Mayo Clinic

This early-stage trial tested a new drug called NXP800 in 7 people with advanced bile duct cancer that had spread or stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could slow tumor growth. The study was terminated early, so results…

This early-phase trial tested a specially modified virus (VSV-IFNb-TYRP1) in 12 people with advanced melanoma that had spread or couldn't be removed. The virus was injected directly into tumors and into a vein to see if it could safely trigger the immune system to attack cancer c…

This early-phase study tested whether combining the immunotherapy drug durvalumab with a special type of radiation called grid therapy could help patients with non-small cell lung cancer whose cancer had stopped responding to durvalumab alone. Only 4 patients were enrolled before…

This study tested the drug abemaciclib in 26 women with triple negative breast cancer that did not respond to standard chemotherapy. The goal was to see if the drug could increase immune cell activity in the tumor before surgery. The trial was stopped early, but results may help …

This study looked at whether adding a precise type of radiation (stereotactic body radiation therapy) to standard chemotherapy could help people with pancreatic cancer that has spread to only a few places in the body. The goal was to see if the combination could better control tu…

This early-stage trial tested a drug called STI-3031, given directly into lymph nodes or vessels using a special device, for people with in-transit melanoma (skin cancer that has spread along lymph channels). The goal was to find a safe dose and check for side effects. Only 3 peo…

This study tested whether adding an immunotherapy drug (bintrafusp alfa) to standard chemotherapy (docetaxel) helps people with advanced non-small cell lung cancer whose disease got worse after prior treatment. Only 10 people enrolled before the study was stopped early. The goal …

This study tested a combination of two drugs, daratumumab and ibrutinib, in people whose chronic lymphocytic leukemia (CLL) had returned or stopped responding to prior treatment. The goal was to see if the combination could shrink or control the cancer better than ibrutinib alone…

This study tested a genetically modified measles virus designed to kill cancer cells without harming healthy ones, compared to standard chemotherapy. It included 17 women with ovarian, fallopian tube, or peritoneal cancer that no longer responded to platinum-based treatments. The…

This study tested a new drug, obinutuzumab, against the standard drug rituximab for people with a rare autoimmune disease that inflames blood vessels (ANCA-associated vasculitis). The goal was to see if obinutuzumab could better stop disease activity and clear harmful antibodies.…

This study tested a precise type of proton radiation (SBPT) for people with liver cancer that had not spread. The goal was to see if this treatment caused fewer liver problems than standard radiation. The trial was stopped early after enrolling only 9 participants, so the results…

This study looked at patients leaving the hospital with a chest tube and valve for a prolonged air leak. Half received antibiotics and twice-weekly phone check-ins; the other half got standard care. The goal was to see if extra monitoring and antibiotics could reduce infections a…

This study tested a combination of two drugs, ibrutinib and ixazomib, in 21 people with Waldenström macroglobulinemia, a rare blood cancer. The goal was to see if the combo could shrink tumors or stop the cancer from growing. The study was stopped early, so results are limited, b…

This study tested a drug called P1101 in 11 people with early myelofibrosis, a bone marrow disorder. The goal was to see if it could shrink the spleen, improve symptoms, or slow the disease. The trial was stopped early, so results are limited.

This study tested whether a special PET scan using a tracer called fluciclovine can help doctors tell the difference between a brain tumor that has come back and damage caused by radiation therapy. About 19 people with brain metastases who had suspicious MRI results took part. Th…

This small pilot study tested whether a special PET scan could detect early, symptom-free heart inflammation caused by immune checkpoint inhibitor cancer drugs. Only 2 people took part before the study ended. The goal was to see if this imaging method could identify hidden heart …

This study compared a standard lung biopsy method (EBUS TBNA) with the same method plus a new laser imaging tool (nCLE) and a dye (fluorescein) to see if it could better diagnose lung cancer in people with small lung nodules. Only 3 people took part before the study was stopped e…

This study tested whether a special smartwatch (LIFELEAF) could measure blood sugar, blood pressure, and heart activity as accurately as standard medical tests. Researchers compared the watch's readings to traditional methods in 87 diabetic patients. The goal was to see if a simp…

This study looked at whether tiny bits of genetic material (extracellular RNA) found in the blood can help doctors diagnose liver cancer or other liver diseases. Researchers planned to enroll about 1,865 people with liver cancer, bile duct cancer, cirrhosis, or chronic liver dise…

This study tested the drug fenofibrate (Lofibra) to see if it could prevent a type of bile duct injury called ischemic cholangiopathy in people who received a liver from a donor after circulatory death. Only 6 participants were enrolled before the study was stopped early. The goa…

This study tested whether a technique called axillary reverse mapping with lympho-venous bypass could prevent lymphedema (arm swelling) in people having lymph nodes removed for breast cancer or melanoma. The approach aimed to reroute lymph fluid to reduce swelling. The study was …

This study tested whether a tamoxifen gel applied to the skin could work as well as the pill form to lower breast cancer risk in women with certain high-risk breast conditions. About 65 women with atypical hyperplasia or lobular carcinoma in situ were planned to take part. The tr…

This study tested a device called SinuSonic that uses sound vibrations and breathing pressure to reduce facial pain and pressure from sinus headaches. It included 27 adults with facial pain lasting more than 3 months. The study was stopped early, and the main goal was to see if t…

This study aimed to see if a paravertebral block (a type of nerve block) reduces pain and hospital stay after open pancreatic surgery compared to no block. Only 2 people took part before the study was stopped. Researchers planned to measure pain scores, complications, and length …

This study aimed to see if the antibiotic rifaximin could reduce bloating in people with diabetic gastroparesis, a condition where the stomach empties slowly. Only 5 adults with diabetes and confirmed slow stomach emptying were enrolled. The trial was terminated early, so results…

This study looked at whether a remote electrical device called Nerivio could reduce the pain of Botox injections for chronic migraine. About 80 people who already get Botox for migraines were to use the device during their injection visit. The study was stopped early, so results …

This study aimed to find the best dose of a pain medicine (hydromorphone) given through a spinal injection to children having back surgery for scoliosis. Researchers wanted to control pain well while reducing side effects like itching. The study was stopped early, but it included…

This study tested the antibiotic rifaximin in 20 people with early-stage HER2-positive breast cancer who had stomach problems from pertuzumab-based chemotherapy. The goal was to see if rifaximin could reduce side effects like diarrhea and belly pain, helping patients stay on thei…

This study aimed to see if remote monitoring devices could help predict how well patients recover after major surgery. Researchers planned to track 56 adults before and after their operation using wearable sensors. The study was terminated early, so results are limited.

This study aimed to find early warning signs of heart failure in people with sarcoma who receive chemotherapy. Researchers used advanced heart ultrasound techniques to track changes over time. The goal was to identify which patients are at highest risk for heart damage, so doctor…

This study looked at whether adding a genetic risk score to standard breast cancer risk tools helps African American and Hispanic women decide on extra screening or prevention. About 19 women took part. The goal was to see if personalized genetic information improves understandin…

This study aimed to find genetic changes in lung tissue and blood that could help predict how squamous cell lung cancer progresses. Researchers planned to collect samples from 200 people having a lung procedure. The study was stopped early and enrolled only 22 participants, so re…

This study tested a device called Brain4Care that measures pressure inside the skull without needing surgery. It included 6 adults with brain lesions at risk of swelling. The goal was to see if the device is safe and effective for monitoring, but the study was stopped early.

This study aimed to see if genome sequencing could help doctors choose better treatments for people with multiple lung cancer tumors. It planned to enroll 100 adults with early-stage lung adenocarcinoma. However, the study was stopped early, so no clear conclusions were reached.

This study looked at whether how well the heart pumps blood affects how quickly patients recover from muscle relaxants given during surgery. It involved 7 adults having elective surgery who needed a special heart monitor. The study was stopped early, so results are limited.

This study tested a device called the Aeonose, which analyzes breath to see if it can tell whether a person is fasting or not. Researchers collected breath samples from adults before and after routine endoscopy procedures. The goal was to see if the device's pattern recognition c…

This study aimed to see if DNA markers found in urine could help detect prostate cancer. Researchers planned to collect urine and prostate fluid samples from 24 men with or at risk for prostate cancer. The study was terminated early, so results are limited.

This study aimed to find out how often people with chronic hepatitis C have a blood condition called monoclonal B-cell lymphocytosis (MBL) and whether treating hepatitis C affects MBL. Researchers collected blood samples from 29 participants before, during, and after hepatitis C …