Can a numbing nose treatment stop migraine pain in its tracks?
NCT ID NCT07764783
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether applying a numbing medicine (lidocaine) to a nerve cluster inside the nose can quickly relieve migraine headaches, facial pain, and neck pain. Adults who have frequent headaches and facial pressure will receive either lidocaine or a saltwater placebo during a short scope-guided procedure. Researchers will track pain levels for 24 hours and monitor headache days over two months to see if the treatment helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A numbing medicine (lidocaine) applied directly to a nerve cluster inside the nose using a scope
- What this could lead to
- If it works, this could offer a quick, drug-free way to stop migraine pain and related facial or neck pain without needing daily pills.
- What could go wrong
- This is a small, early-stage trial, so results may not apply to everyone. The procedure involves placing medicine in the nose, which could cause discomfort or side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 74 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: * Aged 18 years or older * Any race * Any gender * At least 2 of 3 positives (a, b, c) below on the ID Migraine Screener from the American Headache Society: 1. Photophobia 2. Inability to function 3. Nausea * At least 3 months of patient-reported episodic or persistent discomfort, pain, or pressure in the anatomic distribution of the paranasal sinuses, orbits, or nasal cavities. * The patient experiences at least 10 days of headaches and/or FPP within a 30-day period, during the run-in phase. * No evidence of abnormal sinus findings on imaging \[paranasal sinus CT, including cone beam imaging, or MRI (MRI images must include all paranasal sinuses) obtained when symptomatic in the last 12 months prior to presentation. Normal imaging findings included isolated mucus retention cysts 2 cm or less in size and minimal non-circumferential (isolated areas) mucosal thickening (3mm or less). * Normal endoscopy if performed prior to enrollment, defined as the absence of purulent (opaque - white or other discolored - secretions) at the middle meatus or sphenoethmoid recess or nasal polyp disease. * Daily access to a cell phone that can function with the study mobile application * For women of child bearing potential: not pregnant and using a method of contraception during the duration of the study. * The patient can be taking interventional and preventive medications and other treatments before and during the study period, including new medications which will be tracked. The clinical coordinator will ask the patient to refrain from taking any abortive medication, cannabis, and psilocybin 24 hours prior to the procedure visit. Exclusion criteria: * Prior endoscopic sinus surgery within the 3 months prior to enrollment. * Nasal endoscopy if performed prior to enrollment shows severe signs of mucosal infection, (mucopurulent drainage) or nasal polyposis. * A history of anterior skull base neoplasia. * Nasal endoscopy if performed prior to enrollment does not allow visualization of the middle turbinate on endoscopy bilaterally after application of a topical decongestant. * Signs of active or chronic sinusitis on CT (\>3mm mucosal thickening or air fluid level in any paranasal sinus.) * The patient cannot tolerate the use of topical anesthetics or intranasal endoscopy without sedation or general anesthesia * Unable to see the middle meatus with either a nasal speculum or an endoscope * Allergy to lidocaine or other local anesthetics (tertiary amine class 1b). * Is currently using a schedule II narcotic for migraine pain. * Current cocaine use or cocaine use within the last 30 days. * Currently immunocompromised * History or evidence of any other unstable or clinically significant medical condition that in the opinion of the sponsor-investigator/ Principal Investigator, would pose a risk to subject safety or interfere with the study evaluation, procedures or completion. * Has received any investigational agent within 30 days of enrollment. * Plans to participate in a concurrent clinical trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Ear, Nose, & Throat Surgeons of Western New England
Springfield, Massachusetts, 01107, United States
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