will collect blood tests, brain scans, and other health data to find 'biomarkers' that can help doctors choose the right trea…

This study looks at how ketamine reduces suicidal thoughts in people with depression, bipolar disorder, or PTSD. Researchers want to see if blocking a specific brain receptor (AMPA) stops ketamine from working. 30 adults with current suicidal thoughts will receive ketamine with e…

This study uses MRI brain scans to see if psilocybin (the active ingredient in magic mushrooms) changes brain activity in areas that control mood. 50 adults with depression will receive either psilocybin or a placebo during two therapy sessions, and their brains will be scanned r…

This study looks at how a 9-week therapy called Engage & Connect changes brain activity related to social rewards in adults aged 50-80 who have depression and suicidal thoughts. Researchers will use brain scans to measure changes in areas linked to positive feelings. The goal is …

This study talks to 15 children aged 8–12 who have depressive symptoms, and their parents, to learn what everyday stresses they face and how they cope. The goal is to use this information to create a fun app that teaches emotional skills through games. No treatment or medication …

This study looks at how vagus nerve stimulation (VNS) changes the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. It is not a treatment study—it aims to learn how VNS works. About 144 adults aged 18 and olde…