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New study aims to stop second ACL injuries in young female athletes

NCT ID NCT03190889

Prevention Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 150 female athletes aged 14-24 who had already torn their ACL once. The goal was to find out which movement patterns put them at higher risk for a second ACL tear and to test if special rehab exercises could lower that risk. By identifying high-risk athletes early, the researchers hope to prevent career-ending injuries and long-term joint problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

150 people

The number who actually took part.

Started

Aug 2018

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 30 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age, 13 ≥ 30 years * Acute (\< 6 months), first-time, isolated ACL injury * No history of previous knee surgery to either extremity * No low back or lower extremity injury in the year prior to ACL injury necessitating medical care * Pre-injury participation in cutting, jumping or pivoting sports for ≥ 50 hours/year * Mechanism of injury did not involve a direct blow to the knee. * Patients who sustain a medial collateral ligament (MCL) injury are eligible for study participation if medial knee instability is resolved prior to surgery * Patients with simple meniscus tears (i.e., 2 cm vertical longitudinal tear) that do not necessitate alterations in rehabilitation will be eligible for study participation Exclusion Criteria: * History of previous knee surgery to either extremity * Low back or lower extremity injury in the year prior to ACL injury necessitating medical care * Second or greater ACL injury * Greater than 6 months since occurrence of ACL injury * Lack of participation in cutting, jumping, or pivoting sport * Mechanisms of injury involved a direct blow of force to the knee * Patients with MCL injury that exhibits unresolved medial knee instability * Patients with complex, repairable meniscus tears (i.e., radial or root repair) and patients with full thickness articular cartilage lesions will not be eligible for participation secondary to significant alterations to postoperative rehabilitation protocol

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Conditions

The condition(s) this trial relates to.

Athletic Injuries Knee Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acl reconstruction Rehabilitation

Contacts and locations

Locations

  • Emory University

    Flowery Branch, Georgia, 30542, United States

  • Mayo Clinic Square

    Minneapolis, Minnesota, 55403, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

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