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Can a simple ultrasound tell surgeons where tumor ends and healthy brain begins?

NCT ID NCT06630338

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 17, 2026 · Updated 4 times

Summary

This Mayo Clinic study will test whether a special ultrasound technique, called shear wave elastography, can measure how stiff brain tumors are compared to healthy brain tissue during surgery. Researchers will enroll 30 adults with newly diagnosed or recurrent brain tumors. The goal is to see if this method is practical and could one day help surgeons decide exactly how much tissue to remove.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a new tool that helps surgeons better distinguish tumor tissue from healthy brain during operations, potentially improving tumor removal accuracy.
What could go wrong
This is a very early feasibility study with only 30 participants. It is not designed to test treatment outcomes, and the results may not translate into direct patient benefits or change surgical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2027

An estimate. Start dates often move.

Expected to finish

Jun 2034

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults \>= 18 years with a brain tumor diagnosis that will undergo brain surgery with tissue resection as standard of care.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must be at least 18 years old. * Patients must have planned surgery for resection of a newly diagnosed or recurrent brain tumors. * Patients with tumors located in the brain cortex or superficial white matter in which introduction of the ultrasound probe is straightforward and does not pose a risk for intraoperative complications. * Patients must have a Karnofsky performance status ≥ 60%. * Patient or legally authorized representative (LAR) willing to provide written informed consent. Exclusion Criteria: * Patients with deep-seated brain tumors in which introduction of the ultrasound probe poses an increased risk. * Patients with a history of any brain infections. * Patients with implanted devices. * Patients with any other neurological/neurosurgical disease that could affect tissue stiffness. * Patients with any other structural brain defect that could affect tissue stiffness.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm primary brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain neoplasm Brain tumor Recurrent brain neoplasm Recurrent brain tumor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

    Contact Email: •••••@•••••

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