Can a gentle sedative keep ICU patients off ventilators?
NCT ID NCT06259565
First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 32 times
Summary
This study tests whether a sedative called dexmedetomidine can help critically ill patients tolerate non-invasive ventilation (a mask that helps breathing) and avoid needing a breathing tube. About 846 adults with acute respiratory failure will receive either the drug or a placebo. The goal is to see if the drug reduces deaths or the need for intubation.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE RESPIRATORY FAILURE are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Brockville General Hospital
NOT_YET_RECRUITINGBrockville, Ontario, K6V 1S8, Canada
Contact
Contact Email: •••••@•••••
-
Fraser Health Authority
NOT_YET_RECRUITINGSurrey, British Columbia, V3T 0H1, Canada
Contact Email: •••••@•••••
Contact
-
Juravinski Hospital and Cancer Centre
NOT_YET_RECRUITINGHamilton, Ontario, L8V 1C3, Canada
Contact
Contact Email: •••••@•••••
-
North York General Hospital
NOT_YET_RECRUITINGToronto, Ontario, M2K 1E1, Canada
Contact
Contact Email: •••••@•••••
-
Sinai Health System
NOT_YET_RECRUITINGToronto, Ontario, M5G 1X5, Canada
Contact
Contact Email: •••••@•••••
-
St. Joseph's Healthcare Hamilton
RECRUITINGHamilton, Ontario, L8N 4A6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine (a sedative that keeps patients awake and breathing)
What this could lead to
If it works, this could provide a safe way to sedate patients on non-invasive ventilation, reducing the need for intubation and invasive breathing machines.
What could go wrong
This is a large phase 3 trial, but sedation always carries risks like over-sedation or breathing depression. The results may not apply to all types of respiratory failure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.