Can a gentle electric field fix a racing heart?
NCT ID NCT07727330
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial tests whether a procedure called pulsed field ablation can safely treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. About 30 people with frequent premature heartbeats or ventricular tachycardia will receive the treatment using a special catheter. The study will check if the arrhythmia disappears or drops by at least 80% right after the procedure and again six months later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a procedure called pulsed field ablation using a special catheter
- What this could lead to
- If it works, this could offer a new, safer way to correct dangerous heart rhythm problems without the heat or cold used in standard ablation.
- What could go wrong
- This is a small, early-stage study with only 30 people, so results may not apply to everyone. Risks include heart damage, bleeding, or the arrhythmia returning.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Participants must meet all of the following criteria: 1. Age 18 to 75 years, inclusive. 2. Diagnosis of ventricular arrhythmia with an indication for catheter ablation, and scheduled to undergo pulsed field ablation, meeting one of the following conditions: 1. Frequent premature ventricular contractions, defined as a premature ventricular contraction burden greater than 10% of total heartbeats on 24-hour Holter monitoring; 2. Sustained monomorphic ventricular tachycardia; 3. History of malignant ventricular arrhythmias, including sustained polymorphic ventricular tachycardia, ventricular flutter, or ventricular fibrillation, with an indication for catheter ablation. 3. For participants with an indication for implantable cardioverter-defibrillator implantation, the participant has already received an implantable cardioverter-defibrillator or agrees to undergo implantable cardioverter-defibrillator implantation in the near future. 4. Able and willing to provide written informed consent and comply with all study follow-up requirements. Exclusion Criteria: 1. Presence of atrial arrhythmias before the procedure that cannot be treated using the study device. 2. Ventricular arrhythmias caused by electrolyte disturbance, reversible causes, or non-cardiac causes. 3. Severe left ventricular enlargement, defined as left ventricular anteroposterior diameter greater than 80 mm. 4. Left ventricular ejection fraction of 35% or less. 5. New York Heart Association functional class III or IV. 6. Previous cardiac surgery, including patent foramen ovale closure, left atrial appendage closure, cardiac valve repair or replacement, or other cardiac surgery that makes the participant unsuitable for catheter ablation. 7. Significant congenital cardiac anatomical abnormalities that prevent the ablation catheter from accessing the target ablation area. 8. Planned cardiac surgery or other major surgery within the next 12 months that may affect ablation treatment, including heart transplantation, left atrial appendage closure, or patent foramen ovale closure. 9. Intracardiac thrombus, myxoma, occlusion device, or other condition that may interfere with catheter insertion or manipulation. 10. Severe vascular access obstruction, such as an implanted inferior vena cava filter or mural thrombus. 11. Uncontrolled hypertension, defined as persistent systolic blood pressure of 180 mmHg or higher or persistent diastolic blood pressure of 110 mmHg or higher. 12. Severe restrictive or obstructive pulmonary disease or chronic respiratory disease that, in the investigator's judgment, makes the participant unsuitable for cardiac intervention. 13. Obvious bleeding tendency or hematologic disease. 14. Untreated or uncontrolled hyperthyroidism or hypothyroidism. 15. Acute or severe systemic active infection, significant hepatic or renal dysfunction defined as ALT, AST, or creatinine greater than twice the upper limit of normal, malignancy, or end-stage disease. 16. Unstable angina or acute myocardial infarction within 3 months before enrollment. 17. Percutaneous coronary intervention or coronary artery bypass grafting within 3 months before enrollment. 18. Stroke or transient ischemic attack within 3 months before enrollment. 19. Thromboembolic disease. 20. Clear contraindication to interventional procedures or ablation as determined by the investigator. 21. Pregnancy, lactation, or planned pregnancy during the study period. 22. Participation in another drug or medical device clinical trial within 3 months before enrollment. 23. Any condition that, in the investigator's judgment, makes the participant unsuitable for participation in this clinical study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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