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Could a rose geranium spray soothe Chemo-Related nose pain?

NCT ID NCT04620369

Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a nasal spray made from rose geranium in sesame oil can improve symptoms of nasal vestibulitis—like dryness, discomfort, bleeding, and scabbing—in cancer patients receiving chemotherapy. Over 100 participants were randomly assigned to use either the rose geranium spray or a plain saline spray for two weeks. The goal was to see if the herbal spray worked better than saline at easing the most bothersome nose symptom.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
rose geranium in sesame oil nasal spray
What this could lead to
If it works, this could offer a simple, natural option to ease nose discomfort, dryness, and bleeding for cancer patients on chemotherapy.
What could go wrong
This is a completed phase III trial, but the results are not yet widely confirmed. The improvement may be modest or similar to saline, and it only targets symptoms, not the underlying cancer or nasal condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

106 people

The number who actually took part.

Started

Nov 2020

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * REGISTRATION-INCLUSION CRITERIA * Age \>= 18 years and be diagnosed with cancer and receiving chemotherapy * Ability to provide informed consent * Willingness to complete questionnaires * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, 2 * One or more of the following nasal symptoms for which the patient reports they would appreciate treatment. Symptoms must have started after the initiation of systemic, antineoplastic therapies, be attributed to the systemic, antineoplastic therapies, and symptoms must be reported as being moderate (corresponding to a score of 2) or worse on a scale from mild (1) to very severe (4) on at least one of the items below. * Dryness * Discomfort/pain * Bleeding * Scabbing * Sores Exclusion Criteria: * REGISTRATION-EXCLUSION CRITERIA * Predisposition to epistaxis prior to the initiation of cancer-directed therapy (more than once a month over the previous year) * Planned initiation or continuation of any topical nasal treatment other than the studied nasal spray,(such as nasal steroids, Ayr nasal gel, Neosporin ointment or nasal administration of petroleum jelly). Taking Imitrex for migraines is acceptable * Previous exposure to rose geranium in sesame oil nasal spray * Concurrent upper respiratory tract infection * History of allergic or other adverse reactions to sesame oil or essential rose geranium oil * Any other reason that the study clinician or investigator feels precludes safe or appropriate inclusion in this study * Vulnerable populations: pregnant women, prisoners, mentally handicapped * RE-REGISTRATION * The patient will be un-blinded and determined to have been on the saline arm, when initially randomized

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Conditions

The condition(s) this trial relates to.

cancer hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hematopoietic and lymphoid cell neoplasm Malignant solid neoplasm Nasal vestibulitis

Contacts and locations

Locations

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota, 56636, United States

  • Essentia Health - Fosston

    Fosston, Minnesota, 56542, United States

  • Essentia Health - International Falls Clinic

    International Falls, Minnesota, 56649, United States

  • Essentia Health - Park Rapids

    Park Rapids, Minnesota, 56470, United States

  • Essentia Health Cancer Center

    Duluth, Minnesota, 55805, United States

  • Essentia Health Ely Clinic

    Ely, Minnesota, 55731, United States

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota, 55746, United States

  • Essentia Health Saint Joseph's Medical Center

    Brainerd, Minnesota, 56401, United States

  • Essentia Health Saint Mary's - Detroit Lakes Clinic

    Detroit Lakes, Minnesota, 56501, United States

  • Essentia Health Sandstone

    Sandstone, Minnesota, 55072, United States

  • Essentia Health Virginia Clinic

    Virginia, Minnesota, 55792, United States

  • Fairview Grand Itasca Clinic & Hospital

    Grand Rapids, Minnesota, 55744, United States

  • Fairview Northland Medical Center

    Princeton, Minnesota, 55371, United States

  • Fairview Range Medical Center

    Hibbing, Minnesota, 55746, United States

  • Mayo Clinic Health System in Albert Lea

    Albert Lea, Minnesota, 56007, United States

  • Mayo Clinic Health Systems-Mankato

    Mankato, Minnesota, 56001, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • Monticello Cancer Center

    Monticello, Minnesota, 55362, United States

  • Sanford Cancer Center Worthington

    Worthington, Minnesota, 56187, United States

  • Sanford Thief River Falls Medical Center

    Thief River Falls, Minnesota, 56701, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.