New ultrasound technique could spot kidney damage earlier in ADPKD

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (Patients with ADPKD): * Male and female subjects 18 - 40 years of age, inclusive * Previous diagnosis of ADPKD (based on Ravine et al. criteria) * Class 1 according to imaging classification * Estimated GFR\> 90 mL/min/m2 (CKD-Epi equation) * Ability to provide written, informed consent Inclusion Criteria (Healthy Volunteers): * Male and female subjects 18 - 40 years of age, inclusive * Estimated GFR\> 90 mL/min/m2 (CKD-Epi equation) * Ability to provide written, informed consent Exclusion Criteria (Patients with ADPKD): * Class 2 according to imaging classification * A concomitant systemic disease affecting the kidney (e.g., lupus, hepatitis B or C, amyloidosis) * Diabetes mellitus (fasting glucose \> 126 mg/dL or treatment with insulin or oral hypoglycemics). * Predicted urine protein excretion in urinalysis \>1 g/24 hrs. * Subjects having contraindications to or interference with MRI assessments. \[For example ferromagnetic metal prostheses, aneurysm clips, severe claustrophobia, large abdominal/back tattoos, etc.\]. * History of hypersensitivity allergic reactions to ultrasound contrast agents * High-risk cardiac disease (such as unstable hospital in-patients or ICU patients * Patients that are part of an interventional study or are taking tolvaptan * Female subjects that are pregnant Exclusion Criteria (Healthy Volunteers): * Family and/or personal history of kidney disease * Concomitant systemic disease that may affect the kidney * Diabetes mellitus * Predicted urine protein excretion in \>1 g/24 hrs, and or Abnormal urinalysis * Pregnant or lactating women * Subjects having contraindications to or interference with MRI assessments. \[For example ferromagnetic metal prostheses, aneurysm clips, severe claustrophobia, large abdominal/back tattoos, etc.\]. * History of hypersensitivity allergic reactions to ultrasound contrast agents * High risk cardiac disease (such as unstable hospital in-patients or ICU patients