DEPRESSIVE DISORDER
Clinical trials for DEPRESSIVE DISORDER explained in plain language.
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New system aims to keep people with mental illness out of jail, back in treatment
Disease control CompletedThis study tested whether a new police-mental health connection system could help reduce unnecessary arrests and keep people in treatment. When police ran a background check during an encounter, half of the 1,405 participants triggered a message alerting the officer to call a men…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Columbia University • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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Zapping depression: new brain stimulation method tested
Disease control CompletedThis study tested whether a new type of brain stimulation works better for depression than the standard method. Researchers compared three approaches in 60 adults with moderate-to-severe depression: a new multi-channel stimulation, the conventional stimulation, and a sham (fake) …
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: The National Brain Mapping Laboratory (NBML) • Aim: Disease control
Last updated Apr 02, 2026 14:57 UTC
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Brain light treatment tested for depression relief
Disease control CompletedThis study tested whether a non-invasive light therapy, delivered through a headset to the forehead, could help reduce symptoms of major depression. Fifty adults with depression were randomly assigned to receive either real light treatment at different settings or a fake (sham) t…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: NeuroThera DE • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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New school program aims to build courage and prevent depression in native youth
Prevention CompletedThis study tested a new, culturally adapted mental health program designed to prevent anxiety and depression in American Indian children. Researchers worked closely with a tribal community to create a 6-week school program for 28 children aged 8-12. The main goal was to see if th…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Montana State University • Aim: Prevention
Last updated Mar 27, 2026 12:39 UTC
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Simple talk therapy tested to ease common mental health struggles
Symptom relief CompletedThis study tested whether a short, structured counseling program called Problem Management Plus (PM+) could help reduce symptoms of anxiety and depression in adults visiting a primary care clinic in Chile. 56 participants with mild to moderate symptoms were randomly assigned to r…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Chile • Aim: Symptom relief
Last updated Apr 03, 2026 14:41 UTC
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New group therapy tested for teens in mental health crisis
Symptom relief CompletedThis study tested a 16-week group therapy program for teenagers with severe anxiety and depression. The program was adapted for delivery in a Spanish day hospital setting, where teens receive intensive care. Researchers wanted to see if this group format was practical and helpful…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Universidad Nacional de Educación a Distancia • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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New group therapy shows promise for teen mental health
Symptom relief CompletedThis study tested a 16-week group therapy program for Spanish adolescents (ages 11-17) with anxiety or depression. The program taught skills to manage difficult emotions and reduce avoidance behaviors. Researchers measured changes in symptoms and daily functioning over a full yea…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Universidad Nacional de Educación a Distancia • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Personalized pills: can your DNA pick a better antidepressant?
Symptom relief CompletedThis study tested if using a patient's genetic information (DNA) to guide the choice of antidepressant medication works better than standard doctor-led care for cancer patients. 99 adults with cancer and symptoms of depression or anxiety were randomly assigned to either get a DNA…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Symptom relief
Last updated Mar 31, 2026 12:11 UTC
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Can a phone call get you moving and lift your mood?
Symptom relief CompletedThis study tested a new phone-based therapy program designed to help people with depression become more physically active. 65 adults with moderate to severe depression who exercised very little received 10 therapy sessions by phone or video. Researchers wanted to see if this appr…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Mar 30, 2026 14:35 UTC
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Zapping the blues away? brain stimulation tested for depression relief
Symptom relief CompletedThis study tested whether a non-invasive brain stimulation technique could help reduce the physical and emotional symptoms of depression. 57 adults with depression received either real or fake stimulation sessions over two weeks while their symptoms and brain activity were tracke…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Anhui Medical University • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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Phone app aims to ease mental health struggle for those battling opioid addiction
Symptom relief CompletedThis study tested a smartphone app designed to help people who are receiving medication for opioid addiction. The goal was to see if using the app could reduce their anxiety, depression, and drug cravings. 63 adults used the app for four weeks while researchers checked if it was …
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Trustees of Dartmouth College • Aim: Symptom relief
Last updated Mar 30, 2026 14:31 UTC
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Zapping the blues away? brain stimulation tested for severe depression
Symptom relief CompletedThis study tested whether a gentle, non-invasive electrical brain stimulation treatment could reduce suicidal thoughts and ease depression symptoms. It involved 60 adults with depression who received either real or fake stimulation for one week. Researchers used brain scans and q…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Anhui Medical University • Aim: Symptom relief
Last updated Mar 30, 2026 14:31 UTC
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Doctors prescribe art to fight anxiety and depression
Symptom relief CompletedThis study tested whether participating in arts programs like dance, cinema, or theater could improve mental wellbeing and reduce symptoms of anxiety and depression. 382 participants aged 10-99 with various mental health conditions were randomly assigned to either start arts acti…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: KAVADIA ELENI • Aim: Symptom relief
Last updated Mar 30, 2026 14:29 UTC
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Text therapy tested against traditional video sessions for depression relief
Symptom relief CompletedThis study tested whether unlimited text-based therapy is as effective as traditional weekly video therapy for treating depression. Over 1,100 adults with depression participated, receiving either daily text therapy or weekly video sessions. The research also explored what treatm…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Talkspace • Aim: Symptom relief
Last updated Mar 27, 2026 12:38 UTC
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Can a daily yogurt drink stop athletes from getting sick?
Symptom relief CompletedThis study tested whether a daily probiotic milk drink could help reduce cold-like symptoms in triathletes around competition time. Eighty healthy adult triathletes were randomly assigned to drink either the probiotic beverage or a placebo daily for several weeks before and after…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Federal University of São Paulo • Aim: Symptom relief
Last updated Mar 25, 2026 14:08 UTC
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AI steps in to train therapists for psychosis care
Knowledge-focused CompletedThis study tested a new computer program called CBTpro, which uses artificial intelligence to help therapists learn and practice a specific talk therapy for people with psychosis. The tool listens to therapists practice with simulated patients and gives them feedback. Researchers…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated Apr 04, 2026 00:19 UTC
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Scientists search for depression's hidden physical signs in blood
Knowledge-focused CompletedThis study aimed to find biological markers in blood cells that might indicate physical stress related to depression. Researchers examined 300 people with and without depression, measuring factors like telomere length (related to cellular aging) and oxidative stress levels. The g…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Apr 03, 2026 14:41 UTC
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Can instagram posts fight teen depression?
Knowledge-focused CompletedThis study tested whether following a special Instagram account with educational content about depression could help teenagers. 170 teens were asked to follow either a depression education account or a general science account for four weeks. Researchers measured if the educationa…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Ludwig-Maximilians - University of Munich • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:56 UTC
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Pandemic's hidden toll: study reveals mental health crisis among nursing home workers
Knowledge-focused CompletedThis study aimed to understand how the COVID-19 pandemic affected the mental health of nursing home staff in France. Researchers surveyed 501 workers to measure rates of post-traumatic stress, depression, and burnout. The goal was to document the psychological impact of working t…
Matched conditions: DEPRESSIVE DISORDER
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:56 UTC
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Scientists probe the 'Trip' side effect of depression drug
Knowledge-focused CompletedThis study aimed to better understand the temporary feeling of detachment or altered reality that some patients experience after taking the antidepressant Esketamine. Researchers interviewed 15 patients who had this side effect to learn about their experiences. The goal was to ga…
Matched conditions: DEPRESSIVE DISORDER
Phase: NA • Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Researchers ask teens: what do you think of depression info on instagram?
Knowledge-focused CompletedThis study aimed to understand how teenagers perceive and evaluate depression education content delivered through a specific Instagram account called 'ich bin alles' (I am everything). Researchers asked 18 adolescents, some with depression and some without, to share their immedia…
Matched conditions: DEPRESSIVE DISORDER
Sponsor: Ludwig-Maximilians - University of Munich • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:11 UTC
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Scientists track daily mood and blood sugar to map diabetes distress
Knowledge-focused CompletedThis study aimed to understand how mental health conditions like depression and anxiety affect blood sugar control in people with type 1 or type 2 diabetes. Researchers followed 1,290 participants for two years, using smartphone surveys and glucose monitors to track daily moods, …
Matched conditions: DEPRESSIVE DISORDER
Sponsor: Forschungsinstitut der Diabetes Akademie Mergentheim • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:41 UTC