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Can AI unlock the mystery of migraine brain spots?

NCT ID NCT05112289

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study uses advanced MRI scans and artificial intelligence to investigate small brain spots called white matter hyperintensities (WMH) in women with migraine. Researchers aim to tell these spots apart from those caused by other conditions like multiple sclerosis or small vessel disease. The study involves 50 women and does not test any drug or treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better ways to diagnose and distinguish migraine-related brain changes from other diseases.
What could go wrong
This is a small, early-stage observational study with only 50 participants, so results may not apply widely. It does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2021

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 59 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria - Migraine (N=20): * Female only. * Ages 20-45 years. * Presence of WMH on MRI. Exclusion Criteria: * History of SVI and/or history of MS or other neurological disease other than migraine. * History of cancer or organ transplantation. * Contraindication to MRI. * Pregnancy. * History of abnormal brain MRI other than WMH. * Subjects not willing to comply with the study procedures will be removed from the study. Inclusion Criteria - SVI disease (n=10): * Female only * Ages \> 60 years. * Presence of WMH on MRI. Exclusion Criteria: * History of migraine and/or history of MS or other neurological disease other than SVI. * History of cancer or organ transplantation. * History of abnormal brain MRI other than WMH. * Pregnancy. * History of abnormal brain MRI other than WMH. * Subjects not willing to comply with the study procedures will be removed from the study. Inclusion Criteria - MS (n=10): * Female only. * Ages 20-45. * Presence of WMH on MRI. Exclusion Criteria: * History of migraine and/or history of SVI or other neurological disease other than MS. * History of cancer or organ transplantation. * History of abnormal brain MRI other than WMH. * Pregnancy. * History of abnormal brain MRI other than WMH. * Subjects not willing to comply with the study procedures will be removed from the study.

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Conditions

The condition(s) this trial relates to.

migraine disorder multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraine Multiple sclerosis Small vessel ischemic disease

Contacts and locations

Locations

  • Mayo Clinic in Arizona

    Phoenix, Arizona, 85054, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.