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Millions of drug alerts may be misleading: massive study to find out which QT drugs actually harm hearts

NCT ID NCT07374263

Knowledge-focused Sponsor: St. Joseph's Healthcare Hamilton Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether certain medications known to affect the heart's electrical activity (QT-prolonging drugs) actually cause major heart problems in hospitalized adults. Researchers will analyze data from over 990,000 patients across Ontario hospitals, comparing those who had heart events to those who did not. The goal is to improve medication safety and reduce unnecessary warnings that can overwhelm healthcare workers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could clarify which QT-prolonging drugs truly pose heart risks, reducing unnecessary medication alerts and improving patient safety.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 990,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This is a retrospective observational study using de-identified electronic-medical-record data from St. Joseph's Healthcare Hamilton and GEMINI hospitals; no direct participant enrollment or consent is required.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients 18 years of age or older * Admitted to St. Joseph's Healthcare Hamilton or GEMINI hospitals between December 2017 and March 2025 Exclusion Criteria: * Patients \<18 years old * Outpatient encounters

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder long QT syndrome Syncope syncope, familial vasovagal torsades de pointes ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acquired long QT MACE Medication safety Syncope Torsades de pointes Ventricular arrhythmias

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • GEMINI

    RECRUITING

    Toronto, Ontario, M5B 1T8, Canada

  • St. Joseph's Healthcare Hamilton

    RECRUITING

    Hamilton, Ontario, L8N 1Y3, Canada

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