UK migraine study tracks Real-World rimegepant relief
NCT ID NCT06898047
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 250 adults in the UK who already use rimegepant for migraine attacks. Over 12 weeks, they report how quickly the drug eases pain and other symptoms. The goal is to see how consistently rimegepant works in everyday life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Rimegepant (oral lyophilisate)
- What this could lead to
- If successful, this study could confirm how reliably rimegepant works for acute migraine in real-world UK settings, supporting its use.
- What could go wrong
- This is an observational study, not a controlled trial, so results may be less definitive. It only follows people already using the drug, so no new treatment is being tested.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 250 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Nov 2025
- Expected to finish
-
Jul 2026
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult participants living in the United Kingdom, with a migraine diagnosis confirmed by a healthcare professional, experiencing at least 4 migraine attacks per month, with a current prescription of rimegepant for acute treatment of migraine, and, if receving preventive migraine treatment, must be stable before enrollment. Participants will be excluded if they are currently using rimegepant as preventive migraine treatment, if present other specific neurological conditions, if currently prescribed with drugs that may indude or inhibits CYP3A4, or if they are participating in a migraine-related clinical trial. All participants enrolled must acknowledge their participation in the study informed consent.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria 1. UK resident. 2. At least 18 years of age. 3. Migraine diagnosis confirmed by healthcare professional. 4. Current prescription of rimegepant for acute treatment of migraine. 5. Experienced at least 4 migraine attacks per month prior to study enrolment. 6. In the case of participants receiving preventive migraine treatment: * For oral preventives, the treatment must be "stable" i.e., final dosing regimen has been found. * For migraine preventives administered monthly, the participant must have had their most recent treatment within the 3 weeks prior to study enrolment. * For migraine preventives administered quarterly, the participant must have had their most recent treatment within the 2 months prior to study enrolment. * If the last treatment is not within the stipulated period, participants will be asked to provide the date of the next scheduled treatment, after which the participant may be invited back to enrol into the study. 7. Evidence of a personally signed (or acknowledged if obtained electronically or online) and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the study. Exclusion criteria 1. Current use of rimegepant as a preventive migraine medication. 2. Current diagnosis of any of the following conditions: * new daily persistent headache * chronic daily headache * cluster headache * post-traumatic headache * hemicrania continua * major depression * pain syndromes other than migraine (e.g. fibromyalgia) * psychiatric conditions (e.g., schizophrenia) * dementia * significant neurological disorders other than migraine. 3. Current prescription of any of the following medications: * Strong inhibitors of CYP3A4 * Strong or moderate inducers of CYP3A4 4. Patients participating in a migraine-related clinical trial.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Migraine are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pfizer
London, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could your toothpaste be triggering migraines? trial puts it to the test
- Can sleep, neck pain, and fatigue explain Migraine's daily toll?
- Do Gender-Affirming hormones trigger headaches? thai survey probes the question
- Can a pill stop a migraine in two hours?
- Can tai chi or acupuncture rewire the migraine brain?
- Could a migraine injection also heal caregiver burnout?