Mayo Clinic

This early-phase study tested a personalized vaccine made from patients' own white blood cells to treat advanced ovarian, fallopian tube, or primary peritoneal cancer. The vaccine was designed to help the immune system recognize and attack cancer cells. The main goal was to check…

This study tested a virtual program that combines weight management with short mindfulness exercises for obese cancer survivors. The goal was to see if it's feasible and can improve mood, stress, and weight. Nineteen adults who had stage I-III cancer and a BMI of 30 or higher too…

This study tested whether combining two minimally invasive procedures—Hybrid Argon Plasma Coagulation (HAPC) and Endoscopic Sleeve Gastroplasty (ESG)—is safer and more effective for weight loss than ESG alone. 45 adults with obesity (BMI 30-40) who had not succeeded with non-surg…

This study tested a drug called obinutuzumab in 20 adults with a kidney disease called FSGS that did not get better with standard treatments. The goal was to see if the drug could reduce protein in the urine, a sign of kidney damage. Participants received the drug through an IV, …

This study tested whether giving a combination of targeted drugs (vemurafenib and cobimetinib) and an immunotherapy (atezolizumab) before surgery could help patients with high-risk stage III melanoma. 64 adults with advanced melanoma that had spread to lymph nodes took part. The …

This pilot study tested a new way to treat low-risk prostate cancer using MRI-guided laser ablation. Seven men with early-stage prostate cancer received the treatment to see if it was safe and could successfully target and destroy tumors. The goal was to control the disease with …

This study tested a shorter, higher-dose radiation treatment given before breast-conserving surgery for early-stage breast cancer. The goal was to see if this approach could kill more tumor cells and reduce side effects. Twenty-five participants completed the trial, and researche…

This study tested a virtual world-based cardiac rehabilitation program called 'Destination Cardiac Rehab' for people with heart conditions. Over 2,800 participants were randomly assigned to either the virtual program or traditional in-person rehab. The goal was to see if the virt…

This study tested the drug ibrutinib in 35 people with chronic lymphocytic leukemia (CLL) who still had small amounts of cancer cells after their first treatment. The goal was to see if ibrutinib could completely clear those leftover cells from the blood and bone marrow. Ibrutini…

This study tested a shorter course of radiation (hypofractionation) in 52 men who had prostate cancer with high-risk features after their prostate was removed. The goal was to see if giving higher daily doses over fewer days could prevent the cancer from coming back. The approach…

This study looked at whether it is safe and possible to do two heart procedures at the same time in people with atrial fibrillation (irregular heartbeat) and a severe leaky mitral valve. The procedures were MitraClip to repair the valve and Watchman to close a part of the heart w…

This early-stage trial tested whether combining a topical cream (imiquimod) with an immunotherapy drug (pembrolizumab) is safe and effective for people with advanced melanoma that cannot be surgically removed. Seven participants with stage IIIB to IV melanoma were enrolled. The s…

This study tested two drugs, auranofin and sirolimus, together in 29 people with advanced lung cancer that had stopped responding to standard treatments. The goal was to find the best dose and see if the combination could slow or stop cancer growth. The trial focused on safety an…

This study tested whether aiming a laser at the nasal or inferior part of the eye works better to lower pressure in people with open-angle glaucoma. Thirteen adults with high eye pressure received the laser treatment, and researchers measured how much their eye pressure dropped. …

This study tested a combination of two targeted antibodies (pertuzumab and trastuzumab) plus a hormone therapy (enzalutamide) in 7 patients with metastatic castration-resistant prostate cancer that had stopped responding to other treatments. The goal was to see if this mix could …

This study tested whether the drug sotatercept, given for 36 weeks, can improve how the heart and lungs work during exercise in people with pulmonary arterial hypertension (PAH). Thirty adults with PAH took part. The main goal was to see if the drug helps the heart pump blood mor…

This study looked at whether taking a simple sugar supplement every day could improve the health of 20 children with congenital disorders of glycosylation (CDG), a rare genetic condition that affects how the body builds important sugar chains. Researchers measured growth, blood s…

This early-phase study tested whether a colon-targeted butyrate tablet (BKR-017) could help adults with type 1 diabetes improve insulin sensitivity and lower triglycerides. Six participants took the tablets for 28 days alongside their usual care. The goal was to see if this suppl…

This early study tested whether a single infusion of mesenchymal stem cells is safe for people with advanced COPD. Fifteen participants received the treatment and were monitored for any immediate side effects. The goal was to see if the procedure could be tolerated without causin…

This study looked at how an inhaled medication called treprostinil affects exercise ability in people with pulmonary hypertension caused by interstitial lung disease. 29 participants took the drug for 3 months. Researchers measured heart function and breathing efficiency during e…

This study tested whether two types of diabetes medications (DPP4 and SGLT2 inhibitors) are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 adults with these conditions and mild blood sugar issues took the drugs for 4 weeks.…

This study looked at people with stage 2 or 3 non-small cell lung cancer that cannot be removed by surgery. Participants received standard chemotherapy along with different doses of proton beam radiation to find the safest and most effective dose. The goal was to control the dise…

This study tested a treatment for patients with HPV-related throat cancer. It combined high-dose radiation therapy with the chemotherapy drug docetaxel to kill cancer cells more effectively. The goal was to improve tumor control and survival while monitoring side effects like mou…

This study looked at whether doing cardiac rehabilitation at home, or a mix of home and clinic visits, is as effective as going to the clinic for all sessions. 206 adults with heart conditions like heart attack or heart failure took part. The goal was to see if home-based options…

This study tested a drug called daratumumab in 49 patients with multiple myeloma who were eligible for a stem cell transplant. The goal was to see if adding daratumumab before and after transplant could clear more cancer cells from the bone marrow. Results focused on how many pat…

This study looked at how well a special laser (MP-TSCPC) works for people with glaucoma. The goal was to lower eye pressure and reduce the need for eye drops. 65 patients were followed for one year after the laser procedure.

This study tested a combination of two drugs, futibatinib and pembrolizumab, in 14 adults with advanced or metastatic liver cancer that had not responded to prior treatment. The goal was to see if the combination could stop or slow cancer growth. Participants received both drugs,…

This study tested a drug called alisertib, either alone or combined with the hormone therapy fulvestrant, in 96 postmenopausal women with advanced breast cancer that had stopped responding to standard hormone treatments. The goal was to see if these treatments could shrink tumors…

This study tested a shorter radiation treatment called proton-based SABR for men with early-stage prostate cancer. Instead of the usual eight weeks, patients received five treatments over two weeks. The goal was to see if this approach keeps side effects low and maintains quality…

This study looked at kidney transplant patients taking either a once-daily or twice-daily version of the anti-rejection drug tacrolimus. The goal was to see if the once-daily pill led to fewer side effects, better medication adherence, and improved quality of life. 261 adults who…

This study tested a new combination treatment for people with non-Hodgkin lymphoma that had come back. The approach used three steps: first, freezing the tumor to kill cancer cells; second, injecting a personalized vaccine made from the patient's own immune cells; and third, givi…

This study tested whether an artificial intelligence (AI) program can spot early signs of serious liver disease by analyzing a simple heart test (ECG). Researchers included 279 primary care doctors and their adult patients. The goal was to see if the AI tool leads to more new dia…

This study tested a new 3D ultrasound test called QTI to see if it works as well as MRI for finding breast cancer in women with a high risk of the disease. 26 women took part, and researchers compared the results from both scans. The goal was to see if QTI could be a simpler, eff…

This study looked at whether a new type of CT scanner (photon-counting detector CT) can provide clearer images of coronary artery disease compared to standard scans. 243 adults with suspected heart disease were scanned both with and without a drug that stresses the heart. The goa…

This study tested whether an artificial intelligence (AI) tool could help doctors detect cardiac amyloidosis, a rare but serious heart condition, earlier using standard electrocardiograms (ECGs). Over 20,000 patients were involved, with some doctors using the AI-enhanced ECG and …

This study compared two breast cancer screening methods—molecular breast imaging (MBI) and digital breast tomosynthesis (DBT)—in over 3,000 women aged 40-75 with dense breast tissue. MBI uses a small amount of radioactive material to spot active cancer cells, while DBT is a type …

This study looked at whether women can collect their own vaginal samples to test for HPV, the virus that can cause cervical cancer. Researchers compared self-collected samples to those taken by a doctor. The goal was to see if the self-test is accurate and acceptable to patients.

This study tested whether a computer that records heart sounds (called VoqX) can detect heart valve problems like aortic stenosis and mitral regurgitation. Researchers compared the computer's analysis to standard tests like echocardiograms. The goal is to see if this quick, non-i…

This study tested whether a special PET/MR scan using a tracer called F-18 florbetapir can help doctors see amyloid buildup in the nerves of people with amyloidosis. Eight adults with confirmed nerve amyloidosis or other nerve diseases took part. The goal was to see if the scan c…

This study tested whether a special PET scan using a radioactive tracer (68Ga-PSMA) can improve how doctors see and manage advanced liver cancer that has spread. 29 adults with liver cancer not treatable by surgery or transplant took part. The scan targets a protein common on liv…

This study tested whether a special radioactive tracer called 68Ga-PSMA, used with PET/MRI or PET/CT scans, can find liver cancer earlier and more accurately than standard scans. Researchers enrolled 52 people with liver cancer to compare the new imaging method with usual care. T…

This study tested whether an AI tool (DermAI) can help people read skin patch tests for contact dermatitis as accurately as a doctor. 151 participants had their skin reactions analyzed by both AI and human reviewers. The goal is to make remote allergy testing more practical and r…

This study tested whether MRI scans can help diagnose rheumatoid arthritis (RA) earlier in people with joint inflammation but no clear diagnosis. 75 adults with early symptoms were followed for a year. The goal was to see if MRI findings could predict who would develop RA, allowi…

This study tested whether a special type of PET/CT scan (PSMA PET) can help doctors see if treatment is working in patients with metastatic adenoid cystic carcinoma, a rare salivary gland cancer that has spread. Six adults who already had this cancer and were part of another stud…

This study tested a new, noninvasive method called SAVE that uses ultrasound to measure the stiffness of breast lumps. Researchers aimed to see if it can tell benign from malignant masses without a biopsy. The study involved 266 women with breast lesions and compared SAVE results…

This study tested a new global metabolomic approach to diagnose inborn errors of metabolism, such as congenital disorders of glycosylation. Researchers measured specific sugar-related molecules in blood and urine from 240 participants to see if this method works better than tradi…

This study looked at whether people with a history of non-muscle invasive bladder cancer prefer a urine-based molecular test (CxBladder Monitor) or a cystoscopy (a thin tube inserted into the urethra) for routine cancer surveillance. 107 participants tried both methods and report…

This study tested a new ultrasound technique called Nonlinear Elasticity Mapping (NEM) to better tell apart benign and cancerous breast lumps. Researchers measured how breast tissue stiffness changes under pressure in 172 women. The goal was to see if this method could improve di…

This study tested a new ultra-low-dose chest CT technique to find abnormal blood vessels in the lungs of children with hereditary hemorrhagic telangiectasia (HHT). The goal was to see if the scan could use much less radiation than usual while still detecting these vessels clearly…

This study tested whether using social networks could help Hispanic and Somali immigrants in Minnesota lose weight and lower their heart disease risk. About 475 people took part, and researchers measured weight, waist size, and heart health over 6 to 12 months. The goal was to se…

This study looked at 150 female athletes aged 14-24 who had already torn their ACL once. The goal was to find movement patterns that raise the risk of a second tear and test if special rehab exercises can lower that risk. Nearly one-third of athletes who return to sport after an …

This study looked at whether an education program helps low-income, uninsured adults aged 18-45 accept and complete a free HPV vaccine series. The goal is to prevent HPV-related cancers. About 100 people took part, and the study measured how many started and finished the vaccine …

This study tested whether rimegepant, a drug used for migraines, can reduce chronic abdominal pain in people with irritable bowel syndrome (IBS). 39 adults with non-constipation IBS took the medicine and reported their pain levels daily. The goal was to see if the drug could ease…

This small pilot study looked at whether varenicline, a drug used to help people stop smoking, can change how the rectum senses pressure in people with irritable bowel syndrome (IBS) who have chronic belly pain but not constipation. Eight adults took the drug and had balloon test…

This early study tested whether a special injection made from a patient's own blood (called A2MRP) is safe and can help with knee osteoarthritis pain. Twenty adults with moderate knee arthritis received the injection. The main goal was to check for side effects, and researchers a…

This study looked at whether increasing physical activity can improve physical functioning and quality of life in cancer survivors who are over 60 or live in rural areas. About 100 participants completed a 12-week virtual exercise program. Researchers measured changes in enduranc…

This early-stage study tested whether injecting a special mix of cells from a person's own belly fat into their arthritic knee is safe and doable. Nine adults with knee osteoarthritis received the injection. The main goal was to check for side effects, not to prove it works, so r…

This study tested whether distance Reiki therapy can improve quality of life and immune function in 30 adults with multiple myeloma who had a stem cell transplant. Participants received either real distance Reiki, sham (fake) Reiki, or no extra treatment. The goal was to see if R…

This pilot study tested whether acupressure, a non-invasive technique using finger pressure on specific body points, can help reduce anxiety in patients receiving chemotherapy. Thirty adults undergoing chemotherapy at Mayo Clinic who reported at least mild anxiety were offered a …

This pilot study tested whether rimegepant, a medication already used for migraines, could help prevent cluster headaches. Twenty adults with recurrent cluster headaches took the drug and researchers tracked how many attacks they had each week and how severe the pain was. The goa…

This small study tested whether adding brief lifestyle advice (like diet and exercise tips) to standard insomnia therapy (CBT-I) could improve sleep quality. Five adults with chronic insomnia participated. Researchers measured sleep quality and insomnia severity before and after …

This small pilot study tested whether people with eosinophilic esophagitis (EoE) triggered by milk could safely eat baked milk. Seven participants added baked milk to their diet for six weeks. The goal was to see if their esophagus healed and if they could find a safe amount of r…

This study tested a device that gently stimulates a nerve in the neck (nVNS) to see if it reduces symptoms like dizziness and fatigue in teenagers with POTS. Forty adolescents aged 12-19 took part. Researchers measured changes in symptom scores, daily function, and heart rate ove…

This study tested two different painkillers in 32 women having breast reduction surgery. One is a long-acting form (liposomal bupivacaine) and the other is a standard form (bupivacaine hydrochloride). The goal was to see which one provides better pain relief and reduces the need …

This study tested a special pain program for breast cancer survivors who have joint and muscle pain from taking aromatase inhibitors. The program aimed to reduce pain, improve mood and daily function, and help patients keep taking their medication. 105 women with early-stage horm…

This study tested if hypnotherapy delivered online could ease bloating symptoms. 27 adults with bloating as their main stomach issue took part. Researchers measured changes in bloating severity and quality of life using standard questionnaires.

This study looked at 121 people with blocked bile ducts (from benign or malignant causes) to compare how two drainage procedures affect quality of life. One method uses an endoscope through the mouth (ERCP), the other uses a needle through the skin (PTBD). Researchers measured ch…

This study looked at whether using electronic health records to track and manage common cancer symptoms—such as pain, fatigue, sleep problems, anxiety, and depression—can improve quality of life and reduce urgent care visits. Over 50,000 cancer patients took part. The goal was to…

This study tested whether a special conversation guide, built into electronic health records, could help over 81,000 adults use non-drug methods (like ice, heat, or relaxation) to control pain after surgery. The goal was to see if this approach improved pain, physical function, a…

This study tested whether giving methadone as a pill before heart surgery works as well as giving it through an IV during surgery for controlling pain afterward. 41 adults having planned heart surgery took part. Researchers measured how much extra pain medicine they needed and th…

This early study tested the drug dupilumab in 9 adults with moderate to severe chronic itching caused by liver disease. The goal was to see if it could reduce itch intensity. Participants rated their worst itch daily on a 0-10 scale before and after treatment. Results are explora…

This study tested a CBD cream against a placebo cream to see if it could reduce nerve pain, numbness, and tingling in the hands and feet caused by chemotherapy. Forty adults with cancer who had moderate to severe nerve pain used the cream daily for four weeks. The goal was to fin…

This study tested a myofunctional therapy nozzle that fits on a water bottle. By drinking through it daily, users exercise mouth and tongue muscles to potentially improve obstructive sleep apnea and snoring. 43 adults with mild to moderate sleep apnea participated, tracking their…

This study tested whether giving a much higher dose of water pills (diuretics) than usual is safe and works better for people hospitalized with worsening heart failure. Twenty adults received either ultrahigh or standard doses over 24 hours. The main goal was to see if the higher…

This study tested whether a nasal spray made with rose geranium in sesame oil can improve nose symptoms like dryness, discomfort, bleeding, or scabbing in cancer patients receiving chemotherapy. About 106 adults with cancer and nose symptoms joined this phase III trial. Half used…

This study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device, instead of relying solely on nurses. 161 participants were randomly assigned to either self-manage their sedation or receive standard n…

This study tested whether the drug PB can safely reduce excessive urination in people with certain kidney conditions, including inherited nephrogenic diabetes insipidus, lithium-induced diabetes insipidus, and polycystic kidney disease treated with tolvaptan. Thirty-six adults wi…

This study tested two different numbing creams on 22 adults getting laser treatment for sun-damaged skin. Each person tried both creams on different sides of their face to see which one caused less pain and fewer side effects like itching or burning. The goal was to find the best…

This study tested two different pain medicines given during a planned C-section: one injected into the spine (morphine) and one into a vein (methadone). The goal was to see which approach led to less total opioid use in the first two days after delivery. Thirty women participated…

This study tested whether using machine learning to plan radiation treatment reduces side effects for people with head and neck cancer. 204 adults receiving radiation therapy were randomly assigned to either machine-learning-assisted planning or standard planning. The main goal w…

This study tested two treatments—biofeedback (pelvic floor exercises with guidance) and injectable bulking agents (Solesta)—for people with severe fecal incontinence (leakage of stool). 275 adults who did not improve enough with basic management were randomly assigned to one trea…

This study tested whether a 5-minute calming virtual reality (VR) experience could reduce blood pressure and anxiety in adults with suspected white coat hypertension (high blood pressure only in the doctor's office). 79 participants had their blood pressure and anxiety measured b…

This study tested a health coaching program for caregivers of people with advanced lung cancer. 55 caregivers took part in coaching sessions and surveys over 6 months. The goal was to see if coaching could reduce caregiver stress and improve their well-being.

This study tested whether a shorter course of proton therapy (15 sessions) is as safe as the standard longer course (25 sessions) for women who had a mastectomy for breast cancer and need radiation to nearby lymph nodes. 88 women participated. The goal was to see if the shorter s…

This study tested whether a non-opioid painkiller called suzetrigine can help adults control pain and avoid opioids after outpatient facial plastic surgery. 100 adults took the drug as part of their standard pain plan. Researchers tracked how many opioid pills they used and wheth…

This study tested whether a headband that senses brain activity (Muse-S) can help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. Researchers measured changes in sleep quality and stress using questionnaires.

This study tested a team-based care program for 516 people with stage III or IV cancer. The program aimed to help them stay mobile, reduce pain, and improve quality of life. Researchers found that the program helped maintain physical function and eased pain over six months.

This study looked at whether a specific stretch called the sleeper stretch can help CrossFit athletes who have shoulder pain. 26 regular CrossFit participants were included. The goal was to see if the stretch improves shoulder movement, strength, and overall upper body performanc…

This study tested whether weighted blankets can reduce agitation and other behavioral symptoms in people with dementia. Thirty patients from hospital and hospice settings participated. Researchers measured changes in agitation and overall symptom burden using standard scales. The…

This study tested a pain management program for 51 cancer survivors living in rural areas or who are Hispanic. The goal was to see if the program was easy to use and helpful for controlling cancer-related pain. Researchers measured how often participants used the program and how …

This pilot study tested whether vagal nerve stimulation could reduce fatigue and headaches in people with Post-COVID syndrome. 18 participants used the device and reported changes in their symptoms. The goal was to see if this approach is worth studying further.

This study looked at over 386,000 adults with type 2 diabetes to compare four common second-line medications (GLP-1 agonists, SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas) for their effects on heart health and other outcomes. Researchers used existing medical records to …

This study looked at how surgery on unborn babies with birth defects like spina bifida affects the immune system of both the mother and the baby. Researchers wanted to understand if immune system changes might cause some babies to be born too early. The study involved 21 pregnant…

This study looked at 50 adults having spine surgery to see if different ways of closing the wound affect blood flow around the cut. Researchers used a special dye and camera to measure blood flow after closing with three different methods. The goal was to learn which technique mi…

This study looked at whether a blood enzyme called tryptase can help predict knee stiffness and pain after total knee replacement. Researchers measured tryptase levels before and after surgery in 219 people with knee arthritis. The goal was to see if changes in this enzyme are li…

This study used a special brain scan (PET) to look at a protein called tau in people with primary progressive aphasia (PPA) and frontotemporal dementia (FTD). Researchers wanted to see how much tau buildup was in different parts of the brain and if it matched the type of symptoms…

This study looked at immune cells in bone marrow and lymph nodes of kidney transplant donors and recipients. The goal was to create a detailed immune profile to better understand how the immune system responds to transplantation. 288 participants were involved, including both pre…

This study involved 56 older adults (65+) with multiple myeloma to see if a comprehensive geriatric assessment—a series of questions and tests about physical and mental health—along with blood tests, could predict who would have more side effects from chemotherapy. The goal is to…

This study looked at 170 people having surgery to find the best time to place a breathing tube. Doctors checked how easy it was to see the vocal cords and insert the tube at different levels of muscle relaxation. The goal was to improve the process and make intubation safer and m…

This study tested a device called SimPull to see if it helps move patients from one bed to another more easily. Researchers at Mayo Clinic worked with 100 patients who needed heart procedures. They measured how long transfers took, how many staff were needed, and whether clinicia…

This study looked at whether postmenopausal female endurance athletes have stiffer hearts and lower exercise capacity compared to premenopausal women and men of similar age. Researchers measured heart stiffness using MRI and exercise ability with stress tests. The goal was to und…

This study looked at how certain immune cells (eosinophils) interact with fat tissue in people with obesity and insulin resistance. Four participants had fat biopsies and blood tests to measure immune cell levels and inflammation. The goal was to better understand these interacti…

This study looked at how well women of color understand their personal risk of developing breast cancer. Researchers surveyed 324 women aged 18 to 50 with no history of breast cancer. The goal was to measure their perceived lifetime risk and compare it to actual risk, helping to …

This study tested a mobile-friendly app called HERCaRE designed to help Black breast cancer survivors manage life after treatment. The app provides culturally tailored educational materials and health equity resources. Researchers measured how often participants used the app and …

This study tested a new way of using a breathing machine (ventilator) called VentCoach, designed to better protect the lungs of patients with severe breathing problems. 18 adults on ventilators for over 24 hours were included. The main goal was to see if doctors could follow the …

This study looked at whether video visits (telehealth) are as satisfying as in-person clinic visits for people with brain tumors (gliomas) who are taking oral chemotherapy. Thirty patients alternated between telehealth and in-person checkups, and researchers measured their satisf…

This study tested whether a special PET scan (18F-FDOPA-PET) can help doctors better plan surgery and radiation for people with newly diagnosed brain tumors called gliomas. Twenty-four adults took part, and researchers compared the scan results with tissue samples to see if the s…

This study tested whether a wearable device and smartphone app can better track vital signs and symptoms in cancer patients than standard in-clinic checks. About 100 adults with various cancers participated. The goal was to see if remote monitoring could detect complications like…

This study tested whether ultrasound can measure the movement of tendons and nerves inside the wrist. Researchers compared 257 people with and without carpal tunnel syndrome. The goal was to see if ultrasound can detect differences in tissue thickness and motion, which may help u…

This study looked at whether voice and speech patterns change during manic episodes in people with Bipolar I Disorder. Researchers analyzed audio recordings from 17 hospitalized participants for pitch, rhythm, grammar, and word use. The goal was to find objective markers that cou…

This study looked at different methods for taking tissue samples from the bile duct during a procedure called ERCP. Researchers wanted to see which technique was safest and most accurate for diagnosing cancer or other diseases. Over 300 adults with narrowed bile ducts took part. …

This study looked at whether saliva samples can be used to remotely monitor cytomegalovirus (CMV) infection in people receiving treatment for ovarian cancer. Researchers collected both saliva and blood samples from 49 participants to compare accuracy. The goal was to see if at-ho…

This study looked at over 2,400 people with rheumatic diseases who were taking methotrexate. Researchers compared those who had fewer lab tests to those who had standard monitoring to see if it was safe. The goal was to find out if less frequent blood work could still protect aga…

This study looked at how much vitamin D sulfate is in breastmilk and whether it reaches infants. Researchers collected milk samples from 101 breastfeeding mothers before and after they took vitamin D supplements for 28 days. They also tested the babies' saliva and gut contents to…

This study looked at how the way blood samples are collected and processed affects the ability to detect tumor DNA in people with early-stage breast cancer (stages I-III). Researchers tested different blood collection tubes, storage methods, and processing steps to see which ones…

This study looked at whether detergents found in everyday products like toothpaste can make the lining of the esophagus leaky and cause allergic inflammation. Researchers tested 12 healthy volunteers by measuring changes in the esophagus after exposure to detergents. The goal was…

This study tested whether 3D surface images can be used instead of standard CT scans to plan electron radiation therapy for cancer. Researchers used plastic models (not real patients) to compare the accuracy of 3D scans with CT scans. If successful, this approach could reduce rad…

This study looked at how the asthma drug mepolizumab affects gene activity in 20 adults with severe eosinophilic asthma. Researchers collected blood samples before and after 12 weeks of treatment to find which genes changed. The goal was to better understand how the drug works, n…

This study tested a home-based lifestyle program for people with severe sleep apnea and obesity. 17 adults used remote monitoring devices and received health coaching to improve their health and quality of life. The main goal was to see if the system was easy to use and helpful, …

This study tested whether the probiotic Saccharomyces boulardii can improve the gut's ability to keep harmful substances from leaking into the body. Researchers gave healthy adults either the probiotic or a placebo and measured changes in gut permeability and related markers. The…

This study looked at 101 adults with post-traumatic headache after a mild brain injury to find out why some headaches become long-lasting. Researchers tracked headache patterns, pain sensitivity, brain scans, and blood markers over time. The goal was to identify predictors and wa…

This study checked how well a computer-controlled treadmill can create precise balance disturbances. Twelve healthy adults walked on the treadmill while sensors measured the treadmill's movements. The goal was to see if the treadmill's actual movements matched what it was command…

This study looked at how resistance exercise (like weight lifting) improves insulin sensitivity and muscle health in people with insulin resistance and obesity. Researchers studied 58 adults aged 50-75 to understand changes in muscle strength, insulin response, and body compositi…

This study looked at how often patients have lasting muscle weakness after liver transplant surgery when given a drug called Sugammadex. Researchers used a device on the thumb to measure muscle strength in 97 patients. The goal was to understand recovery better and improve anesth…

This small study tested whether a simple pulse flowmeter could detect active bleeding in 13 adults undergoing emergency endoscopy for gastrointestinal bleeding. Researchers compared pulse volume changes before and after the procedure to see if the device could predict bleeding wi…

This study looked at how a drug called LCZ696 (used for heart failure) affects the kidneys and heart in 72 people with type 2 diabetes, some with early signs of heart stiffness and some without. The goal was to understand if this drug can prevent the progression to symptomatic he…

This study from Mayo Clinic talked to 33 adults with brain or central nervous system tumors, along with their caregivers, to learn about their biggest struggles and what kind of support they need. Researchers conducted interviews to understand the patient and caregiver experience…

This study looked at the DNA of breast tumors from 140 people to find out why some cancers are destroyed by standard chemotherapy and others are not. Researchers collected tumor samples before and after treatment to identify genetic changes. The goal is to use this information to…

This study looked at whether certain genes make people more likely to develop primary biliary cirrhosis (PBC), a progressive liver disease. Researchers collected genetic samples from 1,500 people, including PBC patients and their close relatives. The goal was to identify inherite…

This study tested a portable headset that sends tiny electrical currents through the skin to help people hear sounds and speech. Researchers worked with 68 healthy Mayo Clinic employees to find the best settings for the device. The goal was to see if this noninvasive method could…

This study looked at whether a home-based pulmonary rehabilitation program using new technology and health coaching helps people with COPD stick with their recovery plan after leaving the hospital. It compared this approach to the usual method of referring patients to a center-ba…

This study looked at the molecular changes in the skin of 20 breast cancer patients undergoing radiation therapy. The goal was to understand why some patients develop itchy, dry, or red skin (radiation dermatitis). By taking small skin samples, researchers hope to find better way…

This study tested whether a breath analysis test could help diagnose or predict the course of liver diseases, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants to detect unique chemical patterns. The goal was to develop a non-invasive diagnosti…

This study looked at heart changes in 24 people receiving radiation or chemo-radiation for lung or esophageal cancer. Participants had a small heart monitor implanted to track any heart problems that might otherwise go unnoticed. The goal was to better understand how cancer treat…

This study tested a new type of gamma camera (the Veriton system) to see if it produces better images than a standard camera used in nuclear medicine. 41 adults who were already scheduled for a nuclear medicine exam took part. The goal was to compare image quality between the two…

This study looked at 13 people with reflux or swallowing problems to see which breathing positions create the most pressure at the junction between the esophagus and stomach. Researchers used a thin tube to measure pressure while participants performed different breathing maneuve…

This study collected information and samples from 105 breast cancer survivors and healthy volunteers to create a detailed database. The goal is to help researchers better understand long-term health after breast cancer, including the role of gut bacteria. This database will suppo…

This study watched conversations between 37 lung cancer patients and their doctors to create a decision aid. The tool helps patients who have had surgery decide whether to have extra treatment. No drugs were tested; the goal was to improve shared decision-making.

This study looked at whether gradually reducing opioid medications over a long period affects pain, quality of life, and mood in people with chronic non-cancer pain. Eighteen adults on stable opioid doses participated. The goal was to see if tapering causes worsening symptoms com…

This study looked at how well surgical teams and patients adopt non-drug methods for managing pain after surgery, like relaxation or physical therapy. Researchers interviewed 372 patients and care team members to find out what helps or hinders the use of these approaches. The goa…

This study tested a program called Mates in Motion, which helps blood cancer patients and their caregiving partners become more physically active together. The program teaches communication and behavior change skills to support each other in walking and staying active. Researcher…

This study looked at why some people develop lasting headaches after a mild head injury and tested whether the migraine drug erenumab could help. Six adults with new post-traumatic headaches received either the drug or a placebo. The goal was to see if the drug could reduce heada…

This study collected brain wave (EEG) data from 29 people at different stages of Alzheimer's disease, from those with no symptoms to severe dementia. Researchers also included people with a related condition called dementia with Lewy bodies. The goal was to see if EEG patterns co…

This study tested whether a special PET scan (18F-DOPA) can better detect brain tumors during radiation planning for people with newly diagnosed gliomas. About 91 participants received the scan before and during radiation therapy. The goal was to see if this imaging method helps …

This study tested whether a special MRI sequence called ZTE can make bone cement breast biopsy markers easier to see than standard metal markers. Twenty adults with breast cancer took part. Two radiologists scored how well the markers showed up on the scans. The goal was to see i…

This study tested whether a simple, portable ECG device connected to a smartphone could help screen close relatives of people with dilated cardiomyopathy (a weakened heart muscle). 119 adults participated, including patients and their first-degree relatives. The goal was to see h…

This study tested 892 African and Asian immigrants in Minnesota for hepatitis B and C to understand how common these infections are and how they increase the risk of liver cancer. Researchers also looked at viral genetics and immune responses. No treatment was given; the goal was…

This study looked at how obesity changes muscle fiber types and protein production. Researchers measured how fast muscles make new proteins in 48 lean and obese adults. They used exercise and amino acid infusions to see how these factors affect muscle health. The goal was to unde…

This study followed 66 women for 3 months after a scheduled C-section to see how their health and pain changed over time. Researchers used simple scales to track recovery, aiming to find when most women feel back to normal. The goal was to better understand typical recovery patte…

This study looked at whether wearing the InBody Band 3 fitness tracker could help Black prostate cancer survivors become more active, improve their body composition, and feel better overall. Thirteen people took part for six weeks. The goal was to see if using the tracker was pra…

This study aimed to find the highest safe concentrations of midazolam, ketamine, and ondansetron for skin allergy testing. These drugs are commonly used before, during, and after surgery. Researchers tested 21 healthy volunteers to determine doses that would not cause false skin …