Depression leaves a mark on your cells, new study finds
NCT ID NCT01903655
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 300 people to see if depression causes changes in blood cells that show signs of early aging and stress. Researchers measured telomere length and oxidative stress levels to find genetic markers that could help doctors understand how severe a person's depression is and its physical effects. The goal was not to treat depression but to find new ways to measure its impact on the body.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2010
- Finished
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Nov 2012
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Persons who have given their written informed consent * absence of a diagnosis of major depressive disorder throughout the study and no history of psychiatric disorders * diagnosis of a first episode of a major depressive disorder * diagnosis of a recurrent major depressive disorder (at least three episodes) with or without resistance to therapy Remarks: * the diagnosis of major depressive disorder with characteristics of melancholy must be clearly mentioned in the case report form but is not a reason for not being included in the study * the presence of a recent or older attempted suicide must lead to a careful clinical assessment of the diagnosis of depressive disorder and must be clearly mentioned in the case report form. Exclusion Criteria: * Persons not covered by the national Health Insurance Agency * Psychotic or bipolar disorders * Severe personality disorders * cardiovascular disease, proven inflammatory disease and cancer * persons unable to give their consent personally, * persons in emergency situations, * pregnant women, * breast-feeding women
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de Dijon
Dijon, 21079, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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