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New MRI method could unlock secrets of chronic muscle pain

NCT ID NCT05604066

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This study tests a new imaging method called MR Elastography to measure how muscles and their surrounding tissues move in people with myofascial pain syndrome. Researchers will compare results from 106 participants, including those with chronic pain and healthy volunteers. The goal is to find better ways to diagnose and understand this painful condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Apr 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Healthy Volunteer Inclusion Criteria: * Absence of a history of chronic pain in the targeted anatomical location (i.e., lower back and low extremities) that had limited activities of daily living or work * A numerical current pain index of less than 0.5 (on a 10-point Visual Analog Scale) * Able to understand the goal of the project and give informed consent. Healthy Volunteer Exclusion Criteria: * Pregnancy or breastfeeding * Any contraindication to an MRI exam * Previous severe/acute back or low extremity injury (including fracture) * Previous back or low extremity surgery * Back and lower limb deformities * Inability to provide consent. Myofascial-Related Pain Patient Inclusion Criteria: * A history of chronic low back or leg pain (the targeted location will be determined based on the findings in Aim 1) for at least 3 months. (Measured by patient history and physical exam) * A palpable taut band or nodule within the skeletal muscle * Hypersensitive tender spot within the taut band * Recognition of current pain complaint by pressure on the tender nodule/taut band * Painful limit to the full stretch range of motion Myofascial-Related Pain Patient Exclusion Criteria: * Pregnancy or breastfeeding * Any contraindication to an MRI exam * Previous therapy in the area to be treated within 6 months * Previous severe back or low extremity injury (including fracture) or surgery * Any neurological conditions or active systemic disease (e.g. diabetes, peripheral vascular disease, cancer, rheumatoid arthritis) that impaired sensation/pain perception * Severe osteoarthritis * Skin injuries in the area to be treated * Inability to provide consent.

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Conditions

The condition(s) this trial relates to.

myofascial pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myofascial pain

Contacts and locations

Locations

  • Mayo Clinic Minnesota

    Rochester, Minnesota, 55905, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.