MOOD DISORDERS

This study tests whether using a person's genetic information to choose psychiatric drugs leads to better recovery than standard prescribing. About 2,500 adults with depression, anxiety, or psychotic disorders will be randomly assigned to either genetic-guided treatment or usual …

This study tests a program called I-CONNECT for adults 65 and older who have depression or bipolar disorder plus at least two chronic physical conditions like diabetes or high blood pressure. The program assigns a care coordinator who works with the patient's doctor, psychiatrist…

This study tests a program called Resilience Training for college students who have mild psychotic experiences, like unusual thoughts or perceptions. The goal is to see if this training can prevent the development of serious mental illness. Researchers will enroll 192 students ag…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This study tests whether a therapy called imagery rescripting (ImRs) can help reduce depression when delivered by mental health assistants in a doctor's office. About 12 adults with depressive symptoms will receive 5 sessions over 10 weeks, where they work to change negative memo…

This study tests whether giving multiple brain stimulation sessions per day (accelerated) works better than one session per day (conventional) for treating depression in people aged 60 and older. All 280 participants will receive active treatment, but some get the faster schedule…

This study looks at whether a single session of whole-body heat therapy, with or without a cold water plunge, can reduce symptoms of depression. Researchers will enroll 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive…

This study tests a telemedicine program called RxWell that teaches coping skills to manage mood and pain after knee or hip replacement. About 150 adults with anxiety or depression symptoms will use the program before and after surgery. The goal is to see if it reduces the need fo…

This study tests a new online, self-guided course based on dialectical behavior therapy (DBT) for adults with mild-to-moderate depression or anxiety. Up to 40 participants in Ontario will use the 8-week program and complete surveys to see if it is easy to use and helpful. The goa…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they qualify for other research studies at the National Institute of Mental Health. Participants undergo interviews, medical exams, brain scans, and lab te…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different parts of the prefrontal cortex and test how it changes behavior. The goal is to understand which brain cir…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. About 240 adults aged 18-55 who struggle with emotion regulation will be …

This study is creating a large, standardized database of information from 900 people with mood disorders like depression and bipolar disorder. Researchers will collect blood tests, brain scans, and other health data to find 'biomarkers' that can help doctors choose the right trea…

This study aims to improve MRI imaging techniques to better understand how mood and anxiety disorders affect the brain. Researchers will scan the brains of healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to develop…

This study is testing a device called Gaize to see if it can detect changes in eye movements caused by long-term use of psychiatric medications like those for ADHD, depression, or anxiety. Researchers will use standard drug recognition tests in a virtual setting. The goal is to u…

This study looks at 300 people with mood disorders to find out what makes someone more likely to think about or attempt suicide. Researchers will use questionnaires and blood/urine tests to understand biological, psychological, and social factors. The goal is to create a tool tha…