Mayo Clinic

This study tests a new treatment for Multiple System Atrophy (MSA), a rare and deadly brain disease. Researchers are giving patients their own stem cells through a spinal tap to see if it can slow the disease. The trial involves 71 adults aged 30-70 who can still walk without hel…

This study compares two treatments for eosinophilic esophagitis (EoE), a condition that causes swelling and scarring in the esophagus. Researchers will give 60 adults either swallowed budesonide (Eohilia) or injected dupilumab (Dupixent) for 12 weeks to see which better improves …

This study tests whether a precise form of radiation called proton therapy works as well as standard X-ray radiation after surgery for head and neck cancer. About 174 adults with newly diagnosed head and neck cancer will receive either proton or X-ray radiation. The goal is to se…

This study tests a shorter, higher-dose radiation schedule given before surgery for soft tissue sarcoma in the arms, legs, or trunk. The goal is to see if this approach affects wound healing after surgery. About 120 adults with localized, removable sarcoma will take part.

This study looks at how well ablation therapy (using heat or light to destroy abnormal cells) works for people with Barrett's esophagus, a condition that can lead to esophageal cancer. About 600 participants who have or qualify for this treatment will be followed to see if the ab…

This study tests a new treatment for ALS, a disease that weakens muscles over time. Researchers take stem cells from a patient's own belly fat, grow them, and inject them into the fluid around the spine every 3 months for a year. The goal is to see if this is safe and can slow do…

This study tests a special low-calorie, high-protein tube feeding formula in 12 obese adults who rely on tube feeding for most of their nutrition. The goal is to see if it helps them lose weight while keeping muscle mass and improving blood pressure, blood sugar, and cholesterol.…

This early-phase trial tests the safety and best dose of sonidegib combined with the immunotherapy pembrolizumab in people with advanced solid tumors that have spread. The goal is to see if this drug pair can shrink tumors or slow their growth. About 36 adults with cancers like m…

This study looks at whether the beta-blocker carvedilol can prevent or treat heart problems in breast cancer patients receiving HER2-targeted therapy. About 184 adults with HER2-positive breast cancer will be randomly assigned to take carvedilol either preventatively or only afte…

This study tests whether atorvastatin (Lipitor), a widely used cholesterol medication, can safely improve liver damage in people with NASH, a serious fatty liver disease. About 70 adults with confirmed NASH and liver scarring will receive either the drug or a placebo. The goal is…

This study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments like chemotherapy or radiation that could harm their fertility. The goal is to see if the frozen tissue can later be transplanted back to allow pregnancy and live birt…

This early-phase trial tests a specially designed virus that may selectively attack cancer cells while sparing healthy ones. The study includes up to 34 people with advanced or recurrent endometrial cancer. The main goal is to find the safest dose and understand side effects, wit…

This study looks at how two popular weight-loss medications, semaglutide and tirzepatide, change the way the stomach empties food. Thirty adults with obesity or overweight will receive weekly shots of either drug or a placebo for 24 weeks. Researchers will measure stomach emptyin…

This study tests a combination of two drugs, pirtobrutinib and venetoclax, for people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The treatment length is guided by a sensitive blood test that looks for leftover cancer cells (minimal resi…

This study tests whether MR-guided cryoablation—a technique that freezes and destroys cancer tissue—can safely treat prostate tumors that have come back after initial therapy. About 107 participants with biopsy-confirmed soft tissue recurrences in the prostate bed will be followe…

This study tests whether stem cells taken from a patient's own fat and injected into the spine can safely improve movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can restore some funct…

This study tests a combination of two drugs (TTI-622 and pembrolizumab) in about 10 adults with diffuse large B-cell lymphoma that has returned or not responded to prior treatment. The drugs work by helping the immune system recognize and attack cancer cells. The goal is to find …

This study tests a new drug called parsaclisib added to standard chemotherapy (R-CHOP) for people with newly diagnosed, high-risk diffuse large B-cell lymphoma. The goal is to find the safest dose and see if the combination improves treatment response. About 50 adults will take p…

This study tests a new way to give radiation to men whose prostate cancer has returned after surgery. Instead of standard treatment, doctors use daily scans to adjust the radiation beam exactly where it's needed, which may reduce harm to nearby organs. The goal is to see if this …

This study looks at whether a stem cell transplant can help people with a rare genetic brain disease called CSF1R-related leukoencephalopathy. Researchers will track changes in thinking and movement skills in 20 adults who are already scheduled for the transplant. The goal is to …

This early-stage trial tests whether combining a precise type of radiation (SBRT) with immunotherapy can help treat pleural mesothelioma, a rare cancer of the lung lining. About 20 adults with confirmed mesothelioma and measurable tumors will receive the combination. The main goa…

This study tests whether a larynx transplant can safely restore function in people who have lost their voice box due to injury, disease, or surgery. Ten adults with severe laryngeal problems will receive a donor larynx and be monitored for one year to see if the transplant surviv…

This study tests a new combination of drugs for people with multiple myeloma that has returned or no longer responds to standard treatments. The goal is to find the best dose and see if the combination can shrink or control the cancer. About 39 adults will take part, receiving ei…

This early-phase study tests a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and ibrutinib (which blocks certain enzymes that help cancer grow)—in people with advanced melanoma that cannot be surgically removed. The main goals…

This study tests whether giving heated chemotherapy directly into the abdomen during surgery can prevent stomach or gastroesophageal cancer from coming back in the belly lining. It is for 16 adults with high-risk cancer. The approach aims to kill any stray tumor cells that might …

This study tests two types of radiation therapy—proton beam and IMRT—given in shorter courses for men whose prostate cancer has come back and spread only to pelvic or abdominal lymph nodes. The goal is to see if the shorter treatment is safer and causes fewer severe side effects.…

This study compares two approaches to prevent pancreatic leaks after Whipple surgery: a short course of antibiotics plus a drug that reduces pancreatic secretions (octreotide) versus a longer course of antibiotics alone. About 103 adults at intermediate-to-high risk for leaks wil…

This early-stage trial tests a new treatment for multiple myeloma that has returned or stopped responding to standard therapies. The treatment uses a patient's own immune cells (T-cells) that are trained in the lab to recognize and attack cancer cells carrying a protein called MU…

This study tests a new drug (TVB-2640) combined with standard treatments for people with HER2+ breast cancer that has spread and no longer responds to standard therapy. The goal is to see if the combination can shrink tumors or slow the disease. About 17 adults with advanced brea…

This study looks at two standard ways to treat an infection that happens after a hip or knee replacement. Some patients get one surgery to clean the infection, while others get two planned surgeries. Both groups also take long-term antibiotics. The goal is to see which approach w…

This early study tests if stem cells taken from a patient's own belly fat can safely help heal pressure sores or diabetic foot ulcers. Twelve adults will have a small liposuction to collect fat, which is processed to extract stem cells and then placed on the wound with a special …

This study tests a program where community paramedics visit adults with diabetes who have had severe low blood sugar (hypoglycemia). The goal is to help them better manage their diabetes, prevent future emergencies, and improve their quality of life. The program involves educatio…

This study tests whether combining the chemotherapy drug pemetrexed with the immunotherapy drug pembrolizumab can shrink or control advanced salivary gland cancer that has returned or spread. About 45 adults with this rare cancer will receive the combination treatment. The goal i…

This study looks at whether giving vitamin D to cancer patients who are low in it can help them live longer without their disease getting worse. About 565 adults with certain lymphomas or leukemia will either get vitamin D or no extra vitamin D. The goal is to see if vitamin D re…

This study tests whether combining durvalumab (an immunotherapy) with lurbinectedin (a chemotherapy drug) can help control advanced small cell lung cancer that has come back after prior treatment. About 29 adults whose cancer returned or didn't respond to standard chemo and immun…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, an aggressive brain cancer. About 52 adults will receive the combination to see if it improves survival and controls the …

This study tests if a form of estrogen called estradiol can help people with a specific type of triple negative breast cancer that has spread. The cancer must have a protein called ER beta, which may make it sensitive to estrogen. Researchers want to see if the treatment can shri…

This study tests a two-drug combination (niraparib/abiraterone plus prednisone) in men with a specific genetic change (SPOP mutation) in their advanced prostate cancer that has spread and no longer responds to standard hormone therapy. The goal is to see if the drugs can shrink t…

This study is testing a surgery called meniscus root repair for people with a specific type of knee tear. Researchers want to see if the surgery helps patients return to activity and slows down arthritis. About 55 adults aged 18 to 65 will take part. The goal is to find out if th…

This study tests whether a combination of four chemotherapy drugs can improve outcomes for people with high-risk multiple myeloma. The drugs work by killing cancer cells or stopping them from growing. The main goal is to see if the treatment can make the cancer undetectable in te…

This study tests whether fisetin, a natural substance found in fruits and vegetables, can prevent COVID-19 from getting worse in hospitalized adults. The goal is to reduce dangerous inflammation that can lead to severe illness. The trial includes 80 participants aged 60+ or young…

This early-stage study tests whether a patient's own stem cells, taken from fat tissue, can help prevent the failure of the blood vessel connection used for dialysis. About 74 adults with advanced kidney disease will receive the stem cells during fistula surgery. The goal is to s…

This study looks at whether using two metal implants instead of one helps heal broken thigh bones near the knee. About 60 adults with this type of fracture will be treated within 72 hours of injury. Researchers will measure surgery time, blood loss, hospital stay, and early compl…

This study tests a new way to treat ovarian cancer that has come back after standard chemotherapy. Doctors take stem cells from fat tissue, infect them with a specially modified measles virus, and inject them into the belly. The stem cells carry the virus directly to cancer cells…

This study tests a small device called a Coronary Sinus Reducer in 35 adults with a specific type of heart failure (HFpEF) and small blood vessel problems. The device is placed in a heart vein to help lower pressure inside the heart during exercise. Researchers will measure chang…

This study tests whether ultra-low doses of radiation, guided by special brain scans, can slow the worsening of motor symptoms in Parkinson's disease. Twenty adults aged 45 to 70 with early-stage Parkinson's will receive five daily treatments. The goal is to see if this anti-infl…

This early-stage study tests whether a person's own stem cells can be safely injected into the spinal fluid to treat multiple system atrophy (MSA), a rare and serious brain disorder. Thirty adults aged 30-80 with MSA will receive the treatment and be monitored for side effects an…

This early-phase study tests a new drug called WSD0922-FU in 56 people with certain brain cancers (glioblastoma, anaplastic astrocytoma) or lung cancer that has spread to the brain or spinal cord. The drug blocks a protein called EGFR, which helps some cancers grow. The main goal…

This study looks at whether helping people with high blood pressure or prehypertension sleep longer (at least 7 hours a night) can lower their blood pressure. About 110 adults who currently sleep 6.5 hours or less will either receive sleep coaching or general health education for…

This study tests whether the drug metyrapone is safe and effective for people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. About 30 participants will receive the drug and be monitored for side effects. The goal is to see if m…

This study tests if a special camera (fetal cystoscopy) can safely open a blocked bladder in unborn male babies with a condition called LUTO. The procedure uses a laser or balloon to clear the blockage, aiming to protect the baby's kidneys and lungs. About 10 pregnant women carry…

This early-stage study tests a new type of marker that shows up brightly on ultrasound, helping surgeons find and remove cancerous lymph nodes during breast cancer surgery. The study involves 15 adults with breast cancer that has spread to nearby lymph nodes. The goal is to see i…

This study looks at whether removing brain tumors with surgery after chemotherapy or radiation, but before the tumor returns, is safe and works better than waiting. It involves 40 adults who have had prior treatment and still have visible tumor. The goal is to see if this timing …

This study looks at whether a natural substance called fisetin can reduce inflammation and improve stem cell function in people with advanced chronic kidney disease, including those with diabetes. About 30 adults aged 40-80 will take fisetin or a placebo for 14 days. Researchers …

This early-phase trial is testing a combination of two drugs—selinexor and choline salicylate—in 22 adults with certain blood cancers (lymphoma, multiple myeloma, or histiocytic/dendritic cell tumors) that have come back or not responded to prior treatment. The main goal is to fi…

This study tests a new drug called iberdomide combined with three other cancer drugs (daratumumab, bortezomib, and dexamethasone) in people newly diagnosed with multiple myeloma. The goal is to find the best dose of iberdomide and see how well the combination works at killing can…

This study tests whether a shorter, higher-dose radiation treatment works as well as the standard longer course for people with glioblastoma, an aggressive brain cancer. About 170 adults with confirmed glioblastoma will receive either short or standard radiation. The goal is to s…

This study tests whether a patch made from fish skin can help heal anal fistulas and their draining wounds. About 20 adults with this condition will receive the graft and be checked at 6 months. The goal is to see if the fistula closes and stops draining, offering a simpler treat…

This study looks at side effects of a 3-week radiation and chemotherapy treatment for people with pancreatic cancer that hasn't spread. It includes 103 adults with different stages of the disease. Researchers will also take blood samples to measure cancer DNA levels and see how t…

This early-phase study tests whether delivering a person's own fat-derived stem cells directly into an artery is safe for treating moderate to severe ulcerative colitis. About 20 adults aged 18-65 who have not responded to at least two standard medications will receive the treatm…

This study tests a simple, less invasive screening tool—a sponge on a string—to detect Barrett's esophagus and esophageal cancer. Researchers will enroll 450 adults with Barrett's esophagus who are already scheduled for an endoscopy. The goal is to see if DNA markers from the spo…

This study tests a special tool called DESI-MS that helps surgeons tell cancerous from healthy brain tissue during surgery. About 285 adults having brain tumor removal will take part. The goal is to see if this tool can give fast, accurate results to guide the operation.

This study looks at better ways to check for heart damage in adults who have had cancer. Researchers are testing if an AI-powered ECG and a simple blood test can find early signs of heart problems. The goal is to create a nationwide screening program to help cancer survivors stay…

This study collects blood, tissue, and urine samples from 589 adults with different types of kidney or urinary tract tumors, plus healthy controls. Researchers use advanced DNA sequencing to find unique markers (methylated DNA) that could help detect these cancers earlier. The go…

This study tests a new device called magnetocardiography (MCG) that measures the heart's magnetic field. Researchers want to see if it can quickly and accurately tell if chest pain is caused by reduced blood flow to the heart (a heart attack). About 1,000 adults coming to the eme…

This study tests whether an Apple Watch can catch early signs of atrial fibrillation (a common heart rhythm problem) in 2,000 people who are at high risk but haven't been diagnosed yet. Participants wear the watch for long-term monitoring. The goal is to see if this simple device…

This study tests a special MRI technique called MR elastography to see if it can measure high pressure inside the skull without needing a spinal tap. Researchers will compare this method with other noninvasive tests like eye scans and standard MRI signs. About 200 adults with and…

This study checks if an artificial intelligence (AI) program can spot hypertrophic cardiomyopathy (a thickened heart muscle) using ECGs from an Apple Watch or KardiaMobile device. About 183 adults with the condition or who are athletes will take part. The goal is to see if these …

This study tests whether a special PET/CT scan using a radioactive tracer called 68Ga-DOTATATE can better detect neuroendocrine tumors (like neuroblastoma) in children and young adults up to age 30. The scan is compared to the standard MIBG scan to see which one more clearly show…

This study tests a new ultrasound method that uses a contrast agent to create detailed images of blood vessels in the kidneys. Researchers want to see if this can help diagnose chronic kidney disease more accurately. The study includes both healthy volunteers and people with kidn…

This study tests whether taking an over-the-counter probiotic (VSL#3®) can prevent colitis (colon inflammation and diarrhea) in cancer patients receiving immunotherapy. Immunotherapy helps the immune system fight tumors but can cause colitis in up to 45% of patients. The trial en…

This study looks at whether adding a polygenic risk score (a measure of many small genetic factors) to standard risk tools helps women ages 35-75 at high risk for breast cancer decide on prevention steps, such as taking medication, having risk-reducing surgery, or getting extra i…

This study looks at whether giving women a simple self-collection kit for HPV testing at Express Care clinics (which have evening and weekend hours) can increase the number of women who get screened for cervical cancer. About 500 women ages 30–63 who are overdue for screening wil…

This study tests whether a short course of two drugs (glecaprevir/pibrentasvir and ezetimibe) can prevent hepatitis C infection in people who receive a kidney, heart, lung, or pancreas from a hepatitis C-positive donor. About 200 participants who are hepatitis C-negative and awai…

This study looks at whether having an empty bladder before CT simulation for prostate cancer radiation therapy is better than a full bladder. The goal is to see if it reduces urinary symptoms and makes treatment easier for patients. About 168 men with prostate cancer will take pa…

This study looks at whether eating fermented foods like yogurt, sauerkraut, and kimchi can increase the variety of good bacteria in the gut and help ease long COVID symptoms such as fatigue, depression, and anxiety. About 40 adults with long COVID will track their food intake and…

This study looks at whether different types of exercise training can help people with Pulmonary Arterial Hypertension (PAH) feel better and have a better quality of life. Researchers are comparing whole-body aerobic training with leg-only weight training in 45 participants. The g…

This study compares a standard painkiller (bupivacaine) with a slow-release version (Exparel) to control pain after eye removal surgery. About 88 adults having their eye removed will be randomly assigned to receive one of the two painkillers during surgery. The goal is to see if …

This study looks at whether a non-invasive brain stimulation technique called tDCS is practical and well-liked by hospitalized adults with depression that hasn't improved with standard treatments. Ten participants will receive 10 sessions of tDCS alongside their usual care. Resea…

This study tests whether fisetin, a natural substance found in strawberries, can reduce frailty and inflammation in healthy women aged 70 and older. Forty participants will receive either fisetin or a placebo to see if it improves walking speed and other measures of physical func…

This study looks at whether eating only during an 8-hour window, either early or late in the day, helps overweight adults lose weight and improve health. Researchers will track changes in weight, body mass index, and blood sugar levels. The goal is to find out which eating schedu…

This study tests a mobile health app called iPREPARED that helps patients aged 60 and older and their caregivers prepare for a hospital stay. The app provides tips and activities to prevent or reduce delirium (sudden confusion). Researchers want to see if using the app leads to l…

This study looks at whether taking out a ureteral stent (a small tube placed after kidney stone surgery) after 3 days instead of the usual 7 days can reduce bothersome symptoms like pain and urinary issues. About 172 adults having uncomplicated stone treatment will be randomly as…

This small pilot study at Mayo Clinic is testing whether Electromagnetic Transduction Therapy (EMTT) can reduce pain and improve daily function in 20 people with foot or ankle osteoarthritis. Participants receive the non-invasive treatment and report their pain levels and ability…

This study tests a wristband device called Cala TWO that uses nerve stimulation to help reduce hand tremors in people with essential tremor. About 20 adults who are already scheduled for deep brain stimulation surgery will use the device twice daily for three months. Researchers …

This study compares two ways of giving oxygen to high-risk patients (with a BMI of 35 or higher) during an endoscopic ultrasound. One group gets standard oxygen, the other gets a high-flow nasal cannula. Researchers want to see if the high-flow method helps patients wake up faste…

This study tests whether protecting a nerve in the knee during total knee replacement surgery can lower chronic pain afterward. About 178 adults having a first knee replacement took part. Doctors compared the standard approach to one where the nerve end is proactively protected, …

This study looks at how many doses of the steroid dexamethasone work best for people having knee replacement surgery. The goal is to reduce pain, the need for strong painkillers (opioids), and nausea after the operation. About 339 adults having their first knee replacement will t…

This study looks at whether using a 7-inch footstool while on the toilet can improve constipation symptoms. Researchers will compare it to a very low (2-inch) sham stool. About 85 adults with chronic constipation will track their bowel movements to see if the higher stool helps t…

This study tests whether virtual reality (VR) meditation can reduce the impact of fibromyalgia, a condition causing widespread pain and fatigue. About 40 adults with fibromyalgia will try both an active VR meditation program and a sham (fake) VR session to see which one helps mor…

This study tracks how much symptoms improve after a procedure called radiofrequency ablation for thyroid nodules. About 300 people having the procedure will answer a short questionnaire before and after treatment. The goal is to measure symptom relief using a simple scoring syste…

This early-stage study tests whether injecting a patient's own lab-grown stem cells into the hip joint is safe and can reduce pain and improve movement in adults with hip osteoarthritis. Twenty-four people aged 18 to 65 will receive the injections and be monitored for side effect…

This study looks at whether getting a nerve block (paravertebral block) both before and after rib removal surgery helps control pain better than getting it only before surgery. About 50 adults with thoracic outlet syndrome will take part. Researchers will measure pain levels and …

This study was designed to see if a biofeedback device called JOGO can help people with functional tremor, a condition where the body shakes without a clear physical cause. JOGO uses stickers on the skin to measure muscle activity and guides users through training sessions with a…

This study looks at whether a supervised exercise program can improve heart function, exercise capacity, and quality of life in people with heart failure and pulmonary hypertension. About 40 adults with stable heart failure will take part. The goal is to see if exercise can lower…

This study tests a new device called the Catheter Caps Case (C3) for people on dialysis who have a catheter. The goal is to see if it is more comfortable and easier to use than the usual gauze and tape. Ten adults with a tunneled dialysis catheter will try the device for 15 minut…

This study tests if low-level laser therapy (LLLT) combined with patient education can reduce lower back pain. About 60 adults with moderate to severe pain will receive different frequencies of laser treatment. Researchers will measure pain changes using a standard pain scale. Th…

This study tests whether a non-invasive electromagnetic device can help men recover bladder control faster after prostate surgery. 2,100 men who have urinary leakage after radical prostatectomy or HoLEP will receive the treatment. Researchers will measure changes in incontinence …

This study looks at whether giving ketamine during surgery can help reduce chronic nerve pain in people with brachial plexus injuries (nerve damage in the shoulder/arm). About 100 adults scheduled for nerve repair surgery will be randomly assigned to receive either ketamine or a …

This study tests if using virtual reality (VR) goggles during heart procedures can help patients feel more comfortable and reduce the amount of medication they need. Ten adults scheduled for a heart procedure will try VR as an extra tool alongside standard care. Researchers will …

This study tests whether a virtual world-based cardiac rehabilitation program is feasible for heart patients. Five participants will use an online program to improve their cardiovascular health, measured by the American Heart Association's Life's Essential 8 score. The goal is to…

This study looks at whether focused shockwave therapy can reduce pain at the front of the knee after ACL reconstruction surgery. Researchers will enroll 20 adults who had ACL surgery using a patellar tendon or quadriceps tendon graft. Participants will receive the shockwave treat…

This small pilot study at Mayo Clinic is testing whether dry needling (a technique using thin needles to release muscle knots) combined with therapeutic exercise can improve sleep in people with long-term neck pain and sleep problems. The study includes 28 adults aged 18-75 who h…

This study looks at whether taking kava extract, a natural supplement, can lower stress hormone levels and reduce feelings of burnout in nurses. About 200 nurses from Mayo Clinic are taking part. Researchers will measure changes in cortisol and use a standard burnout questionnair…

This study tests a smartphone app called PACTAID in 20 adults with type 1 diabetes who use automated insulin pumps. The app helps manage blood sugar levels during and after exercise. Researchers want to see if the app improves glucose control and heart health.

This study compares two prosthetic hands—the SoftHand Pro and the i-Limb—in 36 people with below-elbow arm amputations. Over 8 weeks, participants perform everyday tasks like grasping and gripping to see which hand works better. The goal is to improve function and quality of life…

This study compares two pain management strategies after knee or hip replacement surgery: using both tramadol and oxycodone versus oxycodone alone. The goal is to see if the combination reduces total opioid use, pain, and side effects. About 560 adults having their first knee or …

This study looks at two ways to fix a specific type of meniscus tear in the knee. One method adds an extra step called centralization. Researchers want to see if this extra step leads to less pain, better function, and higher satisfaction after surgery. About 54 adults with a tor…

This study tests a new device designed to clear blockages in surgical drain tubes. Researchers at Mayo Clinic will enroll 500 adults having abdominal surgery with Jackson-Pratt drains. Nurses will use the device and give feedback on how easy it is to use and how well it works. Th…

This study tests whether using virtual reality (VR) can help reduce anxiety, depression, and emotional distress in people receiving palliative care. Twenty adults with a life expectancy of one year or less will use VR goggles and report their feelings before and after. The goal i…

This pilot study from Mayo Clinic is testing whether virtual reality therapy is safe and tolerable for people with gastroparesis (stomach paralysis). The study aims to enroll 30 adults aged 18-75 with documented gastroparesis. Participants will use VR and report any side effects,…

This early-stage study tests whether a combination of two drugs, dasatinib and quercetin, is safe and feasible for people with mild cognitive impairment or Alzheimer's disease. The drugs target senescent ('zombie') cells that accumulate with aging. Twenty participants aged 55 and…

This study looks at whether the size of a ureteral stent placed after kidney stone surgery affects pain and discomfort. About 100 adults who need a stent on a string after their procedure will rate their pain daily until the stent is removed (usually 7-14 days). The goal is to fi…

This study looks at two different methods for prescribing high-intensity interval training (HIIT) to adults in cardiac rehab. The goal is to see which approach better improves fitness, heart function, and how well muscles use oxygen. About 30 participants with non-surgical heart …

This study tests a wearable device that uses mild electrical stimulation to the inner ear to reduce motion sickness during virtual reality. 40 adults aged 21-55 will attend in-person sessions at Mayo Clinic in Arizona. The device aims to improve comfort and balance during VR use.

This study tests whether aggressive weight loss using semaglutide can improve symptoms in people with obesity-related heart failure with preserved ejection fraction (HFpEF). About 81 participants will receive either semaglutide or a placebo, and researchers will measure heart pre…

This study compares two types of radiation therapy—standard x-ray and proton beam—for women with breast cancer who have had surgery. The goal is to see which method causes fewer serious side effects or unplanned surgeries over two years. About 146 women with stage I to III breast…

This study tests a virtual group therapy program for caregivers of people with advanced cancer or serious life-limiting illness. The therapy helps caregivers connect to meaning and purpose, aiming to reduce feelings of hopelessness and burden. The study will enroll 80 caregivers …

This study tests whether virtual long-term follow-up care using Lin Health can improve daily life for people with fibromyalgia. Researchers will enroll 300 adults from Mayo Clinic's fibromyalgia clinic. Participants will be randomly assigned to receive the virtual behavioral heal…

This study tests whether a natural anti-inflammatory supplement called fisetin can reduce frailty and inflammation in adults aged 70 and older. About 40 participants will take either fisetin or a placebo for a short time. The goal is to see if the supplement lowers blood markers …

This study compares IV acetaminophen (a non-opioid pain reliever) to standard opioid pain care for people hospitalized with a small bowel obstruction. About 18 adults will be enrolled to see if this approach can control pain just as well, while possibly shortening hospital stays …

This study tests whether stem cells from donated bone marrow can safely reduce pain in people with chronic low back pain caused by worn-out facet joints in the spine. About 40 adults will receive the stem cell treatment and be monitored for side effects and pain relief. The goal …

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can be used at home to boost recovery of memory, language, and thinking skills in people with stroke, brain tumors, or neurodegenerative conditions like Parkinson's or Alzheimer's. Participants …

This study tests a 10-week home exercise program for endometrial cancer survivors who live in rural areas or are from underserved groups. Participants do strength training twice a week using a video call. The goal is to see if the program is practical and helps improve physical f…

This study tests three types of wave therapies—focused shockwaves, radial pressure waves, and electromagnetic waves—to see if they help heal lower leg injuries like muscle strains, cartilage damage, and bone bruises. About 200 adults with a doctor-confirmed leg injury will receiv…

This study tests whether using a virtual reality (VR) headset during knee or hip surgery can help patients feel less anxious and reduce the need for sedating drugs. About 50 adults will use VR along with their usual nerve-block anesthesia. The goal is to see if VR improves the su…

This study compares two devices that measure nerve response during surgery when the patient's arms are tucked at their sides. Researchers will check how accurate and consistent these monitors are in 40 people having procedures without muscle relaxants. The goal is to improve moni…

This study looks at how amino acids change the release of glucagon and insulin compared to glucose alone. Researchers will test 30 people who are healthy, have type 2 diabetes, or are obese. The goal is to better understand hormone regulation in these conditions.

This study looks at how reading a person's DNA might improve their medical care. Researchers will analyze the genetic material of 110,000 adults to find hidden risks for diseases. The goal is to use this information for earlier detection, better treatment, or prevention. Particip…

This study tests a new electric bandage that creates hydrogen peroxide to help clean wounds and prevent infection. Researchers at Mayo Clinic are putting the bandage on the healthy skin of 40 volunteers to see if it causes any discomfort, redness, swelling, or allergic reactions.…

This study collects samples from 10,000 Mayo Clinic patients to analyze their genes and other biological data. Researchers will look for links between these findings and health outcomes. The goal is to build a rich database that helps doctors create more personalized care plans i…

This study tests whether a blood protein called chromogranin A (CgA) can help predict if prostate cancer will come back after radiation therapy. Researchers will measure CgA levels before, during, and after treatment in 118 men with prostate cancer. The goal is to see if changes …

This study looks at why minority cancer patients often don't take part in clinical trials. Researchers will survey about 590 patients to understand their challenges and preferences. The goal is to create an educational platform that helps these patients learn about trials and fee…

This study tests a new brain recording system (Brain Interchange) in up to 12 people with drug-resistant epilepsy who are already scheduled for brain monitoring. The system is used externally to see if it can detect special brain signals (high-frequency oscillations) better than …

This study looks at how well treatments for hip problems in children work over many years. Researchers at Mayo Clinic will follow 500 adults who had hip treatment as kids to see if they needed more surgery and how their hip bones changed. The goal is to learn which treatments lea…

This observational study from Mayo Clinic will enroll 100,000 adults to better understand how genes and environment contribute to disease. Participants provide samples, use a mobile app, and complete surveys. The goal is to predict and potentially stop disease early, but this stu…

This study tests a new ultrasound technique to look at tiny blood vessels inside the kidneys of people with autosomal dominant polycystic kidney disease (ADPKD) and healthy volunteers. Researchers want to see if this method can measure blood vessel health without surgery or contr…

This study looks at lymph node tissue from 200 adults who have had any organ transplant. Researchers will check for specific biomarkers to see if they relate to how well the transplant works. The goal is to learn more, not to test a new treatment.

This study is creating a large collection of blood samples and medical information from 72 people in Florida who have various brain blood vessel diseases, such as stroke or dementia. The goal is to build a resource that scientists can use in future research to better understand t…

This study looks at whether different methods of teaching patients about ACL reconstruction surgery can improve their satisfaction, reduce anxiety, and help them remember important information. About 105 adults having ACL surgery at Mayo Clinic in Arizona will take part. The goal…

This study looks at how radiation therapy changes tumor DNA and immune cells in the blood of 217 breast cancer patients. The goal is to learn how these markers respond to treatment, which could help doctors customize radiation plans in the future. Participants are adults with bre…

This study follows 36 people with HER2-positive breast cancer who are receiving the drug T-DM1. Researchers want to learn how often and how severely nerve damage (peripheral neuropathy) occurs during treatment. Participants will report their symptoms through questionnaires, helpi…

This study aimed to see if patients were more satisfied and had better-looking scars when stitches that dissolve were used instead of stitches that need removal after hand surgery for carpal tunnel or trigger finger. The study planned to enroll adults having these common hand ope…

This study aimed to check if a device called LabClasp can accurately estimate blood lactate levels without needing a blood draw. It planned to include healthy adults doing exercise and ICU patients. However, the study was withdrawn before any participants were enrolled.

This study uses MRI scans to better understand white matter hyperintensities (bright spots on brain images) in women with migraines. Researchers will compare these spots to those seen in small vessel ischemic disease and multiple sclerosis. The goal is to classify the underlying …

This study collects DNA, blood, urine, and tissue samples from 5,000 people with rare or undiagnosed diseases, plus their family members. Researchers at Mayo Clinic will analyze these samples to find genetic markers and causes of these conditions. The goal is to create a biobank …

This study tests a new ultrasound technique to measure stiffness in the wrist nerves and tissues of people with carpal tunnel syndrome. Researchers will check 20 volunteers before and after treatment (surgery or a shot) to see if the ultrasound can track improvement. The goal is …

This study collects tissue, blood, and urine samples from 92 men with prostate cancer that has spread. Researchers look for gene changes that might explain how well the cancer responds to standard hormone therapy. The goal is to find biomarkers, not to test a new treatment.

This study tests a new imaging machine called StarGuide NextGen SPECT/CT to see how well it captures pictures of the body after a radioactive tracer is given. About 100 people already scheduled for a nuclear medicine scan will also get a scan on this new system. Doctors will rate…

This study looks at how well blood flows in the breast skin after radiation therapy and after fat grafting. Researchers will use a special ultrasound to measure blood supply in 15 breast cancer patients who had a mastectomy and are getting implant reconstruction. The goal is to l…

This study enrolls 66 healthy adults to provide comparison data for the Mayo Clinic Adult Congenital Heart Disease Registry. Participants must have no heart disease, normal blood pressure, and a BMI of 30 or less. Researchers will measure oxygen use and heart function to better u…

This study looks at whether robotic-assisted knee replacement leads to lower metal levels in the blood compared to the traditional method. About 60 adults having knee replacement will have their blood tested for metals like cobalt and chromium. The goal is to see if the robotic a…

This study tests new, improved fetoscopes (thin tools used to perform surgery on a baby while still in the womb) to see if they are safe and work well. About 100 pregnant women scheduled for fetal surgery will take part. The main goal is to track any side effects, serious problem…

This study looks at whether early support services can help people in Minnesota who are injured or ill stay at work or return to work sooner. About 5,200 adults who recently became unable to work due to a health issue will receive help from a team of partners. The goal is to see …

This study uses brain scans to measure two proteins, amyloid and tau, in people with different forms of Alzheimer's disease. Researchers want to see how these protein levels change over one year. The goal is to better understand the disease, not to test a treatment. About 60 adul…

This study looks at whether people with early-onset Alzheimer's disease have hidden seizures. Researchers will use a portable EEG device to record brain activity for 48 hours in 20 participants. The goal is to learn how common these seizures are, not to treat the disease.

This study looks at how often cannabis withdrawal happens and what symptoms appear in patients hospitalized for bone marrow transplant or CAR-T therapy. Researchers will track 300 adults at Mayo Clinic using a symptom questionnaire. The goal is to better understand withdrawal in …

This study was designed to see if certain drugs could help protect brain function after radiation therapy for brain cancer. It planned to collect spinal fluid samples from adult patients to measure brain metabolism. However, the trial was withdrawn before enrolling any participan…

This study aims to improve how concussions are diagnosed on the field and find ways to prevent them in athletes aged 12 to 30. Researchers will track 4,000 athletes using blood tests, neck strength, and vision training. The goal is to create better return-to-play rules and lower …

This study tests whether a new treatment for children and teens with restrictive eating disorders can be delivered in a primary care setting. The treatment, called Family-Based Treatment for Primary Care (FBT-PC), is adapted from a proven approach. Researchers will enroll 200 par…

This study looks at spinal tissue from 300 children and adults having spine surgery. Researchers want to understand what causes spine deformities and wear-and-tear changes at the molecular level. The goal is to find new ways to treat these conditions.

This study was designed to find out if blood tests taken during and after pregnancy in women with adult congenital heart disease could help predict future heart problems like arrhythmias or heart failure. It planned to enroll pregnant women with congenital heart disease, but the …

This study follows 419 people who do not have pancreatic cancer but are at high risk due to family history or genetic mutations. Researchers collect blood samples yearly to look for biomarkers that might predict or detect pancreatic cancer early. The goal is to improve early diag…

This study tests whether a brain implant can safely track seizures, mood, and thinking in people with epilepsy. Five participants with hard-to-control seizures will use the device, which also delivers brain stimulation to try to prevent seizures. The goal is to see if the system …

This study looks at how growth plates—the areas where bones grow in children—work at the molecular level. Researchers will collect tissue samples from 100 children and teens already having surgery to remove growth plate cartilage. The goal is to find molecules that could one day …

This study uses a special brain scan called DaTSCAN to learn more about aging and diseases like Parkinson's, Alzheimer's, and dementia. Researchers will compare scan results with clinical diagnoses in 500 adults aged 40-90. The goal is to improve understanding and diagnosis of th…

This study checks kidney transplant patients for inherited gene changes that raise cancer risk. Researchers want to see if knowing these risks leads to better cancer screening. The goal is to improve long-term health for transplant recipients.

This study looks at how homocysteine (a natural substance in the blood) and blood vessel function relate to kidney disease severity in people with early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD). Researchers will follow 80 participants aged 15-40 to see if these …

This study tests a special MRI technique called MR Elastography to measure how muscles and their surrounding tissues move in people with myofascial pain syndrome. Researchers will compare 106 adults with and without chronic muscle pain to see if this imaging can spot differences …

This study looks at whether adding a special PET scan (18F-DOPA) to the standard MRI can help doctors better plan radiation treatment for people with certain brain tumors (malignant glioma). About 25 participants will have both scans, and researchers will compare the treatment ar…

This study looks at how exercise changes fat (adipose) tissue and how those changes might improve health as we age or if we have obesity. Researchers will measure immune cells and inflammatory markers in fat tissue samples from 56 healthy adults before and after exercise. The goa…

This study looks at whether a daily supplement called nicotinamide riboside can improve blood vessel flexibility in healthy adults aged 35 to 70. Researchers will measure changes in blood vessel stiffness over time. The goal is to understand how this supplement might support hear…

This study looks at whether weight loss from Roux-en-Y gastric bypass (RYGB) surgery changes bile acids differently than weight loss from cutting calories alone. Researchers will measure bile acid levels in stool samples from 21 adults with severe obesity. The goal is to understa…

This study was designed to see if a rapid whole genome sequencing test on amniotic fluid can diagnose genetic conditions in fetuses faster than current methods. Researchers planned to compare results from amniotic fluid and blood samples from up to 90 families. However, the study…

This study looks at whether regularly checking blood sugar levels without needles can help predict gestational diabetes and preeclampsia in pregnant women. About 100 women with at least one risk factor for gestational diabetes will wear a non-invasive glucose monitor and have the…

This study was designed to see if a large language model (a type of AI) could help doctors write discharge summaries for hospitalized patients more efficiently. The goal was to check if a larger trial is possible, not to directly improve patient health. The study was withdrawn be…

This study looks at how immunotherapy drugs affect balance and hearing in people with cancer. Researchers will test 50 patients before, during, and after treatment to see if their balance changes. The goal is to better understand side effects so doctors can help patients manage t…

This study looks at whether using social media apps too much can make anxiety worse. About 100 adults with mild anxiety or depression will change how they use their smartphones to see if it helps their mental health. The goal is to find healthier ways to use phones, not to stop u…

This study looks at how a mother's emotional health and lifestyle—like stress, fatigue, sleep quality, and diet—might affect the levels of melatonin and sIgA in her breast milk. Researchers will collect milk samples from 120 new mothers who are breastfeeding. The goal is to bette…

This study watches how deep brain stimulation (DBS) helps people with essential tremor over a day. About 50 participants will wear an Apple Watch and do simple tasks to see when the treatment stops working well. The goal is to learn if a smartwatch can measure this, not to change…

This study aims to find 50 people with rare genetic diseases that currently have no good treatment. Researchers will collect blood and tissue samples to understand each person's unique genetic change. The goal is to work with partners to create a custom drug for each participant.…

This study follows 204 people with bladder cancer to see how their treatment (surgery or radiation) affects their quality of life. Participants fill out surveys about physical function, pain, fatigue, mood, and bladder, bowel, and sexual health. The goal is to understand which tr…

This study looks at how common moral distress, moral injury, and post-traumatic stress are among Mayo Clinic nurses. Over 21,000 nurses will fill out surveys to measure these feelings. The goal is to find out which work settings or roles lead to higher stress, so better support c…

This study aims to create an AI system that can measure pain objectively using body signals. Researchers will collect data from 70 people recovering from outpatient plastic surgery. The goal is to help doctors personalize pain medication and reduce the risk of overuse.

This study uses special brain scans (tau PET) to measure how anti-amyloid therapy changes tau protein buildup in people with mild Alzheimer's disease. Researchers will track 135 adults aged 50-90 who are already receiving anti-amyloid treatment at Mayo Clinic. The goal is to bett…

This study tests a new blood test that looks for DNA changes to find leftover or returning liver cancer after surgery. About 36 adults with early-stage liver cancer will give blood samples before and after treatment. The goal is to see if the test can catch cancer coming back ear…

This study tests a new lab method to understand how certain bone marrow cells take up nutrients like glucose and amino acids. Researchers will compare cells from people with a pre-cancer condition called MGUS to cells from healthy volunteers. The goal is to learn more about how t…

This study planned to see if using a blood flow restriction cuff during physical therapy could help people recover strength and movement after biceps or knee tendon repair surgery. It was designed for adults aged 18 to 80. However, the study was withdrawn before any participants …

This study screens 1000 adults aged 40 and older for MGUS, a condition with an abnormal blood protein that can sometimes lead to multiple myeloma. Researchers at Mayo Clinic will use advanced testing to find MGUS across diverse groups in Minnesota. The goal is to learn more about…

This study from Mayo Clinic tests a smartphone app designed to help primary care doctors screen, briefly counsel, and refer patients with substance use disorders to treatment. Researchers will enroll 60 adults to understand what helps or hinders using this digital tool in real cl…

This study aims to find the ideal level of muscle relaxation needed to make inserting a breathing tube (intubation) easier and safer. Researchers will measure muscle twitch strength in 108 adults and compare three different relaxation levels to see which one provides the best con…

This study looks at whether repairing the hip capsule (the tissue around the joint) after hip arthroscopy leads to better hip function and less pain compared to leaving it unrepaired. About 250 adults aged 18 to 50 with hip pain from femoroacetabular impingement (FAI) will be ran…

This study tests new MRI guidance software (Philips iSuite) to see if it helps doctors place needles more quickly and accurately during biopsies and tumor ablations. About 12 people already scheduled for an MRI-guided procedure will take part. The goal is to compare this new soft…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions, using yearly brain scans and other tests to see how the diseases change over time…

This study looks at whether the bacteria living in your gut (the microbiome) can help predict your risk of heart disease. Researchers will collect blood and stool samples from 700 adults who are already having a heart catheterization. They will analyze the blood for signs of infl…

This study was designed to collect and analyze fluid from the part of the brain being removed during epilepsy surgery. The goal was to look for signs of inflammation that might lead to new ways to control seizures in people who don't respond to medication. The study was withdrawn…

This study tests whether removing aged, worn-out cells can improve physical frailty and stem cell health in 30 adults aged 40-80 with moderate-to-severe chronic kidney disease and diabetes. Participants receive a senolytic drug combination, and researchers measure changes in cell…

This study is for people with autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that causes cysts to grow in the kidneys. Researchers want to see if certain markers in the blood and urine can help predict how fast the disease will get worse. About 100 peop…

This study aims to understand how certain gene variants may increase the risk of developing kidney stones. Researchers will analyze blood samples and lifestyle information from 2,900 adults, including those who have had calcium oxalate stones and those who have not. The goal is t…

This study looks at 90 women with hypothalamic amenorrhea (missed periods for months or years) to see if their fertility status is linked to early signs of heart disease. Participants wear a FitBit and answer surveys about stress, activity, and diet. The goal is to understand whi…

This study looks at whether a simple nail-fold microscope test can tell apart two types of a rare stomach condition called GAVE. Researchers will compare 75 adults with GAVE, some with autoimmune disease and some without. The goal is to see if nail blood vessel patterns match sto…

This study compares two methods (electromyography and acceleromyography) for monitoring muscle relaxation during robotic or laparoscopic surgery. The goal is to see which method leads to using less muscle relaxant medication. About 400 adults having planned surgery will take part…

This study is creating a collection of blood and tissue samples from people who have a family history of pancreatic cancer or melanoma. The goal is to give researchers the resources they need to better understand why these cancers run in families and how to detect or treat them e…

This study aims to collect blood or tissue samples and medical information from 1,000 adults with spinocerebellar ataxia or other nucleotide repeat diseases (excluding Huntington's disease), as well as their unaffected family members. The goal is to build a research repository to…

This study looks at whether long-term inflammation raises the risk of endometrial cancer. Researchers collect blood, urine, and tissue samples from women having hysterectomy for either cancer or non-cancer reasons. They compare inflammation markers to better understand how to pre…

This study watches how heart rate, blood pressure, breathing, and oxygen levels change in 500 acutely ill patients admitted to a telemetry unit. Researchers will also look at the effects of different medications and fluids given by various routes. The goal is to better understand…

This study aims to build a registry of 3000 people who do not have pancreatic cancer but have at least two blood relatives with the disease. Participants will complete health questionnaires every two years to track new cancer diagnoses. The goal is to better understand and eventu…

This study measures immune markers in healthy children before and after routine vaccinations to define what a normal response looks like. Researchers will enroll 300 children at specific ages who are scheduled for standard vaccines. The goal is to create a baseline of healthy res…

This study tests whether a smartphone app that analyzes your voice can spot signs of anxiety and depression in people recovering from a heart attack. About 200 adults in cardiac rehab will use the app alongside standard care. The goal is to see if voice analysis can help improve …

This study tests a new needle guide grid that uses MRI technology to help doctors place needles more accurately during prostate biopsies. About 20 people scheduled for an MRI-guided biopsy or ablation will take part. The goal is to see if the new grid reduces the number of needle…

This study collects saliva, blood, and tissue samples from 100 adults with lymphedema to store for future research. No treatment is given. The goal is to build a resource that may help scientists discover biomarkers to improve microvascular treatments down the road.

This study aims to find out how common a widened aorta (the large artery leaving the heart) is among experienced weightlifters aged 35 and older. Researchers will use ultrasound to measure the aorta in 45 people who have been lifting weights for at least 5 years. The goal is to b…

This study follows 260 adults with hypertrophic cardiomyopathy to learn more about heart rhythm problems like atrial fibrillation and ventricular arrhythmias. Researchers want to see if sleep apnea affects these risks. Participants are observed over time, but no new treatment is …

This study from Mayo Clinic is creating a single, standard test to see how well people handle low oxygen (hypoxia) during exercise. Researchers will measure things like breathing, heart rate, and blood oxygen levels in 50 physically active adults. The goal is to find out why some…

This study looks at whether giving primary care doctors coaching or communication classes can make patients more satisfied and reduce doctor burnout. About 45 Mayo Clinic clinicians will take surveys before, right after, and two months after the training. The goal is to see if be…

This study tests whether a mild electrical current applied to the scalp (tDCS) can increase blood flow to the brain in people with Moyamoya disease or similar conditions that reduce blood supply. About 50 participants with thinking problems will receive tDCS and have their brain …

This study surveys 1,200 incarcerated women at a Florida prison to learn about their cancer screening history, risk factors, and barriers to care. The goal is to create a digital education module to improve cancer awareness and screening in prisons. Participants fill out a 15-min…

This study looks at the costs during surgery and how satisfied patients are with their scars after two types of prolapse repair (robotic vs. open surgery). Researchers will track expenses like operating time and supplies, and ask 80 women to rate their scars and overall surgical …

This study looks at whether children with metal plates, screws, or rods have higher metal levels in their blood and tissues. Researchers will test blood and tissue samples from 50 children aged 4–18 who are scheduled for surgery involving metal implants. The goal is to understand…

This study follows 140 breast cancer patients who were part of the original BEAUTY study. Researchers will collect blood and tissue samples over time to learn why some breast cancers respond well to standard chemotherapy while others do not. The goal is to find clues that could l…

This pilot study at Mayo Clinic looks at whether personalized education and genetic counseling can increase genetic testing in people who have a first-degree relative (parent, sibling, or child) with pancreatic cancer. About 50 participants with a family history of the disease wi…

This study aims to understand how social factors—like where someone comes from—affect the way immigrant men from Sub-Saharan Africa and the Caribbean seek care and make decisions about prostate cancer. Researchers will interview 80 men to learn about their experiences and identif…

This study looks at whether a blood test can find tiny bits of HPV DNA from cervical cancer tumors. Researchers will test blood samples from 18 people with cervical cancer before, during, and after treatment. The goal is to see if changes in this DNA can help predict how well tre…

This study follows about 2,480 people who already took part in the CREST-2 trial to see how well two treatments for narrowed carotid arteries work over the long term. The treatments are surgery (carotid endarterectomy) and a less invasive procedure (carotid stenting). The main go…

This study will follow 100,000 adults who have already received genetic testing through the Tapestry program at Mayo Clinic. Researchers want to see if knowing your genetic results changes how often you visit the doctor, your overall healthcare costs, and your quality of life. No…

This study is collecting blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD) to learn more about the condition. Researchers hope this information will lead to better treatments and outcomes. Participants must be between 18 and 85 years old and …

This study looks at how scoliosis (a curved spine) and its treatments—like braces or surgery—affect children's muscles and daily activity. Researchers will track 200 kids aged 9 to 16 using wearable sensors and muscle stiffness tests. The goal is to better understand the conditio…

This study compares two common anesthesia drugs, ketamine and propofol, given at the start of heart surgery to see which one better protects the kidneys from injury. About 200 adults having complex heart surgery at Mayo Clinic will take part. The goal is to find out if ketamine r…

This study looks at how chemotherapy given before surgery affects the immune system in people with operable breast cancer. Researchers will collect blood samples from 38 patients to see how different immune cells change during treatment. The goal is to understand why some patient…

This study tests a new blood test to find early signs of bile duct cancer coming back or getting worse. About 100 adults with suspected or confirmed bile duct cancer who are planning surgery will give blood samples before and after treatment. The goal is to see if certain markers…

This early study at Mayo Clinic tests whether using an automated leg massage device (Neuroglide) each night for one month can improve the brain's waste-clearing system in people aged 50+ with obstructive sleep apnea. Researchers will measure changes in blood markers linked to bra…

This study looks at whether a new scaffold material is safe to use when repairing a nerve after a biopsy. About 20 adults with nerve conditions like peripheral neuropathy will take part. The main goal is to see if using the scaffold causes fewer side effects like pain, swelling, …

This study aims to create a large collection of blood and tumor samples from 300 people whose breast cancer has spread or returned. By linking these samples with medical information, researchers hope to learn why the cancer spreads and why people respond differently to treatments…

This study uses a special MRI technique to measure brain stiffness in people with Alzheimer's, mild cognitive impairment, and healthy volunteers. Researchers want to see if brain stiffness can serve as a new marker to detect Alzheimer's disease. The study involves 450 participant…

This study looks at tiny particles called extracellular vesicles that come from prostate cancer cells. Researchers want to see if levels of these particles in blood and urine change after surgery to remove the prostate. The goal is to learn if these particles can help doctors und…

This study is building a large group of 21,000 people newly diagnosed with non-Hodgkin lymphoma to track their health over time. Researchers will look at medical history, lifestyle, genetics, and treatments to find out what affects survival, side effects, and quality of life. The…

This study tests a new MRI method to see if it can measure scarring in narrowed kidneys. Researchers will scan 24 people with high blood pressure and narrowed kidney arteries. The goal is to see if this MRI technique is reliable and can predict kidney recovery.