Mayo Clinic

This early-stage trial is testing a modified virus designed to infect and kill cancer cells in patients with advanced or recurrent endometrial cancer. The main goal is to find a safe dose and understand the side effects. Some patients also receive an additional oral drug that may…

This early-phase trial is testing a new treatment for ovarian, fallopian tube, or primary peritoneal cancer that has come back after standard therapy. Researchers are using a patient's own fat-derived stem cells to carry a specially engineered measles virus directly to the cancer…

This study is testing if a medication called semaglutide, which is used for weight loss, can improve heart function and symptoms in obese patients with a specific type of heart failure. Researchers will give the drug or a placebo to 81 participants to see if aggressive weight los…

This study is testing a new brain implant system designed to detect early warning signals of epileptic seizures and deliver targeted electrical stimulation to prevent seizures from occurring. Researchers are working with 12 adults and children with drug-resistant epilepsy to see …

This study is looking at whether it's safe and helpful to operate on brain tumors that are still visible after a patient has had chemotherapy or radiation, but before the tumor starts growing again. Researchers want to compare outcomes for people who have this 'pre-recurrent' sur…

This study compares two standard surgical approaches for treating infected hip or knee replacements. Researchers want to know if performing one cleaning surgery or planning for two cleaning surgeries works better to save the artificial joint. All participants will receive long-te…

This study is testing a specific surgical repair technique for meniscus root tears, which are serious knee injuries. Researchers will follow 55 patients aged 18-65 to see if this repair improves knee function and activity levels. They also want to determine if the surgery can del…

This study is testing whether combining two drugs, durvalumab and lurbinectedin, can help control cancer growth in people with extensive stage small cell lung cancer that has come back or stopped responding to their first treatment. The trial aims to see if this combination can k…

This small, early-stage study is testing whether stem cells from a patient's own body fat can help heal serious pressure sores or diabetic foot ulcers. Doctors take a small amount of fat via liposuction, extract the stem cells, and apply them directly to the wound. The main goal …

This small, early-stage study aims to see if a combination of two existing drugs, Dasatinib and Quercetin, is safe and practical for people with mild cognitive impairment or Alzheimer's disease. The drugs target 'senescent' cells, which are old, damaged cells that may contribute …

This study is following 20 adults with a rare, inherited brain disease called CSF1R-related leukoencephalopathy. Researchers want to see if a stem cell transplant can stop or slow the disease's progression. They will carefully measure changes in patients' thinking skills, movemen…

This study is testing whether combining two existing drugs—pemetrexed (chemotherapy) and pembrolizumab (immunotherapy)—can help control advanced salivary gland cancer. It is for adults whose cancer has returned or spread and is not curable with surgery or radiation. The main goal…

This study is testing a small device called a coronary sinus reducer in people with a common type of heart failure where the heart muscle pumps normally but is too stiff to fill properly. The device is implanted in a vein of the heart and is designed to reduce pressure and improv…

This study is testing whether a drug called metyrapone is safe and effective for people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much of the stress hormone cortisol. Researchers want to see if lowering cortisol with this med…

This study aims to find the best strategy to protect heart function in breast cancer patients receiving a specific cancer treatment (trastuzumab) that can sometimes weaken the heart. Researchers are testing whether giving a heart-protecting drug called carvedilol before treatment…

This study is testing a combination of two oral drugs, pirtobrutinib and venetoclax, for people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It aims to see if using a sensitive blood test that detects tiny amounts of leftover c…

This study aimed to test if a drug called AEO could help protect or restore normal brain function in people receiving radiation treatment for brain cancer. Radiation kills cancer cells but can also harm healthy brain tissue. The trial planned to measure drug effects through spina…

This study is testing whether a virtual reality-based cardiac rehabilitation program is practical to run and use. It involves a small group of patients who have recently had a heart-related event or procedure. The main goal is to see if patients can attend the virtual sessions an…

This study compares using two surgical implants versus one implant to repair broken thigh bones near the knee. Researchers will measure surgery time, blood loss, hospital stay, and early complications in 60 previously walking adults. The goal is to determine which approach leads …

This study is testing a procedure called MR-guided cryoablation for men whose prostate cancer has returned after initial treatment. It uses an MRI to guide a probe that freezes and destroys the recurring tumor. The goal is to see if this freezing method is a safe and effective op…

This study is testing a new combination of four drugs for people newly diagnosed with multiple myeloma, a cancer of plasma cells. The goal is to find the safest and most effective dose and see how well the drugs work together to control the cancer. Researchers will closely monito…

This study aims to understand how two weekly injectable medications for obesity—semaglutide and tirzepatide—affect how the stomach works. Researchers will compare these drugs to a placebo in 30 adults with obesity, measuring stomach emptying, feelings of fullness, and body weight…

This early-stage study is testing whether stem cells taken from a patient's own body fat can safely reduce pain and improve function in arthritic hips. Researchers will inject either one or two doses of these processed cells directly into the hip joint of 24 adults with mild-to-m…

This early-stage study is testing whether combining a very precise form of radiation therapy with immunotherapy is safe and feasible for people with mesothelioma, a type of cancer. The goal is to see if this two-part approach can better control the cancer while causing fewer side…

This study is comparing two ways to surgically repair a specific type of knee cartilage tear. Researchers want to see if adding a 'centralization' step during surgery leads to better long-term results, less pain, and a lower chance of needing another surgery. The study will invol…

This study is testing whether a shorter, 3-week radiation schedule before surgery can reduce wound complications for people with soft tissue sarcoma in their arms, legs, or trunk. The trial involves 120 participants who will receive this condensed radiation treatment followed by …

This study is testing a shorter, 3-week course of radiation combined with chemotherapy for people with pancreatic cancer that hasn't spread. Researchers will monitor side effects and collect blood samples before and after treatment to check for cancer DNA. The goal is to see if t…

This study is testing a combination of two drugs, niraparib/abiraterone and prednisone, in men with advanced prostate cancer that has spread and has stopped responding to standard hormone-blocking treatments. The treatment is specifically for patients whose cancer has a particula…

This early-stage study is testing the safety and best dose of a new drug combination for advanced melanoma that has spread or cannot be surgically removed. It combines pembrolizumab, an immunotherapy drug, with ibrutinib, a drug that may block cancer cell growth. The goal is to s…

This study is testing a new two-part treatment for aggressive brain tumors that have returned or worsened. It aims to see if giving the drugs GI-102 and pembrolizumab just before surgery is safe and can help the immune system attack the tumor. The trial is for adults with specifi…

This study is testing a new protective case designed to cover the ends of dialysis catheters. Researchers want to see if it is more comfortable and easier to use than the traditional gauze and tape method. The goal is to reduce the risk of infections and accidental dislodgement f…

This early-stage trial is testing whether a patient's own immune cells can be grown in a lab to fight multiple myeloma that has returned or stopped responding to other treatments. Doctors take T-cells from the patient's blood, grow them to target a specific protein found on cance…

This Mayo Clinic study is testing whether a special fish skin graft can help close anal fistulas (abnormal tunnels) and related non-healing wounds. Researchers will enroll 20 adults with these conditions to see if the treatment stops drainage and infection. The goal is to determi…

This early-stage study is testing if adding a new drug called parsaclisib to a standard chemotherapy regimen (R-CHOP) is safe and more effective for patients with newly diagnosed, high-risk diffuse large B-cell lymphoma. The main goals are to find the safest dose of the new combi…

This early-stage study is testing whether a patient's own fat-derived stem cells can be safely delivered directly into the arteries supplying the colon to treat ulcerative colitis. It involves 20 adults with moderate-to-severe disease that hasn't improved with at least two standa…

This early-stage study is testing whether stem cells taken from a patient's own body fat can help keep their dialysis access point from failing. The cells are applied during the surgery to create the access point. The goal is to see if this approach is safe and can improve how we…

This study tests whether giving drug combinations before surgery can help people with high-risk stage III melanoma. The trial involves 59 participants receiving either targeted cancer drugs, immunotherapy drugs, or both for several weeks before their operation. Researchers want t…

This study is testing if a shorter, more intense course of radiation is safe and effective for men whose prostate cancer has returned or spread to a few lymph nodes. It compares two radiation methods—proton therapy and standard IMRT—to see which one causes fewer serious side effe…

This study aims to see if using ketamine instead of propofol to put patients to sleep at the start of complex heart surgery better protects their kidneys from injury. It will involve 200 adults undergoing major heart procedures at Mayo Clinic. Researchers will compare how often k…

This study is testing whether estradiol, a form of estrogen, can help control advanced triple-negative breast cancer that has a specific biomarker called ER beta. Researchers are giving estradiol pills to 8 postmenopausal women whose cancer has spread and seeing if their tumors s…

This study compares two radiation treatments given after breast cancer surgery. It tests whether a newer, shorter proton beam treatment (5 sessions) causes fewer complications than standard x-ray therapy (25 sessions). The trial involves 146 women with early to mid-stage breast c…

This study is testing whether giving vitamin D supplements to cancer patients who have low vitamin D levels can help improve their survival and delay the need for other treatments. It focuses on people newly diagnosed with certain aggressive lymphomas or a slow-growing type of le…

This study is testing whether a shorter course of antibiotics combined with a medication called octreotide works as well as longer antibiotics after pancreatic surgery. Researchers want to see if this approach reduces hospital stays and prevents a common complication called pancr…

This study follows 2,480 people with narrowed neck arteries for up to 10 years to see which approach best prevents strokes long-term. Participants previously joined a trial comparing artery surgery, stenting, or intensive medication management. Researchers will call participants …

This study is testing whether improving sleep habits can help control high blood pressure. It involves 110 adults with prehypertension or mild stage 1 hypertension who regularly sleep 6.5 hours or less per night. Participants will either follow an 8-week program to extend their s…

This early-stage study is testing a new combination of two drugs, sonidegib and pembrolizumab, for people with advanced solid tumors that have spread. The main goals are to find the safest dose of the combination and see if it helps shrink or control the cancer. The study is enro…

This study is testing whether transplanting a donor voice box (larynx) is a safe and effective way to help people with severe, untreatable damage to their own. It will involve 10 adults who have lost normal voice, swallowing, or breathing function, often due to cancer treatment o…

This study is testing whether adding a new experimental drug, TVB-2640, to standard treatments can help control advanced HER2-positive breast cancer that has spread and is no longer responding to the usual therapies. It involves a small group of patients whose cancer has progress…

This is a first-in-human study to find a safe dose of an experimental pill called WSD0922-FU for people with aggressive brain tumors or lung cancer that has spread to the brain. The pill is designed to block a specific protein (EGFR) that drives these cancers and may be able to r…

This study is testing a new combination of drugs for people with multiple myeloma, a blood cancer, that has come back and stopped responding to standard treatments. The main goals are to find the safest dose of the new drug selinexor when combined with other cancer drugs, and to …

This small pilot study is testing whether a specially designed, low-calorie, high-protein liquid food given through a feeding tube can help obese patients who rely on tube feeding to lose weight. The study will also check if the formula is well-tolerated and if it improves other …

This study compares two treatments for adults with severe fecal incontinence (bowel leakage). First, all participants try a 4-week program of education, diet changes, and exercises. If that doesn't help enough, they are randomly assigned to receive either biofeedback training (to…

This study is testing whether stem cells taken from a patient's own fat tissue and injected into their spinal fluid can slow the progression of multiple system atrophy (MSA), a rare and fatal neurological disease. Researchers are comparing two different dosing schedules against a…

This study is testing whether the drug sotatercept, taken for 36 weeks, improves how the heart and lungs work together during exercise in people with pulmonary arterial hypertension. Researchers will measure heart function, blood flow, and oxygen delivery in 30 participants while…

This study is testing the safety and basic function of a new brain implant system for people with severe, hard-to-treat epilepsy. The device senses brain activity, uses a computer program to predict seizure risk, and can deliver small electrical pulses to try to prevent seizures …

This study is testing if a widely used cholesterol-lowering drug, atorvastatin (Lipitor), can safely improve liver health in adults with NASH, a serious form of fatty liver disease that can lead to scarring. About 70 participants with confirmed liver damage will receive either th…

This study is testing a combination of four chemotherapy drugs to treat a more aggressive form of multiple myeloma, a blood cancer. The main goal is to see if this treatment can make the cancer undetectable in blood tests and keep it that way for at least a year. It is for newly …

This study is testing whether a gentle, non-invasive brain stimulation technique can increase blood flow to the brain. It aims to see if this improved blood flow can help people with certain brain vessel conditions who are experiencing problems with memory and thinking. The study…

This study is testing whether stem cells taken from a patient's own body fat can help improve movement and feeling in people paralyzed by a traumatic spinal cord injury. Doctors inject these specially grown cells into the spinal fluid of 40 adults to see if they are safe and can …

This study is testing two different ways of prescribing high-intensity interval training (HIIT) to see which is better for improving fitness and heart health in people doing cardiac rehabilitation. It involves 30 adults who have had a heart event like a heart attack or stent plac…

This study tests a Minnesota program designed to help workers who get injured or sick stay employed and avoid long-term disability. The program provides early support and workplace accommodations to employees who might otherwise leave their jobs. Researchers are tracking whether …

This early-phase trial is testing the safety and best dose of a two-drug combination (selinexor and choline salicylate) for adults with advanced blood cancers that have returned or stopped responding to standard treatments. The study includes patients with non-Hodgkin lymphoma, H…

This study is looking at how well two FDA-approved ablation procedures work for controlling Barrett's esophagus, a condition that can lead to esophageal cancer. Researchers will follow 600 patients who have received or qualify for these treatments to see if Barrett's tissue retur…

This study is testing whether a short, two-day course of a compound called fisetin can help people with advanced chronic kidney disease. Researchers want to see if fisetin can reduce body-wide inflammation, improve the function of certain repair cells, and help with physical stre…

This study is comparing a new, shorter radiation schedule to the standard, longer one for treating glioblastoma, an aggressive brain cancer. Researchers want to see if the shorter treatment, which delivers higher doses over 1-2 weeks, works as well as the standard 3-6 week treatm…

This study is testing whether very low doses of radiation, guided by special brain scans, can slow the progression of Parkinson's disease. Researchers will give five radiation treatments to 20 participants with early-stage Parkinson's and measure changes in their movement symptom…

This study aims to develop personalized drug treatments for people with rare genetic diseases that currently have no good treatment options. Researchers will work with 50 participants to create custom drugs that target the specific genetic causes of their conditions. The study in…

This study is testing whether stem cells taken from a patient's own body fat and injected into the fluid around their spine can safely slow the progression of ALS. Over 12 months, 75 participants at Mayo Clinic will receive four injections to see if this treatment helps maintain …

This study is testing whether a proven therapy for youth eating disorders can be successfully delivered by primary care doctors. It involves 200 children and teens with restrictive eating disorders and their caregivers. The goal is to make this effective treatment more widely ava…

This Mayo Clinic pilot study aims to see if eating all your daily food within an 8-hour window earlier or later in the day is better for weight loss. It will involve 100 overweight or obese adults. The study will track changes in weight, BMI, blood sugar, and cholesterol, while a…

This study is testing whether an artificial intelligence (AI) program can accurately detect a serious heart condition called hypertrophic cardiomyopathy (HCM) using different types of electrocardiogram (ECG) devices. Researchers are comparing ECGs from standard medical machines w…

This study is testing a new type of MRI scan to see if it can accurately detect and measure scarring (fibrosis) in kidneys. The goal is to create a better, non-invasive way to spot kidney damage early in people with high blood pressure-related kidney disease. Researchers will tes…

This study aims to find better ways to monitor the heart health of adult cancer survivors. Researchers are testing if a simple AI analysis of an ECG (heart tracing) and a blood test can reliably detect early signs of heart damage caused by certain chemotherapy drugs. The goal is …

This study is testing whether a special ultrasound technique can create detailed pictures of tiny blood vessels in the kidneys. Researchers want to see if this method works better for people with chronic kidney disease compared to healthy volunteers. The goal is to improve how do…

This study is testing whether wearing an Apple Watch for long-term monitoring can help detect atrial fibrillation (AFib) earlier in people at high risk. Researchers will enroll 2,000 adults who show signs of potential AFib on a standard heart test but haven't been diagnosed. The …

This study aims to understand how a special brain scan called DaTSCAN can help doctors better diagnose and track brain diseases like dementia, Parkinson's, and REM sleep behavior disorder. Researchers will scan 500 adults aged 40-90 who have one of these conditions and compare th…

This study is testing whether measuring brain stiffness using a special MRI scan can help doctors detect Alzheimer's disease earlier. Researchers will compare brain stiffness measurements in 450 people: some healthy, some with mild memory problems, and some with Alzheimer's. The …

This early-stage study is testing a new type of marker designed to help surgeons locate cancerous lymph nodes more easily during breast cancer surgery. The marker is placed in the lymph node before treatment and surgery. Researchers want to see if it stays visible on ultrasound a…

This study aimed to test a new, non-invasive device called the LabClasp to see if it could accurately estimate blood lactate levels without a needle stick. It planned to test the device on two groups: healthy adults during exercise and critically ill patients in the ICU. The stud…

This study is testing a new type of heart scan called magnetocardiography (MCG) to see if it can quickly and accurately tell if a patient's chest pain in the emergency room is caused by a heart attack or reduced blood flow to the heart. Researchers will compare the MCG scan resul…

This study is testing a new needle guide device designed to help doctors place biopsy needles more accurately during MRI-guided prostate procedures. It aims to see if the special grid helps the needle hit the exact target area in the prostate. The study is enrolling about 20 men …

This study is testing a new technology called DESI-MS to see if it can help surgeons during brain tumor operations. The goal is to quickly tell the difference between healthy brain tissue and cancerous tissue right in the operating room. This could help surgeons remove tumors mor…

This study is developing an AI-powered system to measure pain objectively using body signals, rather than relying on patients' self-reporting. It involves 70 adults recovering from outpatient plastic surgery at home. Researchers hope this technology will help personalize pain med…

This study is testing if a special type of PET scan (using a tracer called 18F-DOPA) can help doctors more accurately plan radiation treatment for malignant brain tumors. It will compare the radiation target areas identified by this new scan with those from the standard MRI scan.…

This study is testing whether a special type of MRI scan, called MR elastography, can accurately measure high pressure inside the skull. Researchers are comparing this scan to other non-invasive methods like eye imaging and ultrasound to see which is best at detecting the problem…

This study is testing a new type of MRI scan called MR Elastography to see if it can better identify and measure myofascial pain. Researchers will compare scans from 106 people with chronic low back or leg pain to scans from healthy volunteers. The goal is to create a more object…

This study is testing a new, simpler way to screen for Barrett's esophagus and esophageal cancer. Researchers are using a small sponge on a string that patients swallow, which collects cells from the esophagus. They are checking if lab tests on these cells can accurately spot dan…

This study aimed to validate a faster genetic test for pregnant women whose babies showed signs of possible genetic disorders. It planned to compare results from a new test on amniotic fluid with standard blood tests. The goal was to speed up diagnosis to help guide care for the …

This study aims to find new chemical markers in the blood and urine that could help detect kidney and bladder cancers. Researchers are collecting samples from 589 people, including those with these cancers and healthy individuals, to compare and identify reliable markers. The goa…

This study is testing a special type of ultrasound to measure stiffness in the wrist before and after carpal tunnel treatment. Researchers want to see if this scan can help doctors better track how well injections or surgery are working. The study involves 20 adults who are alrea…

This study is testing a new type of imaging scan to see if it can better identify and map pediatric neuroendocrine tumors, which are rare cancers. Researchers want to know if this new scan helps doctors more precisely target radiation therapy compared to the standard scan current…

This study tests whether taking an over-the-counter probiotic supplement can prevent a serious side effect of cancer immunotherapy. Up to 45% of patients receiving immunotherapy develop severe colon inflammation and diarrhea, which can delay treatment and require hospitalization.…

This study is testing a procedure where heated chemotherapy is washed through the abdomen during surgery for stomach or gastroesophageal junction cancer. The goal is to kill any stray cancer cells left behind to prevent the cancer from coming back in the abdominal cavity. It is f…

This study aims to prevent concussions in young athletes by training their neck muscles and vision. It will also test if blood samples can help doctors diagnose concussions more accurately. The research involves 4,000 athletes aged 12 to 30.

This study tests whether a short course of two drugs can prevent hepatitis C from spreading when an organ from an infected donor is transplanted into an uninfected patient. It involves 200 kidney, heart, lung, or pancreas transplant recipients who agree to accept an organ from a …

This study offers an experimental procedure to freeze ovarian tissue from girls (newborn to 17 years old) who face medical treatments like chemotherapy that could leave them infertile. The goal is to preserve the tissue so it might be used in the future to help them get pregnant …

This study is testing whether offering easy-to-use, at-home HPV swab kits at walk-in clinics with evening and weekend hours can help more women get screened for cervical cancer. It will involve 500 women aged 30-63 who are overdue for their regular screening. Researchers will com…

This study aimed to test if blood flow restriction therapy helps people recover strength and movement after surgery for a torn knee ligament or biceps tendon. The therapy involves using a cuff to partially restrict blood flow during light exercises. The trial was withdrawn before…

This study is testing whether a natural plant compound called fisetin can help reduce frailty and signs of inflammation in older adults. Researchers at Mayo Clinic are enrolling 40 participants aged 70 and older to take either fisetin or a placebo for a short period. The main goa…

This study tests whether virtual group therapy can help caregivers of patients with advanced cancer or serious illnesses. Caregivers often feel overwhelmed, hopeless, and lose their sense of purpose. The therapy aims to help them reconnect with meaning and reduce their emotional …

This study is testing whether virtual follow-up care through an app called Lin Health helps people with fibromyalgia manage their symptoms and improve daily life. Researchers are enrolling 300 patients from Mayo Clinic's fibromyalgia clinic to compare the app-based program to usu…

This study is testing whether a small change during knee replacement surgery can reduce long-term pain. During the operation, surgeons will either tuck away the end of a specific nerve or leave it as usual. Researchers want to see if protecting this nerve helps patients experienc…

This Mayo Clinic study is testing whether low-level laser therapy combined with educational materials can help reduce lower back pain. Researchers are comparing four different treatment schedules (2, 4, 6, or 8 sessions) to see which works best. The study involves 60 adults with …

This study aims to measure how much a thyroid radiofrequency ablation procedure improves symptoms in patients with thyroid nodules. Researchers will track 300 patients using a symptom questionnaire before and after their treatment. The goal is to better understand how effectively…

This study is testing whether a special high-flow oxygen device helps patients with higher body weight recover faster after endoscopic ultrasound procedures. Researchers want to see if this oxygen method reduces recovery time and makes the procedure go more smoothly compared to s…

This study is testing whether using a footstool to change your posture on the toilet can help relieve constipation. Researchers at Mayo Clinic are comparing a 7-inch footstool to a shorter, 2-inch sham device to see which one better improves bowel movement frequency and symptoms.…

This study aims to find the safest and most effective number of steroid (dexamethasone) doses to give around the time of knee replacement surgery. Researchers will compare giving one, two, or three doses to see which best reduces pain, cuts down on the need for strong opioid pain…

This study is testing whether a drug called fisetin can help prevent hospitalized COVID-19 patients from getting sicker. Researchers want to see if it can reduce dangerous inflammation and help patients breathe easier without needing more oxygen or a ventilator. The trial include…

This study is testing a wrist-worn device called Cala TWO that aims to reduce hand tremors in people with essential tremor. The device works by delivering gentle electrical stimulation to nerves in the wrist. Researchers are measuring how well it helps with daily activities and t…

This study is testing a new plastic clamp designed to help clear fluid from surgical drain tubes. The goal is to see if it's easier for nurses to use and if it helps reduce complications compared to the current method of using fingers. The study will gather feedback from about 80…

This study aims to see if using a smaller ureteral stent after kidney stone surgery reduces pain and discomfort. Researchers will follow 100 patients who have a stent placed after their procedure, contacting them daily to track their pain levels. The goal is to find out if stent …

This Mayo Clinic study is testing whether using virtual reality (VR) can help reduce anxiety, depression, and emotional distress in patients receiving palliative care. It involves about 20 adult patients with a terminal illness who are expected to live a year or less. The researc…

This small pilot study is testing whether a non-invasive electromagnetic therapy can help people with painful foot or ankle arthritis. Researchers at Mayo Clinic are measuring if the treatment reduces pain and improves daily activities like walking. The study involves 20 particip…

This study is testing two ways to manage pain for people having surgery for thoracic outlet syndrome, a condition causing arm and shoulder pain. Researchers want to see if receiving a pain-numbing injection before surgery AND after surgery works better than just getting it before…

This small study is testing whether using virtual reality headsets can help patients feel more comfortable during heart rhythm procedures. Researchers want to see if the VR distraction reduces anxiety and the need for sedative medications. The study will also check if patients li…

This study is testing which of two advanced prosthetic hands—the SoftHand Pro or the Ossur i-Limb—helps people with below-elbow limb loss perform everyday activities better. Over an 8-week period, 36 participants will use each device in their daily lives. Researchers will measure…

This Mayo Clinic study compares how two different procedures for draining blocked bile ducts affect patients' quality of life. Researchers are looking at 206 people with both cancerous and non-cancerous blockages who receive either endoscopic or percutaneous drainage. The goal is…

This study aims to find out if removing ureteral stents three days after kidney stone surgery is as safe and effective as the standard seven days. Researchers will compare symptoms, pain levels, and recovery time in 172 patients to see if earlier removal reduces discomfort withou…

This Mayo Clinic study is testing whether a virtual reality meditation program can help reduce the overall impact of fibromyalgia symptoms. Forty adults with fibromyalgia will try both an active VR meditation program and a sham (fake) VR experience to see which one helps them fee…

This study is testing whether the way patients are taught about their upcoming ACL knee surgery affects how satisfied they are, how anxious they feel, and how well they recover. About 105 patients at Mayo Clinic Arizona are being randomly assigned to receive different types of ed…

This study aimed to see if the type of stitch used to close a wound after common hand surgeries (like carpal tunnel or trigger finger release) made a difference in how the scar looked and how satisfied patients were. It planned to compare stitches that dissolve on their own with …

This small pilot study from Mayo Clinic is testing whether using virtual reality (VR) is safe and tolerable for people with gastroparesis, a condition where the stomach empties too slowly. Thirty adult participants will try either an active VR program or a sham (fake) VR program …

This study is testing whether a 10-week home exercise program, delivered remotely via video calls, can improve physical function and quality of life for survivors of early-stage endometrial cancer. It focuses on participants who live in rural areas or are from historically unders…

This study compares two ways to prepare for prostate cancer radiation therapy: coming with a full bladder or an empty bladder. The standard method requires a full bladder, but this can be difficult for patients to maintain and may cause stress. Researchers want to see if using an…

This study is testing whether using virtual reality (VR) goggles during knee or hip replacement surgery can help patients feel less anxious and need less medication. About 50 patients having surgery with regional anesthesia (numbing a large area) will try VR during their procedur…

This study aimed to test whether a biofeedback device called JOGO could help reduce tremors in people with functional neurological disorder. The device uses wireless stickers to monitor muscle activity and provides feedback to help patients learn to control their shaking through …

This study is testing whether injections of donor stem cells into the spine's facet joints can safely reduce chronic low back pain. It will involve 40 adults who have had back pain for at least 6 months that hasn't improved with standard treatments like physical therapy or medica…

This study compares two pain medication approaches for people recovering from knee or hip replacement surgery. Researchers want to see if combining tramadol and oxycodone works better than oxycodone alone to control pain while reducing overall opioid use and side effects like nau…

This study is testing a special wearable headset designed to reduce the motion sickness people sometimes feel when using virtual reality (VR). The device uses gentle electrical stimulation to help the user's balance system better match what they're seeing. Researchers are measuri…

This small, early-stage study is testing whether a natural plant compound called fisetin can help reduce frailty in older women. Researchers will give fisetin or a placebo to 40 healthy women aged 70 and over to see if it improves their walking speed and reduces signs of inflamma…

This study is testing whether a smartphone app that analyzes a person's voice to detect signs of depression and anxiety can help improve mental health for people recovering from a heart attack. The app is being used alongside standard cardiac rehabilitation to see if it leads to …

This study is testing whether a non-invasive electromagnetic therapy can help men recover bladder control faster after prostate surgery. It will involve 2,100 men who have had surgery and are experiencing urine leakage. The main goal is to see if this technology shortens recovery…

This Mayo Clinic study is testing whether a home-based brain stimulation device, combined with daily activities, can help people recover thinking and language skills after a stroke, brain tumor, or neurodegenerative disease. The research aims to see if this approach is practical …

This study compares two numbing medicines for pain relief after surgery to remove an eye. Researchers want to see if a new slow-release injection provides better, longer-lasting pain control than the standard injection. The trial involves 88 adults having eye removal surgery at M…

This small study is testing if a gentle, non-invasive brain stimulation technique called tDCS is practical and acceptable for hospitalized adults with severe depression that hasn't responded to other treatments. Over five days, participants receive short stimulation sessions whil…

This study aims to understand how amino acids (building blocks of protein) affect the release of two key hormones, glucagon and insulin, in the body. Researchers are comparing healthy individuals, people with obesity, and people with type 2 diabetes to see if their bodies respond…

This study aims to understand why minority cancer patients often don't join clinical trials and to build a better educational tool to help them. Researchers will survey nearly 600 new cancer patients about their knowledge and attitudes, then test different educational approaches.…

This study follows 140 breast cancer patients who were previously in a research trial called BEAUTY. Researchers are collecting long-term health information, blood samples, and sometimes tissue samples from these patients to understand why some cancers respond to chemotherapy whi…

This study aims to understand how the heart changes shape and function after a heart attack. Researchers are observing over 1,500 people in specific Minnesota counties who have had a heart attack. The goal is to learn which patterns of heart change are linked to developing heart …

This study aims to understand how using a person's genetic information can impact their healthcare. It will enroll 110,000 Mayo Clinic patients to sequence their DNA and link that information to their medical records. The goal is to see if this genetic data helps with disease pre…

This study aims to understand how diseases begin by collecting health data from 100,000 Mayo Clinic patients. Participants will provide samples, use a mobile app, and complete surveys to help researchers spot early warning signs. The goal is to learn how to predict and potentiall…

This study aims to understand how the genetic makeup of prostate cancer changes when patients take a standard hormone therapy drug (abiraterone acetate). Researchers will collect tissue, blood, and urine samples from 92 men with advanced prostate cancer before and during treatmen…

This study tests whether sending personalized education about genetic testing guidelines increases how many people get tested when they have a family history of pancreatic cancer. Researchers will work with 40 patients who have a close relative with pancreatic cancer to offer gen…

This small Mayo Clinic study is testing whether a nightly automated massage device can help the brain's natural cleaning system work better in people with sleep apnea. Researchers will enroll 12 adults who already use CPAP machines to see if one month of this therapy changes cert…

This study is collecting information from healthy volunteers to create comparison data for heart disease research. Researchers are measuring how healthy hearts function during exercise to better understand congenital heart conditions. The data will help doctors interpret test res…

This study is testing whether a new type of blood test can help doctors monitor patients with bile duct cancer. The test looks for tiny signs of leftover cancer cells or early signs that the cancer is coming back after surgery or other treatments. Researchers will collect blood s…

This study aims to understand if long-term weightlifting is associated with an enlarged aorta, a condition called thoracic aorta dilatation. Researchers will compare heart ultrasound scans from 45 experienced weightlifters over age 35. The goal is to gather information, not to te…

This study aims to understand if excessive use of social media apps on smartphones can worsen anxiety symptoms. Researchers will observe 100 adults with mild anxiety or depression over 12 weeks, tracking their smartphone habits and mental health scores. The goal is to learn how s…

This study aims to understand how radiation therapy affects breast cancer markers in patients' blood. Researchers will track specific cancer DNA and immune cells before, during, and after radiation treatment. The goal is to gather information that could help doctors personalize b…

This study aims to understand if weight loss from gastric bypass surgery changes bile acid pathways differently than weight loss from a low-calorie diet. Researchers will compare 21 people with obesity who either have surgery or follow a diet plan. Participants will provide blood…

This study aims to understand how receiving genetic test results affects people's healthcare costs, how often they visit doctors or hospitals, and their overall quality of life. It will follow 100,000 adults who have already received their genetic test results from the Tapestry p…

This study aims to learn more about how brain disorders like Parkinson's disease and various dementias progress over time. Researchers will follow 500 adults who have symptoms suggesting a brain disorder, checking in with them yearly. Participants will undergo brain scans, memory…

This study aims to understand how immunotherapy cancer treatments affect patients' balance and hearing. Researchers will follow 50 adult cancer patients for one year, testing their balance and hearing before they start treatment and again at 3, 6, and 12 months. The goal is to ga…

This study aims to see if providing women at high risk for breast cancer with a personalized genetic risk score helps them make decisions about taking preventive medication. Researchers will follow over 700 women for 10 years to see if the score influences their choices and wheth…

This study aims to understand how bracing or surgery for scoliosis affects children's daily activity and back muscle stiffness. Researchers will measure activity using wearable monitors and muscle stiffness using a special ultrasound scan in 200 children, comparing those with sco…

This study aims to screen adults for a blood condition called MGUS and learn more about the genetic and immune factors linked to it. Researchers will enroll 1,000 adults from diverse backgrounds in Minnesota to check for MGUS and collect blood samples and health information. The …

This Mayo Clinic study is testing whether special coaching or communication classes for doctors can improve patient satisfaction and reduce doctor burnout. The research involves 45 primary care clinicians who will complete surveys before and after the training. The goal is to und…

This study aims to see if there is a difference in the amount of metal that gets into a patient's bloodstream after two different types of knee replacement surgery. Researchers are comparing the newer robotic-assisted surgery with the traditional method using cutting guides. They…

This study uses specialized brain scans (PET scans) to see if anti-amyloid Alzheimer's drugs also reduce tau protein tangles in the brain. Researchers will follow 135 patients with mild Alzheimer's symptoms who are already receiving these therapies at Mayo Clinic. The goal is to …

This study aims to understand how Vitamin D from a mother's daily supplement passes into her breastmilk and is then processed by her baby. Researchers are measuring Vitamin D levels in breastmilk before and after 28 days of supplementation in 60 breastfeeding mothers. They are al…

This study aims to measure and understand the levels of moral distress, moral injury, and post-traumatic stress symptoms among nurses at Mayo Clinic. Researchers will survey over 21,000 nursing staff members to identify which workplace settings, specialties, and personal factors …

This study aims to understand the normal range of immune responses in healthy children after they receive routine vaccinations. Researchers will collect small blood samples from 300 children before and after their scheduled shots to measure various immune markers. The goal is to …

This study compares two medical devices that monitor nerve function during surgery when patients' arms are tucked at their sides. Researchers will test both devices on 40 patients undergoing cystoscopy procedures to see which provides more accurate measurements. The goal is to im…

This study aims to understand how and why the breast cancer drug T-DM1 causes nerve damage (peripheral neuropathy) in patients. Researchers will observe 36 patients with HER2-positive breast cancer who are receiving T-DM1 treatment. They will track changes in nerve-related sympto…

This study aims to understand cancer screening awareness and barriers among incarcerated women. Researchers will survey 1,200 women at a Florida prison to learn about their knowledge, screening history, and challenges. The information will be used to create a digital education pr…

This study aims to understand if certain markers found in lymph node tissue can predict how well a patient does after an organ transplant. Researchers will analyze previously collected tissue samples from 200 adults who have undergone transplant surgery. The goal is to gather kno…

This study is collecting samples like blood, tissue, and DNA from 5,000 people with rare or undiagnosed diseases. Researchers will store these samples in a biobank to study them and look for genetic causes of these conditions. The goal is to help diagnose patients and find potent…

This Mayo Clinic study aims to collect detailed health data from 10,000 existing patients to better understand how genetics and environment influence health and disease. Participants will provide samples and health information to build a large research database. The goal is to he…

This study is testing the safety of a new type of electronic bandage that makes hydrogen peroxide, which could one day help treat or prevent wound infections. Researchers are applying small versions of this bandage to the healthy skin of 40 volunteers to check for any skin irrita…

This Mayo Clinic study aims to understand if long-term inflammation in the body increases a woman's risk of developing endometrial (uterine) cancer. Researchers are collecting blood, urine, and tissue samples from 191 women who are having a hysterectomy, either for cancer or for …

This study aims to understand how radiation therapy affects skin blood flow in breast reconstruction patients. Researchers will use a special ultrasound to measure blood supply in the skin before and after a fat grafting procedure. The goal is to gather information that may help …

This study aims to understand if specific inherited gene changes make some people more likely to develop painful kidney stones. Researchers will compare genetic and health information from about 1,800 people with a history of kidney stones to 900 people without stones. The goal i…

This study is building a collection of blood, stool, and urine samples, along with health information, from people with and without Inflammatory Bowel Disease (IBD). Researchers will use this 'biobank' to learn more about what causes IBD and how it progresses. The goal is to gath…

This study is testing a new blood test to see if it can find tiny pieces of HPV DNA from cervical cancer in the bloodstream. Researchers want to see if this test can help predict how well treatment is working and detect if the cancer comes back earlier than current methods. The s…

This study is collecting saliva, blood, and tissue samples from 100 adults with lymphedema to store for future research. The goal is to discover biological markers that could help doctors better understand the disease and optimize future surgical treatments. Participants are not …

This study aims to understand how chemotherapy given before breast cancer surgery affects patients' immune systems. Researchers will collect blood samples from 38 participants with operable breast cancer at different points during their treatment. The goal is to learn how the imm…

This study aims to see if a simple, non-invasive test that looks at tiny blood vessels under the fingernails (nail fold capillaroscopy) can help doctors understand why some people develop a stomach condition called GAVE. Researchers will compare the nail test results in 75 adults…

This study aims to find early warning signs in blood and urine that can predict how quickly a genetic kidney disease will worsen. Researchers will collect samples and perform an MRI scan from 100 patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The goal is to i…

This study aims to see if eating a diet high in fermented foods like yogurt, kefir, and kimchi can change the mix of bacteria in the gut (the microbiome) of people with long COVID. Researchers at Mayo Clinic will enroll 40 adults with long COVID and randomly assign half to eat 6+…

This Mayo Clinic study aims to understand how a mother's emotional state, sleep quality, and diet might influence two important substances in her breast milk: melatonin (related to sleep) and sIgA (an immune protein). Researchers are enrolling 120 new mothers to provide a small b…

This study aims to find out how common certain genetic changes are in kidney transplant patients. These changes can increase the risk of cancer and other diseases. Researchers will test patients' genes and see if the results lead doctors to recommend different cancer screening pl…

This study aims to understand how immigration experiences affect prostate cancer care decisions and survivorship for men from Sub-Saharan Africa and the Caribbean. Researchers will interview 80 immigrant men who have been diagnosed with prostate cancer to learn about their health…

This Mayo Clinic study aims to learn how the health of 500 acutely ill patients changes over time while they are in a special hospital monitoring unit. Researchers will closely track vital signs like heart rate and blood pressure to see how they shift when a patient's condition w…

This study aims to understand the biological processes that control how children's limbs grow. Researchers will analyze small tissue samples taken during routine orthopedic surgeries from up to 100 children and young adults. The goal is to identify molecules that could one day be…

This study aims to understand how bone marrow cells in people with a blood condition called MGUS use nutrients from their surroundings compared to healthy people. Researchers will collect blood and bone marrow samples from 40 participants—some with MGUS and some healthy volunteer…

This study aims to understand how often seizures occur in people with early-onset Alzheimer's disease. Researchers at Mayo Clinic are monitoring 20 participants using a portable EEG device worn for 48 hours to detect brain activity patterns. The goal is to gather information abou…

This study aims to collect tissue samples, blood, and medical information from 300 patients with advanced breast cancer that has spread. Researchers will analyze these samples to understand why breast cancer spreads to other parts of the body and why different patients respond di…

This study is collecting health information and blood or tissue samples from family members of people with pancreatic cancer or melanoma. The goal is to create a research database to help scientists understand if certain cancers can run in families. Over 1,100 participants have c…

This study aims to understand how the benefits of deep brain stimulation for essential tremor change throughout the day. Researchers will have 50 patients already receiving this treatment wear Apple Watches while performing specific tasks to collect movement data. The goal is to …

This study aims to understand how a single session of exercise changes the cells and signals in body fat (adipose tissue). Researchers are studying 56 healthy and obese adults, both young and older, to see how their fat tissue responds during and after cycling. The goal is to lea…

This Mayo Clinic study aims to find out if the types of bacteria living in a person's gut are linked to their risk of heart disease. Researchers will collect blood and stool samples from 700 adults who are already scheduled for a heart catheterization test. By comparing the gut b…

This study aims to understand if taking a daily nicotinamide riboside supplement for 12 weeks improves blood vessel health in healthy adults. Researchers will measure changes in blood vessel stiffness in 200 participants aged 35 to 70. The goal is to gather knowledge that could i…

This study aims to better understand how two proteins, amyloid and tau, build up in the brains of people with different forms of Alzheimer's disease. Researchers will use brain scans to track 60 participants with typical or unusual Alzheimer's symptoms over one year. The goal is …

This study aims to understand how to best implement a digital health app that helps primary care doctors screen for substance use issues and connect patients to treatment. It will enroll 60 participants from Mayo Clinic primary care sites who are at risk for substance use disorde…

This study aims to better understand why pancreatic cancer runs in families by tracking 3,000 people who have relatives with the disease but don't have cancer themselves. Participants complete health questionnaires every two years and may provide a one-time blood sample. The goal…

This was a small pilot study to see if a full-scale trial was possible. It aimed to test whether an AI tool called CURE could help doctors write patient discharge summaries from the hospital more efficiently. The study planned to involve adult heart patients and their doctors at …

This study aims to find better ways to detect pancreatic cancer early in people at high risk due to family history or genetics. Researchers are collecting annual blood samples from 419 participants to look for biological markers that might signal cancer before symptoms appear. Th…

This study aims to build a large, diverse group of 21,000 people newly diagnosed with non-Hodgkin lymphoma to learn what affects their long-term health. It will collect detailed health information, lifestyle factors, and biological samples over time, but does not test a new treat…

This study aims to understand if metal implants (like plates, screws, or rods) used in children's bones release metal into their bloodstream. Researchers are measuring metal levels in the blood and tissues of 50 children aged 4-18 who have these implants. The goal is to learn if …

This study aims to find the ideal level of muscle relaxation for safely placing a breathing tube during surgery. Researchers will measure muscle twitch responses in 108 patients to determine which monitoring ratio provides the best conditions for this common procedure. The goal i…

This study is testing a new, non-invasive ultrasound technique called Super-resolution ultrasound (SRU) to see the tiny blood vessels inside the kidneys. Researchers want to compare these blood vessels in people with early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD…

This study aims to understand what causes spinal deformities and degeneration by analyzing tissue samples from 300 children and adults undergoing spinal surgery. Researchers will examine the molecular makeup of discarded surgical tissue to identify biological markers of disease. …

This study aims to create a single, standard test to understand why some physically active people handle exercise in low-oxygen conditions better than others. Researchers will measure factors like breathing, heart rate, and blood chemistry in 50 participants during a stepwise exe…

This study aims to see if a person's ability to absorb sugar in their gut can predict how much weight they will lose after bariatric surgery. Researchers will enroll 52 people, including those scheduled for surgery and healthy individuals, to measure sugar absorption and related …

This study aims to create a central collection of blood samples and health information from Florida patients with various brain blood vessel diseases, like stroke. Researchers will enroll 72 participants to build this resource, which will be used for future research to better und…

This study aims to see if blood tests taken during and after pregnancy can predict future heart problems in women who were born with a heart condition. Researchers will follow 100 pregnant women with congenital heart disease to see if changes in these blood markers over time give…

This study is testing whether regular, painless glucose (sugar) monitoring during pregnancy can help predict who might develop gestational diabetes or preeclampsia. Researchers will follow 100 pregnant women with risk factors, comparing those who use the non-invasive monitor plus…

This study aims to understand if tiny particles released by prostate cancer cells, found in blood and urine, change after surgery and if they relate to standard blood test results. Researchers will collect samples from about 100 men with prostate cancer before and after their sur…

This study aims to better understand specific brain changes, called white matter hyperintensities, seen on MRI scans. Researchers will compare brain images from 50 women with migraines, small vessel ischemic disease, or multiple sclerosis. The goal is to learn more about these co…

This Mayo Clinic study aims to learn more about irregular heart rhythms in adults with hypertrophic cardiomyopathy, a condition where the heart muscle thickens. Researchers are observing 260 participants using a small implanted heart monitor to track rhythm patterns over time. A …

This study aims to understand why prostate cancer sometimes comes back after radiation treatment. Researchers are testing if changes in a specific blood marker (CgA) after treatment can predict which patients are at higher risk of their cancer returning. The study involves 118 me…