Mayo Clinic

This study tests a vaccine called H2NVAC in people with a very early form of breast cancer called DCIS that has the HER2 protein. The vaccine is given before surgery to see if it can train the immune system to fight the cancer and possibly prevent it from coming back. The main go…

This study tests whether early use of midodrine, a pill that raises blood pressure, can help people with sepsis need less IV medicine and recover faster. About 308 adults with sepsis and low blood pressure will receive midodrine or a placebo. The goal is to see if it reduces time…

This study is testing whether a private Facebook group can help Native American women in Minnesota stay free from opioid use. Participants are women already on medication for opioid use disorder and have been abstinent for at least one month. The study will measure how well the F…

This study tests a new way to treat stomach cancer that has spread to the lining of the abdomen. Doctors will use a robot to remove visible cancer and then deliver heated chemotherapy directly into the belly during surgery. The goal is to help patients recover faster and have few…

This study looks at whether older kidney transplant patients (55+) can safely stop taking one of their anti-rejection drugs (mycophenolate mofetil) while keeping their new kidney healthy. About 350 participants will be randomly assigned to either stop the drug or continue standar…

This study tests whether a special type of breast imaging called molecular breast imaging (MBI) can help doctors take tissue samples (biopsies) from breast abnormalities that are hard to see on standard ultrasound or mammography. About 70 women with a known breast finding will un…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can reduce the number and severity of hot flashes in women after menopause who also have obesity. Researchers will also check if the drug affects biological aging markers. About 40 women aged 46-60…

This study aims to improve how doctors and families discuss scoliosis treatment options. Researchers will record and analyze video conversations between healthcare providers, patients, and their families. The goal is to create a shared decision-making tool that helps patients wit…

This study collects tissue samples from 7,000 adults with lung cancer, COPD, lung transplants, or other chest diseases. The samples are stored in a repository to help researchers better understand how these diseases start, how to diagnose them early, and how to improve treatment.…

This study looks at 100 living kidney donors to see if the amount of fat around the kidney (called PRAT) is linked to worse blood pressure and kidney function after donation. Researchers will compare donors with high and low PRAT by testing blood, urine, and fat samples. The goal…

This study is creating a registry of 100 women diagnosed with extramammary Paget's disease (EMPD) of the vulva or perianal area. Researchers will collect information on treatments, outcomes, and long-term survival, as well as tissue and swab samples to better understand the disea…

This study looks at why some families have more blood cancers like lymphoma, leukemia, and myeloma. Researchers will study the genes and environment of 3000 people who have at least two living relatives with these cancers. The goal is to find inherited factors that raise risk, no…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will block the hormone's action to see how it affects insulin and glucagon release. The goal is to learn why some people develop type 2 diabetes…

This study looks at whether changes in gut bacteria are connected to fatigue and nausea in women receiving chemotherapy for early-stage breast cancer. Researchers will collect stool samples and questionnaires from 70 participants before and after treatment. The goal is to better …

This study uses a surface electromyography (EMG) machine—like sticky patches on the neck—to measure how people with Eosinophilic Esophagitis (EoE) swallow food. Researchers will compare the timing of swallowing preparation and initiation between EoE patients and healthy controls.…

This study tests whether a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spine. It includes up to 5 adults with breast or lung cancer that has spread to the spinal fluid and spine. The goal is to see if…