Mayo Clinic

This early-stage study tests a custom-made vaccine for people with recurrent respiratory papillomatosis (RRP), a rare condition where non-cancerous throat tumors keep coming back. The vaccine is made from the patient's own immune cells and aims to train the body to fight the viru…

This study tests a drug called PLX038 in people with ovarian, peritoneal, or fallopian tube cancer that has spread and no longer responds to platinum chemotherapy. The goal is to see if PLX038 can shrink tumors by blocking enzymes cancer cells need to grow. About 43 adults with a…

This study looks at whether a 12-week barbell strength training program can lower blood pressure and improve cholesterol in adults who are not very active. Researchers will measure changes in blood pressure, cholesterol, and blood sugar in 200 participants. The goal is to see if …

This study looks at whether giving focused radiation to a few growing cancer spots can let patients with metastatic breast cancer stay on their current drug longer. About 45 adults whose cancer has started to progress after at least a year on first-line treatment will receive rad…

This early-stage trial tests the safety and best dose of the drug decitabine when given alongside standard treatments (surgery, radiation, and/or chemotherapy) for people with a type of head and neck cancer that is not caused by HPV and can be surgically removed. The goal is to s…

This study looks at how long people with AL amyloidosis should continue taking daratumumab after their first treatment to keep the disease from coming back. About 96 adults who have already responded to initial daratumumab therapy will be randomly assigned to either a shorter or …

This study tests a drug called obinutuzumab in 20 adults with fibrillary glomerulonephritis, a rare kidney disease. The goal is to see if the drug can reduce protein in the urine and improve kidney function over 12 months. Participants must have a confirmed diagnosis and meet spe…

This phase 2 trial tests whether adding high-dose intravenous vitamin C to standard chemotherapy can help treat blood cancers like lymphoma that have returned or not responded to treatment, as well as related conditions. About 80 adults will receive the combination to see if it i…

This study tests a new treatment for ovarian cancer that has returned after initial therapy. It combines a personalized vaccine made from a patient's own white blood cells (FRalphaDC) with an immunotherapy drug (pembrolizumab). The goal is to safely boost the immune system to rec…

This study is for people with a type of advanced prostate cancer that has spread and no longer responds to hormone therapy. It compares the standard 6 cycles of a targeted radiation drug (Lu-177 PSMA-617) against stopping after 5 cycles, to see if the shorter course can control t…

This early-stage study tests whether injecting donor stem cells directly into the kidney's main artery is safe for people who have rejection after a kidney transplant. The stem cells are meant to reduce inflammation and treat the rejection. The study involves 12 adult kidney tran…

This study looks at whether a weight loss procedure called Endoscopic Sleeve Gastroplasty (ESG) is safe and effective for people with ulcerative colitis who are obese and need or have had colon removal surgery. About 12 participants will be followed to see how much weight they lo…

This study tests whether it is possible to transplant a kidney and a bladder together in people who have both kidney failure and bladder problems. Up to 30 participants aged 1 to 60 will receive the combined transplant and be followed for several years. The goal is to see if the …

This study tests whether giving a targeted drug (enfortumab vedotin) plus an immunotherapy (pembrolizumab) before surgery to remove part or all of the bladder can improve outcomes for people with advanced bladder or upper urinary tract cancer. About 75 adults with cancer that has…

This early-stage trial tests whether stem cells taken from body fat and placed directly into the brain during surgery can help treat glioblastoma that has come back. About 20 adults with recurrent glioblastoma or a related brain cancer will receive the stem cells. The main goal i…

This study tests an oral medication, deucravacitinib, in 12 adults with moderate-to-severe pityriasis rubra pilaris (PRP), a rare skin condition causing red, scaly patches. The goal is to see if the drug safely reduces skin severity, itching, and improves quality of life over 24 …

This study compares two diabetes medications, pioglitazone and empagliflozin, to see which better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18-80 will take one of the drugs, and researchers will measur…

This study tests whether a structured Mediterranean diet can prevent weight gain, improve heart health, and stop fatty liver disease in people who have had a liver transplant. About 80 adults with a higher body weight before transplant will follow the diet for a period. The goal …

This early-phase study tests a new treatment called MC10029, which uses a patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells. The therapy targets a protein called BAFFR found on certain blood cancer cells. The study includes up to…

This trial tests a procedure called TULSA that uses MRI-guided ultrasound to heat and destroy prostate tumors without cutting into the body. It is for men aged 45-80 with low-to-intermediate grade prostate cancer that has not spread. The goal is to see if this approach can contro…

This study tests a radioactive drug called Lutathera for people with a type of brain tumor called meningioma that cannot be surgically removed and has grown after radiation therapy. The drug is given through a vein and aims to kill tumor cells. About 42 participants will be enrol…

This study is for people with advanced liver cancer that cannot be removed by surgery. It tests a treatment that uses the patient's own immune cells, trained in a lab to attack the tumor, combined with immunotherapy drugs and a pneumonia vaccine, all given after high-dose radiati…

This study compares giving a shorter, higher-dose radiation schedule (hypofractionated radiotherapy) either before or after breast cancer surgery. The goal is to see which timing is safer and works better for different types of non-metastatic breast cancer. About 120 adults with …

This early-phase trial tests a specially modified virus (VSV-hIFNβ-NIS) combined with two immunotherapy drugs (ipilimumab and cemiplimab) in adults with relapsed or refractory T-cell lymphoma. The virus is designed to kill cancer cells without harming healthy ones, while the immu…

This study tests whether placing two small drainage tubes (stents) into the gallbladder is more effective than one stent at preventing repeat gallbladder attacks in people who cannot have their gallbladder removed. About 30 adults with gallbladder inflammation or pain will be ran…

This study looks at whether a special clinic focused on heart health and weight can help obese adults with heart disease lose weight and improve their health. About 60 participants will be followed for 12 months to measure weight loss, body mass index, and belly fat. The goal is …

This study tests whether a combination eye drop (Rocklatan) works better than a standard drop (Latanoprost) at lowering eye pressure over a full 24-hour period in adults with open-angle glaucoma or ocular hypertension. About 30 participants will use one drop in each eye nightly. …

This study tests whether giving a shorter, higher-dose radiation therapy along with the chemotherapy drugs FOLFOX before surgery can kill more tumor cells in people with stage I-III esophageal or gastroesophageal junction cancer. About 99 adults who are candidates for surgery wil…

This study aims to find the best weight-loss medication for people with bipolar disorder by matching drugs to specific obesity types (like 'hungry brain' or 'hungry gut'). About 100 adults aged 18-65 with bipolar or schizoaffective disorder and obesity will receive one of three F…

This study tests a new approach for people with pancreatic cancer that cannot be surgically removed. It combines a light-activated drug (verteporfin) with an immunotherapy (pembrolizumab) and standard chemotherapy. The goal is to see if this combination can shrink tumors better t…

This study tests a cryotherapy spray (Tru-Freeze) to treat gastric antral vascular ectasia (GAVE), a condition that causes bleeding in the stomach. About 50 adults who need blood transfusions for GAVE will receive the spray during an endoscopy. The goal is to see if it raises hem…

This study tests whether itraconazole, an antifungal drug, is safe and practical for people with bronchiectasis who have mold growing in their airways. About 30 adults will take the medication for 6 weeks. Researchers will track how many people join and stick with the treatment, …

This study tests a low dose of osilodrostat in 15 adults with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. The goal is to see if the drug is safe and can help balance cortisol levels throughout the day. Participants will take the …

This study tests a new approach for people with advanced bladder or urinary tract cancer that has stopped responding to standard treatments. Researchers want to see if filtering the blood (plasma exchange) before giving two approved cancer drugs can help the drugs work better. Ab…

This study is for people with certain blood cancers (like CLL or lymphoma) who are starting a type of drug called a BTK inhibitor. These drugs can raise blood pressure and increase the risk of heart problems. The study will test if carefully managing high blood pressure can lower…

This study looks at two ways of giving focused radiation to people whose cancer has spread to the brain. One method gives all the radiation in a single session, while the other spreads it over several sessions. The goal is to see which approach better controls the tumors and caus…

This study tests whether a simple saliva test can predict how well people with obesity will respond to the weight-loss drug semaglutide. Researchers will compare weight loss in people with a specific saliva biomarker versus those without it. The goal is to make obesity treatment …

This early study looks at whether eating a magnesium-rich diet and applying magnesium lotion can help keep magnesium levels healthy in people with lymphoma. Magnesium is important for cell health, and low levels are common in sick patients. The study will enroll 60 adults with ly…

This study tests whether adding two drugs, dasatinib and quercetin, to standard CAR-T cell therapy can improve outcomes for people with multiple myeloma that has returned or not responded to prior treatments. About 44 adults who have tried at least three other therapies will rece…

This early-stage trial tests the safety and best dose of adding venetoclax to three different standard drug combinations for people with a specific genetic subtype of multiple myeloma (t(11;14)). About 100 participants will receive one of the combos. The goal is to see if the new…

This study is testing whether taking three oral drugs (methotrexate, erlotinib, and celecoxib) together is safe and practical for people with head and neck cancer that has come back or spread. The trial focuses on patients in rural Midwest areas, aiming to make treatment more acc…

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (cancers like chordoma or osteosarcoma). The goal is to see which treatment provides better quality of life and disease control with fewer side effects. About 72 participants …

This study tests whether a drug called sacubitril-valsartan can improve heart structure and function in adults with congenital heart disease. About 45 participants will be randomly assigned to receive the drug or a placebo. The goal is to see if the drug helps the heart pump bett…

This study tests whether a precise, short-course radiation therapy (SBRT) works as well as a slightly longer radiation approach (hypofractionated radiotherapy) for men whose prostate cancer has returned or spread to a few spots after surgery. About 118 participants will receive o…

This study tests whether having a specially trained community paramedic visit people with heart failure at home can reduce hospital stays and emergency visits compared to standard care. About 75 adults with worsening heart failure will take part. The goal is to see if this home-b…

This early-stage study tests whether repeatedly adding sterile fluid into the womb (amnioinfusion) can help unborn babies with severe kidney defects grow their lungs. Without enough amniotic fluid, these babies often die right after birth from underdeveloped lungs. The goal is to…

This study tests a new drug (BMS-986340) plus standard treatments for advanced pancreatic cancer that has spread or returned. About 43 adults will receive the combination to see if it's safe and shrinks tumors. The goal is to find a better way to control this aggressive cancer.

This study tests whether a smartphone app can help African-American adults with uncontrolled high blood pressure lower their numbers and adopt healthier habits. About 100 participants will use the app or receive standard care, and their blood pressure will be tracked for up to 6 …

This study tests whether adding obinutuzumab to acalabrutinib works better than acalabrutinib alone for people with early-stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are at high risk of their disease getting worse. About 120 adults will be ran…

This study tests whether starting plasma exchange (a blood-filtering treatment) early, rather than waiting as a last resort, leads to better vision and less disability in people with severe optic neuritis (eye nerve inflammation) or transverse myelitis (spinal cord inflammation).…

This study tests a medication called ravulizumab in pregnant women with severe preeclampsia or HELLP syndrome, serious conditions that can harm both mother and baby. The goal is to see if the drug can improve health markers and extend pregnancy duration. About 14 participants wil…

This early-phase study looks at how the body processes a liquid form of the drug avacopan when given through a feeding tube. It involves up to 6 patients with a rare autoimmune disease (ANCA vasculitis) who have severe lung bleeding and need a breathing machine. The goal is to me…

This study tests a procedure that uses extreme cold to freeze and destroy prostate cancer tumors, guided by real-time MRI images. It is for men with early-stage prostate cancer who cannot or do not want surgery or radiation. The goal is to safely remove the cancer while reducing …

This study tests whether a continuous glucose monitor (CGM) can help people with glioblastoma, a serious brain cancer, manage their blood sugar levels and potentially live longer. High blood sugar is common in these patients due to steroid use and is linked to worse outcomes. The…

This early-stage trial tests a new drug called MTI-301 in about 42 adults with advanced solid cancers that have spread or not responded to standard treatments. The drug blocks an enzyme (SCD1) that some cancers need to grow. The main goals are to find a safe dose and check for si…

This early-phase trial is testing whether adding Tumor Treatment Fields (TTF) – a device that sends low-intensity electric fields to the tumor – to a specific chemotherapy combination (protein-bound paclitaxel, cisplatin, and gemcitabine) can help control metastatic pancreatic ca…

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are already receiving standard treatment. The goal is to see which one helps patients leave the hospital sooner and reduces complications. About …

This study tests whether a specific probiotic (De Simone Formulation) can lower bile acid levels in stool for people with bile acid malabsorption or diarrhea who still have their ileum. About 24 adults will receive either the probiotic or a placebo for a set period. The main goal…

This early-phase study tests whether giving a single, precise dose of radiation before surgery can help control high grade glioma (a fast-growing brain tumor) while reducing side effects. About 28 adults with this type of brain tumor will receive radiosurgery before their planned…

This study compares two types of heart pacing for people with heart failure: one guided by artificial intelligence (AI) and one using the standard method. The goal is to see if AI helps the heart pump blood more effectively after six months. About 224 adults with weakened hearts …

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This study looks at whether using a patient's own continuous glucose monitor (CGM) during a hospital stay can help doctors and nurses give better insulin doses. About 150 adults with diabetes who already use a CGM at home will be enrolled. The goal is to see if this approach redu…

This study tests if daratumumab can help people with a rare kidney disease called PGNMID, where abnormal proteins damage the kidneys. The goal is to reduce protein in the urine and improve kidney function. About 40 adults with confirmed PGNMID and significant protein in their uri…

This study tests whether the drug avacopan, combined with a low-dose steroid, can help people with a severe form of IgA nephropathy (a kidney disease). The goal is to reduce protein in the urine and protect kidney function. The trial involves 16 adults whose kidney disease is at …

This study tests a new way of giving radiation therapy for Ewing sarcoma, a type of bone or soft tissue cancer. The radiation dose is tailored to each patient's tumor size and features, with higher doses given over a shorter time. The goal is to better control the tumor at its or…

This study looks at a device called the Coronary Sinus Reducer in 25 people with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (CMD). The device is implanted to improve blood flow to the heart muscle. Researchers will use MRI scans …

This study looks at whether giving radiation alone or with hormone therapy works better for men whose prostate cancer has returned and spread. It also tests if adding pelvic radiation helps stop further spread. About 532 men with recurrent, hormone-sensitive prostate cancer will …

This early-phase trial tests whether combining four drugs (dasatinib, quercetin, fisetin, and temozolomide) is safe and feasible for adults with glioma that has residual disease after prior treatment. The approach uses individual patient feedback from scans and markers to guide t…

This early-phase study tests a new treatment for ovarian cancer that has come back or not responded to standard therapy. Doctors take a patient's own immune cells (T cells), train them in a lab to recognize a protein called MUC1 found on cancer cells, and then give them back to t…

This study tests a treatment called HIPEC for people with pancreatic cancer that has spread to the lining of the abdomen. HIPEC delivers heated chemotherapy directly into the belly during surgery, aiming to kill cancer cells more effectively. The study will enroll 40 adults aged …

This study tests whether giving two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more cancer cells in people with early-stage non-small cell lung cancer. About 60 adults with stage IB to IIIB lung cancer will receive the drug combination, then have their…

This early-stage study tests a new daily pill, onvansertib, for people with chronic myelomonocytic leukemia (CMML) or related blood cancers that have returned or stopped responding to standard therapies. The main goals are to find the safest dose and see if the drug can shrink or…

This study tests whether tadalafil (a drug that relaxes blood vessels) can improve blood flow and reduce organ damage in adults who had the Fontan procedure for a single-ventricle heart defect. About 80 participants will receive either tadalafil or a placebo for several months. T…

This program offers the drug ibudilast to people with ALS who cannot join other clinical trials. The goal is to see if ibudilast can slow down the disease. Participants must meet specific criteria, such as being over 18 and having a confirmed ALS diagnosis. The program aims to pr…

This study is for people with multiple myeloma that has returned or not responded to at least three prior treatments. It tests different doses and schedules of a drug called belantamab mafodotin, which targets and kills cancer cells. The goal is to find a dose that controls the c…

This early-phase study tests a new drug called WSD0628 combined with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after prior treatment. The main goals are to find the safest dose and to see how well the combination works. About 94 ad…

This study tests two immunotherapy drugs, efineptakin alfa and pembrolizumab, in people whose glioblastoma has returned after standard treatment. The goal is to see if this combination can help the immune system fight the tumor and improve survival. About 54 adults with recurrent…

This study is testing a new way to give radiation called minibeam therapy for people with skin or soft tissue tumors that have come back or spread. The treatment uses a special device to split a wide radiation beam into many tiny beams, which may reduce damage to healthy tissue. …

This early-stage study tests whether adding a drug called aldesleukin (IL-2) to standard immunotherapy and chemotherapy can better control stomach cancer that has spread to the abdomen lining. About 15 adults with this condition will receive the combination. The goal is to see if…

This study tests whether turkey tail mushrooms can help treat a common type of breast cancer in post-menopausal women. About 40 women will take the mushroom supplement in the weeks between diagnosis and surgery. Researchers will measure changes in a tumor growth marker (Ki-67) an…

This study tests whether offering financial rewards to both a smoker and a family member helps Alaska Native adults quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive or standard support. Success is measured by a saliva test at …

This study tests a special type of radiation called grid therapy, which delivers high doses to small parts of a tumor, combined with standard immunotherapy for people with stage IV non-small cell lung cancer that has gotten worse on immunotherapy alone. The goal is to see if this…

This study tests whether a combination of three drugs (acalabrutinib, venetoclax, and durvalumab) can help people with Richter transformation, a rare and aggressive lymphoma that develops from chronic lymphocytic leukemia (CLL). The drugs work by blocking cancer growth signals, t…

This study tests whether bone marrow stem cells are safe for people with chronic kidney disease, including those who have had a kidney transplant. About 75 adults will receive stem cells through a vein or directly into the kidney arteries. The goal is to monitor side effects, not…

This study looks at whether giving focused radiation before or after surgery works better for people with cancer that has spread to the brain. About 140 adults who need surgery for a brain tumor will be randomly assigned to receive stereotactic radiosurgery either before or after…

This study tests whether giving two drugs—golcadomide and rituximab—before CAR-T cell therapy can help more people with aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. The goal is to control the disease so patients can proceed to CAR-T, whi…

This early-stage trial tests a new drug, Q702, in about 46 adults with certain blood cancers or related diseases that have not responded to standard treatments. Q702 works by helping the immune system attack cancer cells and supporting normal blood cell production. The main goals…

This early study tests a new way to use a heart-lung machine (ECMO) to keep people with severe lung disease and heart failure alive until they can get a lung transplant. The approach uses a special tube placed across the heart's wall to improve blood flow. Only 4 participants wil…

This study compares three oral medications—atogepant (newer), topiramate, and propranolol (older)—to see which prevents migraines better and is easier to tolerate. About 1,335 adults with migraine will be randomly assigned to one of the drugs and track their headaches for 12 week…

This early-stage trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors. Ab…

This study tests a new way of giving the chemotherapy drug capecitabine to people with metastatic ER-positive, HER2-negative breast cancer. Instead of a fixed dose, the dose is adjusted based on how the tumor responds on scans and blood tests. The goal is to better control the ca…

This study looks at whether taking melatonin for 12 weeks can improve blood pressure in women going through menopause who also have high blood pressure. Researchers will measure nighttime blood pressure and markers of oxidative stress. The goal is to find a simple way to help con…

This study compares a reduced dose of radiation (3 treatments) against the standard 12 treatments for people with indolent non-Hodgkin lymphoma, a slow-growing blood cancer. The goal is to see if the shorter course is safer and still controls the disease. About 112 adults with ce…

This study offers boys aged 0-17 the chance to freeze testicular tissue before starting treatments like chemotherapy or radiation that could cause infertility. The goal is to use this tissue later to help them have biological children. Researchers will track how many pregnancies …

This study tests whether a blood test (NavDx) can help doctors decide the right amount of radiation for people with HPV-related throat cancer. The goal is to give enough treatment to control the cancer while reducing side effects. About 455 adults with certain stages of throat ca…

This early-phase trial tests a genetically modified virus (VSV-IFNβ-NIS) alone or with chemotherapy and immunotherapy drugs in people with blood cancers like multiple myeloma, acute myeloid leukemia, and lymphomas that have returned or not responded to treatment. The virus is des…

This early-stage trial tests whether combining a targeted liver radiation procedure (Y90 radioembolization) with two immunotherapy drugs (durvalumab and tremelimumab) is safe and shows promise for people with bile duct cancer that cannot be surgically removed. The study enrolls 1…

This study is for people with high-risk prostate cancer that has spread to a few other spots. It tests whether giving less hormone therapy (based on each person's risk) along with radiation can control the cancer just as well as the standard longer hormone therapy. The goal is to…

This study tests two drugs, GI-102 and pembrolizumab, given before surgery to people whose aggressive brain cancer (glioblastoma) has returned. The goal is to see if these drugs can shrink the tumor and help the immune system fight the cancer. About 36 adults will take part, and …

This study tests if a smartphone app called SmartWell24 can help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. Researchers will track CPAP usage and quality of life in 40 adults newly diagnosed with sleep apnea. The goal…

This study tests a drug called enfortumab vedotin for people with penile cancer that has spread or cannot be removed by surgery. The drug targets a protein on cancer cells to deliver a toxin that kills them. About 28 adults will take part to see if the drug can shrink tumors and …

This early-stage trial tests a new treatment called sonodynamic therapy for people with glioblastoma that has come back or is getting worse. The treatment combines a drug (5-ALA) that makes tumor cells sensitive to sound waves, with focused ultrasound waves that target and destro…

This study tests a vaccine made from a patient's own white blood cells, designed to train the immune system to attack ovarian cancer cells. It is for people with advanced stage III or IV ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see if the vaccine can …

This study tests a combination of four drugs (iberdomide, daratumumab, elotuzumab, and dexamethasone) in people whose multiple myeloma has returned after previous treatment. The goal is to find the safest dose and see how well the drugs work together to shrink or control the canc…

This study tests a special PET/MRI scan that uses a radioactive tracer to find small pituitary tumors that standard MRI cannot see. About 5 adults with certain hormone disorders will get this scan. If the scan finds a tumor, surgery may be done. The goal is to see if this scan he…

This study looks at whether a new type of CT scanner (PCD-CT) can determine how far rectal cancer has grown as accurately as MRI. About 200 adults with rectal cancer will get both scans, and doctors will compare the results. If PCD-CT works as well, it could offer a faster or mor…

This study tests whether artificial intelligence can make a standard electrocardiogram (ECG) better at finding two common heart conditions: aortic stenosis and diastolic dysfunction. Researchers at Mayo Clinic will enroll 2000 adults aged 60 and older who are already scheduled fo…

This study tests whether using artificial intelligence (AI) to read heart tests (ECG and ultrasound) can find heart disease in people who don't know they have it. About 19,300 participants, including teens, adults, and pregnant women, will get quick AI results. The goal is to see…

This study tests if a safe, non-invasive lung ultrasound can detect rejection or infection in lung transplant recipients who feel fine. Currently, doctors must use a bronchoscopy with biopsy, which carries risks. If ultrasound works, it could reduce the need for these invasive pr…

This study aims to see if a special exercise MRI can help doctors diagnose a type of heart failure called HFpEF, where the heart pumps well but still doesn't work properly. Researchers will study 400 people, including those with HFpEF, those with shortness of breath from other ca…

This study compares a new miniature cryoprobe with standard biopsy forceps to see which method better detects rejection in lung transplant recipients. About 100 participants will be randomly assigned to one of the two biopsy methods. The goal is to find which technique provides h…

This study tests a new ultrasound method called ultrasound microvessel imaging (UMI) to see if it can better detect blood flow in ovarian growths. Better blood flow detection may help doctors more accurately assess cancer risk. About 40 women scheduled for surgery for ovarian les…

This study tests a new, less invasive way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. Instead of using a long tube with a camera (endoscopy), participants swallow a small sponge on a string that collects cells from the esophagus. The collect…

This study tests a new type of PET/CT scan called 18F-TFB to see if it can find thyroid cancer that has returned or spread. About 24 adults with papillary or follicular thyroid cancer will get this scan in addition to their usual iodine scan. The goal is to see if the new scan gi…

This study aims to see if voice recordings can help detect pulmonary hypertension, a serious heart and lung condition. Researchers at Mayo Clinic will collect voice samples from 7,000 people already scheduled for an echocardiogram. They will compare voice patterns to standard tes…

This study tests a simple sponge-on-a-string device that people swallow to collect cells from the esophagus. The goal is to see if this non-invasive test can accurately detect Barrett's esophagus and early signs of esophageal cancer in people aged 50-85 with risk factors like chr…

This study tests whether a special PET scan using GA-68 PSMA-11 can help doctors tell the difference between a returning brain tumor (glioma) and changes caused by previous treatment. About 25 adults with grade 3 or 4 glioma who are already scheduled for surgery will get this sca…

This study aims to develop a new, noninvasive ultrasound method to detect peripheral arterial disease (PAD) earlier and more easily. Researchers will compare this ultrasound technique to standard tests in 400 adults with and without PAD symptoms. If successful, it could offer a s…

This study looks at whether a special ultrasound-guided needle biopsy can accurately determine the stage of bladder cancer. Researchers will compare the biopsy results with the final results from standard surgery. The goal is to see if this less invasive method could be a reliabl…

This study is testing a new breast ultrasound method to see if it can better detect breast cancer and measure how well treatment is working. Researchers will enroll 550 adults with suspicious breast lumps or confirmed breast cancer. The goal is to improve diagnosis and track tumo…

This study tests a new, less invasive way to look for Barrett's esophagus, a condition that can lead to cancer. Instead of a traditional endoscopy, participants swallow a capsule attached to a string that helps doctors see the esophagus clearly. The goal is to see if this method …

This study tests a new imaging method called vibro-acoustography to find and tell apart benign and cancerous thyroid nodules. Researchers will compare this technique to standard ultrasound in 650 people aged 8 and older who are suspected of having thyroid cancer. The goal is to s…

This study tests whether an artificial intelligence (AI) program can correctly identify the cause of narrowed bile ducts during a routine scope procedure. About 100 adults will take part. The AI analyzes video from the scope and aims to tell if the narrowing is cancerous or not, …

This study looks at whether a stool DNA test can accurately detect colorectal cancer or pre-cancerous growths in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will collect blood and stool samples from 750 adults with Lynch syndrome or early-…

This study tests a special PET scan that uses a radioactive tracer called 68Ga-FAPI-46 to highlight pancreatic cancer cells. The goal is to see if this scan can find tumors more accurately than current methods. About 130 adults with localized pancreatic cancer will get the scan b…

This study tests a new 3D ultrasound imaging method to see if it can better diagnose breast masses compared to standard 2D ultrasound. About 125 adult women with a solid breast lesion needing a biopsy will participate. The goal is to improve accuracy in telling benign from malign…

This study aims to create a test that can find endometrial, ovarian, and cervical cancers early using a sample of vaginal fluid or blood. Researchers will look for specific DNA markers and high-risk HPV in about 3,100 women. The goal is to make cancer detection easier and more ac…

This study is testing whether a special ultrasound done during surgery can help doctors better identify pituitary adenomas, especially in people with Cushing's disease. About 110 participants will have their tumors scanned with contrast-enhanced ultrasound, and the images will be…

This study tests a new MRI technique to measure how cerebrospinal fluid (CSF) flows in the brain. Researchers will compare CSF flow in healthy people and those with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understa…

This study tests whether adding a special PET scan (18F-DOPA PET/CT) to standard imaging helps doctors better manage brain tumors. About 47 adults with brain tumors will get this extra scan. The goal is to see if the new scan changes treatment plans in a meaningful way for more t…

This study tests a special dye called pafolacianine that makes cancer cells glow under a special camera during surgery. The goal is to help surgeons see and remove all tumor tissue in children aged 6 months to 17 years with solid cancers in the neck, chest, belly, or pelvis. Abou…

This study is testing a new blood and urine test that looks for DNA markers to detect cancer early and identify where it started. Researchers at Mayo Clinic will collect samples from 6,150 people, including those with and without cancer, to see how accurate the test is. The goal …

This study tests a new 3D ultrasound technology to see if it can better tell whether lymph nodes in breast cancer patients are cancerous or not. About 55 adults who already need a lymph node biopsy or have a clip placed will get this extra scan. The goal is to improve accuracy an…

This study tests artificial intelligence (AI) tools that help doctors interpret heart ultrasound images more accurately and quickly. The goal is to see if AI can speed up the diagnosis of conditions like genetic heart muscle disease, blocked arteries, and cardiac amyloidosis. Up …

This study is testing whether new lab tests (called biomarkers) from blood, stool, cyst fluid, or pancreatic juice can find early signs of cancer in pancreatic cysts. Researchers will collect samples from 800 people with pancreatic cysts and track their health for up to 3 years. …

This study tests whether a special PET/MRI scan can accurately predict if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer will get the scan before surgery to remove the prostate. The goal is to see if the scan can identify who truly n…

This study tests whether a special ultrasound technique called SHAPE can detect high blood pressure in the liver (portal hypertension) without using a needle. Currently, doctors must insert a catheter into a vein to measure this pressure, which is risky and cannot be done often. …

This study tests whether a dye injected during surgery can help doctors see if any cancer cells remain after removing a sarcoma. About 50 adults with bone or soft tissue sarcoma will take part. The dye's accuracy will be compared to standard lab results.

This study tests whether taking a hormone-blocking drug (relugolix) for a few days before a PSMA PET/CT scan can make prostate cancer cells more visible. The goal is to improve detection of cancer that has spread to lymph nodes in men with high-risk prostate cancer. About 30 part…

This study tests a new ultrasound technique called Quantitative Ultrasound Bladder Vibrometry to measure bladder function without using a catheter. Researchers at Mayo Clinic will enroll adults with bladder problems or enlarged prostate to see if this method is accurate. The goal…

This study tests whether a special PET scan can find early scarring in the small bowel of people with Crohn's disease. About 45 adults with Crohn's will get the scan, and researchers will compare those with known strictures to those without. The goal is to see if the scan can det…

This study tests a new MRI technique called 3D DL oZTEo to see if it can better find bone erosions in the hands of people with inflammatory arthritis. About 25 adults who already need a hand MRI will take part. The goal is to improve how doctors detect bone changes that affect tr…

This study aims to reduce colorectal cancer disparities in Black and underserved communities in Phoenix by providing free, home-based screening tests and education. Participants aged 45 and older who meet eligibility criteria will receive a fecal immunochemical test (FIT) kit and…

This study tests whether a structured home exercise plan focused on balance and strength can help people in cardiac rehabilitation improve their physical function, reduce fall risk, and feel more confident. About 128 participants will use a mobile app to follow the program. The g…

This study tests whether taking low-dose aspirin can lower inflammation and reduce the risk of breast cancer in women who have had a baby within the last 10 years. About 60 women planning a breast biopsy will take aspirin and have blood and tissue samples checked for changes. The…

This study tests whether the drug ibrutinib can prevent chronic graft-versus-host disease (GVHD) in people who have received a donor stem cell transplant. About 40 adults who are 50 to 110 days post-transplant will take ibrutinib to block certain immune cells that cause GVHD. The…

This small study tests whether gentle neck traction (a type of stretching) can help people with nerve-related itching on the scalp, arms, or upper back use less medication. Twelve adults who already take gabapentin or pregabalin for itch will try daily home traction for 12 weeks.…

This study tests whether a long-acting numbing medication called Exparel can reduce pain after rib cartilage is removed for nasal surgery. About 60 adults having nasal surgery that requires rib cartilage will receive either Exparel or the standard numbing drug. The goal is to see…

This study tests a surgical technique to prevent thick, painful scars after trigger finger surgery in people who also have Dupuytren's contracture. About 50 adults who have chosen surgery will be randomly assigned to receive either the standard surgery or the new technique. Resea…

This study looks at whether giving cancer treatment at home instead of a hospital can help Black men with advanced prostate cancer feel better and have fewer health disparities. About 77 Black men will try patient-centered home care and share their experiences through surveys. Th…

This study tests if a digital hypnotherapy program can reduce stomach symptoms like pain, bloating, and nausea. Researchers will enroll 100 people with upper gut disorders. Participants will use the program at home and report changes in their symptoms through questionnaires.

This study looks at whether adding a minimally invasive hip procedure (arthroscopy) during a standard hip realignment surgery (PAO) helps people with hip dysplasia recover better. About 106 participants aged 15 to 55 with mild or no arthritis will be randomly assigned to receive …

This study tests two different joint injections for moderate to advanced thumb arthritis: one is an NSAID (ketorolac), the other a corticosteroid (triamcinolone). Researchers want to see which one better eases pain and improves hand function. About 240 adults over 40 whose pain h…

This study tests whether pairing vagus nerve stimulation (a mild electrical pulse to a nerve in the neck) with mobility training can help people who had a stroke at least 6 months ago walk better. About 20 adults with slow walking speed will receive the therapy in clinic. Researc…

This study looks at whether a spinal cord stimulation device can reduce pain and improve daily life for people with nerve damage caused by chemotherapy. About 20 adults who have had chemo-related nerve pain for over six months will receive the treatment. Researchers will track pa…

This study tests if a community-based exercise program can improve memory, attention, and brain health in 160 breast cancer survivors aged 50 and older. Participants will either exercise or receive health education. The goal is to find a safe, accessible way to ease the 'chemo br…

This study tests whether a low-calorie, plant-based diet that mimics fasting can reduce common side effects like rash, diarrhea, and fatigue in cancer patients receiving immunotherapy. Ten adults with advanced cancer will follow the diet and report their symptoms. The goal is to …

This study looks at whether adding low-intensity shockwave therapy to the standard Xiaflex injections can further reduce penile curvature in men with Peyronie's disease. About 60 adults with stable symptoms and a curve between 30 and 90 degrees will be enrolled. Researchers will …

This Mayo Clinic pilot study tests whether controlled changes in oxygen and carbon dioxide levels can help people with long COVID brain fog. The study will measure brain blood flow, heart rate, and symptom changes in 45 participants. It aims to find a safe, non-invasive way to ea…

This study compares giving cancer treatment at home versus in a clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves the overall experience. About 220 participants will be randomly assigned to receive their t…

This study looks at whether a nerve graft during nipple-sparing mastectomy can help restore feeling in the nipple and improve quality of life. About 20 women with early-stage breast cancer will be randomly assigned to receive standard surgery or surgery plus nerve grafting. The m…

This study looks at whether giving cancer therapy at home instead of in a clinic can improve the experience for Black men with advanced prostate cancer. About 38 participants will try both home and clinic treatments to compare safety, side effects, and satisfaction. The goal is t…

This study tests whether a virtual stress reduction program using mindfulness techniques can improve mental health for cancer patients living in underserved or rural areas of Minnesota. About 30 adults with a history of cancer who report high stress will take part. The program is…

This study looks at whether a single dose of intravenous ketamine can rapidly improve symptoms in adults with treatment-resistant depression. Researchers will measure changes in brain chemicals (GABA and glutamate) and depression scores. 30 participants will receive either ketami…

This study aims to find the right dose of a drug called dexmedetomidine to stop shivering in 90% of women during planned cesarean deliveries. About 40 women having scheduled C-sections will receive different doses to see which works best and is safest. The goal is to improve comf…

This study tests whether fucoidan, a supplement from brown seaweed, can reduce fatigue caused by chemotherapy in people with gastrointestinal or gynecological cancer. About 34 participants will take either fucoidan or a placebo for 16 weeks and report their fatigue levels. The go…

This study tests whether a home-based pulmonary rehabilitation program combined with health coaching can improve breathing-related quality of life and physical activity in people with fibrotic interstitial lung disease. About 460 participants will either receive the program or co…

This study looks at whether high-frequency spinal cord stimulation can reduce severe nerve pain in people who have had a brachial plexus injury (a serious shoulder and arm nerve injury). About 20 adults who are already scheduled to get a spinal cord stimulator will report their p…

This study tests whether a newer, shorter radiation method (2 sessions) causes fewer side effects than the standard approach (5 sessions) for men with localized prostate cancer. About 144 participants will receive either the shorter or standard treatment, and their quality of lif…

This study tests whether acupressure—a gentle finger-pressure technique—can reduce anxiety in cancer patients receiving chemotherapy. About 78 adults with cancer will either receive real acupressure or a sham (placebo) version. Researchers will measure anxiety levels before and a…

This study tests whether taking a corticosteroid (prednisone) after ureteroscopy—a surgery to remove kidney stones—can help reduce pain and the need for extra painkillers. About 90 adults who are having this surgery with a stent placed will be enrolled. Researchers will compare p…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests a special pain management program for breast cancer survivors who have joint and muscle pain caused by their hormone therapy (aromatase inhibitors). The program uses cognitive behavioral therapy (CBT) and other techniques to help reduce pain, improve thinking and…

This study tests whether the diabetes drug metformin, combined with a wearable activity tracker, can reduce memory and thinking problems caused by brain radiation. About 100 adults who have had or will have cranial radiation for a brain tumor will participate remotely using a web…

This study from Mayo Clinic looks at how to improve biofeedback treatments for people with a type of constipation called dyssynergic defecation. Researchers will measure changes in rectal and anal pressure, balloon expulsion time, and emptying rates. The goal is to better underst…

This study tests whether a lung rehab program can help people with COPD who live in rural areas. Researchers want to see if it improves quality of life and reduces shortness of breath. About 306 adults aged 40 and older with COPD will take part. The program is designed to bring a…

This study tests whether pyridostigmine, a drug that affects nerve signals, can reduce rapid heartbeat and stabilize blood pressure in people with postural tachycardia syndrome (POTS). About 50 adults with POTS will take either the drug or a placebo for 3 days. The goal is to see…

This study tests whether a personalized exercise program (aerobic and resistance training) done before CAR-T therapy can improve physical fitness and quality of life in adults aged 60 and older with multiple myeloma that has returned or not responded to treatment. About 20 partic…

This study tests whether injecting a numbing medication and a steroid into the scalp nerves can stop a migraine in its tracks and prevent future ones for months. Researchers will enroll 60 people who get 4 to 14 migraines per month. The goal is to see if this nerve block can elim…

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can lower vein pressure and improve heart function in adults with a failing Fontan circulation. About 27 participants will take the drug or a placebo for 3 months. The goal is to see if the drug e…

This study looks at two different anesthesia approaches to see which one causes less confusion and agitation in children when they wake up after surgery. About 400 kids aged 2 to 7 having ear, nose, throat, eye, or urology procedures will be randomly assigned to receive either is…

This study tests a lifestyle behavior program to help people with chronic migraine reduce how often and how severely their headaches happen. Researchers will also look for biological markers linked to improvement. The goal is to see if the program is practical and liked by partic…

This study tests whether Wisconsin ginseng can reduce fatigue in people with solid-tumor cancers. Fatigue is a common and troubling side effect of cancer and its treatment. Researchers will compare ginseng to a placebo in 160 adults to see if it truly helps.

This study tests whether adding immersive virtual reality (VR) therapy to the standard medication linaclotide helps adults with irritable bowel syndrome and constipation (IBS-C) feel better. About 65 participants will receive either real VR or a sham VR alongside their medication…

This study looks at whether one-on-one health coaching over the phone can help people waiting for a lung transplant feel more in control and emotionally stronger. About 230 adults on the transplant list will either get up to 12 coaching sessions or standard care. Researchers will…

This study looks at whether increasing the dose of varenicline or adding another medication (bupropion) helps people with recurrent acute or chronic pancreatitis quit smoking. All 45 participants start with standard-dose varenicline; those still smoking after 6 weeks are randomly…

This study tests if an advanced balance training program can help warfighters with leg injuries (including amputations) improve how they use their injured limb and reduce stumbles and falls. The study will enroll 40 active duty service members and veterans who are already in stan…

This study tests whether giving the cancer drug nivolumab as a shot at home is as safe and effective as getting it in a clinic. About 50 adults with various cancers will try both settings to see which they prefer and how it affects their quality of life. The goal is to reduce the…

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet works better than diet alone for easing IBS with diarrhea. About 20 adults aged 18-70 with moderate-to-severe symptoms will join. The goal is to see if the combo improves pa…

This study tests whether wearing active noise-cancelling headphones with music or a movie can help patients stay calm and need less sedation during knee replacement surgery done under spinal anesthesia. About 200 adults having their first knee replacement will take part. The goal…

This early study at Mayo Clinic tests whether low-dose growth hormone can reduce symptoms of gastroparesis, a condition where the stomach empties slowly. Ten adults with long-term symptoms that haven't improved with standard treatments will receive the hormone and report changes …

This study tests whether a lower dose of steroid injected into the knee works as well as the standard dose for reducing pain and improving function in obese people with knee arthritis. Forty participants will receive either a low or standard dose and report their pain and knee fu…

This study is for people with a rare, aggressive brain tumor called diffuse midline glioma. Instead of the usual 6 weeks of daily radiation, researchers are testing a 2-week course. The goal is to see if the shorter treatment works just as well and helps patients feel better duri…

This early study at Mayo Clinic tests whether coiling a vein in the lower back can safely reduce chronic headaches in people with a rare kidney blood flow condition called nutcracker physiology. Only 4 participants will be enrolled, and the main goal is to check for safety and an…

This study tests whether the Mayo Clinic Diet helps adults with obesity lose at least 5% of their body weight compared to standard care. Researchers will follow 250 participants for up to 52 weeks to see if the diet is practical and sustainable. The goal is to improve weight, bod…

This study tests a personalized approach to giving steroids to adults hospitalized with pneumonia. Instead of a one-size-fits-all dose, doctors will use a blood test (CRP) to decide the right amount and timing for each patient. The goal is to reduce steroid side effects while sti…

This study tests a special tissue wrap placed on nerve bundles during prostate removal surgery. The goal is to see if it helps men recover erectile function and bladder control faster. About 25 men with localized prostate cancer will take part. The wrap is meant to protect nerves…

This study looks at how skin quality and self-esteem change in breast cancer survivors who are starting a type of hormone therapy called aromatase inhibitors. About 35 women with early-stage breast cancer will join. Researchers will use special imaging to track skin changes and s…

This study looks at whether a procedure called foam sclerotherapy can reduce pain and improve quality of life for people with autosomal dominant polycystic kidney disease (ADPKD) who have large, painful cysts in their kidneys or liver. About 100 adults with 1-3 large cysts will r…

This study tests a therapy called accelerated resolution therapy (ART) to help older adults who are caring for a family member with a life-limiting illness. The goal is to see if ART can reduce feelings of grief before and after the loss. The study will involve 440 participants a…

This study explores whether writing and playing relaxing songs can help reduce anxiety in adolescents aged 11-18 with sickle cell disease. About 30 participants will try songwriting and report how it affects their anxiety, mood, and pain. The goal is to see if this creative activ…

This study tests whether two drugs, duloxetine and amitriptyline, can reduce coughing in people with interstitial lung disease (ILD). About 25 adults with a chronic cough for at least 3 months will receive either a low or high dose of one drug or a placebo. The main goal is to se…

This study tests whether Reishi mushroom extract can reduce fatigue and joint/muscle pain in breast cancer patients taking aromatase inhibitors. These side effects often cause patients to stop a helpful medication. The trial will involve 80 adults with ER-positive breast cancer w…

This early study tests whether a mild electrical current applied to the scalp (tDCS) can reduce the number and strength of seizures in people with epilepsy. About 30 adults whose seizures are not controlled by at least two medications will receive the treatment and track their se…

This study tests if using virtual reality (VR) can improve symptoms of non-cardiac chest pain — chest pain that isn't from a heart problem. Ten adults with this condition will try VR sessions, and researchers will measure changes in pain, anxiety, and quality of life using questi…

This study tests whether custom 3D-printed external breast prostheses improve comfort, fit, and emotional well-being for breast cancer patients who had a mastectomy without reconstruction. About 50 adults who have had one or both breasts removed will receive a personalized prosth…

This study looks at whether using a handheld stress management device called CalmiGo, along with usual cardiac rehab, can improve blood vessel health and lower stress in people who recently had a heart attack. About 100 adults will use the device for 12 weeks and have their blood…

This study tests whether injecting lidocaine around the sciatic nerve of the intact leg can reduce phantom or residual limb pain in people who have had a lower leg amputation. About 20 adults with long-term, hard-to-treat pain will receive either the nerve block or a placebo. The…

This study is testing whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain feel better and do more in their daily lives. The app teaches skills to manage pain and improve well-being. Researchers will enroll 300 people across the U.S. to see if the…

This study tests whether a breathing and respiratory muscle training program done at home, with support from a health coach, can help people with non-cystic fibrosis bronchiectasis exercise more and improve lung function. About 50 adults with this chronic lung condition will part…

This study tests whether phone-based health and wellness coaching can reduce stress and improve confidence for caregivers of people waiting for a heart or lung transplant. Thirty adult caregivers will receive coaching sessions and complete questionnaires about their burden and se…

This study tests whether using a computer program (RapidPlan) to plan radiation therapy for prostate cancer leads to fewer side effects than the current method where a human expert creates the plan. About 108 adults with prostate cancer will be randomly assigned to one of the two…

This study looks at how low sodium oxybate, an FDA-approved drug for idiopathic hypersomnia, affects total sleep time in 30 adults aged 18-65. Participants will wear sleep monitors and special earbuds to track sleep. The goal is to see if the drug helps people sleep for long peri…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help ease depression in people with bipolar disorder. Thirty adults aged 18 to 50 will follow the diet for 8 weeks while researchers track mood changes and heart health. The goal is to see if this d…

This study tests if a gentle electrical stimulation on the ear can reduce chronic dizziness. Researchers at Mayo Clinic will give 60 adults with Persistent Postural-Perceptual Dizziness (PPPD) a small device to use at home for 4 weeks. The goal is to see if this non-invasive trea…

This study tests a device called Bioboosti that uses pulsed electromagnetic waves to see if it can improve blood flow to the heart in people with coronary artery disease. About 120 adults who have heart ischemia and cannot have standard procedures like stents or bypass will recei…

This study compares two types of radiation therapy—proton therapy and standard IMRT—given after surgery for endometrial or cervical cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 participants will fill out quality-of-life questionnaires to…

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The trial inv…

This study is testing whether two medications, duloxetine and amitriptyline, can help reduce coughing in people with refractory chronic cough (a cough that lasts over a year and doesn't respond to usual treatments). About 50 adults will receive either the drug or a placebo, and t…

This study looks at whether zavegepant (Zavzpret), a nasal spray already approved for migraines, works well and is safe for people who are also taking CGRP-targeting preventive medications. About 200 adults with 2-8 migraines per month will take zavegepant during an attack and re…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests whether tamsulosin, a drug typically used for prostate problems, can prevent or shorten the time people need a catheter after spine surgery. About 20 adults having certain types of spine surgery will take the drug and be monitored for urinary retention. The goal …

This study looks at whether doing structured breathing exercises can help healthcare workers feel less anxious, stressed, and burned out, and sleep better. About 40 doctors, nurses, and other staff from Mayo Clinic sites will use a mobile app to guide their breathing practice. Th…

This study tests whether giving chemotherapy directly into the bladder at home is safe and works as well as doing it in a clinic. About 40 people with early-stage bladder cancer will receive their usual treatment at home. The goal is to see if home treatment is less disruptive an…

This study tests whether a robotic massage device (EMMA) works as well as a human massage therapist for relieving lower back pain. About 40 adults with lower back pain will receive both types of massage. The main goal is to see if it's possible to run a larger study comparing the…

This study compares two pain medicines—methadone given through an IV and hydromorphone injected near the spine—for women having surgery for gynecologic cancer. About 140 participants will report their pain levels to see which drug provides better relief. The goal is to improve co…

This study tests whether training the muscles used for breathing can help women aged 45-60 with hot flashes. Researchers will measure changes in hot flash frequency, sleep quality, and blood pressure. The goal is to find a simple, time-efficient way to improve symptoms during men…

This study tests if a personalized exercise program before surgery helps people with soft tissue sarcoma recover faster and with less disability. About 30 adults will either follow the exercise plan during standard radiotherapy or receive usual care. The goal is to see if pre-sur…

This study is testing a new type of adjustable skin disk for feeding tubes to see if it helps the skin heal better and causes fewer problems. Researchers at Mayo Clinic will enroll 20 adults who are getting a feeding tube placed. The goal is to see if the new disk is safe and wor…

This study compares an electronic massager called EMMA to a massage from a professional therapist. Researchers want to see if people like the machine as much as a human and if it's practical to use. About 20 adults will try both and share their satisfaction.

This study tests whether using virtual reality (VR) can help reduce pain and the need for strong painkillers in people hospitalized with broken bones. About 100 participants will use VR during their hospital stay. Researchers will measure pain medicine use, hospital stay length, …

This study tests whether training the muscles used for breathing in can improve exercise ability, quality of life, and short-term health outcomes in people who have had a lung transplant. About 30 participants will be enrolled at Mayo Clinic. The goal is to see if this simple, dr…

This study from Mayo Clinic looks at whether stopping opioid use can fix swallowing problems caused by the drugs. Researchers will follow 26 people who are already quitting opioids through a pain rehab program. The main goal is to see how many have their esophageal function retur…

This study tests whether giving methadone as a pill before heart surgery works better than giving it through an IV during surgery to control pain afterward. About 100 adults having planned heart surgery will take part. Researchers will measure how much additional pain medicine pa…

This study looks at whether adding special breathing muscle training to standard cardiac rehabilitation can improve how well the heart and muscles work during exercise in people with heart failure. About 70 adults with heart failure and reduced pumping ability will take part. The…

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve pain from chemotherapy. About 300 participants (patients and their caregivers) will use the app at home. The goal is to reduce nerve symptoms li…

This study looks at whether adding a saltwater rinse (saline irrigation) through a chest tube can improve the standard treatment for people with infected fluid around the lungs (pleural infection). About 60 adults will take part. The goal is to see if this extra step reduces the …

This study tests whether training the muscles used for breathing can improve exercise ability and blood flow in people with heart failure. Researchers at Mayo Clinic will enroll 68 adults who are already on standard heart failure medications. Participants will undergo inspiratory…

This study tests whether a home-based program combining gentle physical activity, mindfulness, and telephone health coaching can reduce fatigue and improve quality of life in people aged 65 and older with multiple myeloma. Participants will use a remote monitoring device and rece…

This study looks at whether eating a whole food plant-based diet can improve sleep apnea and reduce daytime sleepiness. Researchers will measure changes in sleepiness and breathing pauses during sleep in 40 adults. Participants must have mild to moderate sleep apnea and daytime s…

This study tests whether low-dose radiotherapy can ease hand and wrist arthritis pain as well as or better than standard corticosteroid injections. About 165 adults aged 50 and older with moderate to severe hand osteoarthritis will receive one of the two treatments. Researchers w…

This study tests a program called ASCENT that helps cancer survivors manage pain using an educational guide and coaching from community health workers and pain care managers. The goal is to improve pain and reduce the risk of opioid misuse. The study will include 660 adults with …

This study tests if a headband that plays special sounds (acoustic resonance therapy) can improve sleep quality as well as standard cognitive behavioral therapy for people with moderate to severe chronic insomnia. About 60 adults will be randomly assigned to one of the two treatm…

This study looks at whether 12 sessions of Latin dance can improve wellbeing in people who have had a lung transplant. Researchers will measure changes in anxiety, depression, balance, and fear of movement. The study involves 52 participants who are able to walk and have complete…

This study tests whether a diet rich in fermented foods (like yogurt, kimchi, and sauerkraut) is tolerable and can improve quality of life for people who survived a critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation, which …

This early study tests whether a wearable EEG headband (MUSE-S) can help breast cancer survivors manage anxiety and insomnia. About 40 survivors who have had breast cancer in the past 10 years and currently struggle with anxiety and poor sleep will use the headband for guided med…

This study tests a virtual art therapy program for teens and young adults who have had cancer. The goal is to see if it can help with anxiety, depression, stress, and thinking skills. About 30 people aged 10 to 25 who were diagnosed in the past year or finished treatment within 5…

This pilot study from Mayo Clinic tests whether virtual reality (VR) can safely reduce abdominal pain in people with Crohn's disease who are not currently experiencing active inflammation. The study will enroll 15 participants who have ongoing pain despite normal inflammation mar…

This study tests whether a new AI-assisted program, called Reflections: My Story, is practical and acceptable for people with serious illness. The program helps participants create a personal legacy, like a life story, to ease emotional distress. About 40 adults with a high-risk …

This study tests whether a fuzzy compression sock can help wounds heal faster after a leg amputation due to poor blood flow. About 40 adults will either get the special sock or standard care. Researchers will track infections, pain, and how soon a prosthetic leg can be fitted.

This study tests whether a combination of two drugs, neostigmine and glycopyrrolate, can treat severe headaches that sometimes happen after an epidural is placed for labor pain relief. The goal is to see if this treatment can reduce the number of new mothers who need a procedure …

This study tests whether using virtual reality can reduce stomach pain and other digestive symptoms in people with functional dyspepsia. About 30 adults with this condition will try VR sessions and report their symptom changes. The goal is to see if VR offers a safe, drug-free wa…

This study tests whether turning on an extra deep brain stimulation (DBS) electrode in a brain region called the GPe can improve severe insomnia in people with Parkinson's disease. Ten participants aged 40-80 with Parkinson's for 7-20 years and severe insomnia will be enrolled. T…

This study tests if a virtual group therapy program, combining Acceptance and Commitment Therapy (ACT) and compassion-based techniques, can improve psychological well-being in cancer patients. Researchers will enroll 200 adults at Mayo Clinic Arizona who have a cancer diagnosis o…

This study tests whether artificial intelligence in Phonak hearing aids can improve speech understanding for people with hearing loss or cochlear implants. About 500 participants will listen to words and sentences in noisy settings to see if AI noise reduction helps them hear mor…

This study takes leftover breast cancer tissue from patients who still have cancer after initial treatment. Researchers grow these samples in mice and in dishes to create living models of the cancer. These models will be used to test new drug combinations and understand why some …

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study looks at sleep issues in healthy Somali Americans and how they might affect blood pressure. Researchers will measure sleep quality and blood pressure in 240 adults. The goal is to find hidden sleep problems that could raise hypertension risk.

This study is for children and young adults (ages 2 to 21.5) with acute lymphoblastic leukemia or lymphoma who are scheduled to receive the chemotherapy drug calaspargase pegol. The goal is to understand how this drug affects the body's ability to form blood clots. Researchers wi…

This study looks at whether a longer fasting period before an upper endoscopy can lower the chance of stomach contents entering the lungs (aspiration) in people taking GLP-1 receptor agonists, such as Ozempic or Wegovy. Researchers at Mayo Clinic will check the stomachs of 150 ad…

This study uses special MRI scans to map electrical activity in the brain. Researchers will compare scans from healthy volunteers and people with a type of brain tumor called glioma. The goal is to improve how doctors diagnose and monitor brain conditions.

This study compares two methods of collecting bone marrow for bone grafts: one from the hip and one from the shin using the Avitus device. Researchers want to see if the Avitus method produces cells and bone growth factors similar to the standard hip method. The study involves 12…

This study looks at why some women with benign (non-cancerous) breast disease later develop breast cancer. Researchers will examine tissue samples, mammograms, and genetic information from 4,500 women to find patterns that predict cancer risk. The goal is to improve early detecti…

This study tests a new device placed under the scalp that tracks brain activity to forecast seizures in people with drug-resistant epilepsy. Researchers want to see if it's safe and can give early warnings. 12 adults with frequent seizures will wear the device and other sensors f…

This study looks at why insulin fails to properly control fat breakdown in people with upper body obesity. Researchers will test whether the diabetes drug pioglitazone can improve how fat cells respond to insulin. The study involves 64 adults, both non-obese and obese, and aims t…

This study looks at how the body controls blood pressure after a spinal cord injury and whether spinal cord stimulation can improve that control. Researchers will also check how stimulation affects heart function and the immune system. The study involves 80 adults aged 18-50 with…

This early-stage study tests a new type of marker that shows up better on ultrasound for people with breast cancer that has spread to lymph nodes. The marker is placed in the lymph node to help doctors find and remove the right node during surgery. The goal is to see if this mark…

This study aims to learn why high-risk endometrial cancer comes back by analyzing genetic information from 100 participants. Researchers will collect tissue and blood samples to find inherited and cancer-specific genetic changes. The goal is to build a databank for future studies…

This study looks at how tiny organisms in your gut might influence brain tumor growth. Researchers at Mayo Clinic will collect stool, blood, and other samples from 100 people with brain tumors. The goal is to build a sample bank for future research, not to test a new treatment.

This study is testing a small device called a microdialysis catheter that is placed in the brain during surgery to collect fluid samples. The goal is to see if it is safe and can gather useful information (biomarkers) about brain tumors like glioblastoma and metastatic cancer. Ab…

This study aims to find biological markers (biomarkers) that show up in the blood, tissue, or saliva when a person has HPV-related throat cancer, and disappear after successful treatment. Researchers will collect samples from 560 adults with or without the cancer to compare. The …

This study looks at how brain changes relate to speech and language problems in people with progressive apraxia of speech (AOS), a condition that slowly impairs the ability to speak. Researchers will use brain scans and speech tests over time to track these changes. The goal is t…

This study aims to collect tumor samples and medical information from 2000 people with breast cancer that has come back or spread. Researchers will use these samples to study how the cancer changes and responds to treatments. The goal is to better understand the disease and impro…

This study looks at how the heart pumps blood and uses energy in healthy adults of different ages. Researchers will measure heart pressures and blood samples at rest and during exercise. The goal is to better understand normal heart function, not to test a treatment. About 80 hea…

This study aims to find out why people with certain congenital heart conditions, like Tetralogy of Fallot, develop symptoms such as shortness of breath and palpitations, and how their heart structure changes over time. Researchers will use imaging and exercise tests in 300 partic…

This study aims to improve MRI scans for prostate cancer by testing new image-reconstruction methods. Researchers will compare standard and experimental algorithms to see which produces clearer images. About 1000 adults will participate, and no treatment or medication is involved…

This study looks at the fluid made by the pancreas in healthy people. Researchers will collect this fluid during an endoscopy after giving a hormone called secretin. The goal is to learn what normal pancreatic fluid looks like, which can help doctors better understand and treat p…

This study follows 350 adults with stage III-IV melanoma for two years after diagnosis to learn how their quality of life and mental health change. Researchers will also test if a type of talk therapy called cognitive behavioral therapy can help reduce cancer-related stress. The …

This study looks at hair loss in women with breast cancer who are taking hormone therapy (endocrine therapy). While hair loss is a known side effect of chemotherapy, it is less understood with hormone therapy. Researchers will ask 170 women to describe their hair loss symptoms ov…

This study at Mayo Clinic tests new AI image-processing methods (AIR Recon DL and Sonic DL) to see if they can improve MRI quality and shorten scan times for people being screened for prostate or endometrial issues. Sixty adults will receive standard and AI-enhanced scans, which …

This study collects blood and urine samples from 1500 people with bladder cancer. Researchers will use these samples to create better, non-invasive tests for finding bladder cancer early. Participants provide samples once, and no treatment is given.

This study collects medical histories and blood or tissue samples from 500 people with histiocytic disorders to find genetic markers linked to the disease. Researchers will look for specific proteins and changes in immune cells to better understand how these rare conditions work.…

This study looks at how common hormone therapies for breast cancer affect blood sugar control and diabetes risk in postmenopausal women. Researchers will compare women taking aromatase inhibitors, tamoxifen, or no treatment over one year. The goal is to understand if these treatm…

This study looks at whether a special probe can predict who will develop acid reflux after gastric sleeve surgery. Researchers will follow 200 adults to see if measurements taken during surgery can spot early warning signs. The goal is to help doctors prevent or manage this commo…

This study looks at whether recording messages of wisdom and hope can help patients with serious illnesses and their caregivers feel more dignity and support. About 40 adults with chronic or progressive illness will make recordings and answer surveys. The goal is to find where pa…

This study looks at whether taking prescription opioids for chronic pain is linked to changes in the brain's white matter in adults aged 65 and older. Researchers will use MRI scans to measure brain structure in 200 participants over time. The goal is to better understand the lon…

This study tests whether a mobile app can help people with glioma (a type of brain tumor) receive treatment and monitoring at home instead of traveling to a specialist center. The goal is to see if this digital approach is practical and acceptable for patients, especially those w…

This study looks at whether changes in RNA editing can help predict how well people with depression respond to treatment. Researchers at Mayo Clinic will follow 120 adults with unipolar or bipolar depression to track RNA patterns and depression scores. The goal is to better under…

This study looks at whether blood flow in fat tissue differs between healthy younger adults (18-35) and older adults (65-80). Participants will have their fat tissue blood flow measured, provide two small fat samples from the belly, and drink a sugary drink. The goal is to unders…

This study uses a safe, noninvasive light-based technique called fNIRS to measure brain activity in 200 adults with depression, bipolar disorder, or mild cognitive impairment. Researchers will compare brain patterns across groups and link them to symptom severity. The goal is to …

This study is testing whether drinking whole-fat milk can improve cholesterol, blood sugar, and blood vessel function in adults with metabolic syndrome. Researchers will measure changes in blood fats, glucose, and artery health over time. The goal is to understand if whole-fat da…

This study watches how children and their caregivers recover after major cancer surgery using smartwatches and questionnaires. It also looks at blood proteins and metabolites linked to stress. The goal is to find patterns that show how well a child is bouncing back, so doctors ca…

This study tests a new ultrasound technique to look at tiny blood vessels around chronic wounds that won't heal. Researchers want to see if these images match standard wound checks. About 10 adults with diabetic foot or leg ulcers will be scanned. The goal is to learn more about …

This study looks at how your gut and brain work together to control hunger and fullness. Researchers will give 15 healthy adults different food-related sensations (like stomach stretching or tasting food) and use brain scans to see which areas light up. The goal is to better unde…

This study looks at how sex differences may influence the way the body controls blood pressure in people with untreated obstructive sleep apnea (OSA). Researchers will measure blood pressure, artery stiffness, and nerve activity in 60 adults aged 20-70. The goal is to better unde…

This study looks at whether ovarian hormones are linked to aging and Alzheimer's disease in women. Researchers will use brain scans to measure proteins related to Alzheimer's. The study includes women aged 60 and older, including African American women at one site. It aims to und…

This study looks at how often women who have HPV-positive throat cancer, or whose partner has it, get HPV infections in their genital or anal areas. Researchers will compare these rates to similar women without throat cancer. The goal is to better understand the risk of HPV sprea…

This study aims to see if blood samples from cancer patients can be turned into stem cells that mimic how each person reacts to cancer treatments. Researchers will compare cells from patients who had severe side effects to those who did not. The goal is to better understand and e…

This study collects blood, tissue, and health information from up to 20,000 people with pancreas diseases like pancreatic cancer or pancreatitis. Researchers will use these samples and data to better understand these conditions and develop better screening methods in the future. …

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans, brain wave tests, and thinking assessments to learn more about these disorders. The go…

This study is building a large database of people who have had a spontaneous coronary artery dissection (SCAD), a rare type of heart attack. Researchers will look back at medical records and also follow participants forward to learn about risk factors, treatments, and long-term h…

This study looks at how the body's internal clock affects fat tissue in people with and without obesity. Researchers will take small fat samples to measure gene activity over time. The goal is to understand how eating patterns and obesity change these daily rhythms. No treatment …

This study compares noninvasive heart ultrasound (echocardiogram) with invasive right heart catheterization to see if ultrasound can reliably measure heart and lung function. Researchers will study 3,000 people referred for catheterization, measuring heart output and oxygen use d…

This study looks at whether a special MRI technique called magnetic resonance elastography (MRE) can measure stiffness in the heart muscle of people with cardiac amyloidosis. Researchers will enroll 20 adults with this condition to see if the scan is feasible and provides useful …

This study is collecting medical information and biological samples from 15,000 people receiving radiation therapy for cancer at Mayo Clinic. Researchers will analyze how treatment affects side effects, quality of life, and survival. The goal is to improve future care by linking …

This study looks at whether having a baby's first doctor visit and a breastfeeding consultation in one appointment helps mothers breastfeed longer. About 246 new mothers from Mayo Clinic in Wisconsin will take part. Half will get the combined visit, and half will have separate vi…

This study looks at how things like transportation and other social factors make it harder for people with liver or bile duct cancer to get medical care. Researchers at Mayo Clinic will ask 400 adult patients about these barriers. The goal is to understand what gets in the way so…

This study is testing a special PET scan that uses a tracer called 68Ga-FAPI to look for inflammation in the hearts of people with a type of heart failure called HFpEF. The goal is to see if this scan can help doctors better understand and diagnose this condition. About 35 adults…

This study is looking for new genes and blood markers that can help predict who will get arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1000 people, including patients with AVC or unexplained cardiac ar…

This study looks at why some people on a ketogenic diet experience a sharp rise in LDL ("bad") cholesterol. Researchers at Mayo Clinic will test the DNA of 100 adults who have very high LDL on keto to see if specific gene changes are responsible. The goal is to understand the cau…

This study aims to find the most effective brain stimulation settings for people with epilepsy who already have a deep brain stimulation device. Researchers will compare low-frequency and high-frequency stimulation to see which reduces seizures better. About 30 participants will …

This study looks at how often people with metastatic non-small cell lung cancer have trouble sleeping. Researchers will use a simple questionnaire to measure insomnia severity. The goal is to understand how common this sleep problem is in this group, which can help improve future…

This study looks at whether testing people's genes before they start a new medicine can help doctors choose the right drug and dose to avoid side effects. About 66 adults getting a first-time prescription for one of 39 common drugs will be followed for 48 weeks. The goal is to se…

This study collects heart pressure and blood flow data from 50 healthy adults to create a comparison group for a larger registry of people with congenital heart disease. Participants must have no heart conditions, not take heart medications, and meet health criteria. The goal is …

This study sets up Community Living Labs at American Legion Posts to help Black men learn about prostate health and get screened. Community health workers will connect men to doctors and services. The goal is to see if this approach improves access to care and reduces prostate ca…

This pilot study at Mayo Clinic will test whether combining cardiac CT and MRI can better predict which patients with severe mitral regurgitation are at risk for developing heart muscle weakness after valve repair surgery. The goal is to see if this approach is feasible for a lar…

This study looks at the gut microbiome (the bacteria living in your intestines) in people with POEMS syndrome, multiple myeloma, and other plasma cell disorders. Researchers will collect stool samples from 240 participants to compare the types and diversity of gut bacteria. The g…

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers will build a biobank to explore better ways to prevent, detect, and treat cancer. Participants must have a confir…

This study creates a collection of blood, urine, stool, and other samples from up to 9,150 people with cholestatic liver diseases like primary biliary cholangitis and primary sclerosing cholangitis. Researchers will use these samples and health data to better understand how these…

This study watches how the esophagus changes in people getting radiofrequency ablation for Barrett's esophagus with abnormal cells. About 10 adults will have extra measurements during their routine endoscopies. The goal is to gather information that could help doctors predict tre…

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. Participants will attend group meetings led by social workers and complete surveys about their quality of life and mental we…

This study tests whether a smartwatch combined with artificial intelligence can detect early signs of heart damage in people who have had lymphoma or sarcoma. Researchers will monitor 250 survivors over a year using mobile ECGs and the Apple Watch. The goal is to find a simple, c…

This study is a registry that collects information from 10,000 people with blood clots (deep vein thrombosis or pulmonary embolism) treated at Mayo Clinic. Researchers will track how often clots come back, bleeding complications, and survival. The goal is to see how well standard…

This study looks at how multiple sclerosis (MS) damages the autonomic nervous system, which controls things like blood pressure, skin blood flow, and bladder health. Researchers at Mayo Clinic will test 13 people (with and without MS) using simple lab exercises to measure these a…

This study tests new MRI software to see if it can make image-guided ablation procedures safer and more precise. Researchers will compare the new technology to standard MRI in 100 healthy volunteers and patients. The goal is to improve targeting of tumors and assessment of treatm…

This study follows 150 people who need open surgery for complex aortic aneurysms (bulging of the main artery in the belly). Researchers want to see how patients' quality of life changes after the operation. The study does not test a new treatment—it simply collects information to…

This study looks at why fat cells in the belly area don't respond normally to signals that tell them to stop releasing fat. Researchers will give niacin (vitamin B3) to 32 overweight adults and measure how different fat deposits react. The goal is to better understand the biology…

This study tests whether a virtual community health educator (vCHE) can increase referrals to cancer clinical trials for patients and their caregivers. The vCHE is a computer-generated guide that offers personalized, culturally tailored information in English or Spanish. Research…

This study looks at how short-term and long-term exercise affects the immune system of people with slow-growing types of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Researchers want to see if a 12-week exercise program can improve immune function and possibly delay dis…

This early phase trial at Mayo Clinic is studying how two experimental drugs, DFMO and AMXT 1501, change the metabolism of brain tumors (gliomas) in 18 adults. The goal is to measure molecules in the tumor's fluid to understand how these drugs affect tumor growth and survival. Pa…

This study looks at women with a low-risk type of uterine cancer (endometrial cancer) who have very small clusters of cancer cells, called isolated tumor cells, in their sentinel lymph nodes. The goal is to see if these cells are linked to the cancer coming back. Researchers will…

This study is creating a collection of blood samples from people with interstitial lung diseases (ILD) and pneumonia, as well as healthy volunteers. The goal is to build a resource that scientists can use in future studies to find better ways to diagnose and treat these lung cond…

This study looks at how immune cells called T cells change in people with advanced melanoma, lung cancer, or other solid tumors during anti-PD-1 treatment. Researchers will measure specific markers in blood samples to see if they can predict whether the therapy is working or if r…

This study is collecting survey responses from 1,000 people who have had or will have surgery for esophageal cancer or other upper digestive problems. The goal is to create a standard way to measure symptoms and recovery after treatment. The information will help doctors better m…

This study looks at how often patients with blood cancers develop dangerously high ammonia levels after receiving the drug recombinant Erwinia asparaginase. Researchers will monitor 10 children and adults through regular blood tests during their first two treatment cycles. The go…

This study looks at whether a special potato starch supplement can change gut bacteria in people with cirrhosis who have had episodes of confusion (hepatic encephalopathy). Eleven participants will take the starch for 4 weeks, and researchers will measure changes in stool and thi…

This study is observing 120 adults with pulmonary hypertension who are already taking the drug sotatercept at the Mayo Clinic. Researchers will track quality of life, hospital visits, medication changes, and side effects over time. The goal is to understand how well the drug work…

This study tests a new, non-invasive heart scan called magnetocardiography (MCG) to see if it can detect and monitor amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will compare MCG results with standard ECG in 500 adults. The goal is to improv…

This study explores whether specific breathing exercises can boost brain and mental health in people with multiple sclerosis or certain cancers, as well as their caregivers. Researchers will use brain scans to measure oxygen delivery and fluid flow in the brain. The goal is to un…

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way special cells in the pancreas work in people with type 1 or type 2 diabetes. Researchers will measure hormone levels during fasting and high blood sugar. The goal is to understand…

This study looks at whether placing a small device called an Ommaya reservoir under the scalp during a brain tumor biopsy can help doctors safely collect fluid samples over time. About 20 people with suspected or known brain tumors will take part. The goal is to see if this appro…

This study collects blood and bone marrow samples from 80 adults with newly diagnosed acute myeloid leukemia (AML) who are receiving azacitidine plus venetoclax. Researchers will analyze the immune profile to understand how the body responds to treatment. The goal is to use this …

This study explores whether a virtual robot assistant can help Black men recently diagnosed with prostate cancer get the support and information they need. Researchers will work with patients and doctors to build and test the tool, focusing on how well it is accepted and used. Th…

This study is a registry that will track 200 people with spontaneous intracranial hypotension (low spinal fluid pressure) caused by a specific type of leak called a CSF-venous fistula. Researchers want to see how well a procedure called paraspinal vein embolization works to treat…

This study collects blood and spinal fluid samples from 100 people with ALS or similar neurodegenerative disorders. The samples are stored in a biorepository for future research to find biomarkers. Participants include patients and their spouses or partners. The study does not te…

This study looks at how healthy bone marrow plasma cells use a nutrient called glutamine. Researchers will give a special labeled form of glutamine to 20 healthy adults aged 18-60, then take a small bone marrow sample to measure how it's processed. The goal is to test if this met…

This study tracks how adults with curved spines move and walk before and after corrective surgery. About 50 participants will wear motion sensors and be tested in a lab. The goal is to better understand changes in function and stability, not to test a new treatment.

This study is for 100 adults having brain tumor surgery. During the operation, doctors will place a small device called an Ommaya reservoir under the scalp. This device allows them to safely collect spinal fluid samples over time. The goal is to study these samples to find better…

This study looks at how gender-affirming hormone therapy changes muscle function and energy use in transgender and gender-diverse adults. Researchers will measure muscle metabolism and physical fitness in 24 people who have been on hormone therapy for at least 10 months. The goal…

This study aims to understand why some cancer patients develop heart issues after chemotherapy while others do not. Researchers will collect blood samples from 1,000 adults who have had chemotherapy for any type of cancer, especially those who developed heart problems or are at h…

This study looks at how the body's immune cells react to a new type of cancer vaccine called a neoantigen vaccine. Researchers will collect blood samples from 24 people with solid tumors or healthy volunteers to study immune responses. The goal is to learn how to better grow and …

This study aims to understand why fat tissue in the belly area doesn't respond normally to signals that 'turn on' fat cells in people with obesity. Researchers will measure how fat is released from different parts of the body in 24 adults with and without excess weight. The goal …

This study looks at how well African American and rural White men understand genetic information related to prostate cancer. Researchers will use an educational video and surveys to measure genetic literacy and knowledge. The goal is to help men make more informed decisions about…

This study tests whether taking the probiotic Lactobacillus rhamnosus GG (LGG) can prevent or reduce changes in gut bacteria caused by common acid reflux medications (PPIs). Researchers will compare stool samples from 30 healthy adults taking a PPI plus either LGG or a placebo. T…

This study collects bile and bile duct cells from people with Primary Sclerosing Cholangitis (PSC) and healthy volunteers. Researchers will grow these cells into mini-organs called organoids to better understand how PSC progresses and how bile duct cancer develops. The goal is to…

This study looks at how well blood flows through the tiny vessels of the heart in people who have had a spontaneous coronary artery dissection (SCAD). Researchers will use a special ultrasound with contrast dye to measure blood flow and blood pressure changes during stress. The g…

This study enrolls 30,000 people without pancreatic cancer but at higher-than-average risk due to family history or genetic mutations. Researchers will collect blood and tissue samples over time to find ways to detect pancreatic cancer earlier, when it may be more treatable. The …

This study looks at how the gut microbiome (the bacteria living in your digestive system) might influence how well cancer treatments work. Researchers at Mayo Clinic will collect samples from 3000 cancer patients undergoing therapy or stem cell transplants. The goal is to find li…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis or infection in the ICU. The new method adjusts the dose based on the patient's kidney function using doses already available in hospitals. The main goal is to see if doctors and nurs…

This study aims to understand how the autonomic nervous system—which controls things like blood pressure, skin blood flow, and bladder health—is affected after spinal cord injury. Researchers will perform lab tests and have participants wear a smartwatch to track skin sweat, hear…

This study looks at how opioids impact the diaphragm, the main muscle used for breathing. Researchers will measure changes in diaphragm stiffness in adults having leg or hip surgery. The goal is to understand how opioids affect breathing strength, not to provide a treatment.

This study tests a conversation aid that helps lung cancer patients and their doctors make treatment decisions together. About 100 patients with advanced non-small cell lung cancer will use the tool during appointments to see if it improves shared decision-making and satisfaction…

This study looks at how two blood conditions—monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)—affect the bone marrow's ability to fight infections. Researchers will compare bone marrow samples from 50 participants, including people with MBL, people wit…

This study looks at stomach fluid from newborns to see if it can predict which babies will need breathing support for more than 6 hours. Researchers will collect fluid during routine care and use a special algorithm to make predictions. The goal is to improve early detection of r…

This study looks at genetic changes in cancer cells from Indigenous American people in the Southwest. The goal is to learn more about these cancers to improve screening and treatment. Researchers will enroll 300 adults who have or had cancer and identify as Indigenous American. P…

This study looks at how the way doctors act and talk to cancer patients during radiation treatment affects their distress levels. Researchers will ask 5,000 patients about which physician behaviors help or hurt their emotional well-being. The goal is to learn how to improve patie…

This study tests whether a deep brain stimulation (DBS) system already implanted in the brain can accurately detect seizures in 5 adults with drug-resistant epilepsy. Researchers will compare the device's recordings to standard video-EEG monitoring in a hospital setting. The goal…

This study uses brain scans to measure tau protein buildup in people with Progressive Supranuclear Palsy (PSP), a rare brain disorder. Researchers will track how tau levels change over time in 332 participants aged 35 and older. The goal is to better understand the disease, not t…

This study looks at blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. The goal is to learn how the immune system reacts to these treatments. No new therapy is being tested; instead, researcher…

This study tests whether a camera and computer program can measure how severe delirium is in ICU patients over age 50. Researchers will compare the camera's readings with standard tests done by staff. The goal is to create a tool that is easier and more accurate for tracking deli…

This study surveys up to 5,000 people who have been treated for adolescent idiopathic scoliosis, along with their families. The goal is to understand what influences the choice between observation, bracing, or surgery. Researchers will use the results to create a decision aid tha…

This study is testing a mobile app called Vigilant to help monitor side effects in 100 people with skin cancer or melanoma who are starting a specific type of immunotherapy. Participants will use the app to report symptoms, and researchers will see how well it works for tracking …

This study looks at a program designed to help people in Minnesota who have been injured or become ill keep their jobs or return to work. About 1000 adults who live and work in Minnesota will take part. The program connects workers with early support and resources to reduce long-…

This study looks at how the hormone glucagon influences insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or glucose to 60 participants and measure changes in insulin production and sugar processing. The goal is to better understand…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…

This study looks at how well the heart works during exercise compared to rest in people with congenital heart disease. Researchers will use special catheters to measure blood flow and pressures while participants exercise. The goal is to find hidden heart issues that standard res…

This study aims to find out if certain substances in urine and blood can help measure how severe kidney disease is in people with early autosomal dominant polycystic kidney disease (ADPKD). Researchers will collect samples from 60 participants aged 15 to 40 and use MRI to measure…

This study looks at how different types of fat affect how muscles respond to insulin. Healthy adults will receive infusions of palm oil or a fat emulsion through a tube into the small intestine overnight. Researchers will then take muscle samples to see how the fats are processed…

This study aims to find out how many people have non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH. Researchers will use advanced MRI scans to diagnose the condition in 800 adults from Olmsted County, Minnesota. Participants will be followed over time to t…

This study is testing a simple decision aid to help older adults (60+) and their doctors have better conversations about end-of-life care in the emergency department. The goal is to make these talks more comfortable and routine. About 230 participants will give feedback to improv…

This study tests a new screening program for people at high risk of pancreatic cancer. Participants aged 50-85 with recent diabetes and a high risk score will get regular CT scans analyzed by artificial intelligence, plus blood tests. The goal is to see if this approach is practi…

This study follows 700 adults having curative surgery for Cushing syndrome to understand how long it takes for the body's natural hormone system to recover. Researchers will track symptoms of hormone withdrawal and quality of life. The goal is to find factors that predict faster …

This study tests a new neck-strengthening device called TopSpin360 in 60 junior hockey players. Researchers want to see if using the device can increase neck strength and improve measures of brain function, like reaction time and brain wave activity. The goal is to learn more abo…

This study is testing a blood test called DiviTum TKa to see if it can predict when hormone-receptor-positive (HR+) metastatic breast cancer stops responding to treatment. About 100 people starting standard therapies (endocrine therapy with or without a CDK4/6 inhibitor) will giv…

This study aims to see if voice recordings from smartphones can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using a Mayo Clinic app. No treatment is given—the goal is simply to gather information for future AI mode…

This study from Mayo Clinic interviews 20 breast cancer patients who are currently or recently finished radiation therapy. The goal is to understand the physical, emotional, and social effects of radiation dermatitis (skin irritation from radiation). No new treatments are tested;…

This study follows 200 people with sinonasal cancer to see how their disease progresses, how well treatments work, and how their quality of life changes over time. Researchers will also analyze tumor tissue to understand the genetic makeup of these cancers. The goal is to gather …

This study aims to see if a special ultrasound technique can accurately measure the forces produced by the diaphragm, the main breathing muscle. Researchers will compare this new method with standard breathing tests in 24 healthy adults. The goal is to develop a simpler, non-inva…

This study looks at why adults who carry extra weight in their belly area process insulin differently than lean people. Researchers will measure how fat is released from different parts of the body in 48 overweight or obese volunteers. The goal is to better understand the link be…

This study looks at why some people with end-stage liver disease are less likely to be listed for or receive a liver transplant. Researchers will track 100 patients to see who gets on the waiting list and who gets a transplant. The goal is to find ways to make the process fairer …

This study uses mild electrical stimulation on the skin of the lower back to measure how well the spinal cord and leg muscles work in 30 children and teens with spina bifida. Researchers aim to better understand movement problems, not to treat them. Participants will have tests o…

This study uses a blood test to measure organ damage and immune system changes in 1,000 people with sepsis. Researchers want to see if this test can predict survival and how long patients stay in the ICU. The study does not provide a new treatment, but aims to better understand t…

This study aims to find the specific genes and mutations that cause rare, inherited forms of kidney stone disease. Researchers will analyze DNA from up to 6,000 participants to understand how these genetic changes lead to stones. The goal is to use this knowledge to develop bette…

This study watches how the body controls blood pressure after a spinal cord injury. Researchers will track changes over time to see if they can predict future medical issues. About 18 adults with recent or long-term injury will take part. The goal is to better understand risks, n…

This study tests whether a live video connection to a newborn specialist (neonatologist) can improve survival and reduce serious health problems in at-risk babies born in community hospitals. About 950 babies and their doctors will take part. The main goal is to see if this appro…

This study aims to find normal levels for a new blood and urine test that looks for DNA markers of cancer. Researchers will collect samples from 10,000 adults without known cancer to establish a baseline. The goal is to improve future cancer screening methods.

This study aims to understand why some people develop long-lasting low blood cell counts (cytopenia) after CAR-T therapy for multiple myeloma or certain lymphomas. Researchers will analyze participants' genes to find changes that might increase this risk. The goal is to better pr…

This study looks at whether drinking beetroot juice (which contains nitrate) before sleep can change how well you sleep and how your blood vessels and nerves work at night. It involves 60 healthy adults in two age groups (18-35 and 65-80). The goal is to understand the body's nig…

This study looks at how focused ultrasound affects the fluid around brain tumors. Six adults having brain tumor surgery will have tiny catheters placed to collect samples from areas treated and not treated with ultrasound. The goal is to understand how ultrasound changes the tumo…

This study uses robotic biopsies to collect tissue samples from people with suspected or high-risk lung cancer. The goal is to analyze the samples for genetic changes that might help diagnose cancer and build a databank for future research. About 40 adults scheduled for a standar…

This study looks at how the body handles oxidative stress in people with early-stage autosomal dominant polycystic kidney disease (ADPKD). Researchers will measure markers of damage and antioxidant activity in blood and urine, and use MRI to measure kidney size. The goal is to fi…

This study looks at how insulin and glucagon interact to control blood sugar levels when people haven't eaten. Researchers will compare people with normal blood sugar and those with prediabetes to better understand what goes wrong. The goal is to learn more about fasting glucose …

This study aims to find gene changes that cause spontaneous coronary artery dissection (SCAD), a condition where blood vessels in the heart tear on their own. Researchers will analyze DNA from 2000 people who have had SCAD, along with some family members. The goal is to better un…

This study aims to find genetic heart problems that might explain why some people with epilepsy die suddenly. Researchers will test 600 adults aged 18-50 with epilepsy, seizures, or related events, plus their blood relatives. They use advanced gene sequencing to look for known he…

This study looks at how long-term inflammation impacts muscle function and how older adults respond to exercise. Researchers will measure muscle protein building rates in 120 older participants. The goal is to better understand age-related muscle decline, not to test a treatment.

This study enrolls 5,000 people at high risk for pancreatic cancer to collect blood, pancreatic juice, and medical images over 10 years. Researchers will use these samples to develop and validate tests for early detection, including AI-assisted analysis. Participants must be 18 o…

This study tests a new, non-invasive way to measure blood flow in the legs using an air-filled bladder placed under a compression cuff. Researchers want to see if this method can help detect deep vein thrombosis (DVT) more easily. About 500 adults who recently had a leg ultrasoun…

This study places cancer patients in special hospital rooms equipped with cameras, microphones, and temperature sensors. The goal is to see if these tools can help nurses and doctors detect early signs of confusion, falls, sleep trouble, or mood changes. About 134 patients and th…

This study aims to identify and distinguish two different types of Progressive Apraxia of Speech, a condition that affects a person's ability to speak clearly. Researchers at Mayo Clinic will use clinical imaging and testing on 47 participants to better understand these speech pr…

This study looks at how people with spontaneous coronary artery dissection (SCAD) and fibromuscular dysplasia (FMD) respond to different types of exercise. Researchers will measure changes in blood pressure, breathing, and symptoms during and after aerobic and resistance exercise…

This study is looking at a protein called TRPC6 in the blood to see if it can predict which breast cancer patients will develop heart problems from chemotherapy. Researchers will collect blood samples from 200 patients to study genetic changes linked to heart damage. The goal is …

This study uses advanced genetic testing (next generation sequencing) to look for early warning signs of pre-myeloid cancers and bone marrow failure in 2000 people. Participants have certain blood abnormalities or genetic markers that may increase their risk. The goal is to bette…

This study aims to learn how the trillions of tiny organisms living in and on our bodies (the microbiota) influence health and disease. Researchers at Mayo Clinic will collect samples from 5,000 adults to compare the types and amounts of these organisms. The goal is to better und…

This study looks at how common low vitamin D levels are in African American men with prostate cancer, and whether correcting those levels can improve immune function. Researchers will measure vitamin D and immune cells in blood samples before and after supplementation. The goal i…

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study compares two methods for double lung transplant: doing the surgery without a heart-lung machine (off-pump) versus using a special support machine called VA ECMO. The goal is to see which method leads to fewer serious lung problems after surgery. About 228 adults gettin…

This study looks at whether mindfulness and meditation techniques can help mothers of premature babies in the NICU produce more breastmilk and feel less stressed. About 40 mothers will learn mindfulness practices and researchers will measure milk volume, stress hormones, and bond…

This study is creating a large registry of up to 100,000 women with Functional Hypothalamic Amenorrhea (FHA), a condition where the body stops producing enough estrogen due to stress, low weight, or excessive exercise. Researchers will track participants over time using questionn…

This study explores the link between physical activity and thinking skills (like memory and attention) in people who survived cancer as teens or young adults. Researchers will use computer-based brain games to measure cognitive performance. The goal is to understand how exercise …

This study collects cerebrospinal fluid (the liquid around the brain and spine) from 400 adults with brain tumors. Researchers will analyze these samples to find biomarkers—natural signs that show how a tumor is behaving. The goal is to help doctors diagnose, monitor, and treat b…

This study looks at how common sleep apnea is in Somali-American adults and how it affects their heart health. Researchers will compare 600 Somali, African, Asian, and European participants to find genetic and physical risk factors. The goal is to better understand sleep problems…

This study explores whether a special MRI technique can detect changes in muscle and connective tissue after hands-on therapy (Tuina) for myofascial pain. About 78 adults with chronic low back pain will be randomly assigned to receive Tuina therapy or standard home care. Research…

This study looks at how sleep apnea changes fat tissue and whether those changes increase the risk of heart disease. Researchers will take small fat samples from the belly and thigh of 120 adults with sleep apnea. The goal is to understand the link between sleep apnea, fat tissue…

This study looks at whether the standard A1C blood sugar test is accurate for people with type 2 diabetes who have a Left Ventricular Assist Device (LVAD). Researchers will compare A1C results with data from a continuous glucose monitor (CGM) worn for 3 months. The goal is to see…

This study looks at how losing a lot of weight and keeping it off changes the way the body breaks down fat in response to insulin. Researchers will measure fat tissue inflammation and insulin's ability to control fat release in 30 people before and after bariatric surgery. The go…

This study looks at how people feel and function after two different surgeries for bladder cancer: partial cystectomy (removing part of the bladder) and radical cystectomy (removing the whole bladder). Researchers will compare quality of life and urinary symptoms between the two …

This study looks at why older adults respond differently to strength training. Researchers will track 300 people aged 65 and older who are at risk for mobility problems. Participants will do progressive resistance training, and scientists will measure changes in physical function…

This study looks at how renin, a protein in the blood, changes when the heart-lung machine is used during open heart surgery. Researchers will measure renin levels in 100 adults before, during, and after surgery. The goal is to see if renin can help doctors decide when to give me…

This study at Mayo Clinic aims to test two new imaging methods to measure the strength and movement of the aorta, the body's main artery. Researchers will compare results from 30 people with and without an abdominal aortic aneurysm. The goal is to better understand how the aorta …

This study aims to learn more about Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed, causing pain and nausea. Researchers will use questionnaires and a breath test to measure symptoms and stomach function in 30 adults with GAV…

This study looks at how inflammation in fat tissue is connected to fat buildup in the liver and insulin resistance in people with severe obesity. Researchers will measure liver stiffness and markers of inflammation in 60 adults who are having gastric bypass surgery. The goal is t…

This study is collecting blood and tissue samples from 200 people who are having a procedure to treat a narrowed carotid artery. The goal is to gather information about the plaque that builds up in the artery. No new treatments are being tested. The study simply aims to help rese…

This study is a patient registry for people with or suspected of having 24-hydroxylase deficiency, a rare condition that affects calcium levels. Researchers at Mayo Clinic will collect health information from up to 600 participants to better understand the disease's symptoms and …

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) changes how the stomach works. Researchers will measure stomach emptying and capacity in 16 adults who already have the device. The goal is to understand the connection, not to test…

This study looks at whether a video and a special doctor's visit can help young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start planning their future medical care early. The goal is to see if these tools are helpful and easy to use. About 50 people…

This study from Mayo Clinic is watching how a blood test that can detect many types of cancer is used in everyday doctor visits. About 500 adults who have already had or are scheduled for this test will take surveys about their feelings, satisfaction, and the costs that follow. T…

This study looks at how often people who take proton pump inhibitors (PPIs) for acid reflux develop a condition called small intestinal bacterial overgrowth (SIBO). Researchers will use breath tests and symptom questionnaires to measure this in 50 adults. The goal is to better un…