Could antidepressants quiet a stubborn cough?
NCT ID NCT05110144
First seen Jan 21, 2026 · Last updated May 21, 2026 · Updated 13 times
Summary
This study is testing whether two medications, duloxetine and amitriptyline, can help reduce coughing in people with refractory chronic cough (a cough that lasts over a year and doesn't respond to usual treatments). About 50 adults will receive either the drug or a placebo, and their cough frequency will be measured over 8 weeks. The goal is to see if these drugs can ease this frustrating symptom.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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