DEPRESSIVE DISORDER

This study tests whether nicotine patches can improve mood and thinking in older adults (60+) with depression. Participants who completed a prior blinded trial will receive open-label nicotine patches for up to 12 weeks. The goal is to see if nicotine helps with depression sympto…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training. The goal is to improve attention and reduce depression symptoms. About 70 adults with m…

This study compares standard cognitive behavioral therapy (CBT) to CBT plus a group training called Kiesler Circle Training (KCT) that focuses on improving interpersonal skills. 156 adults with depression or anxiety and above-average social difficulties are participating. The goa…

This study looks at whether taking vitamin D supplements for six months can help people with depression feel better. Researchers will compare a low dose (10 micrograms) to a high dose (100 micrograms) and track participants for up to 6 years. The goal is to see if vitamin D impro…

This study watches 192 teens aged 12–20 who are already getting therapy for anxiety, depression, or OCD. Researchers will compare Cognitive Behavioral Therapy (CBT) and Brief Strategic Therapy (BST) to see which helps more with symptoms, self-esteem, and quality of life. No new t…

This research looks at a program that places social workers in children's primary care clinics across Indiana to provide quick mental health help. The goal is to see if this approach helps more kids get diagnosed and treated early for conditions like depression, anxiety, and cond…

This study explores whether a personalized therapy method called Process-based Therapy is practical in regular mental health clinics. About 40 adults with depression or anxiety will try this approach, and researchers will measure how satisfied patients and therapists are. The goa…

This study uses advanced heart scans (coronary CT angiography) to understand why people with rheumatoid arthritis face higher risks of heart disease, lung problems, and depression. Researchers will follow 4,000 participants aged 50-75 for up to 10 years, collecting blood samples,…

This study is creating a large network of researchers and clinics across Texas to track the health of 5000 young people (ages 8-20) who have depression or thoughts of suicide. The goal is to build a registry and develop models to predict outcomes, not to test a new treatment. Par…