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Vitamin d pills tested as depression booster in Long-Term study

NCT ID NCT02521012

Symptom relief Sponsor: Kuopio University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether taking vitamin D supplements for six months can improve depression symptoms. About 319 adults with depression are getting either a low or high dose of vitamin D daily, while continuing their usual treatment. Researchers will track their mood and health for up to 6 years to see if vitamin D makes a lasting difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin D (as a dietary supplement)
What this could lead to
If it works, this could point toward vitamin D as a simple, low-cost add-on to improve depression treatment outcomes.
What could go wrong
This is a follow-up of an earlier trial, and the results are not yet published. Vitamin D may not significantly improve depression beyond standard care, and high doses could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

319 people

The number who actually took part.

Started

Nov 2015

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients referred to the recruitment sites for treatment for depression * mild, moderate or severe depression, * mild, moderate or severe episode of recurrent depression Exclusion Criteria: * bipolar or psychotic depression * psychotic disorder * severe substance abuse * disabilities in senses that affect functioning and severely threat completing the trial * diseases that affect vitamin D metabolism (such as sarcoidosis, hypercalcemia, hypofunction of kidney) * pregnancy or lactation * current use of high dose vitamin D supplementation * current use of high dose calcium supplementation

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder endogenous depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression Depressive disorder

Contacts and locations

Locations

  • Welbeing Servivces County of North Savo, Kuopio University Hospital, Department of Psychiatry

    Kuopio, Finland

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