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Scientists probe muscle tenderness to unlock headache mysteries

NCT ID NCT07514208

Knowledge-focused Sponsor: Universitat Internacional de Catalunya Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares 120 adults with primary headaches (migraine or tension-type) to healthy individuals. Researchers will measure tenderness in head and neck muscles and general pain sensitivity elsewhere in the body. The goal is to understand how these factors relate to headache disorders and other chronic pain conditions, which may improve future diagnosis and treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could improve how doctors assess and diagnose primary headaches by linking tenderness patterns to underlying pain mechanisms.
What could go wrong
This is an observational study, not a treatment trial. It will not directly test any therapy, and results may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adults recruited from neurology and orofacial pain clinical settings as well as from the general population. Participants with primary headache disorders will be recruited through headache specialists and clinicians working in participating centers. Eligible patients must have a confirmed diagnosis of primary headache according to the International Classification of Headache Disorders third edition and be under stable medical treatment. Healthy control participants will be recruited from the community, including students and university staff, and will be screened using a structured questionnaire to exclude individuals with clinically relevant headache disorders. All participants will be adults able to understand the study procedures and provide informed consent. Recruitment will take place at clinical and academic centers in Spain and Germany.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria Adults diagnosed with primary headache disorders, including migraine or tension-type headache, according to the International Classification of Headache Disorders third edition. Diagnosis confirmed by a headache specialist. Stable medical treatment for headache for at least six months prior to participation. Ability to understand and communicate in Spanish, English, or German. Ability to provide written informed consent. Exclusion Criteria Presence of secondary headache disorders or clinical suspicion of secondary headache based on screening criteria. Recent onset of undiagnosed headache or unilateral neck pain associated with neurological or neuropathic symptoms. Severe dermatological conditions or injuries affecting the head, neck, or intraoral region that could interfere with clinical examination. Recent fractures affecting the head or cervical region. Previous diagnosis of uncontrolled psychiatric disorders or neurodegenerative diseases. Pregnancy.

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Conditions

The condition(s) this trial relates to.

headache disorder hypnic headache migraine disorder temporomandibular joint disorder Tension-Type Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic overlapping pain disorders Migraine Primary headache disorders Tension headache Tension-type headache

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • International University of Cataluña

    Barcelona, Barcelona, 08021, Spain

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