St. Joseph's Healthcare Hamilton

This study tests two digital treatment programs for people recently released from prison who have a history of substance use problems. The goal is to see if these programs are practical and helpful in preventing relapse and return to prison. About 20 participants will use the dig…

This study tests whether a dye called indocyanine green (ICG) can help surgeons see the exact boundary of a lung cancer tumor during robotic surgery. The dye makes the healthy lung glow, leaving the cancerous segment dark. The surgeon then removes only that dark segment, sparing …

This study tests whether the sedative dexmedetomidine can help critically ill patients tolerate non-invasive ventilation (a mask that helps breathing) and avoid needing a breathing tube. About 846 adults with acute respiratory failure will receive either the drug or a placebo. Th…

This study tests a new psychological therapy designed for people whose depression is linked to difficult childhood experiences. The therapy aims to improve mood, emotional control, and distressing thoughts. Researchers will also look at biological changes in the blood. The trial …

This study tests whether Multiprofen-CC cream, applied three times daily, reduces pain in adults with hand osteoarthritis. Forty-two participants will use both the active cream and a placebo for two weeks each, in random order. Researchers will measure pain, hand function, and si…

This study tests a new way to remove small lung tumors using a 3D computer model and a dye that makes the tumor glow during surgery. The goal is to help surgeons remove only the diseased part of the lung, avoiding a full lobe removal. About 32 adults with early-stage lung cancer …

This study tests a 4-week mindfulness program designed specifically for new mothers and birthing parents with clinical anxiety. Researchers will measure changes in anxiety, emotion regulation, and body awareness using questionnaires and brain scans. The goal is to see if this min…

This study is building a Canadian platform to collect standardized biomarker data from 900 people with mood disorders like depression and bipolar disorder. The goal is to create a large, organized pool of participants and data that can be used in future trials to match individual…

This study looks at whether DNA from blood, sputum, lung fluid, and breath can help find genetic changes in non-small cell lung cancer. Researchers will collect samples from 210 patients before and after surgery, then follow them for 24 months to check for cancer return. The goal…

This study looks at whether teaching female undergraduate dieters about genetics and healthy eating can shift their beliefs about weight control. Participants will watch educational videos and complete questionnaires on body image, self-esteem, and eating habits. The goal is to s…

This study looks at whether certain medications known to affect the heart's electrical activity (QT-prolonging drugs) actually cause major heart problems in hospitalized adults. Researchers will analyze data from over 990,000 patients across Ontario hospitals, comparing those who…

This study explores whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) is safe and tolerable for older adults with mild memory or thinking problems. Thirty participants aged 60-90 will receive one of three types of dTMS coils. …