MIGRAINE

This study looks at how well the drug rimegepant works to prevent migraines in 100 people with episodic or chronic migraine. Participants will take rimegepant and report changes in their monthly migraine days over three to twelve months. The goal is to see if the drug reduces mig…

This study tests an investigational drug called MEDI0618 to see if it can safely reduce the number of migraine headache days in adults who have episodic migraines (4 to 14 migraine days per month). About 488 participants will receive either the drug or a placebo as a shot under t…

This study compares three oral medications—atogepant (newer), topiramate, and propranolol (older)—to see which prevents migraines better and is easier to tolerate. About 1,335 adults with migraine will be randomly assigned to one of the drugs and track their headaches for 12 week…

This study looks at the long-term safety of eptinezumab in 600 children and teens aged 6 to 17 who have chronic or episodic migraine. Participants must have completed a previous study of the same drug. The main goal is to track side effects over time, with additional measures of …

This study tests if a daily pill called ubrogepant can prevent migraines that happen around a woman's period. About 496 women with menstrual migraines will take the pill or a placebo for 7 days each cycle. The goal is to see if it reduces the number of migraine days and is safe t…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial expressions, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) …

This study is checking the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults with chronic or episodic migraines. About 3000 people whose doctors prescribe atogepant will take the pill as usual and be followed for up to 12 wee…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) works better than CBT alone for preventing migraines in children aged 7-17. Researchers will track headache days and disability over time. The goal is to find the best first-…

This study tests a new device that gently stimulates the inside of the nose to prevent migraines. About 110 adults with migraines will use the device at home every other day for six weeks. Researchers will track how many migraine days they have compared to a group that starts tre…

This study tests a medicine called rimegepant, a tablet that dissolves under the tongue, to prevent migraines in adolescents aged 12 to 17 who have chronic migraine (15+ headache days per month). About 200 participants will take either rimegepant or a placebo every other day for …

This study tests if the drug rimegepant can prevent migraines in children and teens aged 6 to 18 who have frequent migraines. About 640 participants will receive either the drug or a placebo for 12 weeks. The goal is to see if rimegepant reduces the number of migraine days each m…

This study tests a new group therapy program for teens aged 13-17 with migraine. The program combines high-intensity interval training, progressive muscle relaxation, and education sessions over 18 weeks. Researchers want to see if it reduces how often migraines happen, how long …

This study is testing a mind-body program delivered by nurses to help children and teens with migraine have fewer headache days. The program combines different treatment parts to find the best approach. About 260 kids with migraine will take part. The goal is to see if this progr…

This study tests if blocking the middle meningeal artery with a special glue can safely reduce migraine days in people with hard-to-treat chronic migraines. About 70 adults aged 18-65 with chronic migraine will receive the procedure. The goal is to see if this approach can preven…

This study tests whether injecting a long-lasting numbing medicine (Exparel) near a nerve bundle in the nose can reduce severe face and head pain from conditions like migraine and cluster headache. About 15 adults who already get relief from a numbing spray will receive either th…

This study compares two injection methods for knee osteoarthritis pain: one into trigger points (muscle knots) and one into the joint space. About 1,036 adults aged 45+ with knee pain will receive either treatment and be followed for 2 years. The goal is to see if the simpler tri…

This study is testing a drug called rimegepant to see how well it stops migraine pain and if it causes side effects. About 100 adults with migraines will take the pill during an attack and report their pain levels. The goal is to find a fast, effective treatment for migraine suff…

This study looks at whether a pain-relief device called TENS (which uses mild electrical pulses) combined with exercise can help women with migraine feel less pain and do more in daily life. Researchers will track pain, disability, muscle strength, sleep, and quality of life in 3…

This study tests whether basic body awareness therapy (gentle movement and mindfulness exercises) combined with lifestyle advice can reduce migraine attacks and improve sleep and daily function. Forty adults with migraine will track their headaches, disability, sleep quality, and…

This study is testing a new way to treat migraines by using mild electrical stimulation on an artery in the head. The goal is to see if the procedure is safe and practical for people whose headaches don't get better with standard treatments. About 12 adults with chronic migraines…

This study looks at whether taking a steroid pill (dexamethasone) after a nerve block can stop migraines from returning within 72 hours. About 84 adults with migraines who get relief from a nerve block in the emergency room will be randomly assigned to also receive the steroid or…

This study tests if a procedure called bilateral middle meningeal artery embolization is safe and possible for people with hard-to-treat chronic migraines. The procedure uses a plug-like material (Onyx) to block arteries in the scalp, which may reduce migraine-causing substances …

This study tests a lifestyle behavior program to help people with chronic migraine reduce how often and how severely their headaches happen. Researchers will also look for biological markers linked to improvement. The goal is to see if the program is practical and liked by partic…

This study tests whether a new biodegradable heart device can reduce migraine days better than a standard metal device in people with a common heart hole called PFO. About 400 adults aged 18-65 with frequent migraines and PFO will be randomly assigned to receive either device. Th…

This study tests whether combining green light therapy with a gentle, non-invasive brain stimulation technique (tDCS) can reduce how often migraines happen and how bad they hurt. Researchers will enroll 40 adults with frequent migraines. Participants will use both treatments and …

This study looks at whether the migraine drug eptinezumab can stop a migraine attack while it is being infused. Researchers will measure how quickly headache pain and other bothersome symptoms go away. The study involves 50 adults with migraine who are already receiving eptinezum…

This study tests whether ubrogepant, a drug already approved for adults, can safely and effectively treat migraine headaches in children and teens aged 6 to 17. About 1,059 participants will receive either the drug or a placebo during a migraine attack. The main goal is to see if…

This study follows 1000 adults with migraine who are prescribed atogepant by their doctors. Researchers want to see how well the drug works in real-world settings over 2 years. Participants continue their normal care with no extra tests or visits.

This study follows 700 people with migraine who are taking newer preventive drugs (anti-CGRP medications) to see how well they work in everyday life. Researchers will track changes in monthly headache days and migraine impact over two years. The goal is to understand real-world b…

This study tests if taking rimegepant before a known trigger (like exercise, alcohol, or stress) can prevent a migraine from starting. 60 adults with migraine will take the pill before their trigger and report if a headache occurs within 24 hours. The goal is to see if preemptive…

This study compares two non-drug virtual programs for adults with migraine. Both involve 8 weekly online sessions and extra learning materials. Participants keep their usual medications. The goal is to see which program better reduces migraine-related disability and improves well…

This study tests whether a home-based virtual reality (VR) program that uses brain activity to guide relaxation can help teens aged 10–16 with migraine. Participants will use a VR headset three times a week for four weeks. Researchers want to see if the program is easy to use and…

This study compares two fast-dissolving migraine tablets—rimegepant (Nurtec ODT) and rizatriptan (Maxalt MLT-ODT)—in adults coming to the emergency room with a migraine. The goal is to see which one provides better pain relief within 60 to 120 minutes. About 80 participants will …

This study looks at whether the antidepressant vortioxetine can help people who have both depression and migraine. About 31 adults with moderate to severe depression and episodic migraine will take vortioxetine for 12 weeks. Researchers will track changes in mood, anxiety, and mi…

This study tests a new nasal spray called PRT-064040 for treating moderate to severe migraines quickly. About 456 adults aged 18-75 with a history of migraines will receive either the spray or a placebo. The goal is to see if the spray can stop pain and other bothersome symptoms …

This study tests whether adding magnesium to a common migraine drug (prochlorperazine) provides better pain relief for people in the emergency department. About 100 adults with migraines will receive either the standard drug alone or the standard drug plus magnesium. Researchers …

This study looks at whether Xeomin (a Botox-like drug) can prevent migraines in 60 adults who have either a traumatic brain injury or an anomalous health incident (like those reported by diplomats). Participants get Xeomin injections and report their headache pain and frequency o…

This study looks at whether zavegepant (Zavzpret), a nasal spray already approved for migraines, works well and is safe for people who are also taking CGRP-targeting preventive medications. About 200 adults with 2-8 migraines per month will take zavegepant during an attack and re…

This study tests whether a weekly dose of cabergoline can reduce the number of migraine days in adults who have 4 to 14 migraines per month. About 150 participants will receive either a low dose, a higher dose, or a placebo for 12 weeks, followed by 12 weeks where everyone gets t…

This study compares two medicines, flunarizine and propranolol, to see which works better at reducing migraines in children aged 8 to 15. The goal is to lower how often migraines happen and improve daily life. The study uses a special score called PedMIDAS to measure disability. …

This study looks at whether a 16-week supervised aerobic exercise program, combined with a session on pain education, can help women aged 18 to 48 who have migraines. Researchers will measure changes in headache-related disability, pain sensitivity, and quality of life. The goal …

This study tests a program called RELAXaHEAD, a smartphone-based behavioral approach to help people with migraines manage their condition remotely. Researchers will enroll 356 adults who have migraines and track changes in disability and quality of life over several weeks. The go…

This study looks at whether taking ubrogepant during the earliest signs of a migraine (called prodrome) can prevent the headache from becoming moderate or severe. About 189 adults with 4-10 migraine days per month will take the drug as prescribed by their doctor and track their s…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study follows pregnant women with migraine who either took the medication rimegepant or did not, to see how it affects mothers and their babies. Researchers will track birth defects, pregnancy complications, and infant health up to 12 months after birth. The goal is to gathe…

This study tracks the safety of two migraine medicines, Ubrelvy and Qulipta, when taken during pregnancy. Researchers will compare health outcomes for mothers and babies up to 12 months old among about 1,900 pregnant women with migraines in the U.S. and Canada. The goal is to see…

This study looks at how migraine affects thinking skills like memory and attention, and how it relates to emotions like anxiety and depression. Researchers will test 150 adults with migraine to understand these connections better. The goal is to learn more about migraine's impact…

This online registry tracks 550 pregnant women with migraines to see if a nerve-stimulation device (CEFALY) is safe and helpful during and after pregnancy. Participants keep their usual treatments and fill out six short surveys over 12 months. No clinic visits are needed.

This study looks at how sleep problems and stress can trigger migraine attacks in adults. About 80 people with episodic migraine will wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give…

This study is for pregnant women with migraine who have taken or not taken the drug AIMOVIG. Researchers will compare the number of babies born with major birth defects in each group. The goal is to understand if AIMOVIG is safe to use during pregnancy.

This study is for 350 adults with frequent or chronic migraines. Researchers want to find clues—like genes, brain scans, and symptoms—that can predict if a specific antibody treatment will help. The goal is to save time and improve quality of life by matching the right treatment …

This study looks at why some people with migraine don't get relief from triptan medications. Researchers will measure levels of tryptophan, a natural substance that affects pain and inflammation, in 144 adults who either respond well or poorly to triptans. The goal is to understa…

This study looks at how migraine, neck pain, and lower back pain may share common causes in the nervous system. Researchers will measure pain sensitivity, thinking patterns, and disability in 179 adults with migraine and related spine pain. The goal is to better understand these …

This study looks at how the mind and body respond to migraine treatments, including placebos. Researchers will give 60 adults with chronic migraine four different treatment conditions in random order. The goal is to better understand how expectations and side effects influence tr…

This study uses a powerful 7T MRI scanner to look at brain structure and function in people with migraine, visual snow, or epilepsy, and compares them to healthy volunteers. The goal is to better understand how these conditions affect the brain and why they often occur together. …

This study will follow 10,000 people aged 12 and older with primary headaches (like migraine or tension-type headache) or medication-overuse headache. Researchers will collect data on genetics, brain scans, thinking skills, and daily life impact. The goal is to better understand …

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or healthy vision will pa…

This study watches how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or migraines, as well as healthy volunteers. Over two years, participants wear activity trackers and light sensors, answer daily mood questions on…

This study looks at whether adding AI-assisted education to standard migraine education helps people understand their condition better. About 140 adults newly diagnosed with migraine will take part. They will answer questions about migraine before and after education to see if th…