MIGRAINE

This study tests a new medication called Lu AG09222 to see if it can prevent migraines in people who have already tried 1 to 4 other preventive treatments without success. About 874 participants will receive either the drug or a placebo to find the best dose. The main goal is to …

This study tested a wearable device called Nerivio that uses gentle electrical pulses to prevent migraines. 150 people with chronic migraine used the device regularly for 3 months. Researchers measured how much their monthly migraine days decreased and how they felt overall. The …

This study aimed to test a new combination of naltrexone and acetaminophen for treating migraine headaches quickly. It was designed for adults with migraines and would have compared the combo to each drug alone and a placebo. However, the study was withdrawn before any participan…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

This study looks at how well Rimegepant works for treating migraine attacks in everyday life. About 3,000 adults with migraines in China will take the drug as needed and report their pain levels, satisfaction, and quality of life over a year. The goal is to see if Rimegepant prov…

This study aimed to see if a nasal spray called zavegepant could quickly stop migraine pain in adults. Participants would have used the spray at home for up to 4 migraine attacks. However, the study was withdrawn before enrolling anyone, so no results are available.

This study looks at how well the drug atogepant works to prevent migraines in 500 adults in Italy. Participants have migraine with or without aura, or chronic migraine. The main goal is to see if the drug reduces the number of migraine days per month after three months of treatme…

This small study tests whether inhaling cannabis can quickly stop a migraine headache. Twenty adults with migraines will try three different strengths of cannabis and a placebo to see which one works best for pain and other symptoms like nausea or light sensitivity. The study is …

This study tests whether an online program called Migraine Manager can help teens ages 11 to 17 with migraines have fewer headache days. About 160 teens will be split into two groups: one using the tool and one receiving general health information. The program focuses on building…

This study looks at whether acupuncture can reduce migraine pain and signs of brain stress or inflammation. Researchers will compare three gentle methods—laser, electro, and traditional acupuncture—in 75 adults with migraines. They will track pain levels and check blood for infla…

This study tests whether a mindfulness-based program (MBCT) delivered by phone or video can help people with migraines and depressive symptoms. 145 adults with 4-20 headache days per month and mild to moderate depression are taking part. The goal is to see if the program is feasi…

This study tests whether desvenlafaxine, a medication typically used for depression, can reduce how often and how severe migraines are in people who get them frequently. About 440 adults with episodic migraines will take the drug or a placebo for 12 weeks. The main goal is to see…

This study tests whether atogepant can quickly relieve migraine attacks in 1300 adults aged 18-75 with a history of migraines. Participants receive either atogepant or a placebo during the first part, then all receive atogepant in the open-label phase. The main goal is to see if …

This study tests whether a client-centered coping skills training program can reduce pain, improve quality of life, and lower disability in people with migraine. Sixty adults with migraine will be followed for 6 months. The training focuses on helping participants develop persona…

This study tests a small device that sends gentle electrical pulses to nerves far from the head (ultra-distal TENS) to ease migraine pain and symptoms like nausea. About 200 adults with frequent migraines will use the device during attacks. The goal is to see if it can reduce hea…

This study aimed to test a procedure called middle meningeal artery embolization for people with chronic migraines that don't get better with medication. The goal was to see if blocking a specific blood vessel in the head could reduce migraine disability and pain. However, the st…

This study tests whether a smartphone app that guides slow, paced breathing can help adults with chronic migraine have fewer headaches and feel better. Thirty participants will use the app for 10 minutes daily over 8 weeks. The goal is to see if this simple, at-home technique is …

This study looks at how well the migraine drug ubrogepant helps adults in Canada function during and after a migraine attack, and how satisfied they are with the treatment. About 167 participants will take the drug as prescribed by their doctor and be followed for up to 12 weeks.…

This study looks at whether omega-3 supplements (like fish oil) can reduce migraine pain and improve daily life for children and teens aged 10 to 17. Over 12 weeks, researchers will measure changes in blood omega-3 levels and track pain, disability, and emotional well-being. The …

This study tests if a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for two doses. Researchers will track migraine days and…

This study tests a new vibrating device (VCR) on the belly, back, or head to see if it can safely reduce chronic pain from conditions like pelvic pain, abdominal pain, low back pain, or migraine. About 50 adults with moderate to severe pain will try the device or a placebo. The g…

This study tests whether the drug erenumab can prevent migraines in children (ages 6 to under 12) and adolescents (12 to under 18) who have episodic migraines. About 457 participants will receive either erenumab or a placebo. The main goal is to see if the drug reduces the number…

This study looks at whether using the Nerivio wearable device more often than the label says is safe for people with migraine. Researchers are checking for side effects in 2000 participants who used the device at high frequency. The goal is to understand the safety of extra use, …

This study looks at whether inhaling essential oils like lavender and peppermint can change how sensitive people with migraine are to pressure pain. Two hundred adults with migraine will inhale one of four scents (lavender, peppermint, both, or a plain control) for 15 minutes. Re…

This study looks at whether practicing Transcendental Meditation (TM) can lower how often migraines happen and how much they affect daily life. Thirty adults with migraines will learn TM and practice it twice a day for 20 minutes. Researchers will track migraine days and quality …

This study tests a nasal spray device called MIG-SPRAY in 45 adults with migraine to see how well it is tolerated. Participants are randomly assigned to use the device or not, and they report any side effects and migraine episodes daily. The goal is to compare side effects, migra…

This study aimed to use high-frequency brain signals to better understand how the brain works in people with epilepsy, migraines, and other conditions. Researchers planned to create a database of these signals to improve diagnosis and treatment. However, the study was withdrawn b…

This study looks at how people with primary headaches (like migraines or tension headaches) experience pain compared to healthy individuals. Researchers will measure tenderness in head and neck muscles and general pain sensitivity in other body areas. The goal is to better unders…

This study looks at whether brain scans (MRI) can predict which migraine patients will have fewer headaches after taking CGRP antibodies, a newer type of migraine medicine. Researchers scanned the brains of 219 adults with frequent migraines before and 12 weeks after starting tre…

This study follows 250 UK adults with migraine who already use rimegepant for acute attacks. Over 12 weeks, participants complete daily surveys to report how quickly they get pain relief and improvement in other symptoms. The goal is to understand how consistently rimegepant work…

This study aimed to see if holistic education could help people manage stress and related conditions like anxiety, fatigue, and PTSD. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who agreed to a smoke-free, drug-free, and alcohol-free lifestyle. The …

This study looks at how a high-fat, high-carb meal affects inflammation and blood vessel function in young women with migraine compared to those without. Researchers will measure markers of heart disease risk after the meal. The goal is to understand why women with migraine may h…

This study uses MRI scans to better understand white matter hyperintensities (bright spots on brain images) in women with migraines. Researchers will compare these spots to those seen in small vessel ischemic disease and multiple sclerosis. The goal is to classify the underlying …

This study looks at whether alexithymia (trouble recognizing or describing emotions) is linked to how often women get migraines. Researchers will survey 350 women aged 12-65 with migraine to see if those with higher alexithymia scores have more frequent headaches. No treatment is…

This study explores how changing sex hormone levels during puberty relate to migraine pain and sensitivity in adolescents aged 11 to 15. Researchers will measure pain responses and hormone levels in both teens with migraines and healthy controls. The goal is to better understand …

This study followed 100 adults with migraine who received a nerve treatment called pulsed radiofrequency to the back of the head. Researchers measured changes in pain sensitivity and migraine-related disability over 3 months. The goal was to learn how the treatment might affect t…

This study aims to find biological markers (biomarkers) for headaches like migraine and cluster headache. Researchers will use capsaicin (from chili peppers) and ice water to trigger headache-related responses in 371 participants. The goal is to better understand how these headac…

This study looks at how two migraine treatments—CGRP inhibitors and Botox injections—affect bladder symptoms like urgency, frequency, and pain. Researchers will follow 200 women with migraines and bladder issues, using questionnaires before and 3 months after treatment. The goal …

This study aims to understand the risks of birth defects, miscarriage, stillbirth, and low birth weight in pregnant women with migraine who took the drug rimegepant. Researchers will compare these outcomes to similar women who did not take the drug. The study is observational, me…

This study looks at how headaches, especially migraines, impact the work and daily life of Libbs employees. Researchers will analyze data from over 1,300 workers who previously filled out questionnaires through a health app. The goal is to understand headache patterns, their effe…