Mayo Clinic

This study is testing whether a standard bladder cancer treatment can be safely and effectively delivered in patients' homes instead of requiring frequent clinic visits. It involves 40 adults with early-stage bladder cancer who would normally receive liquid chemotherapy directly …

This study is testing a new combination treatment for advanced liver cancer that cannot be removed by surgery. Doctors take a patient's own immune cells, grow and train them in a lab to attack cancer, and then inject them directly into the tumor after radiation. This personalized…

This study compares two methods for planning radiation therapy for prostate cancer. It tests whether a computer program called RapidPlan, which automatically creates treatment plans, is as safe as the current standard where a human specialist designs the plan. The main goal is to…

This study is testing a personalized vaccine made from a patient's own immune cells to see if it can prevent or delay the return of advanced ovarian, fallopian tube, or primary peritoneal cancer. The vaccine is designed to teach the immune system to recognize and attack cancer ce…

This study is testing the safety and best dose of a new type of radiation therapy called minibeam radiation. It uses a special device to split radiation into very narrow beams, aiming to better target tumors while potentially sparing more healthy tissue. The trial is for adults w…

This study is testing whether a medication called sacubitril-valsartan can improve heart structure and function in adults who were born with heart defects. Researchers will compare the drug against a placebo in 45 participants to see if it helps the heart work better and improves…

This study tests whether giving higher, more targeted doses of radiation over a shorter time can better control Ewing sarcoma tumors, especially larger ones. Researchers will personalize radiation doses based on tumor size and characteristics, aiming to reduce cancer recurrence a…

This study is testing whether following a structured Mediterranean diet can help people who have received a liver transplant. Researchers want to see if this diet prevents unhealthy weight gain, improves heart health, and reduces the risk of developing fatty liver disease. The st…

This small pilot study is testing whether gentle neck traction at home can help people with nerve-related itch reduce their medication doses. Researchers want to see if this simple physical approach can control symptoms for people with persistent itch on their scalp, arms, and up…

This study is creating a registry to test whether blocking problem veins near the spine can effectively treat spinal fluid leaks that cause severe headaches. Researchers will follow 200 people with confirmed spinal fluid leaks who undergo this vein-blocking procedure. The goal is…

This study is testing a new type of clinic designed to help obese adults who also have heart disease. The goal is to see if the clinic helps participants lose weight, improve their diet and fitness, and better manage their heart condition over one year. Researchers will track wei…

This study aims to see if it's safe and effective to slowly stop one common anti-rejection drug (Mycophenolate Mofetil) in kidney transplant recipients aged 55 and older. Researchers will use special blood tests to closely monitor patients for signs of organ rejection or infectio…

This study is testing a two-drug combination (golcadomide and rituximab) as a 'bridge' treatment for adults with aggressive B-cell lymphoma that has returned or not responded to prior therapy. The goal is to control the cancer and improve patients' health so they can proceed to a…

This study is testing a new combination of two immunotherapy drugs, efineptakin alfa and pembrolizumab, for adults whose aggressive brain cancer (glioblastoma) has come back. The goal is to see if giving these drugs before and after surgery helps the immune system fight the cance…

This small Mayo Clinic study is testing if a dietary supplement made from potato starch can help people with advanced liver disease (cirrhosis) who experience episodes of confusion or brain fog, known as hepatic encephalopathy. Researchers want to see if the starch changes gut ba…

This study aims to see if stopping opioid pain medication can resolve swallowing problems and chest pain caused by long-term opioid use. Researchers will follow 26 patients enrolled in an opioid cessation program at Mayo Clinic. They will check if these esophageal issues improve …

This study is testing if a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spinal cord. Up to 5 patients with advanced breast or lung cancer will wear the device for most of the day to see if it can help …

This study is testing whether a specific probiotic blend can help people with bile acid diarrhea. Researchers want to see if the probiotic changes the levels of bile acids in stool and improves symptoms like loose stools. About 24 adults with a confirmed diagnosis will take eithe…

This study is testing if a shorter, more precise form of radiation therapy is as effective as the standard longer course for treating prostate cancer that hasn't spread. Men with localized prostate cancer will be randomly assigned to receive either two treatments of a newer, adap…

This study is testing whether combining three chemotherapy drugs with Tumor Treating Fields (TTF)—a wearable device that creates low-intensity electric fields to disrupt cancer cell division—can help control metastatic pancreatic cancer. The trial will enroll 40 adults with newly…

This study is testing whether a non-invasive device that uses pulsed electromagnetic waves can improve blood flow to the heart in people with coronary artery disease. The 120 participants will use the device at home daily for 12 weeks while researchers measure changes in heart bl…

This study is testing whether stronger medication combinations can help people with pancreatitis quit smoking. All 45 participants will first try a standard quit-smoking drug. Those who still smoke after 6 weeks will try either a higher dose of that drug or add a second medicatio…

This early-stage trial is testing whether giving a single, precise, high-dose radiation treatment (radiosurgery) *before* surgery can help control aggressive brain tumors (high-grade gliomas) better and with fewer side effects. The study will find the safest and most effective do…

This study is testing whether a handheld stress-management device, used daily like an inhaler, can improve blood vessel health and lower future heart disease risk in people recovering from a heart attack. One hundred participants in cardiac rehab will either use the device along …

This study is testing a new, personalized vaccine designed to teach the body's immune system to recognize and attack a patient's specific cancer. It is being given alongside an existing immunotherapy drug (pembrolizumab) to adults with advanced solid tumors that have spread. The …

This study aims to find the best settings for a brain stimulation device to help control seizures in people with epilepsy. Researchers are testing whether low or high frequency stimulation works better for patients who already have a brain implant. The study will measure changes …

This early-stage study is testing whether adding a drug called aldesleukin directly into the abdomen, along with standard immunotherapy and chemotherapy, can better treat stomach cancer that has spread to the abdominal lining. The goal is to see if this combination can shrink the…

This study is testing whether patients with advanced prostate cancer that has spread can safely take a break from their targeted radiation treatment. Researchers want to see if stopping treatment after 5 cycles and only resuming if the cancer worsens works as well as getting the …

This study is testing a special type of heart-lung machine to see if it can safely support very sick patients with severe heart failure caused by lung disease while they wait for a lung transplant. It will involve a small group of 4 adults who are already on the transplant list b…

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and time spent in medical facilities, pote…

This study is testing whether a small device implanted under the scalp can safely predict when a seizure is about to happen in people whose epilepsy is not controlled by medication. The device records brain waves and works with wearable sensors to create a seizure forecast. The g…

This study is testing a procedure called TULSA, which uses MRI-guided ultrasound to heat and destroy prostate cancer tumors. It aims to be a less invasive alternative to surgery for men with low to intermediate risk cancer, with a key goal of preserving urinary control and sexual…

This early-stage study is testing whether eating magnesium-rich foods and using a magnesium lotion can help maintain healthy magnesium levels in the blood of people with lymphoma who are not currently on chemotherapy. Researchers want to see if this approach is practical for pati…

This study is testing a new way to deliver radiation therapy for a serious type of brain tumor called diffuse midline glioma. Instead of the standard 6-week treatment, patients receive a shorter, 2-week course. The main goal is to see if this shorter schedule is as effective at c…

This early study is testing whether a personalized combination of four drugs can safely help control glioma (a type of brain tumor) that has come back or remained after previous treatment. The approach uses regular scans and fluid tests to guide which drug combination might work …

This study is testing whether an oral medication called deucravacitinib is safe and effective for treating pityriasis rubra pilaris (PRP), a rare inflammatory skin condition. It will enroll 12 adults with moderate-to-severe PRP to see if the drug improves their skin symptoms and …

This study is testing whether a minimally invasive stomach-reducing procedure can help obese patients with ulcerative colitis lose weight before they undergo major colon removal surgery. Researchers want to see if this approach is safe and effective for this specific group of pat…

This study is testing whether adding two drugs, dasatinib and quercetin, to a standard CAR-T cell therapy regimen works better for patients with multiple myeloma that has returned or stopped responding to other treatments. The goal is to see if this combination helps the CAR-T ce…

This study is testing a smartphone app called PACTAID, designed to help adults with type 1 diabetes manage their blood sugar levels during and after exercise. Participants will use the app while on their automated insulin pump system for several weeks. The goal is to see if the a…

This study is testing a procedure called HIPEC, which delivers heated chemotherapy directly into the abdomen, for people with pancreatic cancer that has spread to the abdominal lining. The goal is to see if this approach helps patients live longer and controls the cancer better t…

This study is testing whether a special smartphone app can help African-American adults with uncontrolled high blood pressure manage their condition better than standard care alone. About 100 participants will use the app for education and home blood pressure tracking, while rese…

This study aims to find out if giving a precise, high-dose radiation treatment before surgery works better than giving it after surgery for brain tumors that have spread from other cancers. It will enroll 140 adults with a single brain tumor that surgeons can remove. The main goa…

This study is testing whether a private Facebook support group can help Native American women in Minnesota stay off opioids and continue their recovery medication. Researchers will enroll 60 women who are already in recovery and using medication for opioid use disorder. The goal …

This study is testing whether a very low 1 mg dose of the drug osilodrostat is safe and can help control mild, ongoing overproduction of the stress hormone cortisol from the adrenal glands. It will involve 15 adults who have a benign adrenal tumor and related health issues like h…

This study aims to find out which type of focused radiation therapy works better for patients with cancer that has spread to the brain. It compares a single, high-dose treatment to a series of smaller doses spread out over time. Researchers want to see which method better control…

This early-stage trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in patients with metastatic breast cancer. The goal is to see if the virus can safely infect and kill cancer cells while also stimulating the patient's immune system to att…

This early study is testing a new, non-invasive treatment for glioblastoma, a fast-growing brain cancer that has returned or worsened. The treatment combines a special drug with focused ultrasound waves, guided by an MRI machine, to try to kill cancer cells without surgery. The m…

This study is testing whether letting hospital staff monitor data from patients' personal continuous glucose monitors (CGMs) leads to better blood sugar control during hospital stays. 150 adults with diabetes who use CGMs at home will be randomly assigned to either have their CGM…

This study is testing whether gentle electrical stimulation applied to the scalp can reduce the number and intensity of epileptic seizures. Researchers are enrolling 30 adults with epilepsy that hasn't been well-controlled by medications to try at-home stimulation sessions. The g…

This study is testing how well the Mayo Clinic Diet works for helping people lose a significant amount of weight (more than 5%) and keep it off for up to a year, compared to their usual routine. Researchers will follow 250 adults with a body mass index (BMI) of 25 or higher. They…

This study is testing whether using a continuous glucose monitor (CGM) can help people with glioblastoma, a serious brain cancer, manage their blood sugar levels during treatment. High blood sugar during radiation is linked to worse survival, and steroids used in treatment often …

This Mayo Clinic study is testing whether itraconazole, an antifungal medication, is a practical and safe treatment option for adults with bronchiectasis who also have mold growing in their airways. The small pilot trial with 30 participants will check if patients can stick with …

This study is testing if a drug called daratumumab, given as an injection, can help people with a rare kidney disease called PGNMID. The main goal is to see if the treatment can reduce the amount of protein leaking into the urine and improve kidney function over 12 months. Resear…

This study is for adults with early-stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not yet needed treatment but are at high risk of their disease getting worse. It compares a cancer-fighting pill (acalabrutinib) taken alone to the same pill …

This study is testing a new pre-surgery treatment plan for early to mid-stage esophageal cancer. It combines a shorter, more intense 3-week radiation schedule with a specific chemotherapy regimen (FOLFOX) to try to kill more cancer cells and potentially have fewer side effects. T…

This study is testing a radioactive drug called Lutathera for patients with a type of brain tumor called meningioma that cannot be removed by surgery and has continued to grow after radiation treatment. The drug is given through an IV and is designed to find and kill tumor cells.…

This study is testing whether following a strict high-fat, low-carbohydrate (ketogenic) diet can help reduce depressive symptoms in people with bipolar disorder. Researchers will enroll 30 adults with bipolar depression to follow the diet and closely track changes in their mood, …

This early-stage study is testing a new oral drug called onvansertib for people with rare, aggressive blood cancers that have come back or stopped responding to available treatments. The main goals are to find a safe dose and see if the drug can help control the disease. The stud…

This early-stage trial is testing whether stem cells from donated body fat can be safely injected into the brain during surgery to treat aggressive brain cancer that has returned. The study aims to find the safest dose and see if these cells can slow tumor growth and improve surv…

This study is testing if a new drug called PLX038 can shrink tumors in people with advanced ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to standard platinum-based chemotherapy. The drug works by blocking enzymes that cancer cells need to grow…

This early-stage study is testing a new personalized treatment for ovarian cancer that has returned or stopped responding to standard therapies. Doctors take a patient's own immune cells, grow and train them in a lab to recognize cancer, and then infuse them back into the patient…

This study compares two types of radiation therapy for men whose prostate cancer has returned or spread to a few spots after initial surgery. It tests if a shorter, more precise 5-treatment course (SBRT) works as well as a longer 20-treatment course, with potentially fewer side e…

This study is testing whether giving standard cancer treatments at home is as safe and effective as giving them in a clinic. It aims to see if receiving care at home reduces stress, improves quality of life, and is preferred by patients with advanced cancers. About 220 participan…

This study is for people with advanced bladder or upper urinary tract cancer that has spread. It tests if using two standard cancer drugs first, followed by surgery to remove the bladder or ureter, helps control the cancer better and for longer. The goal is to see if this combine…

This early-stage study is testing a new, personalized vaccine made from a patient's own immune cells. It aims to see if the vaccine is safe and can trigger an immune response against the virus that causes recurrent, non-cancerous growths in the throat. The study will enroll 9 adu…

This study is testing a new combination of four medications for people whose multiple myeloma has come back after prior treatment. The first goal is to find a safe dose, and the second is to see how well the combination works at controlling the cancer. It combines an experimental…

This study is testing whether the medication tadalafil can improve blood flow and organ function in adults born with a serious heart defect who had a Fontan surgery. Researchers will compare tadalafil to a placebo in 80 participants to see if it helps their heart and lungs work b…

This study is testing a two-part treatment for stomach cancer that has spread to the abdominal lining. Doctors use a robotic system to perform minimally invasive surgery to remove visible tumors, then bathe the area with heated chemotherapy. The goal is to see if this combined ap…

This early-stage study is testing whether a new treatment is safe for people whose body is rejecting a transplanted kidney. Doctors will infuse special cells, taken from donor fat tissue, directly into the artery of the transplanted kidney. The main goal is to see if this procedu…

This study aims to find the best length of maintenance therapy for people with AL amyloidosis, a rare disease where abnormal proteins damage organs. After successful initial treatment, 96 participants will receive either a shorter (3-6 cycles) or longer (18 cycles) course of the …

This study is testing a new four-drug combination for people with advanced pancreatic cancer that has spread or come back. It combines a new immunotherapy drug (BMS-986340) with an existing immunotherapy (nivolumab) and two standard chemotherapy drugs. The main goals are to see i…

This study compares two prescription eye drops to see which one better controls eye pressure over a full 24-hour period in people with glaucoma or high eye pressure. Thirty adults will use one drop in each eye nightly for two weeks while researchers measure pressure changes day a…

This study is testing whether a new, more personalized method for dosing a common antibiotic (cefepime) works better for very sick patients in the ICU with serious infections like sepsis. The main goal is to see if doctors and nurses find the new dosing method easy to use in a re…

This study aims to find the best weight loss medication for people with bipolar disorder by first identifying their specific eating patterns, like 'emotional hunger' or 'hungry gut.' Researchers will match 100 participants to one of three FDA-approved weight loss drugs or a no-me…

This study is testing if different doses and timing of the drug belantamab mafodotin can work better for people with multiple myeloma that has come back or stopped responding to other treatments. The drug is designed to target and kill myeloma cells. Researchers want to see if th…

This study is testing whether less aggressive treatment works as well as more intensive therapy for prostate cancer that has returned or spread. Researchers are comparing different approaches, including targeted radiation alone versus radiation combined with hormone-blocking drug…

This early-stage trial is testing a new treatment for patients whose blood cancers have returned or not responded to standard therapies. The treatment uses a modified virus that is designed to selectively infect and kill cancer cells while sparing healthy ones. Researchers are st…

This study is testing whether taking melatonin supplements for 12 weeks helps lower nighttime blood pressure in women going through perimenopause who have high blood pressure. Researchers will compare melatonin to a placebo pill in 70 participants. The goal is to see if this comm…

This study is testing if a simple saliva test can identify which people with obesity are most likely to respond well to the weight loss medication semaglutide. Researchers will compare weight loss in people who test positive or negative on the saliva test while taking the drug or…

This study is testing whether a drug called avacopan, given with a low dose of steroids, can help control a serious, fast-progressing form of kidney disease called crescentic IgA nephropathy. It will involve 16 adults with this condition to see if the treatment safely reduces pro…

This study is testing whether a medication called dapagliflozin, taken for six months, can help control heart pressures and improve symptoms in adults with a failing Fontan circulation—a complex heart condition they were born with. Researchers will measure changes in heart pressu…

This study is testing a new combination treatment for pancreatic cancer that cannot be removed by surgery or has spread. The approach uses a light-activated drug injected into the tumor to help the patient's own immune system, boosted by an immunotherapy drug (pembrolizumab), bet…

This study is testing if giving an oral medication called midodrine early on can help people with sepsis and low blood pressure get off strong intravenous (IV) medications sooner. Researchers hope this will lead to shorter stays in the intensive care unit and hospital, and a more…

This study compares two methods for placing heart pacing wires in people with heart failure. Researchers want to see if using artificial intelligence (AI) to guide the placement works better than the standard method. The goal is to improve heart function and reduce hospital visit…

This study tests whether combining a specialized radiation technique called grid therapy with standard immunotherapy can help control advanced lung cancer that has worsened despite current treatments. Grid therapy delivers high radiation doses to small tumor areas, potentially ki…

This program tests whether providing early support helps Minnesota workers who get injured or sick stay employed and avoid long-term disability. It connects eligible workers with services to help them keep working or return to work quickly. The goal is to help people maintain the…

This early-stage study is testing the safety of a three-part treatment for advanced bile duct cancer in the liver that cannot be removed by surgery. Doctors combine a targeted radiation treatment (Y90 radioembolization) with two immunotherapy drugs (tremelimumab and durvalumab) t…

This early-stage study is testing the safety and best dose of a drug called decitabine when added to standard surgery and radiation for a specific type of head and neck cancer not linked to HPV. The goal is to see if decitabine makes the cancer cells more sensitive to the standar…

This study is testing whether doctors can safely give less hormone-blocking therapy to men with high-risk prostate cancer. Researchers will group patients by risk level and give them radiation plus a shorter course of hormone therapy. The goal is to see if this personalized appro…

This is an early-stage study testing a new type of personalized cell therapy called MC10029 for adults with B-cell blood cancers that have come back or stopped responding to standard treatments. Researchers will first find the safest dose and then see if the therapy can shrink tu…

This study is testing whether giving two immunotherapy drugs before surgery can help the body's immune system attack and shrink early-stage non-small cell lung cancer. The goal is to kill more cancer cells before the tumor is removed, potentially leading to better long-term resul…

This study is testing whether a freezing spray can stop abnormal blood vessels in the stomach from bleeding. Researchers will enroll 50 adults with a condition called GAVE who have needed recent blood transfusions. They'll compare hemoglobin levels and transfusion needs for 6 mon…

This study is testing a weekly procedure for pregnant women whose unborn babies have no kidneys or severe kidney blockage. The procedure adds fluid to the womb to help the baby's lungs develop, which is critical for survival after birth. The goal is to see if this approach can he…

This study aims to find out which of three oral medications works best to prevent migraine attacks in adults. Researchers will compare a newer drug, atogepant, against two older, commonly used drugs, topiramate and propranolol. About 1,335 participants will be randomly assigned t…

This early-stage trial is testing the safety and best dose of a drug called venetoclax when combined with other standard multiple myeloma medications. It is for patients with a specific genetic feature in their cancer cells called t(11;14). The goal is to see if adding venetoclax…

This study aims to understand and better manage high blood pressure and heart risks in people with certain blood cancers who are taking a specific type of medication called a BTK inhibitor. Researchers will closely monitor 100 patients for one year to see how often these side eff…

This study is testing whether stem cells taken from bone marrow are safe for people with chronic kidney disease, including those who have had a kidney transplant. Researchers will give these cells to 75 adults and closely monitor them for any side effects. The goal is to see if t…

This study compares two common antibiotics—azithromycin and doxycycline—for adults hospitalized with pneumonia. Researchers want to see which one helps patients spend fewer days in the hospital and recover faster. The trial includes 1,120 participants who are already receiving st…

This study aims to help people recover better after surgery to cure Cushing syndrome, a rare hormone disorder. Researchers want to understand why some patients have a harder time after surgery with withdrawal symptoms and muscle weakness. They are testing if a mindfulness app (MU…

This early-stage study is testing a vaccine called H2NVAC in patients with a specific type of early, non-invasive breast cancer (DCIS) that has a protein called HER2. The goal is to see if the vaccine is safe, find the right dose, and learn if it can stimulate the patient's own i…

This study is testing whether the drug enfortumab vedotin can help control advanced penile cancer that has spread or cannot be surgically removed. The drug is designed to target cancer cells specifically and deliver a cancer-killing agent directly to them. Researchers will measur…

This study is testing whether starting a blood-filtering treatment called plasma exchange early, versus waiting to see if it's needed later, leads to better recovery for people with severe eye nerve or spinal cord inflammation. It will enroll 382 adults who have recently develope…

This early-phase study is testing a new treatment approach for patients with T-cell lymphoma that has returned or stopped responding to standard therapies. Researchers are combining a genetically modified virus designed to attack cancer cells with two immunotherapy drugs that hel…

This study is testing whether a small device that stimulates a nerve in the neck, used during walking therapy, can help people walk better after a stroke. Researchers want to see if this combination is safe and can improve walking speed and leg function for adults who had a strok…

This study is testing whether giving a shorter, more intense course of radiation therapy *before* breast cancer surgery is as safe and effective as giving it *after* surgery. It aims to see if the pre-surgery timing can reduce side effects and treatment time for 120 patients with…

This study is testing whether adding low-intensity shockwave therapy to standard Xiaflex injections works better for men with Peyronie's disease. Researchers want to see if the combined treatment reduces penile curvature more effectively and improves sexual function. The trial wi…

This study is testing a flexible approach to chemotherapy for advanced breast cancer that has spread. Researchers want to see if adjusting the dose of the drug capecitabine based on how the tumor responds—using scans and blood tests—can help control the cancer longer while possib…

This program provides the experimental drug ibudilast to people with ALS who cannot join regular clinical trials. It aims to see if the drug can slow down ALS progression while studying blood markers of nerve damage. The program is open to adults diagnosed with ALS who meet speci…

This study is testing whether giving prostate cancer treatment at home is as safe and effective as receiving it in a clinic. Black men with advanced prostate cancer will receive part of their standard treatment at home with remote monitoring. Researchers want to see if home treat…

This study is testing a new adjustable disk designed for feeding tubes placed in the stomach or small intestine. Researchers want to see if this new disk helps the skin around the tube heal better and causes fewer problems like irritation or infection. They will check how well th…

This study is testing a combination of three drugs—acalabrutinib, venetoclax, and durvalumab—to see if they can help control a rare and aggressive cancer called Richter transformation. Richter transformation occurs when a slower-growing blood cancer (CLL) suddenly changes into a …

This study is testing if adding high-dose vitamin C (given through an IV) to standard chemotherapy can help patients whose lymphoma has returned or hasn't responded to treatment. It also tests vitamin C alone for certain pre-leukemia conditions. The goal is to see if vitamin C ma…

This study is testing if a minimally invasive procedure to block a specific vein in the back is safe and can help people with severe, daily headaches. It is for adults whose headaches are linked to a specific vein abnormality and have not improved with standard medications. Resea…

This study is testing whether taking turkey tail mushroom extract can slow the growth of breast cancer tumors in the weeks between diagnosis and surgery. It involves 40 post-menopausal women with a common hormone-driven type of breast cancer who are not yet on other cancer drugs.…

This study is testing if patient care for brain tumor survivors can be done remotely using online tests and a smartwatch. It also compares whether adding the diabetes drug metformin helps protect memory and thinking skills that can decline after head radiation. About 100 adults w…

This study is testing whether the medication ravulizumab can help control severe preeclampsia and HELLP syndrome, dangerous blood pressure disorders that can occur during pregnancy. The trial will involve 14 pregnant individuals who develop these conditions before 34 weeks of pre…

This study is for people with painful gallbladder disease who cannot have their gallbladder removed. It tests whether placing two small drainage tubes (stents) is better than placing just one at preventing future painful attacks. Researchers will compare which group has fewer fla…

This study is testing if a special fluorescent dye can help surgeons see tumor edges better during sarcoma removal surgery. The dye is injected before the operation and glows under a special camera, potentially helping the surgeon leave less cancerous tissue behind. Researchers w…

This study is testing whether paying Alaska Native families helps smokers quit for good. It compares a program offering cash rewards for quitting to standard support materials. Researchers will track if smokers in the payment group are more likely to stay smoke-free for 6 and 12 …

This study is testing whether a smartphone app called SleepWell24 can help people newly diagnosed with sleep apnea use their CPAP machine more regularly. Researchers want to see if the app helps people reach the goal of using the machine at least 6 hours a night. They will also t…

This study is testing if a simple blood test can help doctors personalize radiation treatment for people with HPV-related throat cancer. The goal is to give patients just enough treatment to control their cancer while reducing harsh side effects. Researchers will assign patients …

This early-stage study is testing a new oral medication called Q702 for patients with advanced blood cancers and rare immune cell disorders that have not responded to standard treatments. The main goals are to find the safest dose and see what side effects occur. Researchers hope…

This study compares two types of radiation therapy given after surgery for head and neck cancer. It tests whether a newer, more precise proton therapy works as well as standard X-ray therapy at keeping cancer from returning, while potentially causing fewer side effects like swall…

This study is testing whether a shorter, lower-dose course of radiation therapy works as well as the standard, longer course for treating slow-growing non-Hodgkin lymphoma. The main goal is to see if the shorter treatment causes fewer immediate side effects while still controllin…

This is the first study in people testing a new oral drug called MTI-301 for advanced solid cancers that have spread or cannot be removed by surgery. The main goal is to find the highest safe dose and understand the drug's side effects in 42 patients whose cancers have not respon…

This study is for people with advanced bladder or urinary tract cancer that has spread and stopped responding to standard treatments. Researchers want to see if a procedure called therapeutic plasma exchange—which filters certain proteins from the blood—can help patients respond …

This study is for people with metastatic breast cancer whose current medication is working well but who have a few new spots of cancer growth. Researchers want to see if using very precise, high-dose radiation on just those few spots can control them, allowing patients to safely …

This study aims to determine if adding a minimally invasive camera procedure (hip arthroscopy) during standard hip dysplasia surgery leads to better pain relief and function compared to the standard surgery alone. Researchers will enroll 106 patients aged 15-55 with hip dysplasia…

This study is testing whether a mobile app can help deliver and monitor treatment for adults with glioma brain tumors from home. The goal is to improve access to specialized care for patients who live far from major cancer centers or face other barriers. Participants will use the…

This study is testing a small device called a Coronary Sinus Reducer in people with a specific type of heart failure where the heart pumps normally but still causes symptoms like shortness of fatigue. The goal is to see if the implant improves blood flow to the heart muscle. Rese…

This study compares three different approaches for treating pelvic bone cancers (sarcomas) to see which one works best. Researchers are testing carbon ion radiation therapy against traditional surgery and proton radiation therapy. They want to find out which treatment gives patie…

This study is testing whether a special PET scan can detect very early signs of heart inflammation in cancer patients taking immunotherapy drugs. Researchers want to see if this scan can identify patients at risk before they develop serious heart problems. The study involves 30 a…

This study aims to see if a person's voice can reveal signs of pulmonary hypertension, a serious condition of high blood pressure in the lungs. Researchers will analyze voice recordings from 7,000 patients who are already scheduled for a standard heart ultrasound at Mayo Clinic. …

This study aims to develop a new test to detect endometrial, ovarian, and cervical cancers. Researchers will collect vaginal fluid and blood samples from over 3,000 women to check for specific cancer markers. The goal is to create a less invasive way to find these cancers earlier…

This study is testing whether a new type of CT scanner, called a Photon-Counting Detector CT, can determine how far rectal cancer has grown as accurately as an MRI scan. About 120 adults with rectal cancer will have both scans to compare the results. The goal is to see if this ne…

This study is testing whether a simple 'sponge-on-a-string' device can accurately detect Barrett's esophagus and early esophageal cancer. The goal is to create an easier screening method that doesn't require a full endoscopy procedure. Researchers will enroll about 1,550 adults a…

This study is testing a new biopsy technique to improve how doctors determine the stage of bladder cancer before surgery. Researchers will use ultrasound to guide a needle to take a tissue sample from the bladder tumor. They will compare the results from this new method to the fi…

This study is testing whether a new type of PET scan can detect early scarring (fibrosis) in the small intestines of people with Crohn's disease. Researchers want to see if this scan can spot scarring before it becomes a severe stricture that narrows the bowel. The study will com…

This study is testing a special fluorescent dye called pafolacianine to see if it helps surgeons better identify and remove solid tumors in children and teenagers during cancer surgery. The dye is injected before surgery and glows under a special near-infrared camera, potentially…

This Mayo Clinic study is testing whether a new type of breast ultrasound can better detect breast cancer and monitor how well treatment is working. The research involves 550 participants who will undergo special ultrasound scans to see if this method can identify cancerous tissu…

This study is testing whether a new type of CT scanner, called a Photon Counting Detector CT, can give doctors clearer and more useful pictures of the heart's arteries. Researchers will compare images from this new scanner to standard heart scans in 450 patients with suspected co…

This study is testing a new screening program to see if it can find pancreatic cancer earlier in people at high risk. The program uses repeated CT scans analyzed by artificial intelligence (AI) and regular blood draws. Researchers want to see if this approach is practical and eff…

This study is testing whether artificial intelligence (AI) can accurately detect two heart conditions—aortic stenosis and diastolic dysfunction—from routine electrocardiogram (ECG) tests. Researchers will enroll 2,000 adults aged 60+ who are already scheduled for a clinical ECG. …

This study is testing whether a special type of breast scan, called molecular breast imaging (MBI), can help doctors take more accurate tissue samples (biopsies) from suspicious breast lumps. It aims to help when standard ultrasound or mammogram images aren't clear enough to guid…

This study aims to test two investigational devices that measure blood flow in leg veins to help detect deep vein thrombosis (DVT). Researchers will enroll 500 participants who recently had an ultrasound to check for blood clots. The study compares measurements from an air-filled…

This study is testing a new type of MRI scan to see if it can better detect bone damage in the hands of people with inflammatory arthritis. Researchers will compare the new scan to standard MRI and X-ray images. The goal is to improve the accuracy of diagnosis and help doctors be…

This study is testing a new type of heart scan called magnetocardiography (MCG) to see if it can better detect and monitor amyloidosis, a disease where abnormal proteins build up in organs. Researchers will enroll 500 adults with amyloidosis to compare the new MCG scan against st…

This study is testing a new, non-invasive ultrasound method to see if it can accurately measure bladder muscle function. The goal is to provide a better, more comfortable way to diagnose conditions like overactive bladder and help select treatments for enlarged prostate. Particip…

This study aims to find better ways to tell if a pancreatic cyst is at high risk of becoming cancer. Researchers will collect blood, stool, and fluid samples from 800 people with concerning pancreatic cysts. They will compare these new test results to see which ones most accurate…

This study is testing whether smartwatch technology and artificial intelligence can reliably monitor heart function in people who have survived lymphoma or sarcoma. Researchers want to see if these wearable devices can detect early signs of heart problems caused by cancer treatme…

This study is testing a new type of PET/CT scan to see if it can create clearer pictures of pancreatic cancer. The scan uses a special tracer that attaches to specific cells found in and around tumors. Researchers hope this method will help doctors better diagnose and plan treatm…

This study aims to establish normal ranges for a new cancer screening test that analyzes DNA in blood and urine. Researchers will collect samples from 10,000 healthy volunteers without known cancer to determine what test results look like in people without the disease. The goal i…

This study is testing a new type of brain scan to see if it can better tell the difference between a brain tumor that has come back and side effects from previous treatment. It involves 25 adults with high-grade glioma who are already scheduled for brain surgery. Researchers will…

This study is testing a simple, swallowable sponge device called Cytosponge as an easier way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. The goal is to see if this non-invasive test, which collects cells from the esophagus, can accurately id…

This study is testing a new approach to detect cancer early using simple blood and urine tests. Researchers want to see if these tests can accurately find cancer and even identify where in the body it started. The study will involve 6150 people, including those with and without c…

This study is testing a new type of imaging scan to see if it can accurately tell whether prostate cancer has spread to nearby lymph nodes. If successful, this scan could help doctors decide which patients truly need to have their lymph nodes removed during prostate cancer surger…

This early study is testing a new 3D ultrasound imaging technology to see if it can better evaluate lymph nodes in people with breast cancer. Researchers want to know if this 3D method is more accurate than standard 2D ultrasound at telling if a lymph node is cancerous or benign.…

This study is testing whether a special type of MRI scan done during exercise can help doctors better diagnose, understand, and predict risks for a common form of heart failure. Researchers will compare the scan results in 400 people: those with heart failure, those with shortnes…

This study is testing a new combined PET/MRI scan to find small pituitary tumors that regular MRI scans can't detect. It involves up to 5 adults with hormone disorders caused by these tumors, but whose current scans are unclear. The goal is to see if this new scan can accurately …

This study is testing whether a special ultrasound technique can accurately detect high blood pressure in the veins leading to the liver, a condition called portal hypertension. Researchers want to see if this non-invasive method works as well as the current standard test, which …

This study aims to develop a test to predict which newborns will need prolonged breathing support. Researchers will analyze a small sample of stomach fluid routinely collected after birth from 500 babies born at 32 weeks or later. The goal is to create a tool that helps doctors i…

This study is testing new AI-powered image processing techniques to see if they can make MRI scans for pelvic cancers faster and produce clearer pictures. It will involve 60 adults who are already scheduled for scans to check for prostate or endometrial cancer. The goal is to see…

This study is testing whether new technical improvements to MRI machines can create clearer pictures of the prostate. The goal is to improve both scans that use a contrast dye and those that don't, potentially leading to better diagnosis. Up to 1,000 adult participants will have …

This study is testing a new type of ultrasound imaging to see if it can better evaluate growths on or near the ovaries. The goal is to improve the ability to tell if a growth is cancerous before a patient has surgery. Researchers will enroll 40 women who are already scheduled for…

This study is testing a new 3D ultrasound imaging method to see if it can improve the diagnosis of breast masses. Researchers will enroll 125 adult women who have a solid breast lesion and are scheduled for a biopsy. They will compare the new 3D images to standard 2D ultrasound i…

This study is testing new ultrasound imaging techniques that use sound waves to measure tissue stiffness and movement. Researchers want to see if these methods can better identify which thyroid nodules are cancerous and which are benign, potentially reducing unnecessary biopsies.…

This study is testing whether a simple lung ultrasound can safely detect rejection or infection in lung transplant patients, without needing invasive biopsies. Researchers will compare ultrasound results to the standard biopsy procedure in 90 adult transplant recipients who feel …

This study is testing a new ultrasound imaging technique used during surgery to help surgeons better see and remove pituitary tumors. The goal is to more accurately identify the tumor tissue while leaving healthy pituitary tissue alone, which could lead to better surgical results…

This study is testing a new type of PET/CT scan using a tracer called F-18 TFB to see if it can find recurrent or spreading thyroid cancer more accurately than current standard scans. Researchers will enroll 24 adults with papillary or follicular thyroid cancer who are already sc…

This early-stage study is testing a new type of biopsy marker designed to be easier for surgeons to see on ultrasound scans during breast cancer operations. The marker is placed in a cancerous lymph node before treatment and is meant to help guide surgeons to the correct node for…

This study is testing if a short course of hormone-blocking pills can make prostate cancer cells 'light up' more brightly on a special imaging scan. The goal is to help doctors see smaller or hidden areas of cancer that have spread, particularly to lymph nodes, in men with high-r…

This study is testing a new neck-training device to see if it can help prevent concussions in junior hockey players. Researchers will measure changes in neck strength, reaction time, and brain function in 60 healthy players. The goal is to see if stronger neck muscles can better …

This study aims to reduce colon cancer disparities by providing free at-home screening tests and education to Black and underserved communities in Phoenix. Participants receive a simple stool test kit, complete a health questionnaire, and get support navigating follow-up care if …

This study is testing whether adding a home-based balance and strength exercise program, delivered through a smartphone app, to standard cardiac rehab helps people feel more confident, function better, and reduces their risk of falling. Researchers will compare two groups: one do…

This study offers an experimental procedure to freeze and store testicular tissue from boys (ages 0-17) who are about to undergo cancer treatments like chemotherapy or radiation that have a high risk of causing permanent infertility. The goal is to preserve the tissue so it might…

This study is testing if a drug called ibrutinib can prevent chronic graft-versus-host disease (GVHD) in patients who have received a donor stem cell transplant. GVHD is a serious condition where the donor's immune cells attack the patient's body. The trial will enroll 40 adults …

This study is testing whether a genetic test can help prevent harmful side effects from common medications. Researchers will give the test to some primary care patients before they start a new prescription to see if it helps doctors choose safer drugs or doses. The goal is to red…

This study is testing whether taking a daily low-dose aspirin can reduce inflammation in breast tissue, which might help prevent breast cancer in women who have recently had a baby. It involves 100 women under age 45 who have given birth within the last 10 years and need a breast…

This study is testing whether a series of digital hypnotherapy sessions can help reduce symptoms like stomach pain, bloating, and nausea in people with chronic upper gastrointestinal disorders. Researchers will compare the hypnotherapy program to an educational module in 100 part…

This small pilot study is testing whether using virtual reality (VR) is a safe and helpful way to improve the mental well-being of cancer patients during treatment. Participants will use a VR headset to experience relaxing, immersive environments like forests or coral reefs. The …

This study is testing if the medication tirzepatide (Zepbound), known for weight loss, can also reduce the frequency and severity of menopausal hot flashes and slow down biological aging. It will involve 40 postmenopausal women with obesity who experience frequent, bothersome hot…

This study aims to improve a treatment called biofeedback for adults with chronic constipation caused by a specific muscle coordination problem. Researchers will measure how well biofeedback helps people empty their bowels more easily and reduces their symptoms. The goal is to ma…

This study is testing whether a home-based exercise and coaching program can help people with progressive lung scarring diseases feel better and be more active. It compares the home program to usual medical care in 460 participants. The goal is to see if making rehabilitation mor…

This early study is testing whether low-dose growth hormone can improve symptoms like nausea, pain, and bloating in people with gastroparesis (stomach paralysis). Researchers at Mayo Clinic will enroll 10 patients who haven't gotten enough relief from standard treatments. They'll…

This study is testing whether a spinal cord stimulation device can help reduce pain and improve quality of life for people suffering from nerve damage caused by chemotherapy. Researchers will follow 20 patients who have already had a successful trial with the device to see how mu…

This study is testing whether a custom 3D-printed external breast prosthesis can improve comfort, fit, and emotional well-being for people who have had a mastectomy and did not have surgical reconstruction. Researchers will create personalized prostheses using 3D scans and compar…

This study is testing whether a phone app can effectively teach family caregivers how to perform safe, specialized massage techniques to help cancer survivors manage long-term nerve pain and numbness caused by chemotherapy. The goal is to reduce these symptoms for patients while …

This study is testing whether a 6-week online support group curriculum helps young adult cancer survivors adjust to life after treatment. The program, led by social workers, provides education and peer support about coping with survivorship challenges. Researchers want to see if …

This study tests whether educational videos and guided appointments help young adults with advanced cancer discuss and document their future medical care preferences. Researchers want to see if these tools make it easier for patients to have these important conversations early in…

This study is testing whether adding specific breathing muscle exercises to standard cardiac rehabilitation helps people with heart failure. It will measure if this combination improves blood flow to the legs and reduces the oxygen cost of breathing during exercise. The goal is t…

This study is testing whether a special low-calorie, plant-based diet can help reduce the side effects that cancer patients experience during immunotherapy. The diet, which mimics fasting, will be given to 10 patients with advanced cancer who are receiving specific immunotherapy …

This study is testing if combining a baby's first doctor checkup with a breastfeeding support visit into one appointment helps mothers breastfeed for longer. Researchers will compare moms who have the combined visit to those who have the two visits separately. The goal is to see …

This study is testing whether a home-based breathing training program, supported by a health coach, can help people with non-cystic fibrosis bronchiectasis. Researchers want to see if the training improves how far participants can walk, how well their lungs work, and their overal…

This study is testing whether a personalized exercise program before surgery helps people with soft tissue sarcoma in the leg recover better. Patients receive standard radiation and surgery, but half also do special exercises for 8 weeks beforehand. The goal is to see if this 'pr…

This study is testing whether taking a beetroot-based supplement at night can help people sleep better and improve heart and blood vessel health. Researchers will measure changes in sleep quality, daytime sleepiness, and blood pressure in healthy adults. The goal is to see if thi…

This study is testing whether an online mindfulness program can help reduce stress and anxiety in cancer patients who live in rural Minnesota, where mental health services are harder to access. The program teaches techniques to help manage stress from home. Researchers will measu…

This study is testing a new surgical method to see if it reduces scarring and other complications for people with Dupuytren's contracture who are having trigger finger surgery. Researchers want to know if removing a specific cord in the palm, instead of just cutting it, leads to …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is observing whether a device that delivers high-frequency electrical stimulation to the spinal cord can reduce chronic nerve pain in the arm. It will follow 20 adults with severe brachial plexus injuries who are already scheduled to receive this implant. Researchers w…

This study is testing whether using virtual reality (VR) can help reduce stomach pain and other digestive symptoms in people with functional dyspepsia. Researchers at Mayo Clinic will have 30 participants use VR to see if it eases symptoms like abdominal pain, nausea, bloating, a…

This study is testing whether blocking several nerves in the scalp with a numbing medicine and a steroid can stop a migraine attack in progress and prevent future ones for several months. Researchers are comparing blocking just two nerves to blocking up to ten nerves to see which…

This study is testing a special pain management program designed to help breast cancer survivors who experience joint and muscle pain as a side effect of their hormone-blocking medication. The program uses counseling and coping techniques to reduce pain, improve mood and thinking…

This study is testing if a pain-relieving injection (like Lidocaine) around the sciatic nerve in a person's healthy leg can reduce hard-to-treat phantom or residual limb pain in their amputated leg. Researchers at Mayo Clinic are recruiting 20 adults with lower limb amputation wh…

This study is testing whether taking a dietary supplement called kava extract can help reduce stress and feelings of burnout in nurses. Researchers at Mayo Clinic will enroll 200 surgical nurses to see if kava lowers the stress hormone cortisol and improves their mood, sleep, and…

This study is testing whether a structured breathing practice is a practical and acceptable way to help teenagers with anxiety and depression. It involves 40 teens, ages 12-17, from both rural and non-rural areas. The main goal is to see if the breathing program is easy to use an…

This Mayo Clinic study is testing if a wearable headband that uses gentle sound therapy (Acoustic Resonance Therapy) can help people with chronic insomnia as much as the current standard treatment, which is a type of talk therapy called CBT-I. The study will enroll 60 adults with…

This Mayo Clinic study is testing if breathing controlled mixtures of air with slightly less oxygen and more carbon dioxide can help people with Long COVID who have 'brain fog.' Researchers will measure changes in brain blood flow, heart rate, and cognitive test scores to see if …

This study compares two types of radiation therapy given after surgery for cervical or endometrial cancer to see which causes fewer short-term side effects. Researchers want to know if proton radiation causes less bowel and bladder irritation than standard intensity-modulated rad…

This study is testing whether a home-based program can help reduce fatigue and improve quality of life for older adults living with multiple myeloma. Participants will follow a gentle daily activity plan that includes mindfulness, flexibility, and walking, while also receiving we…

This small pilot study is testing whether a special type of compression stocking, called a 'Fuzzy Wale' stockinet, can help people heal better after a below-the-knee amputation due to poor leg circulation. Researchers will compare it to the standard compression stocking to see if…

This study is testing if two existing medications, duloxetine and amitriptyline, can reduce the frequency and severity of chronic cough in people with interstitial lung disease (ILD). It will involve about 25 participants who will try different doses of the medications or a place…

This study is testing whether using noise-canceling headphones with music or a movie can help patients need less sedation medication during knee replacement surgery. Researchers will compare patients who use the headphones to those who don't to see if it reduces the amount of sed…

This study is testing whether regular phone coaching sessions can help caregivers of patients waiting for a heart or lung transplant. The goal is to reduce the stress of caregiving and increase the caregiver's confidence in managing their role. The study will enroll about 30 prim…

This study aims to see if American ginseng can help reduce the severe fatigue that many cancer patients experience, whether they are currently on treatment or not. It will compare ginseng capsules to a placebo (a dummy pill) in 160 adults with solid tumors who report significant …

This small Mayo Clinic study is testing whether using virtual reality (VR) can help improve symptoms for people with non-cardiac chest pain. Researchers want to see if the VR treatment is practical and acceptable to patients before planning a larger trial. They will also check if…

This study is testing whether a combination of two existing drugs (neostigmine and glycopyrrolate) can effectively treat severe headaches that sometimes occur after an epidural procedure during childbirth. The goal is to help new mothers avoid needing a more invasive treatment ca…

This study is testing if two existing medications, duloxetine and amitriptyline, can reduce how often people with a hard-to-treat chronic cough need to cough. It will involve 50 participants who have had a persistent cough for over a year. The study will carefully compare differe…

This Mayo Clinic study is testing whether structured breathing exercises can help reduce burnout, stress, anxiety, and depression in healthcare workers. The research will follow 40 clinical care professionals who use a mobile app to practice breathing techniques. The main goal is…

This study is testing whether Reishi mushroom extract can help reduce fatigue and joint pain in breast cancer patients taking aromatase inhibitor medications. 80 participants will take either the extract or a placebo for four weeks, then switch, to see which helps more. The goal …

This study aims to see if a specific combination of anesthesia drugs (sevoflurane with dexmedetomidine) is better at preventing post-surgery confusion and agitation in young children than a standard drug (isoflurane). It will involve 400 children aged 2-7 having common surgeries …

This Mayo Clinic study is testing whether low-dose radiation therapy works better than steroid injections for reducing pain and improving hand function in people with hand osteoarthritis. Researchers will enroll 165 participants aged 50+ who have significant hand pain. The study …

This study is testing whether a medication called pyridostigmine can help people with Postural Tachycardia Syndrome (POTS). POTS causes symptoms like a racing heartbeat, dizziness, and fatigue when standing up. Researchers will compare the drug to a placebo (inactive pill) in 50 …

This study is testing how well and how safe a nasal spray called zavegepant works for quickly treating migraine attacks. It is for people who are already taking certain daily or monthly medications to prevent migraines. Researchers want to see if the spray relieves headache pain …

This study is testing a new lifestyle and behavior program to help manage chronic migraine. Researchers will enroll 60 adults who have had chronic migraine for at least a year to see if the program is practical and acceptable. The main goals are to check if people can stick with …

This study is testing if giving methadone as a pill before surgery works as well as giving it through an IV during surgery to control pain afterward. It involves 100 adults having planned heart surgery. The main goal is to see which method better reduces the need for strong paink…

This study aims to see which type of injection works better for reducing pain from moderate to severe thumb base arthritis: a common steroid shot or an anti-inflammatory drug (NSAID) shot. Researchers will compare pain relief, hand function, and grip strength in 240 adults. The g…

This study is testing whether acupressure, a technique using finger pressure on specific body points, can help reduce anxiety in people receiving chemotherapy for cancer. Researchers will compare real acupressure to a 'sham' version in 78 adult cancer patients who report signific…

This study is testing whether adding virtual reality (VR) relaxation therapy to a standard IBS medication (linaclotide) helps people feel better than just taking the medication alone. Researchers will compare two groups: one gets the real VR program, and the other gets a fake (sh…

This study is testing whether a daily routine of guided breathing exercises can improve brain health and mental well-being. It is enrolling patients with multiple sclerosis or certain cancers, as well as their caregivers, to see if the practice reduces symptoms like fatigue, anxi…

This Mayo Clinic study is testing if adding the medication mirtazapine to a low-FODMAP diet helps people with IBS-D feel better than using the diet alone. The low-FODMAP diet avoids certain hard-to-digest carbs. Researchers want to see if the combination reduces abdominal pain, d…

This study is testing whether a gentle, non-invasive electrical stimulation device worn on the ear can help reduce chronic dizziness. Researchers at Mayo Clinic will enroll 60 adults who have experienced persistent dizziness for at least three months. Participants will use the de…

This study is observing whether injecting a special foam into large, painful cysts can help people with inherited polycystic kidney or liver disease. Researchers will follow 100 patients for about a year to see if the procedure reduces pain, shrinks the cysts, and improves their …

This study is testing whether online group therapy sessions can help cancer patients cope with the stress and emotional challenges of their diagnosis and treatment. Researchers want to see if these virtual meetings improve patients' psychological flexibility, reduce distress, and…

This study is testing whether a lower dose of steroid injection works as well as the standard dose for relieving knee arthritis pain and improving function. The research focuses on obese patients with knee osteoarthritis who are already planning to get a steroid injection. Doctor…

This study aims to find the best dose of a medication called dexmedetomidine to stop shivering in women having planned C-sections. Researchers will enroll 40 women who experience moderate to severe shivering during their procedure. They will test different doses to find the one t…

This study is testing whether a special nerve graft surgery can restore nipple sensation for breast cancer patients having a nipple-sparing mastectomy. Researchers want to see if patients are willing to join a study comparing standard surgery to surgery with the nerve graft. They…

This small, early study is testing whether a wearable headband that guides meditation can help breast cancer survivors manage anxiety and insomnia. Forty participants who report these symptoms will use the headband at night and for short daily meditations over 8 weeks. The main g…

This study is testing whether a dietary supplement called fucoidan, derived from brown seaweed, can help prevent or reduce the severe fatigue that often comes with chemotherapy. It will involve 34 adults with gastrointestinal or gynecological cancers who are starting a specific t…

This study is testing whether a new artificial intelligence feature in hearing aids can help people hear and understand speech better, especially in noisy environments. It will involve 500 people with hearing loss, including those who don't use hearing aids, those who do, and peo…

This study is testing if adding a steroid medication (prednisone) to standard pain medicine helps people feel better after surgery to remove kidney stones. Researchers will enroll 90 adults who are having this surgery and getting a temporary internal tube called a stent. They wil…

This small pilot study from the Mayo Clinic is testing whether using virtual reality (VR) headsets can help reduce abdominal pain in people with Crohn's disease who still have pain even when tests show their inflammation is under control. About 15 participants will use a VR heads…

This study is testing if a medication called tamsulosin can help patients urinate normally after spine surgery. It aims to reduce the need for catheters, lower the risk of infections, and shorten hospital stays. The trial is enrolling 20 adults undergoing specific types of spine …

This study is testing whether training the muscles used for breathing can help people recover after a lung transplant. Researchers will work with 30 lung transplant patients to see if this training improves their exercise ability and quality of life. The goal is to find better wa…

This study compares two different approaches to managing pain after surgery for gynecologic cancers. Researchers want to see if methadone given through an IV works as well as hydromorphone given as a spinal injection. The trial involves 140 patients undergoing abdominal surgery a…

This study aims to see if skincare consultations can improve skin appearance and quality of life for breast cancer survivors who are starting aromatase inhibitor therapy. Researchers will enroll 25 postmenopausal women with early-stage breast cancer to track skin changes using sp…

This study is testing whether participating in 12 Latin dance sessions can help people who have received a lung transplant feel better. Researchers want to see if dancing improves anxiety, depression, fear of movement, balance, and breathing. The study will enroll 52 participants…

This study is testing whether a special breathing exercise program can help people with a specific type of heart failure. Researchers want to see if strengthening the breathing muscles improves blood flow to muscles during exercise and helps people exercise longer. The study will…

This study is testing whether a short, four-session therapy can help older adults who are caring for a dying family member and experiencing severe grief. Researchers want to see if this therapy can reduce distressing grief symptoms both before and after their loved one passes awa…

This study is testing whether eating more fermented foods like yogurt, kimchi, and sauerkraut can help people recover mentally and emotionally after a life-threatening illness like severe COVID-19. Researchers want to see if this diet improves gut health, reduces inflammation, an…

This Mayo Clinic study is testing whether a new AI-assisted program is practical and helpful for people with serious illness. The program guides patients through creating a personal life story document with a trained helper, aiming to reduce emotional and existential distress. Re…

This study is testing whether a personalized exercise program in the weeks before CAR-T cell therapy can help older adults with recurrent multiple myeloma. Researchers want to see if this 'prehabilitation' improves patients' physical strength, fitness, and quality of life both be…

This study is testing whether wrapping delicate nerves with a special protective tissue during prostate cancer surgery can help men recover better. The goal is to see if this wrap can reduce common side effects like erectile dysfunction and urinary incontinence after the operatio…

This study is testing whether adjusting the settings on a deep brain stimulation implant can help improve sleep for people with Parkinson's disease who have severe insomnia. Researchers will enroll 10 participants who already have the implant and see if stimulating a different br…

This study tests a digital coaching program called ASCENT to help cancer survivors manage their pain better. Participants receive personalized guidance from health coaches and learn pain management techniques through phone or video calls. The goal is to improve pain control while…

This study aims to understand the daily life and emotional well-being of people in the first two years after treatment for advanced melanoma. It will also test if a specific type of talk therapy (CBT-C) can help reduce cancer-related stress and improve quality of life. The resear…

This study is testing whether a virtual art therapy program can help young adult cancer survivors cope with emotional challenges like anxiety and depression. Researchers want to see if this online approach is practical and helpful for participants aged 18-25. The program involves…

This study is testing whether a songwriting activity can help teenagers with sickle cell disease feel less anxious and better manage their emotions. Researchers want to see if participants find the creative process practical, enjoyable, and helpful for their mental well-being. Th…

This study tests whether people find an electronic massage machine practical and satisfying compared to a human massage therapist. Twenty participants will receive both types of massage in random order. Researchers want to know if the machine is a feasible alternative to professi…

This study is testing whether a long-acting numbing medicine (EXPAREL®) works better than the standard shot (XYLOCAINE®) to reduce pain after surgeons remove a piece of rib cartilage for nasal surgery. Researchers will enroll 60 people having this specific surgery and measure the…

This study is testing whether a smartphone app can help Black and LGBTQ+ adults better manage their chronic pain. Researchers want to see if using the app is practical and helpful for 300 people who have had pain for at least 3 months that interferes with daily life. The app teac…

This study aims to understand how common undiagnosed sleep problems are in healthy Somali American adults. Researchers will measure participants' sleep patterns and blood pressure over 24 hours to see if poor sleep is linked to higher blood pressure. The goal is to gather knowled…

This study aims to build a large database of people who have experienced a spontaneous coronary artery dissection (SCAD), a rare and poorly understood heart condition. Researchers will collect medical information from up to 2,500 participants to identify patterns in who gets SCAD…

This study aims to find a safer way to prepare patients taking GLP1 receptor agonists (like Ozempic or Wegovy) for upper endoscopy procedures. Researchers want to see if having patients fast for a longer period before the procedure reduces leftover stomach contents, which could l…

This study aims to understand how focused ultrasound affects the area around brain tumors. During planned surgery, researchers will use sound waves to temporarily open the brain's protective barrier in some tumor areas. They will then place tiny tubes to collect fluid from treate…

This study aims to see if taking a specific probiotic supplement can help strengthen the intestinal lining in healthy people. Researchers will give participants a short course of a common painkiller known to temporarily increase gut permeability (a 'leaky gut' state) to test the …

This study aims to collect bile samples and medical information from people with Primary Sclerosing Cholangitis (PSC) and people without liver disease. Researchers will use these samples to grow tiny 3D liver-like structures called organoids in the lab. By studying these organoid…

This study aims to understand the connection between physical activity and memory or thinking skills in young adults who have finished cancer treatment. Researchers will enroll 100 survivors aged 18+ who were diagnosed with cancer between ages 15-39. Participants will wear an act…

This study is testing a special, thin catheter during brain surgery to collect tiny fluid samples from the tumor area. The goal is to find chemical signals (biomarkers) in the fluid that could help doctors better understand, diagnose, and monitor brain tumors like glioblastoma. T…

This study aims to understand if changes in the community of bacteria in the gut (the microbiome) are connected to why some women experience severe fatigue and nausea during chemotherapy for early-stage breast cancer. Researchers will collect stool and blood samples from about 70…

This study aims to understand genetic differences in cancers affecting Indigenous American communities, who face worse cancer outcomes than other groups. Researchers will collect tumor samples and genetic data from 300 Indigenous American cancer patients and survivors to identify…

This Mayo Clinic study aims to understand why insulin doesn't properly control fat breakdown in people with upper body obesity. Researchers will examine fat cells from 64 volunteers, including both non-obese and obese adults, to identify specific proteins involved. They'll also t…

This study aims to understand how our brains and gut hormones work together to make us feel hungry or full. Researchers will measure brain activity and hormone levels in healthy volunteers while they experience different feelings of fullness from a balloon, calories, or tasty foo…

This study aims to understand why some cancer patients develop heart problems after chemotherapy while others do not. Researchers will collect blood samples and review medical records from 1,000 adults who have been treated for cancer. The goal is to find biological markers that …

This study aims to understand why people born with certain heart defects later develop symptoms like shortness of breath and irregular heartbeats. Researchers will observe 300 adults with conditions like repaired Tetralogy of Fallot to learn how their hearts change over time. The…

This study aims to understand how a hormone called GLP-1, produced naturally in the pancreas, affects blood sugar regulation in people with prediabetes. Researchers will temporarily block this hormone's action in 60 participants to measure its specific effects on insulin and gluc…

This study aims to understand how different treatments for early-stage bladder cancer affect patients' quality of life over time. Researchers will follow 704 survivors for three years, asking them to complete surveys about their physical, emotional, and social well-being. The goa…

This study is creating a large registry of people at high risk for pancreatic cancer to help develop better early detection methods. Researchers will collect blood samples, pancreatic fluid, and medical images from 5,000 participants over 10 years. The goal is to use this data to…

This study is testing whether video calls with specialized newborn doctors (neonatologists) can help improve care for high-risk babies born in community hospitals. It will measure if this remote support reduces deaths and serious health problems in the first week of life. The tri…

This study aims to understand how patients move and walk after major spinal deformity surgery. Researchers will use motion sensors and lab tests to measure walking speed, step length, and trunk stability. The goal is to gather detailed information about recovery and function, not…

This study aims to understand why some breast cancer patients develop heart problems after certain chemotherapy drugs. Researchers will collect blood samples from 200 patients to look for a specific marker (TRPC6) that might predict this risk. The goal is to learn how to identify…

This study aims to predict which patients will develop acid reflux after sleeve gastrectomy weight loss surgery. Researchers will use a special measurement tool during an endoscopy procedure before surgery to take measurements. They'll follow patients for up to 5 years to see if …

This study aims to develop a better MRI method to measure how cerebrospinal fluid flows in the brain. Researchers want to compare fluid movement between healthy adults and people with conditions like Alzheimer's disease or hydrocephalus. The goal is to improve diagnosis and under…

This study aims to understand how a non-invasive electrical stimulation device placed on the skin over the spine affects leg muscle weakness, stiffness, and coordination in children and young adults with spina bifida. Researchers will test the device on 30 participants to map how…

This study aims to develop a new MRI scanning method to see how muscles and connective tissues change in people with chronic low back pain. Researchers will compare scans and pain reports from people receiving hands-on Tuina therapy to those receiving standard home care. The goal…

This study aims to understand how the body's immune cells respond to an experimental cancer vaccine. Researchers will collect blood samples from 24 participants, including people with solid tumors and healthy individuals, to analyze immune reactions. The goal is to learn how thes…

This study aims to understand how a progressive speech disorder called apraxia of speech changes the brain over time. Researchers at Mayo Clinic will use repeated brain scans and speech tests to track 50 patients with this condition. The goal is to learn how brain changes relate …

This study aims to better understand Progressive Supranuclear Palsy (PSP), a rare brain disorder, by measuring how much tau protein builds up in patients' brains. Researchers will use special brain scans to track tau levels over time in 332 participants with PSP. The study is obs…

This study collects blood and tissue samples from patients with recurrent or metastatic breast cancer to create a research resource. Researchers will use these samples to better understand how breast cancer spreads and responds to treatments. The study involves 2,000 participants…

This study is creating a patient registry to collect information about people with 24-hydroxylase deficiency, a rare genetic condition that affects how the body processes vitamin D. Researchers aim to enroll up to 600 patients and family members to better understand symptoms, dis…

This is a survey study, not a treatment trial. Researchers want to understand what factors influence families when choosing between observation, bracing, or surgery for adolescent scoliosis. The goal is to use the survey results to create a decision-making tool that helps future …

This study aims to understand how a healthy heart and metabolism work during rest and exercise across different ages. Researchers will measure heart pressures, blood flow, and how the heart uses energy in 80 healthy volunteers. The goal is to create a detailed picture of normal f…

This study is creating a large collection of tissue and blood samples from people with lung diseases, including cancer and transplant patients. The purpose is to build a research bank to help scientists better understand the causes, improve early detection, and develop future tre…

This study aims to understand how gender-affirming hormone therapy affects muscle health and metabolism. Researchers will measure muscle function, body composition, and energy use in transgender and gender diverse adults. The goal is to gather knowledge about the body's physical …

This study aims to collect genetic samples from cancer patients to build a library of information. Researchers will analyze DNA and tissue samples to identify genetic markers that could help prevent, detect, or treat cancer better in the future. The study is recruiting 350 partic…

This study aims to understand how different bladder cancer surgeries affect patients' daily lives. Researchers will compare 1,000 patients who had part of their bladder removed with those who had their entire bladder removed. By reviewing medical records and asking patients to fi…

This study aims to better understand how spinal cord injuries affect automatic body functions like blood pressure control, heart rate, and temperature regulation. Researchers will perform lab tests and have participants wear smartwatches to track these functions in 69 people with…

This study aims to understand how common low vitamin D levels are in Black men with prostate cancer and whether taking vitamin D supplements can improve their immune system function. Researchers will enroll 220 participants with either localized or metastatic prostate cancer who …

This study aims to learn more about histiocytic disorders, a group of rare diseases. Researchers will collect health information, blood samples, and tissue samples from 500 people diagnosed with these conditions. The goal is to identify genetic patterns and potential targets for …

This study aims to understand if women's ovarian hormones are connected to how they age and their risk of developing Alzheimer's disease. Researchers are enrolling 614 women aged 60 and older to complete cognitive tests, physical function assessments, and specialized brain scans.…

This study aims to understand why high-risk endometrial (uterine) cancer comes back after treatment. Researchers will collect blood and tissue samples from 100 patients to analyze their cancer's genetic makeup. The goal is to identify genetic patterns that might help predict recu…

This study is testing a new blood analysis method to track organ damage and immune system exhaustion in people with sepsis. Researchers will enroll 1,000 adult patients with sepsis to see if specific markers in the blood can reveal which organs are being affected and how severely…

This study is testing a special high-resolution ultrasound machine to see if it can detect tiny blood vessels around chronic wounds. Researchers want to learn if this imaging can help doctors better monitor how well wounds are healing over time. The study involves people with non…

This study aims to gather detailed heart and lung function data from healthy volunteers to create a comparison group for a registry of adults with congenital heart disease. Researchers will enroll 50 healthy participants to undergo heart and lung pressure measurements and MRI sca…

This study aims to understand how common obstructive sleep apnea is among Somali-Americans and how it might affect their heart health. Researchers will compare 600 adults of Somali, African, Asian, and European descent, some with and some without sleep apnea. The goal is to ident…

This study aims to understand whether finding very small clusters of cancer cells in the first lymph nodes near the uterus affects the chance of cancer returning in patients with low-risk endometrial cancer. Researchers will follow 212 patients who have already had surgery and ha…

This study aims to understand how two related blood conditions—monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)—affect the bone marrow's ability to produce cells that fight infections. Researchers will compare blood and bone marrow samples from 50 peop…

This study is testing the safety and practicality of placing a small, permanent device called an Ommaya reservoir during brain tumor surgery. The device, placed under the scalp, allows doctors to easily collect spinal fluid multiple times after surgery. The goal is to use these r…

This study aims to find biological markers, or 'fingerprints,' in blood and saliva that can tell when a person has HPV-related throat cancer and when they don't. Researchers will collect samples from 440 people with and without head and neck cancers to compare. The goal is to dis…

This study aims to find better ways to detect pancreatic cancer early, when it's easier to treat. Researchers will follow 30,000 people who are at high risk for the disease due to family history, genetic mutations, or certain pancreatic cysts. The study involves collecting blood …

This study is testing special hospital rooms equipped with sensors, cameras, and microphones to monitor cancer patients. The goal is to see if this technology can spot early signs of problems like confusion, falls, or sleep issues before they become serious. Researchers hope this…

This study aims to understand how untreated obstructive sleep apnea affects blood pressure control differently in men versus women. Researchers will measure blood pressure, artery stiffness, and nervous system activity in 60 adults with sleep apnea. The goal is to gather knowledg…

This study aims to understand how men at risk for prostate cancer comprehend genetic testing information. Researchers will recruit 90 African American and rural White men to watch an educational video and participate in discussions. The goal is to see if the video improves their …

This study aims to gather information to better understand Extramammary Paget's Disease (EMPD), a rare skin condition affecting the genital and anal areas. Researchers will collect data, tissue samples, and swabs from 100 women with EMPD to learn about treatment outcomes, long-te…

This study aims to better understand the journey of patients with sinonasal cancer. Researchers will follow 200 patients to track survival rates, cancer recurrence, and how treatments affect daily life and well-being. They will also analyze tumor tissue to learn about the genetic…

This study explores whether providing cancer care at home is a practical and preferred option for Black men with advanced prostate cancer. Researchers want to understand if home care can reduce healthcare disparities and improve quality of life. The study involves surveys, interv…

This small pilot study aims to see if using special heart scans (CT and MRI) can help predict which patients might develop heart muscle weakness after surgery to fix a leaky heart valve. Researchers will enroll 30 adults with severe mitral valve leakage who are scheduled for robo…

This study aims to find people at risk for developing blood cancers and bone marrow failure syndromes before they get sick. Researchers will use advanced genetic testing on blood, bone marrow, and saliva samples from up to 2,000 participants. The goal is to identify early warning…

This study aims to collect detailed information about how patients recover after open surgery for complex aortic aneurysms. Researchers will follow 150 patients at Mayo Clinic for up to five years after their operations, tracking their quality of life, complications, and overall …

This study aims to develop better MRI methods to map electrical properties in the brain. It involves 120 participants, including healthy volunteers and people with a type of brain tumor called glioma. The goal is to improve how doctors can see and understand brain function and he…

This study aims to better understand heart and lung vessel diseases by comparing different measurement techniques. Researchers will enroll 3,000 patients who are already scheduled for a standard invasive heart pressure test. They will compare results from that test with non-invas…

This study aims to understand how a single dose of ketamine affects specific brain chemicals in people with depression that hasn't responded to other treatments. Researchers will use MRI brain scans and blood tests to measure changes in chemicals linked to mood, comparing them to…

This study aims to understand if common hormone therapies for breast cancer affect how the body controls blood sugar and might increase diabetes risk. Researchers will compare 66 postmenopausal women—some taking specific cancer drugs, others not—by checking their blood sugar leve…

This study is testing whether a special communication tool helps doctors and patients with non-small cell lung cancer make treatment decisions together more effectively. The tool guides conversations about treatment options, benefits, and risks while considering each patient's pe…

This study aims to understand how the bacteria living in our digestive system might influence brain tumor growth and how patients respond to treatments. Researchers will collect samples like stool, blood, and saliva from 100 adults undergoing brain tumor surgery. By analyzing the…

This study aims to understand how exercise affects the immune systems of people with slow-growing blood cancers like chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma. Researchers will measure immune cell activity in about 70 participants before and after a sin…

This study is testing a new type of PET scan to see if it can detect and measure scarring in the heart muscle of people with a specific kind of heart failure (HFpEF). Researchers will compare scans from 35 people with HFpEF to scans from people with another heart condition and he…

This early study aims to understand how two oral drugs affect the chemical environment inside brain tumors. Researchers will study 18 adults with a type of brain cancer called glioma who are already scheduled for surgery. After removing part of the tumor, a tiny tube will be plac…

This study aims to understand how inflammation in body fat is connected to liver damage and insulin resistance in people with severe obesity. Researchers will examine tissue samples from 60 participants who are already scheduled for gastric bypass surgery. The goal is to gather k…

This Mayo Clinic study aims to learn more about how the trillions of microbes living in and on our bodies are connected to our health. Researchers will collect samples from 5,000 adults to compare the microbes of healthy people with those who have various diseases. The goal is to…

This study is testing a mobile app called Vigilant to see if it can help patients track side effects from their melanoma immunotherapy at home. The goal is to understand if remote monitoring helps catch serious side effects earlier. About 100 patients starting a specific two-drug…

This study aims to understand how well a new ultrasound imaging technique measures diaphragm muscle strength compared to standard breathing tests. Researchers will test 24 healthy adult volunteers using both methods during different breathing exercises. The goal is to gather know…

This study aims to better understand the skin reactions that breast cancer patients experience during radiation therapy. Researchers will interview 20 patients about how these skin changes affect their physical comfort, emotions, and daily activities. The goal is to gather firsth…

This study aims to understand if changes in a person's RNA can help predict how well they will respond to antidepressant medications. Researchers will enroll 120 adults with unipolar or bipolar depression and measure their RNA alongside their treatment progress. The goal is to ga…

This study aims to see if adding a genetic risk score to standard breast cancer risk assessments helps African American and Hispanic women make more informed decisions about screening and prevention. Researchers will follow 50 women with elevated breast cancer risk for 10 years t…

This study aims to better understand why some women with benign breast conditions develop cancer later. Researchers will analyze tissue samples, mammograms, and genetic information from 4,500 women who had benign breast biopsies. The goal is to identify patterns that predict futu…

This study aims to understand how a common diabetes drug (liraglutide) and blood sugar control affect a specific hormone (GLP-1) produced inside the pancreas. Researchers will compare these effects in 60 people with Type 1 and Type 2 diabetes who use insulin. The goal is to learn…

This study aims to understand why some older adults benefit more from strength training than others. Researchers will measure how 300 sedentary adults aged 65+ respond to a supervised weightlifting program. The goal is to identify biological factors that explain differences in im…

This study aims to understand why some people experience a large spike in 'bad' cholesterol (LDL) when they start a ketogenic diet. Researchers at Mayo Clinic are recruiting 100 adults who have had this reaction to see if specific genetic differences are the cause. The goal is to…

This study is testing a new type of MRI scan to see if it can safely and effectively measure how stiff the heart muscle is in people with cardiac amyloidosis. Researchers will compare scans from about 20 patients who have this condition to scans from healthy people. The goal is t…

This is a small pilot study to test a new research method. It aims to see how healthy bone marrow cells use a nutrient called glutamine for energy. The study involves 20 healthy volunteers and compares two different lab techniques. The goal is to gather basic knowledge, not to tr…

This Mayo Clinic study aims to understand how opioid pain medications affect the diaphragm muscle's ability to generate force during breathing. Researchers will measure diaphragm stiffness using ultrasound in 69 adults having lower extremity orthopedic surgery. The study seeks to…

This study aims to understand if women diagnosed with HPV-positive throat cancer, or the female partners of these patients, have a higher chance of also having high-risk HPV infections or related conditions in the genital area. It will observe 154 participants, who will complete …

This study is creating a large collection of blood, saliva, stool, and other samples from people with rare liver diseases and healthy volunteers. The goal is to help researchers better understand diseases like Primary Sclerosing Cholangitis (PSC) and Primary Biliary Cholangitis (…

This study is testing whether a virtual community health educator—a photo-realistic digital guide—can help more cancer patients and their caregivers get referred to clinical trials. It focuses on increasing participation from groups that are often underrepresented in research. Th…

This study aims to build a large registry of 100,000 women who have stopped having periods due to early estrogen loss, a condition called Functional Hypothalamic Amenorrhea (FHA). The goal is to better understand how common this condition is, who it affects, and its impact on wom…

This study aims to understand the role of cellular stress in early-stage autosomal dominant polycystic kidney disease (ADPKD). Researchers will enroll 40 young adults (ages 18-30) with early ADPKD and healthy volunteers to compare them. Participants will provide blood and urine s…

This study is creating a large collection of medical information and biological samples from people with various pancreatic conditions. Researchers will collect blood, saliva, leftover tissue, and survey data from up to 20,000 participants. The goal is to build a resource that he…

This study is testing a blood test called DiviTum®TKa to see if it can predict early whether standard hormone-based treatments for advanced breast cancer will stop working. Researchers will measure a specific marker in the blood of 100 patients with hormone-positive, HER2-negativ…

This study aims to understand how children and their families recover from the stress of major cancer surgery. Researchers will have children and a caregiver wear smartwatches, answer questionnaires, and provide extra blood samples during routine draws to look for patterns linked…

This study aims to understand how a leukemia drug called calaspargase pegol affects the blood's ability to clot in children and young adults. Researchers will observe 15 patients aged 2-21 who are already scheduled to receive this drug as part of their standard cancer treatment. …

This study is testing whether a virtual robot assistant can help Black men newly diagnosed with prostate cancer. The app provides support with healthcare navigation, emotional needs, and practical resources. Researchers want to see if patients find the virtual assistant helpful a…

This study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…

This study aims to understand how obstructive sleep apnea changes fat tissue and may increase the risk of heart disease and diabetes. Researchers will compare small fat samples from 120 adults with sleep apnea to samples from healthy individuals. The goal is to identify specific …

This study aims to understand if common heartburn medications (proton pump inhibitors) can lead to an overgrowth of bacteria in the small intestine, a condition called SIBO. Researchers will recruit 50 adults with heartburn symptoms who haven't taken these medications recently. P…

This study is creating and testing a decision aid tool to help emergency room doctors have better conversations with older patients about their end-of-life care preferences. Researchers are working with 230 patients aged 60+ who are at high risk for serious illness, along with th…

This study aims to understand how the immune system reacts during standard treatments for HER2-positive breast cancer. Researchers will collect blood and tissue samples from 230 patients with stage I-IV breast cancer who are receiving or have received anti-HER2 drugs like trastuz…

This study aims to better understand how blood flows through the smallest heart vessels in people who have experienced spontaneous coronary artery dissection (SCAD). Researchers will use a special stress test with ultrasound contrast to measure blood flow, blood pressure, and hea…

This study aims to understand how real-life challenges like transportation, childcare, and job status affect a patient's ability to receive care for liver and bile duct cancers. Researchers will enroll 400 adult patients to complete surveys and provide samples. The goal is to ide…

This study is testing two new imaging techniques to see if they can help doctors better understand the strength and stress in the wall of the aorta, the body's main artery. It will enroll 30 people, including those with an abdominal aortic aneurysm and those without. The goal is …

This study aims to learn how a new blood test that screens for many types of cancer works in real-world doctor's offices. Researchers will enroll 500 adults who are getting the test as part of their regular care. They will track the test's results, its financial impact, and how i…

This Mayo Clinic study aims to find out if a simple voice recording from your smartphone can help monitor your heart health. Researchers will collect voice samples and health data from up to one million adult participants using a special app. The goal is to see if artificial inte…

This study aims to better understand hair loss caused by hormone therapy drugs used to treat breast cancer. Researchers will follow 170 women with breast cancer who are taking different types of hormone therapy. By having patients regularly report their hair loss symptoms, the st…

This study is testing whether a deep brain stimulation implant already used for epilepsy can also accurately detect seizures as they occur. It involves 5 adults with drug-resistant epilepsy who already have the specific implant. Researchers will compare the implant's seizure read…

This study aims to find new biological markers in blood and urine that can better show how severe early-stage autosomal dominant polycystic kidney disease (ADPKD) is. Researchers will enroll 60 young patients (ages 15-40) with early, mild disease. They will compare different mark…

This study aims to understand if taking a specific probiotic can help maintain healthy gut bacteria in people using common acid reflux medications (PPIs). Researchers will enroll 30 healthy adults to see if the probiotic prevents medication-related changes to the microbes in thei…

This study aims to understand if people with epilepsy who are at high risk of sudden death might have an underlying genetic heart condition. Researchers are recruiting 600 adults with epilepsy or their family members to provide DNA samples for genetic testing. The goal is to iden…

This study aims to collect and analyze genetic information from people at moderate to high risk for lung cancer. Researchers will use tissue from standard biopsies and saliva or blood samples to build a detailed database of genetic data. The goal is to create a resource for futur…

This study aims to better understand how Alzheimer's disease and Lewy body disease affect the brain over time. Researchers will observe 90 participants—including people with these conditions and healthy individuals—using brain scans, memory tests, and measurements of brain wave a…

This study aims to understand if the types of bacteria in the gut are different in people with rare blood disorders like POEMS syndrome and AL amyloidosis. Researchers will compare stool samples from 240 people, including newly diagnosed patients, those in remission, and healthy …

This study aims to understand why fat tissue in the abdomen responds differently to the body's natural fat-burning signals in people with obesity compared to those without. Researchers will measure how fat cells release fatty acids in 24 adults with different body types. The goal…

This Mayo Clinic study explores how sharing messages of wisdom and hope affects the sense of dignity in cancer patients and their caregivers. Forty participants with cancer and their caregivers will record messages about their experiences and complete surveys about dignity before…

This study aims to better understand swallowing difficulties in people with Eosinophilic Esophagitis (EoE). Researchers will use painless surface sensors to measure muscle activity during swallowing in 30 participants—some with EoE and some healthy volunteers. The goal is to gath…

This study aims to understand how a vagus nerve stimulator (VNS), a device used to treat severe depression or epilepsy, affects how the stomach works. Researchers will measure how quickly the stomach empties and how much it expands after a meal in 16 people who already have the V…

This study aims to understand why certain blood and lymph cancers sometimes run in families. Researchers are enrolling families where at least two blood relatives have been diagnosed with these cancers. The goal is to learn how genetics and environmental factors might work togeth…

This study aims to find the safest concentrations of three common anesthesia drugs for skin allergy testing. Researchers will test these concentrations on 60 volunteers without drug allergies to establish reliable testing methods. The goal is to help doctors accurately identify p…

This study aims to understand why some breast cancers survive standard drug treatments before surgery. Researchers will collect leftover tissue and blood samples from about 1,000 patients whose cancer remained after initial therapy. They will use these samples to grow the cancer …

This study aims to understand how different types of fats delivered to the gut affect muscle cells and contribute to insulin resistance, a key problem in obesity and type 2 diabetes. Researchers will compare two fat infusions (palm oil and Intralipid) against a saline control in …

This study aims to predict which cancer patients might experience serious side effects from their treatments. Researchers will take blood samples from 30 adult cancer patients and turn their cells into heart and nerve cells in the lab. By testing these lab-grown cells with cancer…

This study is testing new MRI scanning methods to see if they can improve image quality and speed during MRI-guided surgical procedures. Researchers are enrolling 100 healthy volunteers or patients already scheduled for MRI-guided procedures. The goal is to determine if this new …

This study aims to understand why many patients develop low blood cell counts after receiving CAR-T therapy for certain blood cancers. Researchers will collect genetic and tissue samples from patients before and after treatment to look for inherited or acquired gene changes linke…

This study aims to understand how the hormones insulin and glucagon work together to control fasting blood sugar levels in people with prediabetes. Researchers will measure how the body's sugar production responds to insulin and analyze hormone patterns in 60 participants. The go…

This study aims to collect blood and spinal fluid samples from people with ALS and their family members to build a research library. Researchers will use these samples in future studies to look for biological markers that could help diagnose ALS earlier or track how the disease p…

This Mayo Clinic study aims to understand how the body's automatic functions like blood pressure control change after spinal cord injury. Researchers will monitor 18 people with recent or long-standing spinal cord injuries to see if these changes can predict who might develop add…

This study aims to understand the real-life experiences and challenges faced by people with brain cancer and those who care for them. Researchers will interview about 80 patients and their caregivers to learn about their symptoms, burdens, and what treatment outcomes matter most …

This study aims to gather data comparing a newer bone graft product (Avitus, taken from the shin) to the traditional method of taking bone marrow from the hip. It will enroll 12 adults who need bone graft for foot or ankle fusion surgery. Researchers will analyze the cells and gr…

This study aims to better understand Gastric Antral Vascular Ectasia (GAVE), a condition where blood vessels in the stomach enlarge and can cause pain, nausea, and bleeding. Researchers will measure how often these symptoms occur and how they relate to how well the stomach emptie…

This study aims to understand how a doctor's behavior and other aspects of care affect emotional distress in cancer patients. Researchers will survey 5,000 adults undergoing or recently finished with radiation therapy at Mayo Clinic. The goal is to identify what specific doctor a…

This study aims to understand how the immune system changes when patients with acute myeloid leukemia (AML) receive standard chemotherapy. Researchers will collect blood and bone marrow samples from 80 adults receiving treatment to analyze their immune profiles. The goal is to ga…

This study aims to learn if heart tests done during exercise reveal more problems than tests done at rest in people with congenital heart disease. Researchers will enroll 200 adults who are already scheduled for a standard heart catheterization procedure. The goal is to gather in…

This study aims to understand why some patients with advanced cancers like melanoma and lung cancer respond well to a common immunotherapy (anti-PD-1), while others do not. Researchers will collect blood samples from 500 patients to measure specific markers in immune cells during…

This study aims to find out how common insomnia is in people whose lung cancer has spread to other parts of the body. Researchers will review medical records and ask 60 participants to complete a sleep questionnaire. The goal is to better understand this specific symptom burden i…

This study aims to understand why older adults' muscles don't respond well to exercise. Researchers will examine whether inflamed body fat releases substances that interfere with muscle repair and growth after exercise. The study involves 120 younger and older adults who will und…

This study is testing a new community-based program designed to improve prostate health education and access to services for Black men. It will set up 'Community Living Labs' at local American Legion posts in Florida, using trained community health workers to connect men with inf…

This study aims to understand how cancer-related genetic mutations differ among various ethnic populations. Researchers will collect blood or saliva samples from 1,800 cancer patients from diverse backgrounds to identify genetic patterns. The findings could help create more perso…

This study aims to understand how spinal cord stimulation affects blood pressure control, heart function, and immune response in people with spinal cord injuries. Researchers will measure these body functions in 80 participants, including people with spinal cord injuries and heal…

This study aims to collect blood and urine samples from people being evaluated for bladder cancer. Researchers will store these samples to help develop future tests that can detect bladder cancer earlier without invasive procedures. The goal is to create a resource that improves …

This study aims to collect tumor tissue samples from patients with various cancers to test a new diagnostic platform called Elephas. The goal is to see how accurately this tool can predict whether patients will respond to immunotherapy treatments before they begin. Researchers wi…

This study aims to understand how substantial, long-term weight loss after bariatric surgery improves the body's ability to regulate fat breakdown with insulin. Researchers will measure inflammation and fat cell function in 30 adults with severe obesity before and one year after …

This Mayo Clinic study aims to understand how multiple sclerosis affects the body's automatic control systems that regulate blood pressure, heart rate, and other vital functions. Researchers will compare 13 people with MS to healthy volunteers using lab tests that measure how wel…

This study aims to understand if taking prescription opioids for chronic pain causes changes in the brain structure of adults aged 65 and older. Researchers will enroll 200 people with ongoing knee or shoulder pain. Half will receive a real opioid pain medication for 6 weeks, and…

This study is testing whether a small device called an Ommaya reservoir can be safely placed during a brain tumor biopsy. The device allows doctors to collect fluid samples from around the brain over time without repeated spinal taps. Researchers hope these samples will help them…

This study aims to learn how often and in which children a leukemia drug causes a dangerous buildup of ammonia in the blood. Researchers will observe 10 pediatric patients receiving the drug Rylaze®. They will track who develops this condition by checking blood ammonia levels mul…

This study aims to understand how the esophagus changes during treatment for Barrett's esophagus, a condition that can lead to cancer. Researchers will measure stiffness and lining health in 10 patients receiving standard radiofrequency ablation therapy. The goal is to gather inf…

This study aims to understand how blood flow in fat tissue differs between younger and older healthy adults. Researchers will compare 24 participants aged 18-35 with those aged 65-80, measuring blood flow before and after drinking a sugary drink and taking small fat tissue sample…

This study aims to understand if the thickness of fat surrounding a donated kidney influences the donor's future kidney function and blood pressure. Researchers will follow 100 living kidney donors for about 6 months after their surgery, measuring their fat, blood pressure, and k…

This study aims to find out how many adults in Olmsted County, Minnesota, have a common liver condition called NAFLD (fatty liver disease) and its more serious form, NASH. Researchers will enroll 800 local residents to gather detailed health information and track their long-term …

This study aims to understand how the bacteria in our digestive system (gut microbiome) influence how well cancer treatments work. Researchers will collect stool and blood samples from 3,000 cancer patients undergoing treatment or stem cell transplants. By analyzing these samples…

This Mayo Clinic study is exploring whether teaching mindfulness and meditation techniques to mothers can help them while they pump breastmilk for their premature babies in the Neonatal Intensive Care Unit (NICU). Researchers will measure if these relaxation practices are linked …

This study aims to build a large collection of genetic and health information from people with inherited ataxia diseases and their family members. Researchers will enroll 1000 participants, including patients, unaffected relatives, and healthy volunteers, to create a detailed res…