Mayo Clinic

This study follows 80 babies with a severe birth defect called congenital diaphragmatic hernia (CDH). Some will have a special surgery (FETO) while still in the womb to help their lungs grow. Researchers want to see if these babies survive and have fewer health problems compared …

This study tests whether spironolactone, a medication often used for heart failure, can reduce stiffness in the aorta (the main artery) in people with a thoracic aortic aneurysm. The goal is to see if it can help control the disease and lower the risk of dangerous complications. …

This study tests whether adding a lab-modified virus (VSV-IFNβ-NIS) to standard immunotherapy drugs (ipilimumab and nivolumab) can shrink tumors in people with advanced or metastatic clear cell kidney cancer. About 18 adults will receive the combination treatment. The goal is to …

This study tests a smartphone app designed to help people with bipolar disorder who also struggle with alcohol or drug use. Researchers at Mayo Clinic want to see if the app is easy to use and acceptable to patients, and whether it can reduce cravings and substance use. The study…

This study tests whether a nurse-led education program can reduce hospital readmissions for patients with conditions like heart failure, COPD, or obesity who are having hip or knee replacement. About 300 participants will either receive the extra nurse support or standard care. T…

This study tests a new drug called ABBV-383 in 38 adults with Waldenström macroglobulinemia, a rare blood cancer that has come back or stopped responding to prior treatments. The drug is a monoclonal antibody designed to block cancer growth. The trial has two phases: first, findi…

This study looks at whether giving the drug goserelin as a shot in the upper buttock works as well as giving it in the belly to suppress ovarian function in premenopausal women with hormone-positive breast cancer. About 98 women who are already getting monthly belly injections wi…

This study tests whether lisinopril, a common blood pressure medication, can reduce high red blood cell counts in people with polycythemia (a condition causing thick blood). Researchers will measure changes in hemoglobin, hematocrit, and erythropoietin levels in 30 participants o…

This early study tests whether a patient's own stem cells, taken from their fat, can safely prevent bile duct complications after a living donor liver transplant. About 20 adults with end-stage liver disease will receive these cells during their transplant surgery. The main goal …

This study tests whether using a mild electrical device to stimulate the vagus nerve, along with nicotine patches, can help people stop smoking. About 150 adults who smoke at least 10 cigarettes a day and want to quit will receive 12 weeks of treatment. Success is measured by whe…

This study compares two standard medicines, sodium bicarbonate and THAM, used to treat metabolic acidosis (too much acid in the blood) during heart surgery. About 250 adults having heart surgery with a heart-lung machine will take part. The goal is to see if both drugs work equal…

This study tests whether the drug Bimzelx (bimekizumab) can improve skin symptoms in adults with pityriasis rubra pilaris, a rare condition causing red, scaly patches. About 12 participants will receive the drug for 24 weeks, and doctors will measure how much the skin clears. The…

This study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted to the hospital with heart failure will be randomly a…

This study tests whether adding the drug axatilimab to standard care can prevent graft-versus-host disease (GVHD) in blood cancer patients receiving a stem cell transplant from a donor. GVHD occurs when donor cells attack the patient's body, causing symptoms like skin rash, dry e…

This study tests whether a special PET scan (FET PET/CT) can better locate tiny pituitary tumors that cause Cushing disease. About 50 adults with confirmed Cushing disease who are scheduled for surgery will receive the scan before their operation. The results will be compared to …

This study aims to find protein markers in urine and blood that can help doctors identify different types of kidney cancer without needing a tissue biopsy. Researchers will analyze stored urine samples and collect blood from 300 patients before and after kidney surgery. The goal …

This study tests if a smartphone app can analyze voice patterns to help diagnose and track myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Researchers will compare voice samples from 40 people with ME/CFS and those without. The goal is to find unique voice signatures…

This study tests a new digital device that measures how clearly you see. Researchers will compare the device's results to standard eye exams. About 150 adults from an eye clinic will take part. The study also collects voice recordings of letters to improve speech recognition for …

This study tests three new methods to diagnose Barrett's esophagus and esophageal cancer: an AI tool that predicts risk, a simple sponge-on-a-string test, and nurse navigation to help patients complete screening. About 1,010 adults at higher risk will be enrolled. The goal is to …

This study tests whether taking low-dose aspirin can reduce inflammation and prevent endometrial cancer in postmenopausal women who have certain changes in their uterine lining. About 25 women will be randomly assigned to take aspirin or not, and researchers will measure inflamma…

This study looks at whether offering self-collection for cervical cancer screening and HPV vaccination in places like the emergency department can help more women get tested and vaccinated. It involves 100 women aged 18-65 who are eligible for screening or vaccination. The goal i…

This study tests if a numbing injection near certain neck nerves, given before heart bypass surgery, can prevent a common complication called atrial fibrillation (an irregular heartbeat). About 450 adults having bypass surgery will receive either the nerve block or a placebo. The…

This study tests if health and wellness coaching helps people with papillary or follicular thyroid cancer follow their treatment plans and live healthier lives. About 20 adults who have had thyroid surgery and take levothyroxine will receive coaching sessions. The goal is to see …

This study tests a virtual reality assistant (ViRA) designed to help Black men who have just been told they have prostate cancer. The ViRA offers emotional support, education, and help finding resources for daily needs like food and housing. Researchers will see if using the ViRA…

This study looks at whether taking tranexamic acid pills after hip replacement surgery can reduce pain, swelling, and help people walk sooner. About 101 adults having their first hip replacement will take the drug or a placebo for a few days after surgery. The goal is to see if t…

This study tests whether THC alone or combined with CBD can improve sleep in people with solid organ cancer who have insomnia. About 69 participants will receive either THC, a 1:1 mix of THC and CBD, or a placebo. The goal is to see if these cannabis-based treatments help ease in…

This study compares two common shoulder replacement surgeries—anatomic and reverse—for people with shoulder arthritis and an intact rotator cuff. About 108 participants will be randomly assigned to one surgery and followed for a year to measure pain, function, and quality of life…

This study tests whether taking dronabinol (a synthetic cannabis-like drug) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. T…

This study tests whether daily light therapy (phototherapy) can reduce behavioral and psychological symptoms like agitation in people with dementia. Researchers will enroll 70 adults with dementia who are admitted to specific hospital units. The main goal is to see if the 5-day l…

This study tests whether dry needling with electrical stimulation can improve sleep quality, reduce leg movements, and ease symptoms in people with restless legs syndrome. Researchers will track changes using sleep trackers and questionnaires. The study aims to enroll 20 adults a…

This study tests whether a program called Meaning-Centered Psychotherapy is practical and helpful for stem cell transplant survivors and their caregivers. The program focuses on helping pairs stay connected to what matters, cope with tough experiences, and communicate better duri…

This study tests if guided meditation using the Muse headband can help people sleep better, feel less stressed, and think more clearly. Researchers will track sleep patterns and mood in 40 adults with normal or mildly impaired thinking. Participants will use the headband at home …

This study looks at whether adding a neutral shoe insert to standard physical therapy can reduce pain and improve function in people with long-term lateral hip pain (greater trochanteric pain syndrome). About 36 adults with hip pain lasting over 3 months will be randomly assigned…

This study compares a physical activity program to a health education program to see if exercise can improve memory and attention in Hispanic women aged 50 and older who have been treated for early-stage breast cancer. Researchers will measure changes in thinking skills and brain…

This study tests whether an artificial intelligence virtual assistant (AIVA) can help plastic surgery patients by reducing the number and length of phone calls to the clinic. Researchers will track phone calls and satisfaction among 200 adult patients at Mayo Clinic Florida. The …

This study aims to understand how resistance exercise (like lifting weights) improves the way muscles use sugar and respond to insulin. Researchers will measure how muscles build proteins in response to insulin. The study involves 16 sedentary adults who are weight-stable and not…

This study aims to see if placing electrodes exactly over the ulnar nerve matters for stimulating hand muscles. Researchers will compare using ultrasound versus measuring wrist width to find the nerve. About 40 English-speaking adults without nerve or wrist problems will take par…

This study uses a special PET scan to look for signs of inflammation in the brains of people with Post-COVID syndrome (Long COVID). Researchers want to see if this imaging method can help understand the condition better. Ten adults who had COVID-19 and are now experiencing long-t…

This study will check how well pulse oximeters measure oxygen in the blood by comparing their readings to actual blood samples. About 20 healthy adults, including people with dark skin, will take part. The goal is to see if these devices work accurately for everyone.

This study tests a special ultrasound technique to measure how stiff brain tumors and healthy brain tissue are during surgery. Researchers will collect data from 30 adults having brain tumor removal to see if this method can help guide future surgeries. The goal is to learn, not …

This study looks at 100 patients having planned brain surgery to clip an aneurysm. Some take daily aspirin, others do not. Researchers will track bleeding during surgery and on CT scans afterward to understand the risks. The goal is to help doctors decide whether to stop or conti…

This study looks at how a cannabis-based drug (Dronabinol) affects blood pressure and heart function in healthy adults aged 21-40 who use cannabis occasionally. Researchers will measure blood pressure, heart rate, and nerve activity to understand the body's response. The goal is …

This early study tests if a tiny device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the microperfusion catheter placed temporarily during their operation. The goal is to see if the device works and is safe, not…

This study looks at how chemotherapy drugs for gastrointestinal cancer can damage blood vessels, causing chest pain or heart problems. Researchers will use a device called EndoPAT to measure blood vessel function in 60 patients before, during, and after treatment. They will also …

This study looks at whether people with spontaneous coronary artery dissection (SCAD) feel more comfortable talking to an AI avatar instead of a human clinician before their appointment. About 150 patients will try the avatar and then answer questions about their satisfaction. Th…

This study looks at how long the drug calaspargase pegol stays at effective levels in the blood of children with acute lymphoblastic leukemia or lymphoma. Researchers will measure drug activity and check if higher levels are linked to more side effects. About 20 children will tak…

This study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood in women aged 45 to 60. Researchers will compare heart function between women using MHT and those who are not. The goal is to better understand the relationship between menopause, h…

This study will observe 600 adults with heart valve disease who are scheduled for valve procedures. Researchers want to understand how changes in lung blood vessels affect heart function and recovery. The goal is to find patterns that predict improvement in tricuspid regurgitatio…

This study asks 25 Black women aged 45+ with a uterus how they feel about using a DNA test on vaginal fluid to find endometrial cancer early. Participants will have a 30-minute virtual interview to share their thoughts. The goal is to understand if this test is acceptable for fut…

This study compares a new heart test called magnetocardiography (MCG) to the standard ECG in 100 adults with Long QT syndrome and atrial fibrillation. The goal is to see if MCG can more accurately predict who will have complications during treatment with a heart medication. Parti…

This study looks at how a specific gene change (rs7903146) affects the body's ability to produce insulin and control blood sugar. Researchers will give 80 healthy adults a drug that blocks a hormone called GLP-1 to see how their pancreas responds. The goal is to understand why th…

This study tests a new device that records brain activity and delivers small electrical pulses to prevent seizures in people with epilepsy that doesn't respond to medication. The device is used externally (not implanted) in a hospital setting. The goal is to see if the system can…

This study looks at how fat tissue in the upper body reacts after a meal, comparing normal-weight people to those with obesity. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue works, not…

This study looks at how insulin affects muscle, blood, and the body in people with type 1 diabetes. Researchers will measure protein changes when insulin is low and blood sugar is high. About 70 adults with type 1 diabetes will take part. No treatment is tested; the goal is to le…