MIGRAINE

This study looks at 45 adults with migraine with aura and a small hole in the heart (PFO). It aims to see if closing the hole improves brain function, thinking, and mood. Participants will have brain scans and tests before and up to 12 months after the procedure. The goal is to u…

This study looks at whether anti-IL-6 medications, already used for inflammatory arthritis, can also reduce migraine attacks. About 320 adults with both a rheumatologic condition and migraines will report if their headaches improve. The goal is to see if targeting inflammation he…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce migraine headache intensity, improve sleep quality, and lower disability in people with episodic migraine. About 102 adults aged 18-45 will receive either real or sham stimula…

This study tests whether eating a low-glutamate diet can reduce the number and severity of migraines in adults. About 40 participants will either follow the diet or continue their usual eating habits. Researchers will track migraine days, symptoms, and blood markers to see if die…

This study tests whether a new drug called NB001 can quickly stop migraine pain and other bothersome symptoms. About 120 adults with migraines will receive either NB001 or a placebo. The main goal is to see if more people are pain-free and symptom-free two hours after taking the …

This study tests whether a fully online mindfulness program is a practical and helpful option for teenagers who get migraines. Researchers will compare a virtual mindfulness group to a virtual headache education group. The goal is to see if teens will join and stick with the prog…

This study tests whether a personalized physiotherapy program—including exercises and education—can reduce pain, fatigue, and improve daily function in people with migraine. Fifty adults with migraine will be randomly assigned to either the personalized program or standard physio…

This study tests a smartphone app called Health enSuite Migraine, designed to help adults aged 18-50 manage their migraine headaches. The app teaches techniques like stress management, relaxation, and trigger tracking. Researchers will track if using the app reduces the number of…

This study checks if a new version of a migraine drug works the same as the approved one. It involves 36 healthy adults who will take both forms and have their blood tested. The goal is to see if the new form is just as effective and safe, which could give patients more options.

This pilot study tests whether manual lymphatic drainage (a gentle massage technique) can reduce migraine pain and improve quality of life. Twenty adults aged 20-55 who have migraines at least 4 times per month will receive either the massage or no treatment. Researchers will mea…

This study tests whether a mind-body mobile app combined with a guided gentle movement program can help people with chronic pain feel better. About 100 adults aged 19 to 75 with pain lasting at least 6 months will use the app and do weekly movement sessions for 6 weeks. Researche…

This study tests whether osteopathic manual therapy—gentle techniques on the neck and head—can reduce how often migraines happen and how much they interfere with daily life. Researchers will compare the therapy to usual care in 45 adults aged 18 to 50 who have frequent migraines.…

This study will follow 460 adults with migraine who are getting a greater occipital nerve block for the first time. Researchers want to find out which patient traits (like age, migraine type, or headache patterns) predict whether the injection will reduce headache days. Participa…

This study looks at how sensitive people with migraine are to pressure and touch, and how that relates to their headache burden and quality of life. Researchers will compare two methods of measuring pain sensitivity in 102 adults with episodic or chronic migraine. The goal is to …

This study aims to understand how the brain's motor cortex controls inhibition in people with migraines compared to healthy individuals. Researchers will use a non-invasive technique called transcranial magnetic stimulation (TMS) to measure brain signals in 20 participants. The g…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples to measure a molecule called CGRP. The goal is to find differences between women who have…

This study will look at 25 adults with MOGAD, a rare disease affecting the brain and nerves, to find out how often headaches happen and what they are like. Researchers will collect information from medical records and follow patients over time. The goal is to better understand he…

This study looks at how migraine headaches relate to pain sensitivity, work stress, and muscle pain in people who work at desks. Researchers will compare 159 office workers with and without migraine to find patterns. The goal is to better understand these connections and help imp…

This study compares how people with migraine and healthy volunteers imagine movements, and looks at whether these mental abilities are linked to body awareness, balance, anxiety, and depression. About 136 adults aged 18-65 will take part, using questionnaires, mental tasks, and b…

This study looks at whether a natural brain chemical called adrenomedullin can cause migraine attacks in people who already get migraines. Researchers will give the chemical to 26 adults with migraine without aura, after they have taken a preventive migraine drug (erenumab). The …